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1. Full Text Tissue microarrays: construction and use
by Remotti, Helen
Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2013, Volume 980, pp. 13 - 28
Tissue microarrays (TMAs) enable high-throughput tissue analysis by selecting a large number of -paraffin-embedded donor tissue block cores and transferring... 
Immunohistochemistry | High-throughput tissue array protocol | Image analysis | Tissue microarrays | Formalin-fixed paraffin-embedded tissue | In situ hybridization | Bioinformatics | Image Processing, Computer-Assisted | Humans | Histocytochemistry | Tissue Array Analysis - instrumentation | Neoplasms - diagnosis | Biomarkers, Tumor | Tissue Array Analysis - methods
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2. Full Text Long-lived intestinal tuft cells serve as colon cancer-initiating cells
by Westphalen, C. Benedikt and Asfaha, Samuel and Hayakawa, Yoku and Takemoto, Yoshihiro and Lukin, Dana J and Nuber, Andreas H and Brandtner, Anna and Setlik, Wanda and Remotti, Helen and Muley, Ashlesha and Chen, Xiaowei and May, Randal and Houchen, Courtney W and Fox, James G and Gershon, Michael D and Quante, Michael and Wang, Timothy C
Journal of Clinical Investigation, ISSN 0021-9738, 03/2014, Volume 124, Issue 3, pp. 1283 - 1295
Doublecortin-like kinase 1 protein (DCLK1) is a gastrointestinal tuft cell marker that has been proposed to identify quiescent and tumor growth-sustaining stem... 
MEDICINE, RESEARCH & EXPERIMENTAL | IN-VITRO | CAM KINASE-LIKE-1 | ENTERIC NERVOUS-SYSTEM | COLORECTAL-CANCER | GROWTH-FACTORS | ALPHA-GUSTDUCIN | EPITHELIAL-CELL | SELF-RENEWAL | COLUMNAR STEM-CELLS | DIPHTHERIA-TOXIN | Diphtheria Toxin - pharmacology | Adenocarcinoma - pathology | Intestinal Mucosa - innervation | Receptors, G-Protein-Coupled - metabolism | Colon - pathology | Mice, Inbred C57BL | Cells, Cultured | Homeostasis | Colon - immunology | Colon - innervation | Colonic Neoplasms - metabolism | Mice, Knockout | Cell Lineage | Adenocarcinoma - metabolism | Animals | Intestinal Mucosa - immunology | Colonic Neoplasms - pathology | Mice, Inbred CBA | Mice | Neoplastic Stem Cells - physiology | Protein-Serine-Threonine Kinases - metabolism | Intestinal Mucosa - pathology | Colon cancer | Gene mutations | Gastrointestinal system | Physiological aspects | Development and progression | Genetic aspects | Identification and classification | Medical research | Colon | Mutation | Kinases | Rodents | Stem cells
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3. Full Text Crypt Apoptotic Body Counts in Normal Ileal Biopsies Overlap with Graft Versus Host Disease and Acute Cellular Rejection of Small Bowel Allografts
by Sung, Diana, MD and Iuga, Alina C., MD and Kato, Tomoaki, MD and Martinez, Mercedes, MD and Remotti, Helen E., MD and Lagana, Stephen M., MD
Human Pathology, ISSN 0046-8177, 2016, Volume 56, pp. 89 - 92
Crypt apoptosis in intestinal epithelium is an important diagnostic feature of graft versus host disease (GVHD) and acute cellular rejection (ACR) of... 
Pathology | Graft-versus-host disease | Intestinal transplant | Crypt apoptosis | Ileal biopsy | Acute cellular rejection | CRITERIA | INTESTINAL TRANSPLANTATION | PATHOLOGY | REPRODUCIBILITY | Predictive Value of Tests | Ileum - pathology | Humans | Middle Aged | Male | Ileum - immunology | Graft vs Host Disease - immunology | Allografts | Extracellular Vesicles - immunology | Intestinal Mucosa - immunology | Colonoscopy | Female | Graft Rejection - pathology | Databases, Factual | Acute Disease | Extracellular Vesicles - pathology | Intestinal Mucosa - transplantation | Treatment Outcome | Graft vs Host Disease - pathology | Biopsy | Organ Transplantation - adverse effects | Graft Rejection - immunology | Ileum - transplantation | Immunity, Cellular | Apoptosis | Intestinal Mucosa - pathology | Bone marrow | Transplantation | Consortia | Motility | Disease | Transplants & implants | Mortality | Infections | Small intestine | Tumors
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4. Full Text Pathology perspective on endoscopic full thickness resection
by Fazlollahi, Ladan and Remotti, Helen E
Techniques in Gastrointestinal Endoscopy, ISSN 1096-2883, 01/2019, Volume 21, Issue 1, pp. 7 - 12
Recent advances in minimally invasive endoscopic approaches have introduced new resection techniques including the Endoscopic Full Thickness Resection (EFTR)... 
