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American journal of respiratory cell and molecular biology, 08/2019
Journal Article
EUROPEAN RESPIRATORY JOURNAL, ISSN 0903-1936, 09/2019, Volume 54, Issue 3
A proportion of patients with fibrosing interstitial lung diseases (ILDs) develop a progressive phenotype characterised by decline in lung function, worsening... 
SIGNAL-TRANSDUCTION | SURVIVAL | BIBF 1120 | RESPIRATORY SYSTEM | CHEMOKINE CCL18 | TRIPLE ANGIOKINASE INHIBITOR | TYROSINE KINASE INHIBITOR | IDIOPATHIC PULMONARY-FIBROSIS | SYSTEMIC-SCLEROSIS | T-CELLS | FIBROBLASTS
Journal Article
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1809, pp. 59 - 67
The lung parenchyma is comprised of many cells including the structurally important stromal fibroblasts. Fibroblasts function to produce extracellular matrix... 
Cell culture | Isolation | Lung digestion | Pulmonary fibroblasts
Journal Article
American Journal of Physiology: Lung Cellular and Molecular Physiology, ISSN 1040-0605, 07/2016, Volume 311, Issue 1, pp. L87 - L87
During homeostasis two distinct macrophage (M omicron ) populations inhabit the lungs: tissue M omicron (often called interstitial M omicron ) and resident... 
Journal Article
American Journal of Respiratory Cell and Molecular Biology (Online), 02/2017, Volume 56, Issue 2, p. 150
Idiopathic pulmonary fibrosis (IPF) is a progressive, fibrosing interstitial lung disease in which macrophages serve as producers of profibrotic signaling... 
Intervention | Genotype & phenotype | Pulmonary fibrosis | Disease | Lungs | Rodents | Roles | Gene expression
Journal Article
American Journal of Respiratory Cell and Molecular Biology (Online), 02/2017, Volume 56, Issue 2, pp. 150 - 150
Journal Article
Physiological Reports, 08/2018, Volume 6, Issue 16, pp. e13794 - n/a
TGF beta is a multifunctional cytokine that is important in the pathogenesis of pulmonary fibrosis. The ability of TGF beta to stimulate smooth muscle actin... 
Idiopathic pulmonary fibrosis | pulmonary fibrosis | KGF | Fibroblast growth factor 10 | Pathogenesis | Genomics | Lung diseases | Smooth muscle | Genomes | Research | Surfactants | Ribonucleic acid--RNA | Epithelium | Gene expression | Cell growth | Researchers | Pulmonary fibrosis | Lungs | Actin | Fibrosis | Fibroblasts | Extracellular matrix | Software | Fibroblast growth factor receptor 7 | Supplementation | Alveoli | Growth factors
Journal Article
Cancer Prevention Research, ISSN 1940-6207, 01/2009, Volume 2, Issue 1, pp. 74 - 83
The latency period for lung tumor progression offers a window of opportunity for therapeutic intervention. Herein, we studied the effect of oral silibinin (742... 
CANCER-CELLS | CARCINOMA-CELLS | METASTASIS | CARCINOGENESIS | ONCOLOGY | ADENOCARCINOMA | MOUSE | MICE | CHEMOPREVENTION | TUMORIGENESIS | PROGRESSION
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 2014, Volume 50, Issue 4, pp. 825 - 837
Idiopathic pulmonary fibrosis (IPF) is a relentless, fibrotic parenchymal lung disease in which alternatively programmed macrophages produce profibrotic... 
