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Journal Article
The Journal of Physiology, ISSN 0022-3751, 01/2018, Volume 596, Issue 2, pp. 197 - 215
Journal Article
The Journal of Physiology, ISSN 0022-3751, 01/2018, Volume 596, Issue 2, p. 197
Key points We used a mouse expressing a light-sensitive ion channel in [beta]-cells to understand how [alpha]-cell activity is regulated by [beta]-cells. Light... 
Animal models | Computer simulation | Glucagon | Secretion | Gap junctions | Diabetes mellitus | Paracrine signalling | Stimulation | Activation | Glucose | Beta cells | Cell activation | Mathematical analysis | Rodents | Light | Computer applications | Ion channels | Mathematical models | Somatostatin | Islets of Langerhans | Pancreas | Diabetes mellitus (non-insulin dependent) | Electrical junctions
Journal Article
Cell Metabolism, ISSN 1550-4131, 11/2012, Volume 16, Issue 5, pp. 625 - 633
Journal Article
Science, ISSN 0036-8075, 1/2010, Volume 327, Issue 5962, pp. 217 - 220
Several common genetic variations have been associated with type 2 diabetes, but the exact disease mechanisms are still poorly elucidated. Using congenie... 
Beta cells | Receptors | Fasting | Congenic strains | Genetic loci | Reports | Type 2 diabetes mellitus | Diabetes | Exocytosis | Insulin | Insulin secretion | PANCREATIC B-CELLS | GLUCOSE-HOMEOSTASIS | ACTIVATION | EXOCYTOSIS | GK RATS | MULTIDISCIPLINARY SCIENCES | INSULIN-SECRETION | BETA-CELLS | LOCI | IDENTIFICATION | GENOME-WIDE ASSOCIATION | Receptors, Adrenergic, alpha-2 - genetics | Up-Regulation | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Receptors, Adrenergic, alpha-2 - metabolism | Secretory Vesicles - metabolism | Adrenergic alpha-Antagonists - pharmacology | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Rats, Inbred Strains | Young Adult | Adrenergic alpha-2 Receptor Agonists | Insulin-Secreting Cells - metabolism | RNA Interference | Adult | Cell Membrane - metabolism | Animals, Congenic | Cyclic AMP - metabolism | Insulin Secretion | Genetic Predisposition to Disease | Genetic Association Studies | Risk Factors | Rats | Insulin - metabolism | Animals | Adolescent | Adrenergic alpha-Agonists - pharmacology | Aged | Polymorphism, Single Nucleotide | Adrenergic alpha-2 Receptor Antagonists | Blood Glucose - metabolism | Type 2 diabetes | Epinephrine | Physiological aspects | Genetic aspects | Research | Gene expression | Cellular biology | Polymorphism | Index Medicus | Cell Membrane | Adrenergic | Single Nucleotide | Endokrinologi och diabetes | Type 2 | Inbred Strains | Congenic | Insulin-Secreting Cells | Endocrinology and Diabetes | alpha-2 | Adrenergic alpha-Agonists | Adrenergic alpha-Antagonists | Cyclic AMP | Blood Glucose | Secretory Vesicles | Diabetes Mellitus
Journal Article
Nature Communications, ISSN 2041-1723, 06/2017, Volume 8, Issue 1, pp. 15652 - 15652
Journal Article
Journal Article
Diabetologia, ISSN 0012-186X, 02/2013, Volume 56, Issue 2, p. 340
  Voltage-gated calcium channels of the L-type have been shown to be essential for rodent pancreatic beta cell function, but data about their presence and... 
Journal Article
Diabetologia, ISSN 0012-186X, 02/2013, Volume 56, Issue 2, p. 340
Voltage-gated calcium channels of the L-type have been shown to be essential for rodent pancreatic beta cell function, but data about their presence and... 
Type 2 diabetes | Glucose metabolism | Pancreatic beta cells | Calcium channels | RNA | Genes | Resveratrol | Genetic aspects | Universities and colleges | Glucose | Insulin | Dextrose
Journal Article
Nature Communications, ISSN 2041-1723, 06/2017, Volume 8, p. 15652
Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion, but the mechanisms underlying insulin secretion failure are not... 
Clinical Medicine | Endokrinologi och diabetes | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Journal Article | Endocrinology and Diabetes
Journal Article
Molecular Endocrinology, ISSN 0888-8809, 06/2009, Volume 23, Issue 6, pp. 893 - 900
Nicotinamide adenine dinucleotide phosphate (NADPH) enhances Ca2+-induced exocytosis in pancreatic β-cells, an effect suggested to involve the cytosolic redox... 
CELLS | THIOREDOXIN-INTERACTING PROTEIN | RAT PANCREATIC-ISLETS | GLUCOSE | DISEASE | ENDOCRINOLOGY & METABOLISM | Immunohistochemistry | Cell Survival - drug effects | Glutaredoxins - metabolism | Gene Silencing - drug effects | Intracellular Space - drug effects | Subcellular Fractions - drug effects | Calcium - metabolism | Rats | Glucose - pharmacology | Protein Transport - drug effects | Exocytosis - drug effects | Gene Knockdown Techniques | Insulin - metabolism | Insulin-Secreting Cells - metabolism | Intracellular Space - enzymology | Animals | Insulin-Secreting Cells - drug effects | Oxidation-Reduction - drug effects | Thioredoxins - metabolism | Insulin-Secreting Cells - cytology | NADP - metabolism | Insulin Secretion | Subcellular Fractions - enzymology | Insulin-Secreting Cells - enzymology | Index Medicus | Original Research | Insulin-Secreting Cells/cytology/drug effects/enzymology/secretion | Exocytosis/drug effects | Protein Transport/drug effects | Cell and Molecular Biology | Insulin/secretion | Cell Survival/drug effects | Oxidation-Reduction/drug effects | Thioredoxins/metabolism | Gene Silencing/drug effects | Calcium/metabolism | Subcellular Fractions/drug effects/enzymology | Intracellular Space/drug effects/enzymology | NADP/metabolism | Glucose/pharmacology | Glutaredoxins/metabolism | Cell- och molekylärbiologi
Journal Article
Islets, ISSN 1938-2014, 01/2014, Volume 6, Issue 1, pp. e28095 - e28095
Journal Article
EBioMedicine, ISSN 2352-3964, 08/2016, Volume 10, Issue C, pp. 185 - 194
Journal Article
DIABETOLOGIA, ISSN 0012-186X, 10/2012, Volume 55, pp. S203 - S203
Conference Proceeding
DIABETOLOGIA, ISSN 0012-186X, 09/2010, Volume 53, pp. S128 - S128
Conference Proceeding