Pathologic staging | Early gastric cancer | Early colorectal cancer | Full thickness biopsy | Subepithelial lesions | Endoscopic Submucosal Dissection (ESD) | Gastrointestinal stromal tumor | Endoscopy | Metastasis | Health aspects | Cells | Colorectal cancer
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5. Full Text The steatohepatitic variant of hepatocellular carcinoma and its association with underlying steatohepatitis
by Salomao, Marcela and Remotti, Helen and Vaughan, Roger and Siegel, Abby B and Lefkowitch, Jay H and Moreira, Roger Klein
Human Pathology, ISSN 0046-8177, 2012, Volume 43, Issue 5, pp. 737 - 746
Summary Steatohepatitis and metabolic syndrome are increasingly recognized as important risk factors for development of hepatocellular carcinoma. We have... 
Pathology | Hepatocellular carcinoma | NAFLD | NASH | Metabolic syndrome | Steatohepatitis | UNITED-STATES | FATTY LIVER-DISEASE | NONALCOHOLIC STEATOHEPATITIS | PATHOLOGY | STELLATE CELL ACTIVATION | CRYPTOGENIC CIRRHOSIS | DIABETES-MELLITUS | OBESITY | MEN | CANCER-RISK | Liver - pathology | Fatty Liver - pathology | Humans | Middle Aged | Fatty Liver - complications | Liver Neoplasms - complications | Male | Carcinoma, Hepatocellular - complications | Carcinoma, Hepatocellular - pathology | Adult | Female | Liver Neoplasms - pathology | Aged | Liver cancer | Carcinoma | Liver diseases | Hepatoma | Risk factors | Cancer | Studies | Hepatitis | Oxidative stress | Disease | Rodents | Liver cirrhosis | Tumors
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6. Full Text Smad4 loss synergizes with TGFα overexpression in promoting pancreatic metaplasia, PanIN development, and fibrosis
by Garcia-Carracedo, Dario and Yu, Chih-Chieh and Akhavan, Nathan and Fine, Stuart A and Schönleben, Frank and Maehara, Naoki and Karg, Dillon C and Xie, Chuangao and Qiu, Wanglong and Fine, Robert L and Remotti, Helen E and Su, Gloria H
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, p. e0120851
Aims While overexpression of TGF alpha has been reported in human pancreatic ductal adenocarcinoma (PDAC), mice with overexpressed TGF alpha develop... 
ADENOCARCINOMA | MULTIDISCIPLINARY SCIENCES | EPIDERMAL-GROWTH-FACTOR | INTRAEPITHELIAL NEOPLASIA | FACTOR RECEPTOR | CANCER | EXPRESSION | CARCINOMA | PROGRESSION MODEL | TRANSGENIC MICE | BETA | Biomarkers - metabolism | Gene Expression | Signal Transduction | Humans | Carcinogenesis - genetics | Pancreas - pathology | Epithelial Cells - pathology | Mice, Transgenic | Pancreatic Ducts - pathology | Gene Knockout Techniques | Smad4 Protein - metabolism | Disease Progression | Transforming Growth Factor alpha - genetics | Metaplasia - pathology | Pancreatic Diseases - genetics | Pancreatic Diseases - pathology | Acinar Cells - pathology | Animals | Smad4 Protein - genetics | Fibrosis | Mice | Smad4 Protein - deficiency | Metaplasia - genetics | Pancreatitis - metabolism | Vimentin | Adenocarcinoma | Immunohistochemistry | Collagen (type I) | Metastasis | Inactivation | Smad4 protein | Mimicry | Signal transduction | Epidermal growth factor | Fibroblasts | Tumorigenesis | Qualitative analysis | Lesions | Pancreas | Phenotypes | Deactivation | Ducts | Pancreatitis | Connective tissue growth factor | Gene expression | Zinc | Flox | Pathology | Metaplasia | Signaling | Hedgehog protein | Pancreatic cancer | Cyclooxygenase-2 | Sulfate | Zinc sulfate | Health risk assessment
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7. Full Text Identification of recurrent mutational events in anorectal melanoma
by Yang, Hui Min and Hsiao, Susan J and Schaeffer, David F and Lai, Chi and Remotti, Helen E and Horst, David and Mansukhani, Mahesh M and Horst, Basil A
Modern Pathology, ISSN 0893-3952, 02/2017, Volume 30, Issue 2, pp. 286 - 296
Anorectal melanoma is a rare disease that carries a poor prognosis. To date, limited genetic analyses confirmed KIT mutations as a recurrent genetic event... 
