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NATURE COMMUNICATIONS, ISSN 2041-1723, 08/2019, Volume 10, Issue 1, pp. 3562 - 14
Molecular chaperones such as Hsp40 and Hsp70 hold the androgen receptor (AR) in an inactive conformation. They are released in the presence of androgens,... 
SUBSTRATE-SPECIFICITY | DNAK | STRUCTURAL BASIS | MOLECULAR CHAPERONES | MULTIDISCIPLINARY SCIENCES | BINDING DOMAIN | TRANSACTIVATION DOMAIN | TRANSGENIC MOUSE MODEL | PROMOTES | ONSET | HEAT-SHOCK-PROTEIN | Binding | Animal models | Oligomerization | Transcription | Activation | Hsp70 protein | Agglomeration | Chaperones | Hsp40 protein | Augmented reality | Atrophy | Androgens | Quality control | Conformation
Journal Article
PLoS biology, 07/2017, Volume 15, Issue 7, p. e2002183
Nonmembrane-bound organelles that behave like liquid droplets are widespread among eukaryotic cells. Their dysregulation appears to be a critical step in... 
tau Proteins - metabolism | Temperature | Humans | Protein Aggregation, Pathological | Cells, Cultured | RNA - metabolism
Journal Article
Science Translational Medicine, ISSN 1946-6234, 2019, Volume 11, Issue 485, p. eaat3005
Tau inclusions are a shared feature of many neurodegenerative diseases, among them frontotemporal dementia caused by tau mutations. Treatment approaches for... 
MEDICINE, RESEARCH & EXPERIMENTAL | RHES | PROTEIN | MOUSE MODEL | DISEASE | NEURODEGENERATION | DEGRADATION | AUTOPHAGY | LONAFARNIB | PHASE-I | DIFFERENTIAL EXPRESSION ANALYSIS | CELL BIOLOGY
Journal Article
Scientific reports, 04/2018, Volume 8, Issue 1, p. 6382
The misfolding and accumulation of tau protein into intracellular aggregates known as neurofibrillary tangles is a pathological hallmark of neurodegenerative... 
Journal Article
Analytical Chemistry, ISSN 0003-2700, 08/2016, Volume 88, Issue 16, p. 8272
  Capillary electrophoresis (CE) has been identified as a useful platform for detecting, quantifying, and screening for modulators of protein-protein... 
Proteins | Adsorption | Capillary electrophoresis | Heat shock proteins | Binding sites
Journal Article
Analytical Chemistry (Washington), ISSN 0003-2700, 08/2016, Volume 88, Issue 16, pp. 8272 - 8272
Capillary electrophoresis (CE) has been identified as a useful platform for detecting, quantifying, and screening for modulators of protein-protein... 
Proteins | Binding | Flow cytometry | Separation | Heat shock proteins | Electrophoresis | Crosslinking | Calorimetry
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2014, Volume 289, Issue 3, pp. 1402 - 1414
Background: There has been an expansion of the number of Hsp70 cochaperones in mammals, providing the opportunity for combinatorial assembly of permutations... 
Protein Complexes | Protein Misfolding | Cochaperones | HIGH-THROUGHPUT SCREEN | MOLECULAR CHAPERONES | BIOCHEMISTRY & MOLECULAR BIOLOGY | QUALITY-CONTROL | Hsp40 | Protein Folding | HSP110 CHAPERONES | HEAT-SHOCK-PROTEIN | NEGATIVE REGULATOR | Isothermal Titration Calorimetry | J-DOMAIN | ATP HYDROLYSIS | STRUCTURAL BASIS | Molecular Chaperone | HSC70 CHAPERONE | ATPases | Protein-Protein Interactions | Adaptor Proteins, Signal Transducing - chemistry | Molecular Chaperones - metabolism | Transcription Factors - chemistry | Humans | Multiprotein Complexes - genetics | Molecular Chaperones - chemistry | DNA-Binding Proteins - metabolism | HSP110 Heat-Shock Proteins - chemistry | Multiprotein Complexes - metabolism | HSP70 Heat-Shock Proteins - chemistry | HSP40 Heat-Shock Proteins - chemistry | Recombinant Proteins - metabolism | HSP40 Heat-Shock Proteins - metabolism | HSP40 Heat-Shock Proteins - genetics | Molecular Chaperones - genetics | Recombinant Proteins - chemistry | HSP70 Heat-Shock Proteins - genetics | Recombinant Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | HSP70 Heat-Shock Proteins - metabolism | Transcription Factors - metabolism | HSP110 Heat-Shock Proteins - genetics | Multiprotein Complexes - chemistry | Apoptosis Regulatory Proteins | Adaptor Proteins, Signal Transducing - genetics | Adaptor Proteins, Signal Transducing - metabolism | HSP110 Heat-Shock Proteins - metabolism | Protein Binding - physiology | Protein Synthesis and Degradation
Journal Article
Analytical Chemistry, ISSN 0003-2700, 10/2013, Volume 85, Issue 20, p. 9824
  Methods for identifying chemical inhibitors of protein-protein interactions (PPIs) are often prone to discovery of false positives, particularly those caused... 
Proteins | Molecules | Flow cytometry | Fluorescence | Biochemistry | Biological assays
Journal Article
Analytical Chemistry (Washington), ISSN 0003-2700, 01/2013, Volume 85, Issue 20, pp. 9824 - 9824
Methods for identifying chemical inhibitors of protein-protein interactions (PPIs) are often prone to discovery of false positives, particularly those caused... 
Proteins | Platforms | Inhibitors | Capillarity | Fluorescence | Electrophoresis | Assaying | Screens
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2014, Volume 289, Issue 3, pp. 1402 - 1414
Journal Article
Chemistry & Biology, ISSN 1074-5521, 08/2014, Volume 21, Issue 8, pp. 919 - 920
Gaucher’s disease is a hereditary deficiency of the enzyme β-glucocerebrosidase (GCase) that is most commonly treated by enzyme replacement therapy. In this... 
ERDJ3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | GAUCHER-DISEASE | Glucosylceramidase - genetics | HSP40 Heat-Shock Proteins - metabolism | Humans | Endoplasmic Reticulum - metabolism | Mutant Proteins - metabolism | Glucosylceramidase - metabolism | Gaucher Disease - enzymology | Enzymes
Journal Article