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JOURNAL OF MOLECULAR BIOLOGY, ISSN 0022-2836, 08/2016, Volume 428, Issue 16, pp. 3282 - 3294
The hexosamine biosynthetic pathway (HBP) is highly dependent on multiple metabolic nutrients including glucose, glutamine, and acetyl-CoA. Increased flux... 
signaling | GLCNACYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLCNAC TRANSFERASE | glycosylation | CELL-GROWTH | TET PROTEINS | N-ACETYLGLUCOSAMINE TRANSFERASE | HEXOSAMINE BIOSYNTHESIS | O-GIcNAcylation | PATHWAY | cancer | FATTY-ACID SYNTHASE | OGT
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 05/2010, Volume 29, Issue 19, pp. 2831 - 2842
Cancer cells upregulate glycolysis, increasing glucose uptake to meet energy needs. A small fraction of a cell's glucose enters the hexosamine biosynthetic... 
Glucose metabolism | Breast cancer | FoxM1 | O-GlcNAc | OGT | p27(Kip1) | CELLS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | breast cancer | GLYCOSYLATION | BETA | CELL BIOLOGY | ONCOLOGY | INSULIN-RESISTANCE | GLUCOSE | GENETICS & HEREDITY | INHIBITORS | glucose metabolism | NUCLEOCYTOPLASMIC PROTEINS | EXPRESSION | LINKED N-ACETYLGLUCOSAMINE | Humans | N-Acetylglucosaminyltransferases - genetics | Acetylglucosamine - metabolism | Breast Neoplasms - metabolism | Gene Knockdown Techniques | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Breast Neoplasms - enzymology | N-Acetylglucosaminyltransferases - deficiency | Forkhead Transcription Factors - metabolism | Neoplasm Invasiveness - pathology | Base Sequence | Female | Gene Expression Regulation, Neoplastic - drug effects | Matrix Metalloproteinase 2 - metabolism | Enzyme Inhibitors - pharmacology | Oncogene Proteins - metabolism | N-Acetylglucosaminyltransferases - metabolism | Up-Regulation - drug effects | Matrix Metalloproteinase 2 - genetics | Phenotype | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | N-Acetylglucosaminyltransferases - antagonists & inhibitors | Cell Proliferation - drug effects | Mice | Cell Transformation, Neoplastic - drug effects | Cell Cycle - drug effects | Forkhead Box Protein M1 | Post-translational modification | Care and treatment | Control | Transcription factors | Transferases | Physiological aspects | Genetic aspects | Research | Proteins | Glucose | Gene expression | Metabolism | Cell cycle
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2012, Volume 287, Issue 14, pp. 11070 - 11081
Background: Cancer cells display altered metabolism and expression of the nutrient sensor O-linked beta-N-acetylglucosamine transferase (OGT). Results: Through... 
METABOLISM | INSULIN-RESISTANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR FOXM1 | GENE-EXPRESSION PROFILES | GLCNAC TRANSFERASE | MECHANISMS | GLYCOSYLATION | NUTRIENT SENSOR | PROGRESSION | BREAST | Cell Proliferation | Gene Expression Regulation, Neoplastic | Bone Neoplasms - secondary | N-Acetylglucosaminyltransferases - genetics | Male | Vascular Endothelial Growth Factor A - genetics | Acetylglucosamine - metabolism | Neovascularization, Pathologic - enzymology | Neoplasm Metastasis | Prostatic Neoplasms - genetics | N-Acetylglucosaminyltransferases - deficiency | RNA Interference | Forkhead Transcription Factors - metabolism | Matrix Metalloproteinase 9 - genetics | Proteolysis | Prostatic Neoplasms - blood supply | Prostatic Neoplasms - pathology | Neoplasm Invasiveness | Forkhead Transcription Factors - genetics | N-Acetylglucosaminyltransferases - metabolism | Matrix Metalloproteinase 2 - genetics | Animals | Bone Neoplasms - prevention & control | Cell Transformation, Neoplastic | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Mice | Mutation | Forkhead Box Protein M1 | Cyclin-Dependent Kinase Inhibitor p27 - genetics | Molecular Bases of Disease | Angiogenesis | Vascular Endothelial Growth Factor (VEGF) | Epithelial Cell | Prostate Cancer | Metabolism | O-GlcNAc | FoxM1 | OGT | Invasion
Journal Article
Cell, ISSN 0092-8674, 2001, Volume 107, Issue 4, pp. 513 - 523
In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that LRP5, encoding the low-density lipoprotein receptor-related protein... 