METASTATIC MELANOMA | DESMOPLASTIC MELANOMA | DISTINCT SUBTYPES | MUCOSAL MELANOMAS | FEMALE GENITAL-TRACT | MALIGNANT MELANOMAS | CUTANEOUS MELANOMA | PROTEIN EXPRESSION | KIT GENE MUTATION | PATHOLOGY | ANAL-CANAL EPITHELIUM | Exons | Humans | Middle Aged | Male | Anus Neoplasms - pathology | Signal Transduction - genetics | Melanoma - pathology | Phosphoproteins - genetics | RNA Splicing Factors - genetics | Rectal Neoplasms - genetics | Melanoma - genetics | Proto-Oncogene Proteins B-raf - genetics | Anus Neoplasms - genetics | Aged, 80 and over | Female | Aged | Rectal Neoplasms - pathology | Mutation | Neurofibromin 1 - genetics
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8. Full Text Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal
by Kindblom, LG and Remotti, HE and Aldenborg, F and Meis-Kindblom, JM
American Journal of Pathology, ISSN 0002-9440, 05/1998, Volume 152, Issue 5, pp. 1259 - 1269
The interstitial cells of Cajal (ICC) form a complex cell network within the gastrointestinal tract wall where the function as a pacemaker system. Expression... 
HUMAN COLON | AUTONOMIC NERVE TUMORS | TRACT | HUMAN SMALL-INTESTINE | PROTOONCOGENE C-KIT | W-LOCUS | TYROSINE KINASE | SMOOTH-MUSCLE TUMORS | ELECTRICAL-ACTIVITY | HIRSCHSPRUNGS-DISEASE | PATHOLOGY | Immunohistochemistry | Antigens, CD34 - metabolism | Stromal Cells - pathology | Humans | Middle Aged | Stromal Cells - metabolism | Male | Cell Nucleus - ultrastructure | Proto-Oncogene Proteins c-kit - metabolism | Stem Cells - metabolism | Gastrointestinal Neoplasms - pathology | Phenotype | Organelles - ultrastructure | Adolescent | Aged, 80 and over | Adult | Female | Aged | Cell Differentiation | Extracellular Matrix Proteins - metabolism | Gastrointestinal Neoplasms - metabolism
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9. Full Text Plasma‐thrombin cell blocks: Potential source of DNA contamination
by Sung, Simon and Sireci, Anthony N and Remotti, Helen E and Hodel, Vaishali and Mansukani, Mahesh M and Fernandes, Helen and Saqi, Anjali
Cancer Cytopathology, ISSN 1934-662X, 11/2019
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10. Full Text HER2 Heterogeneity in Gastroesophageal Cancer Detected by Testing Biopsy and Resection Specimens
by Fazlollahi, Ladan and Remotti, Helen E and Iuga, Alina and Yang, Hui-Min and Lagana, Stephen M and Sepulveda, Antonia R
Archives of Pathology and Laboratory Medicine, ISSN 0003-9985, 04/2018, Volume 142, Issue 4, pp. 516 - 522
Context.-In advanced gastric, esophageal, and gastroesophageal junction adenocarcinomas (GE-GEJ-AC) that overexpress ERBB2 (erb-b2 receptor tyrosine kinase 2... 
