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European heart journal, ISSN 0195-668X, 02/2019
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 03/2019, Volume 380, Issue 11, pp. 1022 - 1032
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 05/2019, Volume 73, Issue 19, pp. 2451 - 2453
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 03/2019, Volume 380, Issue 11, pp. 1033 - 1042
The effects on lipid profiles of pharmacologic inhibition of ATP citrate lyase, an enzyme in the cholesterol–biosynthesis pathway upstream of HMGCR (the target... 
MEDICINE, GENERAL & INTERNAL | METAANALYSIS | INHIBITION | EFFICACY | SAFETY | RISK | PCSK9 | DENSITY-LIPOPROTEIN-CHOLESTEROL | CORONARY-HEART-DISEASE | CITRATE LYASE | GENOME-WIDE ASSOCIATION | ATP Citrate (pro-S)-Lyase - antagonists & inhibitors | Fatty Acids - therapeutic use | Diabetes Mellitus - genetics | Humans | Middle Aged | Male | Risk | Dicarboxylic Acids - pharmacology | Cardiovascular Diseases - genetics | Hypercholesterolemia - drug therapy | Dicarboxylic Acids - therapeutic use | Neoplasms - genetics | Mendelian Randomization Analysis | Cholesterol, LDL - blood | Female | Odds Ratio | Genetic Predisposition to Disease | Membrane Proteins - genetics | ATP Citrate (pro-S)-Lyase - genetics | Lipoproteins - blood | Hypolipidemic Agents - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Triglycerides - blood | Hypolipidemic Agents - therapeutic use | Hydroxymethylglutaryl CoA Reductases - genetics | Fatty Acids - pharmacology | Care and treatment | Control | Cholesterol, LDL | Genetic aspects | Cardiovascular diseases | Health aspects | Risk factors | Citric acid | Plasma | Lipoproteins (low density) | Medical research | Biomedical research | Heart attacks | Lipids | Cardiovascular disease | Grants | Low density lipoprotein | Cholesterol | Studies | Genetic variance | Acids | Councils | Coronary vessels | Biomarkers | Coenzyme A | Diabetes | Drug therapy | Health risk assessment | Statins | Cancer | Reductase | Index Medicus | Abridged Index Medicus
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 05/2019, Volume 73, Issue 19, pp. 2451 - 2453
Benn et al. (1)have shown recently that the prevalence of familial hypercholesterolemia (FH) is about 1:250 individuals in an unselected general population, in... 
acute coronary syndrome | ezetimibe | statins | familial hypercholesterolemia | myocardial infarction | PCSK9 | young adult | prevention | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | ADULTS | PREVALENCE | CORONARY-ARTERY-DISEASE | Survival analysis | Cardiovascular disease | Hypercholesterolemia | Low density lipoprotein | Mortality | Statins
Journal Article
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 175
Mixed dyslipidemia (MD; elevated triglycerides [TG], apolipoprotein B [ApoB], and non-high-density lipoprotein cholesterol [non-HDL-C], and decreased HDL-C) is... 
Lipoproteins (low density) | Therapeutic applications | Diabetes mellitus | Dyslipidemia | Lipids | Triglycerides | Apolipoproteins | Cholesterol | Apolipoprotein B | Fenofibrate | Diabetes | Cardiovascular diseases | Diabetes mellitus (non-insulin dependent) | Lipoproteins (high density) | Statins
Journal Article
Atherosclerosis, ISSN 0021-9150, 09/2019, Volume 288, pp. 194 - 202
Elevated lipoprotein(a) [Lp(a)] levels are considered a causal factor for cardiovascular disease. In phase 3 ODYSSEY trials, alirocumab reduced levels of... 
Cholesterol-lowering drugs | PCSK9 | Alirocumab | lipoprotein(a) | Low-density lipoprotein cholesterol | Cardiovascular risk
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2019
Individuals with diabetes and elevated LDL-C are at particularly high risk of atherosclerotic cardiovascular disease. ODYSSEY CHOICE I (NCT01926782) assessed... 
Journal Article
Circulation, ISSN 0009-7322, 11/2018, Volume 138, Issue Suppl_1 Suppl 1, pp. A15790 - A15790
IntroductionAntisense based RNA therapies have been associated with off-target immunological and hematological side-effects, in particular thrombocytopenia.... 
Journal Article
Circulation, ISSN 0009-7322, 11/2018, Volume 138, Issue Suppl_1 Suppl 1, pp. A15532 - A15532
IntroductionThe ORION-1 trial demonstrated that dosing with inclisiran, an RNAi therapeutic inhibiting PCSK9 synthesis in the liver, robustly lowers LDL-C.... 
Journal Article
Circulation, ISSN 0009-7322, 11/2018, Volume 138, Issue Suppl_1 Suppl 1, pp. A13189 - A13189
IntroductionVascular perturbation in acute coronary syndrome (ACS) is linked to inflammation. Bromodomain and extraterminal (BET) proteins coordinate gene... 
Journal Article
Journal Article
Atherosclerosis, ISSN 0021-9150, 09/2019, Volume 288, pp. 85 - 93
Guidelines recommend high-intensity statins for patients with atherosclerotic cardiovascular disease (ASCVD). Subgroups with comorbidities that increase... 
PCSK9 | Cardiovascular disease | Renal disease | Diabetes mellitus | Low-density lipoprotein cholesterol | Index Medicus
Journal Article
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