MINERAL DENSITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | OSTEOBLAST LINEAGE | MOLECULAR-CLONING | MICE | DIFFERENTIATION | BETA-CATENIN | OSTEOPOROSIS | CELL-DEATH | FAMILY | CELL BIOLOGY | Wnt2 Protein | Humans | Child, Preschool | Male | Bone Density - genetics | Wnt Proteins | Mesoderm - cytology | Wnt-5a Protein | Eye - embryology | Osteoporosis - genetics | Animals, Outbred Strains | Dishevelled Proteins | Bone Morphogenetic Proteins - pharmacology | Child | Organ Culture Techniques | Transforming Growth Factor beta | Signal Transduction | Chromosomes, Human, Pair 11 - genetics | Adaptor Proteins, Signal Transducing | Skull - cytology | Wnt3 Protein | Mice | Receptors, LDL - physiology | COS Cells | Species Specificity | LDL-Receptor Related Proteins | DNA, Complementary - genetics | Recombinant Fusion Proteins - physiology | Cercopithecus aethiops | Culture Media, Conditioned - pharmacology | Recombinant Proteins | Transfection | Receptors, LDL - deficiency | Stromal Cells - drug effects | Adult | Female | Phosphoproteins - physiology | Proteins - physiology | Receptors, LDL - genetics | Bone Morphogenetic Protein 2 | Low Density Lipoprotein Receptor-Related Protein-5 | Mice, Inbred C57BL | Zebrafish Proteins | Proto-Oncogene Proteins - genetics | Phosphoproteins - genetics | Eye Abnormalities - genetics | Genes, Recessive | Syndrome | Proteins - genetics | Animals | Proto-Oncogene Proteins - physiology | Heterozygote | Osteoblasts - metabolism | Stromal Cells - cytology | Wnt4 Protein | Osteoporosis | Bones | Density | Low density lipoproteins | Proteins | Cell research | Lipoproteins | Growth | Analysis | Physiological aspects | Receptors, LDL | Mesoderm | Osteoblasts | Recombinant Fusion Proteins | Eye | Life Sciences | Stromal Cells | Eye Abnormalities | Phosphoproteins | Proto-Oncogene Proteins | Bone Density | Biochemistry, Molecular Biology | Culture Media, Conditioned | Skull | Chromosomes, Human, Pair 11 | Bone Morphogenetic Proteins | DNA, Complementary
Journal Article
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, ISSN 0022-3069, 06/2017, Volume 76, Issue 6, pp. 479 - 479
Journal Article
BMC BIOLOGY, ISSN 1741-7007, 07/2019, Volume 17, Issue 1, pp. 52 - 14
Journal Article
CELL, ISSN 0092-8674, 10/2002, Volume 111, Issue 1, pp. 29 - 40
We have utilized in vitro three-dimensional epithelial cell cultures to analyze the role of apoptosis in the formation and maintenance of a hollow glandular... 
PROGRAMMED CELL-DEATH | SURVIVAL | BREAST EPITHELIAL-CELLS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | LINE | EXTRACELLULAR-MATRIX | DIFFERENTIATION | CANCER | TRANSGENIC MICE | CELL BIOLOGY
Journal Article
Oncogene, ISSN 0950-9232, 01/2017, Volume 36, Issue 4, pp. 559 - 569
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2017, Volume 76, Issue Suppl 2, p. 1339
BackgroundThis consensus derives from a previous study of Demographic and Clinical Characteristics by the PANLAR OA study group, reporting significant... 
Knee | Rheumatology | Clinical trials | Arthritis | Management | Osteoarthritis | Hand | Patients | Hip
Journal Article
Cell Cycle, ISSN 1538-4101, 06/2011, Volume 10, Issue 11, pp. 1712 - 1713
Journal Article
Journal Article