MEDICINE, RESEARCH & EXPERIMENTAL | PROGNOSTIC-FACTOR | AMPLIFICATION | GASTRIC-CANCER | ADENOCARCINOMA | JUNCTION CANCER | SCORING SYSTEM | MEDICAL LABORATORY TECHNOLOGY | PATHOLOGY | CARCINOMA | Immunohistochemistry | Tyrosine | Care and treatment | Surgery | Monoclonal antibodies | Medical tests | Diagnosis | Cancer | Usage | Genetic aspects | Research | Stomach cancer | Esophageal cancer | Metastasis | Hybridization | Kinases | Patients | Cancer therapies | ErbB-2 protein | Esophagus | Studies | Chemotherapy | Histopathology | Epidermal growth factor | Biopsy | Medical prognosis | Tumors
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11. Full Text HHLA2 is a novel immune checkpoint protein in pancreatic ductal adenocarcinoma and predicts post-surgical survival
by Yan, Han and Qiu, Wanglong and Koehne de Gonzalez, Anne K and Wei, Ji-Shu and Tu, Min and Xi, Chun-Hua and Yang, Ye-Ran and Peng, Yun-Peng and Tsai, Wei-Yann and Remotti, Helen E and Miao, Yi and Su, Gloria H
Cancer Letters, ISSN 0304-3835, 02/2019, Volume 442, pp. 333 - 340
HHLA2 is a newly identified member of the B7 immune checkpoint family, but its function and crosstalk with immune cells is not fully understood. To gain... 
IPMN | HHLA2 | Checkpoint costimulator | Pancreatic ductal adenocarcinoma | Prognostic significance | ONCOLOGY | IMMUNOTHERAPY | B7 FAMILY | CANCER | EXPRESSION | T-CELLS | MEMBER | Adenocarcinoma | Immunohistochemistry | Slopes | Crosstalk | Clinical trials | Cytotoxicity | Tissue analysis | Tissues | B7 antigen | Proteins | Signal transduction | Receptors | Cell growth | Lymphocytes | Surgery | Conflicts of interest | Lesions | Immune system | Antigens | Cytokines | Therapeutic applications | Invasiveness | Survival | Chemotherapy | Hospitals | Immune checkpoint | Pancreatic cancer | Medical prognosis | Ligands | Islets of Langerhans | Cancer | Tumors
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12. Full Text Rare pancreatic tumors
by Steinman, Jonathan and Steinman, Jonathan and Zaheer, Atif and Zaheer, Atif and Kluger, Michael D and Kluger, Michael D and Remotti, Helen and Remotti, Helen and Hecht, Elizabeth M and Hecht, Elizabeth M
Abdominal Radiology, ISSN 2366-004X, 2/2018, Volume 43, Issue 2, pp. 285 - 300
In this review, we will focus on rare pancreatic tumors. Most of these tumors do not have distinct characteristic appearances so the key to diagnosis requires... 
CT | Medicine & Public Health | MRI | Hepatology | Pancreatic ductal adenocarcinoma | Gastroenterology | Pancreas cancer | Acinar tumors | Imaging / Radiology | Pancreas | GASTROINTESTINAL STROMAL TUMOR | MR-IMAGING FEATURES | CYSTIC NEOPLASMS | RADIOLOGIC-PATHOLOGICAL CORRELATION | ADENOSQUAMOUS CARCINOMA | COMPUTED-TOMOGRAPHY | ACINAR-CELL-CARCINOMA | OF-THE-LITERATURE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | SOLID-PSEUDOPAPILLARY TUMORS | INTRADUCTAL TUBULOPAPILLARY NEOPLASMS | Diagnosis, Differential | Contrast Media | Humans | Pancreatic Neoplasms - pathology | Rare Diseases - diagnostic imaging | Rare Diseases - pathology | Pancreatic Neoplasms - diagnostic imaging | Medical colleges | Pancreatic cancer | Stem cells | Demographics | Demography | Mesenchyme | Imaging | Differential diagnosis | Diagnostic systems | Diagnosis | Lesions | Neoplasms | Tumors
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13. Full Text Pancreatic DCLK1+ cells originate distinctly from PDX1+ progenitors and contribute to the initiation of intraductal papillary mucinous neoplasm in mice
by Qiu, Wanglong and Remotti, Helen E and Tang, Sophia M and Wang, Elizabeth and Dobberteen, Lily and Lee Youssof, Ayman and Lee, Joo Hee and Cheung, Edwin C and Su, Gloria H
Cancer Letters, ISSN 0304-3835, 06/2018, Volume 423, pp. 71 - 79
PanINs and IPMNs are the two most common precursor lesions that can progress to invasive pancreatic ductal adenocarcinoma (PDA). DCLK1 has been identified as a... 
