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Tetrahedron Letters, ISSN 0040-4039, 10/2019, Volume 60, Issue 40, p. 151104
In the course of our drug discovery programs, we had need to access chiral, 2-substituted thiomorpholines and their oxidized congeners, thiomorpholine... 
Thiomorpholine | Enantioselective | Organocatalysis | Thiomorpholine 1,1-dioxide | PROTECTED MORPHOLINES | CHEMISTRY, ORGANIC | ALDEHYDES | DERIVATIVES | PIPERAZINES
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 03/2019, Volume 60, Issue 10, pp. 743 - 745
This communication details the first total synthesis of the 13-membered macrolide, (−)-Melearoride A, as well as unnatural (+)-Melearoride A. The synthesis... 
Macrolides | Melearoride A | Asymmetric alkylation | Total synthesis | CHEMISTRY, ORGANIC | Synthesis | Drug discovery | Organic compounds
Journal Article
Pesticide Biochemistry and Physiology, ISSN 0048-3575, 10/2018, Volume 151, pp. 10 - 17
The majority of commercialized insecticides target the insect nervous system and therefore, neural proteins are well-validated targets for insecticide... 
Thallium-flux | Insect nervous system | Insecticide | Vector biology | Potassium | Insecticide discovery | K-CL COTRANSPORTER | MALPIGHIAN TUBULES UMT | PHYSIOLOGY | NEUROTRANSMISSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUSCEPTIBILITY | ANOPHELES-GAMBIAE | ENTOMOLOGY | FLUID SECRETION | INHIBITION | RESISTANCE | STRAIN | CHLORIDE
Journal Article
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 09/2019, Volume 84, Issue 18, pp. 12187 - 12191
A concise formal total synthesis of pericoannosin A, by the synthesis of an advanced intermediate of pericoannosin A, was achieved in eight steps from... 
CHEMISTRY, ORGANIC
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 05/2019, Volume 29, Issue 10, pp. 1211 - 1214
This letter describes a diversity-oriented library approach to rapidly assess diverse heterocycles as bioisosteric replacements for a metabolically labile... 
mGlu | Negative allosteric modulator (NAM) | Structure-activity relationship (SAR) | VU6019278 | Metabotropic glutamate receptor
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2019, Volume 29, Issue 10, pp. 1211 - 1214
This letter describes a diversity-oriented library approach to rapidly assess diverse heterocycles as bioisosteric replacements for a metabolically labile... 
Negative allosteric modulator (NAM) | Structure-activity relationship (SAR) | mGlu7 | VU6019278 | Metabotropic glutamate receptor
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2019, Volume 29, Issue 10, p. 1211
This letter describes a diversity-oriented library approach to rapidly assess diverse heterocycles as bioisosteric replacements for a metabolically labile... 
Surveys | Medical colleges | Neurosciences | Lubrication and lubricants | Drug discovery | Glutamate | Blood proteins | Protein binding
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2019, Volume 62, Issue 3, pp. 1690 - 1695
Herein, we report the discovery of a new, orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 (mGlu ) negative allosteric modulator (NAM)... 
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 12/2017, Volume 8, Issue 12, pp. 1326 - 1330
Herein, we report the structure–activity relationships within a series of mGlu7 NAMs based on an... 
negative allosteric modulator | VU6010608 | metabotropic glutamate receptor 7 | long-term potentiation
Journal Article
ACS medicinal chemistry letters, ISSN 1948-5875, 12/2017, Volume 8, Issue 12, p. 1326
Herein, we report the structure-activity relationships within a series of mGlu NAMs based on an -(2-(1... 
Journal Article
PLoS neglected tropical diseases, ISSN 1935-2727, 12/2018, Volume 12, Issue 12, p. e0006984
Journal Article
The Journal of Immunology, ISSN 0022-1767, 04/1999, Volume 162, Issue 8, pp. 4943 - 4951
Journal Article
Environmental Toxicology and Pharmacology, ISSN 1382-6689, 12/1998, Volume 6, Issue 4, pp. 257 - 265
Airway epithelium is the primary target tissue for respiratory viruses as well as an important target of ozone (O sub(3)) toxicity. A change in the severity of... 
Journal Article
The British Journal for the History of Science, ISSN 0007-0874, 12/2008, Volume 41, Issue 4, pp. 613 - 614
Journal Article
Journal Article
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