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Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 6759 - 13
Aging-associated decrease in internal anal sphincter (IAS) tone (AADI) is a major contributor in the rectoanal incontinence (RI). To determine the pathogenesis... 
FECAL INCONTINENCE | ACTIVATION | BASAL TONE | RAT | PATHWAY | SMOOTH-MUSCLE TONE | MULTIDISCIPLINARY SCIENCES | RHO-KINASE | RHOA/ROCK | UP-REGULATION | EXPRESSION | G protein-coupled receptors | Biotinylation | Thromboxane A2 | Smooth muscle | Arrestin | Sphincter | Muscle contraction | Contraction | Protein turnover | b-Arrestin | Polymerase chain reaction | Internalization | Angiotensin | Aging | Colon | Angiotensin II | Regulatory proteins
Journal Article
Journal Article
Gastroenterology, ISSN 0016-5085, 2009, Volume 136, Issue 3, pp. 1109 - 1112
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 2013, Volume 304, Issue 8, pp. G723 - G731
Singh J, Rattan S. Role of PKC and RhoA/ROCK pathways in the spontaneous phasic activity in the rectal smooth muscle. Am J Physiol Gastrointest Liver Physiol... 
Phasic activity | Rectoanal incontinence | Smooth muscle | Protein kinase C | Rho kinase | CALPHOSTIN-C | PROTEIN-KINASE-C | FECAL INCONTINENCE | PHYSIOLOGY | LIGHT-CHAIN PHOSPHATASE | rectoanal incontinence | smooth muscle | RHO-KINASE | PHOSPHATASE-TARGETING SUBUNIT | phasic activity | NITRIC-OXIDE | INTERNAL ANAL-SPHINCTER | INHIBITOR Y-27632 | GASTROENTEROLOGY & HEPATOLOGY | protein kinase C | MYOSIN PHOSPHATASE | Phosphorylation - physiology | Maleimides - pharmacology | rhoA GTP-Binding Protein - metabolism | Phorbol 12,13-Dibutyrate - pharmacology | Fecal Incontinence - metabolism | rho-Associated Kinases - antagonists & inhibitors | Carcinogens - pharmacology | Rectum - physiology | rho-Associated Kinases - metabolism | Protein Kinase C - metabolism | Indoles - pharmacology | Muscle, Smooth - physiology | Phosphorylation - drug effects | Amides - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Protein Kinase C - antagonists & inhibitors | Fecal Incontinence - physiopathology | Rats, Sprague-Dawley | Naphthalenes - pharmacology | Rectum - enzymology | Animals | Signal Transduction - drug effects | Muscle Contraction - drug effects | Muscle Contraction - physiology | Signal Transduction - physiology | Pyridines - pharmacology | Muscle, Smooth - enzymology | Physiological aspects | Cellular signal transduction | Research | Health aspects | Protein kinases | Neuroregulation and Motility
Journal Article
Gastroenterology, ISSN 0016-5085, 2008, Volume 134, Issue 7, pp. 2179 - 2181
Journal Article
Gastroenterology, ISSN 0016-5085, 2015, Volume 148, Issue 4, pp. S-299 - S-299
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 09/2012, Volume 303, Issue 6, pp. 713 - 722
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 11/2006, Volume 291, Issue 5, pp. 830 - 837
The internal anal sphincter (IAS) tone is important for the rectoanal continence. The RhoA/Rho kinase (ROK) pathway has been associated with the... 
Internal anal sphincter | Regulatory targeting subunit of myosin light-chain phosphatase | Spontaneous tone | Endogenous inhibitory protein of PPICα | Catalytic subunit of myosin light-chain phosphatase | RHO-ASSOCIATED KINASE | SIGNAL-TRANSDUCTION PATHWAYS | PHYSIOLOGY | INHIBITORY PROTEIN | LIGHT-CHAIN PHOSPHATASE | PHOSPHORYLATION | spontaneous tone | CPI-17 | CA2+ SENSITIVITY | CONTRACTION | internal anal sphincter | endogenous inhibitory protein of PPIC delta | catalytic subunit of myosin light-chain phosphatase | INTERNAL ANAL-SPHINCTER | GASTROENTEROLOGY & HEPATOLOGY | MYOSIN PHOSPHATASE | regulatory targeting subunit of myosin light-chain phosphatase | Immunoblotting | Male | Muscle Proteins - biosynthesis | RNA - isolation & purification | Phosphoprotein Phosphatases - biosynthesis | rho-Associated Kinases | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Muscle, Smooth - physiology | Protein Phosphatase 1 | Isometric Contraction - physiology | Amides - pharmacology | Muscle Tonus - physiology | Phosphoproteins - biosynthesis | Protein-Serine-Threonine Kinases - physiology | Carrier Proteins - biosynthesis | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Phosphoproteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Muscle Proteins - genetics | Carrier Proteins - genetics | RNA - biosynthesis | Animals | Phosphoprotein Phosphatases - genetics | Muscle Contraction - physiology | Pyridines - pharmacology | In Vitro Techniques | Intracellular Signaling Peptides and Proteins - physiology
Journal Article
Gastroenterology, ISSN 0016-5085, 2012, Volume 142, Issue 5, pp. S-898 - S-898
Journal Article
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 06/2007, Volume 292, Issue 6, pp. 1747 - 1756
Sustained contractions of smooth muscle cells (SMC) maintain basal tone in the internal anal sphincter (IAS). To examine the molecular bases for the myogenic... 
Smooth muscle tone | Tonic smooth muscle | RhoA/ROCK | CA2+ SENSITIZATION | PROTEIN-KINASE-C | PHYSIOLOGY | RHO-KINASE | RELAXATION | smooth muscle tone | ESOPHAGEAL | LIGHT-CHAIN PHOSPHORYLATION | SIGNAL-TRANSDUCTION | CIRCULAR MUSCLE | CONTRACTION | tonic smooth muscle | GASTROENTEROLOGY & HEPATOLOGY | MYOSIN PHOSPHATASE | Phosphorylation | Guanine Nucleotide Dissociation Inhibitors - metabolism | Phosphoprotein Phosphatases - metabolism | Maleimides - pharmacology | Male | rhoA GTP-Binding Protein - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Anal Canal - metabolism | Dose-Response Relationship, Drug | Muscle, Smooth - drug effects | Botulinum Toxins - pharmacology | Rectum - drug effects | Protein Kinase C - metabolism | rho-Associated Kinases | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Anal Canal - cytology | Indoles - pharmacology | Anal Canal - enzymology | Anal Canal - drug effects | Myocytes, Smooth Muscle - metabolism | Protein Phosphatase 1 | Protein-Serine-Threonine Kinases - metabolism | Amides - pharmacology | Myocytes, Smooth Muscle - enzymology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Rectum - metabolism | Cells, Cultured | Rats | rhoA GTP-Binding Protein - antagonists & inhibitors | Protein Kinase C - antagonists & inhibitors | Muscle, Smooth - metabolism | Rats, Sprague-Dawley | Rectum - enzymology | Animals | Carrier Proteins - metabolism | Rectum - cytology | Signal Transduction - drug effects | Muscle Contraction - drug effects | ADP Ribose Transferases - pharmacology | Myosin Light Chains - metabolism | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Muscle Relaxation - drug effects | Muscle, Smooth - cytology | Muscle, Smooth - enzymology
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 1477 - 10
Journal Article
Journal Article
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