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1. Full Text Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells
by Karamitros, D and Stoilova, B and Aboukhalil, Z and Hamey, F and Reinisch, A and Samitsch, M and Quek, L and Otto, G and Repapi, E and Doondeea, J and Usukhbayar, B and Calvo, J and Taylor, S and Goardon, N and Six, E and Pflumio, F and Porcher, C and Majeti, R and Gottgens, B and Vyas, P
NATURE IMMUNOLOGY, ISSN 1529-2908, 01/2018, Volume 19, Issue 1, pp. 85 - 85
The hierarchy of human hemopoietic progenitor cells that produce lymphoid and granulocytic-monocytic (myeloid) lineages is unclear. Multiple progenitor... 
LINEAGE COMMITMENT | DENDRITIC CELLS | RNA-SEQ | MULTIPOTENT PROGENITORS | HEMATOPOIETIC STEM-CELLS | BONE-MARROW | IN-VIVO | HUMAN CORD BLOOD | DIFFUSION MAPS | DIFFERENTIATION | IMMUNOLOGY | Myeloid Progenitor Cells - metabolism | Lymphoid Progenitor Cells - metabolism | Humans | Cells, Cultured | Gene Expression Profiling - methods | Hematopoiesis - genetics | Transplantation, Heterologous | Cell Separation - methods | Cell Differentiation - genetics | Animals | Single-Cell Analysis - methods | Mice | Hematopoietic Stem Cell Transplantation - methods | Cell Lineage - genetics | Usage | Chemistry, Analytic | Research | Cells | Monocytes | Myeloid cells | Populations | Cord blood | Transcription | Cells (biology) | Stem cells | Macrophages | Leukocytes (granulocytic) | Hemopoiesis | Life Sciences
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2. Full Text Genome-wide association study identifies five loci associated with lung function
by Kähönen, Mika and Albrecht, Eva and Obeidat, Ma'en and Mustelin, Linda and Froguel, Philippe and Burton, Paul R and Johansson, Åsa and Jankovic, Stipan and Grallert, Harald and Imboden, Medea and Hartikainen, Anna-Liisa and Delplanque, Jérôme and Porteous, David J and Olin, Anna-Carin and Schnabel, Eva and Holloway, John W and Ebrahim, Shah and Zgaga, Lina and MacLeod, Andrew K and Sayers, Ian and Rudan, Igor and Tobin, Martin D and Ripatti, Samuli and Wain, Louise V and McArdle, Wendy L and Evans, David M and Cooper, Matthew N and Smith, George Davey and Spector, Tim D and Völzke, Henry and Deloukas, Panos and Jarvelin, Marjo-Riitta and Blakey, John D and Strachan, David P and Cooper, Cyrus and Schulz, Holger and Campbell, Harry and Huffman, Jennifer E and Hall, Ian P and Rudnicka, Alicja R and James, Alan L and Rantanen, Taina and Lawlor, Debbie A and Morris, Andrew D and Nyberg, Fredrik and Ramasamy, Adaikalavan and Wright, Alan F and Karrasch, Stefan and Palmer, Lyle J and Wild, Sarah H and Repapi, Emmanouela and Hui, Jennie and Morris, Richard W and Elliott, Paul and Polašek, Ozren and Shaheen, Seif and Britton, John R and Igl, Wilmar and Heliövaara, Markku and Johnson, Toby and Bouatia-Naji, Nabila and Homuth, Georg and Dennison, Elaine and McKeever, Tricia M and Granell, Raquel and Pouta, Anneli and Gyllensten, Ulf and Zaboli, Ghazal and Soranzo, Nicole and Hingorani, Aroon D and Vitart, Veronique and Koch, Beate and Zhao, Jing Hua and Barroso, Inês and Wilson, James F and Kaprio, Jaakko and Jackson, Cathy and Wareham, Nicholas J and Loos, Ruth J F and Grkovic, Ivica and Peltonen, Leena and Torén, Kjell and Probst-Hensch, Nicole M and Wannamethee, S Goya and Pavord, Ian D and Gläser, Sven and Naluai, Åsa Torinsson and Henderson, John and Wichmann, H Erich and Surakka, Ida and Mangino, Massimo and Whincup, Peter H and Zhai, Guangju and Hayward, Caroline and Wellcome Trust Case Control Consor and NSHD Resp Study Team and Wellcome Trust Case Control Consortium and NSHD Respiratory Study Team and The NSHD Respiratory Study Team and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för genetik och patologi and Uppsala universitet
Nature Genetics, ISSN 1061-4036, 01/2010, Volume 42, Issue 1, pp. 36 - 44
Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested... 
