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Rheumatology (Oxford, England), ISSN 1462-0324, 08/2019
To examine the role of Tie2 signalling in macrophage activation within the context of the inflammatory synovial microenvironment present in patients with RA... 
Journal Article
Arthritis Research & Therapy, ISSN 1478-6354, 09/2017, Volume 19, Issue 1
Background: Endoplasmic reticulum (ER) stress has proinflammatory properties, and transgenic animal studies of rheumatoid arthritis (RA) indicate its relevance... 
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 03/2012, Volume 71, Issue 3, pp. 424 - 431
Background Histone deacetylase inhibitors (HDACi) display potent therapeutic efficacy in animal models of arthritis and suppress inflammatory cytokine... 
CELLS | ACTIVATION | SYNOVIAL FIBROBLASTS | ACETYLATION | IMMUNE-RESPONSES | INFLAMMATION | IN-VIVO | RHEUMATOLOGY | C-JUN | NF-KAPPA-B | TRICHOSTATIN-A | Antirheumatic Agents - administration & dosage | Humans | Histone Deacetylase Inhibitors - administration & dosage | Synovial Membrane - pathology | Synovial Membrane - drug effects | Transcription Factor AP-1 - metabolism | Dose-Response Relationship, Drug | Arthritis, Rheumatoid - metabolism | Inflammation Mediators - metabolism | Hydroxamic Acids - administration & dosage | Antirheumatic Agents - pharmacology | Hydroxamic Acids - pharmacology | Fibroblasts - metabolism | Interleukin-6 - genetics | RNA, Messenger - genetics | Cells, Cultured | Synovial Membrane - metabolism | Arthritis, Rheumatoid - pathology | Macrophages - metabolism | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Fibroblasts - drug effects | NF-kappa B - physiology | Interleukin-6 - biosynthesis | Histone Deacetylase Inhibitors - pharmacology | Macrophages - drug effects | Enzyme inhibitors | Rheumatoid arthritis | Patient outcomes | Drug targeting | Dosage and administration | Research | Drug therapy | Interleukin-6 | Transcription factors | Cytokines | Colleges & universities | Inflammation | Kinases | Gene expression | Proteins | Rodents | DNA methylation | Epigenetics | Fibroblasts | Tumor necrosis factor-TNF | Deoxyribonucleic acid--DNA
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 02/2016, Volume 75, Issue 2, pp. 422 - 429
ObjectiveTo investigate the effects of BET bromodomain protein inhibition on inflammatory activation and functional properties of rheumatoid arthritis synovial... 
EPIGENETICS | ACTIVATION | SECUKINUMAB | CHROMATIN | DOUBLE-BLIND | ANTI-INTERLEUKIN-17A MONOCLONAL-ANTIBODY | RHEUMATOLOGY | BET PROTEIN | Immunohistochemistry | Tumor Necrosis Factor-alpha - metabolism | Gene Expression - drug effects | Humans | Lipopolysaccharides - metabolism | Arthritis, Rheumatoid - enzymology | Matrix Metalloproteinase 3 - metabolism | Nuclear Proteins - metabolism | RNA, Messenger - metabolism | Synovial Membrane - metabolism | Heterocyclic Compounds, 4 or More Rings - pharmacology | Osteoarthritis - genetics | Osteoarthritis - enzymology | Transcription Factors - metabolism | Arthritis, Rheumatoid - genetics | Interleukin-1beta - metabolism | Interleukin-8 - metabolism | Toll-Like Receptors - metabolism | Matrix Metalloproteinase 1 - metabolism | Interleukin-6 - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - metabolism | Fibroblasts - metabolism | Epigenetic inheritance | Care and treatment | Interleukins | Tumor necrosis factor | Rheumatoid arthritis | Dosage and administration | Research | Enzymes | Immunoglobulins | Statistical analysis | Disease | Cytokines | Laboratories | Gene expression | Variance analysis | Bone surgery | Studies | Proteins | Pathology | Rodents | DNA methylation | Epigenetics | Fibroblasts | Tumor necrosis factor-TNF | Chemokines | Deoxyribonucleic acid--DNA
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 02/2012, Volume 71, Issue Suppl 1, pp. A59 - A59
Backgroundand objectives Forkhead box O (FoxO) transcription factors, regulated by phosphatidlyinositol 3-kinase and reversible acetylation, integrate... 
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 02/2012, Volume 71, Issue Suppl 1, pp. A80 - A81
Background and objectives Vascular remodeling promotes immune cell infiltration and provides nutrients to hyperplastic tissue in the synovial tissue of... 
Journal Article
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 05/2001, Volume 2, Issue 5, pp. 369 - 377
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 01/2017, Volume 76, Issue 1, pp. 277 - 285
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 03/2010, Volume 184, Issue 5, pp. 2718 - 2728
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 7, p. e21772
The aim of this study was to provide more insight into the question as to why blockade of CCR1, CCR2, and CCR5 may have failed in clinical trials in rheumatoid... 
CHEMOKINE RECEPTOR EXPRESSION | CONTROLLED CLINICAL-TRIAL | COLLAGEN-INDUCED ARTHRITIS | ANTAGONIST | SYNOVIAL TISSUE | MACROPHAGES | BIOLOGY | DOUBLE-BLIND | INFLAMMATORY DISEASE | PERIPHERAL-BLOOD | PROOF-OF-CONCEPT | Monocytes - cytology | Receptors, CCR2 - immunology | Humans | Middle Aged | Synovial Fluid - metabolism | Male | Monocytes - immunology | Case-Control Studies | Receptors, CCR5 - immunology | Dose-Response Relationship, Drug | Arthritis, Rheumatoid - metabolism | Antibodies, Neutralizing - immunology | Piperidines - pharmacology | Arthritis, Rheumatoid - drug therapy | Antibodies, Neutralizing - therapeutic use | Monocytes - pathology | Aged, 80 and over | Adult | Female | Chemokine CCL2 - metabolism | Chemokine CCL5 - metabolism | Receptors, CCR1 - immunology | Phenylurea Compounds - therapeutic use | Antibodies, Neutralizing - pharmacology | Chemotaxis - drug effects | Monocytes - drug effects | Receptors, CCR - immunology | Piperidines - therapeutic use | Receptors, CCR - antagonists & inhibitors | Aged | Phenylurea Compounds - pharmacology | Arthritis, Rheumatoid - immunology | Receptors, CCR1 - antagonists & inhibitors | Rheumatoid factor | High-definition television | Arthritis | Analysis | CC chemokine receptors | Leukocyte migration | RANTES | Migration | Blocking antibodies | Clinical trials | Antibodies | Inflammatory diseases | Recruitment | CCR1 protein | Receptors | Immunology |