Inflammation | Pulmonary fibrosis | Tumor necrosis factor-α | Macrophages | FUNCTIONAL DIVERSITY | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BLEOMYCIN-INDUCED PNEUMONOPATHY | CELL BIOLOGY | tumor necrosis factor-alpha | macrophages | GROWTH-FACTOR-BETA | CYTOKINE PRODUCTION | inflammation | RESPIRATORY SYSTEM | pulmonary fibrosis | TRANSFORMING GROWTH-FACTOR-BETA-1 | ALVEOLAR MACROPHAGES | TNF-ALPHA | UP-REGULATION | EXPRESSION | Idiopathic Pulmonary Fibrosis - genetics | Macrophages, Alveolar - pathology | Tumor Necrosis Factor-alpha - genetics | Male | Tacrolimus Binding Proteins - metabolism | Tumor Necrosis Factor-alpha - deficiency | fas Receptor - metabolism | Idiopathic Pulmonary Fibrosis - metabolism | Recovery of Function | Bleomycin | Time Factors | fas Receptor - genetics | Lung - metabolism | Disease Models, Animal | Lung - pathology | Lung Compliance | Hydroxyproline - metabolism | Mice, Inbred C57BL | Cells, Cultured | Receptor, Macrophage Colony-Stimulating Factor - genetics | Mice, Transgenic | Lung - physiopathology | Remission Induction | Mice, Knockout | Tacrolimus Binding Proteins - genetics | Tumor Necrosis Factor-alpha - pharmacology | Animals | Macrophages, Alveolar - drug effects | Lung - drug effects | Idiopathic Pulmonary Fibrosis - pathology | Idiopathic Pulmonary Fibrosis - physiopathology | Mice | Macrophages, Alveolar - metabolism | Idiopathic Pulmonary Fibrosis - drug therapy | Original Research | tumor necrosis factor-α
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 01/2018, Volume 58, Issue 1, pp. 66 - 78
Idiopathic pulmonary fibrosis is a progressive lung disease with complex pathophysiology and fatal prognosis. Macrophages (MΦ) contribute to the development of... 
C-FLIP | RNA-seq | IPF | Fibrosis | Macrophage | Gene deletion | Macrophages | Proteins | FADD protein | Bleomycin | Clonal deletion | Rodents | FLIP protein | Fibroblasts | Alveoli | Growth factors | Enzymes | CD11b antigen | Lung diseases | c-FLIP protein | Inflammation | IL-1β | Ribonucleic acid--RNA | Asthma | Monocytes | Pulmonary fibrosis | Cell death | Medical prognosis | Ligands | Chemokines | Apoptosis | macrophage | fibrosis | Original Research | c-FLIP
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 08/2018, Volume 198, Issue 3, pp. 390 - 392
Planimetric analysis may be biased by tissue inflation and shrinkage, cell loss during sectioning, the overrepresentation of larger cells in two-dimensional... 
REPAIR | RESPIRATORY SYSTEM | REGENERATION | SIZE | MICE | PROLIFERATION | CRITICAL CARE MEDICINE | Flow Cytometry - methods | Lung Injury - pathology | Reproducibility of Results | Animals | Alveolar Epithelial Cells - pathology | Mice | Disease Models, Animal | Proteins | Flow cytometry | Lungs | Biopsy | Cell division | Hypoxia | Surfactants | Cell adhesion & migration | Correspondence
Journal Article
American Journal of Physiology (Consolidated), ISSN 0002-9513, 07/2016, Volume 311, Issue 1
During homeostasis two distinct macrophage (M[empty set]) populations inhabit the lungs: tissue M[empty set] (often called interstitial M[empty set]) and... 
Phagocytes | Genetic aspects | Lungs | Health aspects | Analysis | Genetic engineering
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2011, Volume 187, Issue 1, pp. 527 - 537
Idiopathic pulmonary fibrosis (IPF) is associated with the accumulation of collagen-secreting fibroblasts and myofibroblasts in the lung parenchyma. Many... 
Journal Article
American Journal of Pathology, The, ISSN 0002-9440, 2015, Volume 185, Issue 4, pp. 909 - 912
This commentary highlights the article by Sisson et al, which establishes the importance of the myocardin-related transcription factor/serum response factor... 
Pathology
Journal Article
American Journal of Physiology, ISSN 1040-0605, 06/2018, Volume 314, Issue 6, p. L998
Rheumatoid arthritis (RA)-associated interstitial lung disease (RA-ILD) develops in ~20% of patients with RA. SKG mice, which are genetically prone to... 
Tyrosine | Early intervention | Pneumonia | Respiratory function | Medical treatment | Lung diseases | Hydroxyproline | Medical services | Collagens | Arthritis | Injection | Studies | Pulmonary fibrosis | Rheumatoid arthritis | Collagen | Fibrosis | Mice | Protein-tyrosine kinase
Journal Article
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