SOX9 | KLF4 | DCLK1 | Pancreatic IPMN | DOUBLECORTIN | DUCTAL ADENOCARCINOMA | MARKER | TUMOR | INDUCTION | IDENTIFICATION | CAM KINASE-LIKE-1 | ONCOLOGY | STEM-CELL | TUFT CELLS | DIFFERENTIATION | Adenocarcinoma | Immunohistochemistry | Animal models | Pathogenesis | Kinases | Phosphatase | Rodents | Bone marrow | Tumorigenesis | Lesions | Pancreas | Immunoglobulins | Invasiveness | Cell lineage | Clustering | Progenitor cells | Studies | Metaplasia | Pancreatic cancer | Stem cells | Cells (biology) | Biomarkers | Genetic engineering | Immunofluorescence | Niches | Tumors
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14. Full Text Can diffusion‐weighted imaging serve as a biomarker of fibrosis in pancreatic adenocarcinoma?
by Hecht, Elizabeth M and Liu, Michael Z and Prince, Martin R and Jambawalikar, Sachin and Remotti, Helen E and Weisberg, Stuart W and Garmon, Donald and Lopez‐Pintado, Sara and Woo, Yanghee and Kluger, Michael D and Chabot, John A
Journal of Magnetic Resonance Imaging, ISSN 1053-1807, 08/2017, Volume 46, Issue 2, pp. 393 - 402
Purpose To assess the relationship between diffusion‐weighted imaging (DWI) and intravoxel incoherent motion (IVIM)‐derived quantitative parameters (apparent... 
intravoxel incoherent motion (IVIM) | fibrosis | stromal desmoplasia | pancreas | diffusion weighted imaging (DWI) | pancreas adenocarcinoma (PAC) | ABDOMINAL MRI | DIFFERENTIAL-DIAGNOSIS | DUCTAL ADENOCARCINOMA | MUCIN-PRODUCING TUMOR | CANCER | B-VALUES | STROMAL BIOLOGY | COEFFICIENT | CARCINOMA | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | RESONANCE CHOLANGIOPANCREATOGRAPHY | Motion | Reproducibility of Results | Prospective Studies | Humans | Middle Aged | Image Interpretation, Computer-Assisted | Linear Models | Male | Healthy Volunteers | Young Adult | Algorithms | Adenocarcinoma - physiopathology | Image Processing, Computer-Assisted | Diffusion Magnetic Resonance Imaging | Fibrosis | Biomarkers | Adult | Female | Aged | Adenocarcinoma - diagnostic imaging | Pancreatic Neoplasms - physiopathology | Pancreatic Neoplasms - diagnostic imaging | Adenocarcinoma | Pancreatic cancer | Histochemistry | Health insurance industry | Statistical analysis | Readers | Histopathology | Perfusion | Echo surveys | Correlation analysis | Imaging | Diffusion effects | Diffusion coefficient | Pancreas | Tumors
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15. Full Text INI1 negative hepatoblastoma, a vanishing entity representing malignant rhabdoid tumor
by Fazlollahi, Ladan, MD and Hsiao, Susan J., MD, PhD and Mansukhani, Mahesh M., MD and Glade Bender, Julia L., MD and Kung, Andrew L., MD, PhD and Yamashiro, Darrell J., MD, PhD and Remotti, Helen E., MD
Human Pathology: Case Reports, ISSN 2214-3300, 2018, Volume 12, Issue C, pp. 42 - 47
AbstractMalignant rhabdoid tumors (MRT) represent a distinct group of aggressive tumors usually occurring in infancy involving a variety of anatomic locations... 
Pathology | Malignant rhabdoid tumor | SMARCB1 | Hepatoblastoma | INI1
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16. Full Text Implementation of next generation sequencing into pediatric hematology-oncology practice: Moving beyond actionable alterations
by Oberg, Jennifer A and Glade Bender, Julia L and Sulis, Maria Luisa and Pendrick, Danielle and Sireci, Anthony N and Hsiao, Susan J and Turk, Andrew T and Dela Cruz, Filemon S and Hibshoosh, Hanina and Remotti, Helen and Zylber, Rebecca J and Pang, Jiuhong and Diolaiti, Daniel and Koval, Carrie and Andrews, Stuart J and Garvin, James H and