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British Journal of Pharmacology, ISSN 0007-1188, 06/2010, Volume 160, Issue 4, pp. 919 - 930
Background and purpose:  The major drug-metabolizing enzymes for the oxidation of oxycodone are CYP2D6 and CYP3A. A high interindividual variability in the... 
CYP3A | drug-drug interactions | CYP2D6 | pharmacodynamics | oxycodone | oxymorphone | experimental pain | genetic polymorphism | drug–drug interactions | Pharmacodynamics | Oxycodone | Genetic polymorphism | Experimental pain | Drug-drug interactions | Oxymorphone | MORPHINE | CONTROLLED-RELEASE OXYCODONE | P-GLYCOPROTEIN | PAIN | METABOLISM | PHARMACOKINETICS | IN-VIVO | ORAL OXYCODONE | PHARMACOLOGY & PHARMACY | CODEINE | RECEPTOR-BINDING | Cytochrome P-450 CYP2D6 Inhibitors | Humans | Middle Aged | Analgesics, Opioid - pharmacology | Male | Young Adult | Analgesics, Opioid - adverse effects | Drug Interactions | Pain Threshold - drug effects | Adult | Oxycodone - adverse effects | Metabolic Detoxication, Phase I - genetics | Oxymorphone - blood | Cytochrome P-450 CYP2D6 - genetics | Oxycodone - therapeutic use | Reflex, Pupillary - drug effects | Oxycodone - pharmacology | Double-Blind Method | Enzyme Inhibitors - pharmacology | Analgesics, Opioid - therapeutic use | Genotype | Psychomotor Performance - drug effects | Polymorphism, Genetic | Cross-Over Studies | Oxycodone - pharmacokinetics | Phenotype | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP3A - metabolism | Analgesics, Opioid - pharmacokinetics | Cytochrome P-450 CYP2D6 - metabolism | Drug therapy | Enzymes | Pain | Pain perception | Ketoconazole | Toxicity | Cytochrome P450 | Gene polymorphism | Electrical stimuli | Side effects | Analgesics | Metabolites | Quinidine | Drug interaction | Oxidation | Pharmacokinetics | CYP2D6 protein | Research Papers
Journal Article
Nature Methods, ISSN 1548-7091, 10/2013, Volume 10, Issue 10, pp. 965 - 971
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2010, Volume 160, Issue 4, pp. 907 - 918
Journal Article
Journal Article
Cell Death and Disease, ISSN 2041-4889, 05/2015, Volume 6, Issue 5, pp. e1767 - e1767
Journal Article
Immunity, ISSN 1074-7613, 2008, Volume 28, Issue 5, pp. 651 - 661
Journal Article
by Hoffman, L. M and Donson, A. M and Nakachi, I and Griesinger, A. M and Birks, D. K and Amani, V and Hemenway, M. S and Liu, A. K and Wang, M and Hankinson, T. C and Handler, M. H and Foreman, N. K and Zakrzewska, M and Zakrzewski, K and Fendler, W and Stefanczyk, L and Liberski, P. P and Massimino, M and Gandola, L and Ferroli, P and Valentini, L and Biassoni, V and Garre, M. L and Sardi, I and Genitori, L and Giussani, C and Massimi, L and Bertin, D and Mussano, A and Viscardi, E and Modena, P and Mastronuzzi, A and Barra, S and Scarzello, G and Cinalli, G and Peretta, P and Giangaspero, F and Boschetti, L and Schiavello, E and Calareso, G and Antonelli, M and Pecori, E and Di Meco, F and Migliorati, R and Taborelli, A and Witt, H and Sill, M and Wani, K and Mack, S. C and Capper, D and Pajtler, K and Lambert, S and Tzaridis, T and Milde, T and Northcott, P. A and Kulozik, A. E and Witt, O and Collins, V. P and Ellison, D. W and Taylor, M. D and Kool, M and Jones, D. T. W and Korshunov, A and Ken, A and Pfister, S. M and Makino, K and Nakamura, H and Kuroda, J.-i and Kuratsu, J.-i and Toledano, H and Margolin, Y and Ohali, A and Michowiz, S and Johann, P and Tabori, U and Walker, E and Hawkins, C and Taylor, M and Yaniv, I and Avigad, S and Hoffman, L and Plimpton, S. R and Stence, N. V and Vibhakar, R and Lourdusamy, A and Rahman, R and Ward, J and Rogers, H and Grundy, R and Punchihewa, C and Lee, R and Lin, T and Orisme, W and Dalton, J and Aronica, E and Smith, A and Gajjar, A and Onar, A and Pounds, S and Tatevossian, R and ...
Neuro-Oncology, ISSN 1522-8517, 06/2014, Volume 16, Issue suppl 1, pp. i17 - i25
Journal Article
Science, ISSN 0036-8075, 12/2018, Volume 362, Issue 6419, pp. 1171 - 1177
In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding... 
PROTEIN | GENE | LANDSCAPE | VIRUS ENTRY REQUIRES | INFORMATION | MULTIDISCIPLINARY SCIENCES | GENOMIC ALTERATIONS | CRISPR-CAS9 | RECEPTOR | VECTORS | DROSOPHILA EYE | Loss of Function Mutation | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Antineoplastic Agents - therapeutic use | Pyridazines - pharmacology | Gene Knockdown Techniques | MAP Kinase Signaling System - genetics | Antineoplastic Agents - pharmacology | Gain of Function Mutation | Imidazoles - therapeutic use | Pyridazines - therapeutic use | Proto-Oncogene Proteins p21(ras) - metabolism | Transcription Factors - physiology | Signal Transduction | Imidazoles - pharmacology | Transcription Factors - genetics | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - epidemiology | Drug Resistance, Neoplasm - genetics | Animals | Protein Kinase Inhibitors - therapeutic use | Fusion Proteins, bcr-abl - antagonists & inhibitors | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Drosophila melanogaster | Ubiquitination - genetics | Leucine zipper | Genetic research | Ras genes | Genetic aspects | Research | Drug resistance | BCR protein | Transcription | Leukemia | Guanosine | Homology | Leucine | Kinases | Inactivation | Genetic screening | Cullin | Proteins | Signal transduction | Ubiquitination | Triphosphatase | Localization | Fusion protein | Protein-tyrosine kinase | Tyrosine | Phenotypes | Deactivation | Sarcoma | Myeloid leukemia | Adapters | Drosophila | MAP kinase | Abl protein | Ras protein | Chronic myeloid leukemia | Leucine zipper proteins | Signaling | Inhibitors | Isoforms | Fruit flies | Mutation | Adapter proteins
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 01/2010, Volume 11, Issue 1, pp. 63 - 69
Journal Article
Journal Article