MORTALITY | POPULATION | IN-VITRO | VARIANTS | ADVANCED GLYCATION ENDPRODUCTS | GENETICS & HEREDITY | RECEPTOR | HEALTH | IDIOPATHIC PULMONARY-FIBROSIS | HEIGHT | CANCER | Spirometry | Meta-Analysis as Topic | Thrombospondins - genetics | Humans | Male | Gene Expression Profiling | Pulmonary Disease, Chronic Obstructive - physiopathology | Receptors, Serotonin, 5-HT4 - genetics | RNA, Messenger - metabolism | Forced Expiratory Volume | Glutathione Transferase - genetics | Female | Lung - metabolism | Microfilament Proteins - genetics | Receptor for Advanced Glycation End Products | Pulmonary Disease, Chronic Obstructive - genetics | RNA, Messenger - genetics | Lung - physiopathology | Lung - physiology | Genome, Human - genetics | Tensins | Vital Capacity | Polymorphism, Single Nucleotide | Respiratory Function Tests | Genome-Wide Association Study - methods | Receptors, Immunologic - genetics | Usage | Lung diseases, Obstructive | Care and treatment | Messenger RNA | Physiological aspects | Pulmonary function tests | Research | Diagnosis | Risk factors | Genetics | Statistics | Expected values | Meta-analysis | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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3. Full Text CTAS: a CT score to quantify disease activity in pulmonary sarcoidosis
by Benamore, Rachel and Kendrick, Yvonne R and Repapi, Emmanouela and Helm, Emma and Cole, Suzanne L and Taylor, Stephen and Ho, Ling-Pei
Thorax, ISSN 0040-6376, 12/2016, Volume 71, Issue 12, pp. 1161 - 1163
BackgroundA major gap in the management of sarcoidosis is the lack of accessible and objective methods to measure disease activity. Since 90% of patients have... 
RESPIRATORY SYSTEM | HRCT | Severity of Illness Index | Young Adult | Humans | Middle Aged | Sarcoidosis, Pulmonary - diagnostic imaging | Vital Capacity - physiology | Tomography, X-Ray Computed - methods | Adult | Female | Male | Aged | CT imaging | Usage | Care and treatment | Sarcoidosis | Radiologists | Practice | Diagnosis | Health risk assessment | Medical imaging
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4. Full Text Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function
by Artigas, María Soler and Wain, Louise V and Repapi, Emmanouela and Obeidat, Ma'en and Sayers, Ian and Burton, Paul R and Johnson, Toby and Zhao, Jing Hua and Albrecht, Eva and Dominiczak, Anna F and Kerr, Shona M and Smith, Blair H and Cadby, Gemma and Hui, Jennie and Palmer, Lyle J and Hingorani, Aroon D and Wannamethee, S. Goya and Whincup, Peter H and Ebrahim, Shah and Smith, George Davey and Barroso, Inês and Loos, Ruth J. F and Wareham, Nicholas J and Cooper, Cyrus and Dennison, Elaine and Shaheen, Seif O and Liu, Jason Z and Marchini, Jonathan and Dahgam, Santosh and Naluai, Torinsson and Olin, Anna-Carin and Karrasch, Stefan and Heinrich, Joachim and Schulz, Holger and McKeever, Tricia M and Pavord, Ian D and Heliövaara, Markku and Ripatti, Samuli and Surakka, Ida and Blakey, John D and Kähönen, Mika and Britton, John R and Nyberg, Fredrik and Holloway, John W and Lawlor, Debbie A and Morris, Richard W and James, Alan L and Jackson, Cathy M and Hall, Ian P and Tobin, Martin D and SpiroMeta Consortium and Med Res Council Natl Survey Hlth D and Medical Research Council National Survey of Health and Development (NSHD) Respiratory Study Team and the SpiroMeta Consortium and Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy and Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi and Sahlgrenska akademin and Institute of Biomedicine, Department of Microbiology and Immunology and Institute of Medicine, Department of Public Health and Community Medicine
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 10/2011, Volume 184, Issue 7, pp. 786 - 795
Rationale: Genomic loci are associated with FEV1 or the ratio of FEV1 to FVC in population samples, but their association with chronic obstructive pulmonary... 
FVC | Genome-wide association study | Modeling risk | FEV | COMMON VARIANTS | METAANALYSIS | SUSCEPTIBILITY | REFERENCE VALUES | SAMPLE | modeling risk | RESPIRATORY SYSTEM | genome-wide association study | FEV1 | COHORT | PULMONARY-DISEASE | CRITICAL CARE MEDICINE | Forced Expiratory Volume - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Middle Aged | Europe - epidemiology | Vital Capacity - genetics | Male | Receptors, Serotonin, 5-HT4 - genetics | Pulmonary Disease, Chronic Obstructive - epidemiology | Genetic Variation | Tensins | Glutathione Transferase - genetics | Thrombospondin 1 - genetics | Adult | Female | Aged | Polymorphism, Single Nucleotide | Receptors, Immunologic - genetics | Microfilament Proteins - genetics | Receptor for Advanced Glycation End Products | Pulmonary Disease, Chronic Obstructive - genetics | MEDICIN OCH HÄLSOVETENSKAP | MEDICAL AND HEALTH SCIENCES
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5. Full Text DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation
by Godfrey, Laura and Crump, Nicholas T and Thorne, Ross and Lau, I-Jun and Repapi, Emmanouela and Dimou, Dimitra and Smith, Alastair L and Harman, Joe R and Telenius, Jelena M and Oudelaar, A. Marieke and Downes, Damien J and Vyas, Paresh and Hughes, Jim R and Milne, Thomas A
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 2803 - 15
Enhancer elements are a key regulatory feature of many important genes. Several general features including the presence of specific histone modifications are... 
SUPER-ENHANCERS | CHROMATIN | SIGNATURES | MULTIDISCIPLINARY SCIENCES | CELL IDENTITY | TRANSCRIPTION | MLL-FUSION PROTEINS | GENE-EXPRESSION | LEUKEMIA | HISTONE MODIFICATIONS | LOCUS | Enhancers | Chromatin | Lysine | Leukemia | DNA methylation | Histones | Acetylation | Methylation
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6. Full Text Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells article
by Karamitros, Dimitris and Stoilova, Bilyana and Aboukhalil, Zahra and Hamey, Fiona and Reinisch, Andreas and Samitsch, Marina and Quek, Lynn and Otto, Georg and Repapi, Emmanouela and Doondeea, Jessica and Usukhbayar, Batchimeg and Calvo, Julien and Taylor, Stephen and Goardon, Nicolas and Six, Emmanuelle and Pflumio, Francoise and Porcher, Catherine and Majeti, Ravindra and Göttgens, Berthold and Vyas, Paresh
Nature Immunology, ISSN 1529-2908, 01/2018, Volume 19, Issue 1, pp. 85 - 97
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7. Full Text SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells
by Chagraoui, Hedia and Kristiansen, Maiken S and Ruiz, Juan Pablo and Serra-Barros, Ana and Richter, Johanna and Hall-Ponselé, Elisa and Gray, Nicki and Waithe, Dominic and Clark, Kevin and Hublitz, Philip and Repapi, Emmanouela and Otto, Georg and Sopp, Paul and Taylor, Stephen and Thongjuea, Supat and Vyas, Paresh and Porcher, Catherine
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5375 - 17
During development, it is unclear if lineage-fated cells derive from multilineage-primed progenitors and whether active mechanisms operate to restrict cell... 
MESODERMAL CELLS | PROGENITORS | DEFINITIVE HEMATOPOIESIS | RYBP | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | MOUSE | COMPLEXES | DIFFERENTIATION | EXPRESSION | SCL | Heart | Gene silencing | Polycomb group proteins | Phenotypes | Transcription factors | Cell fate | Specifications | Mesoderm | Genomes | Gene expression | Blood | Hemopoiesis
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8. Full Text Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation
by Mead, Adam J and Neo, Wen Hao and Barkas, Nikolaos and Matsuoka, Sahoko and Giustacchini, Alice and Facchini, Raffaella and Thongjuea, Supat and Jamieson, Lauren and Booth, Christopher A.G and Fordham, Nicholas and Di Genua, Cristina and Atkinson, Deborah and Chowdhury, Onima and Repapi, Emmanouela and Gray, Nicki and Kharazi, Shabnam and Clark, Sally-Ann and Bouriez, Tiphaine and Woll, Petter and Suda, Toshio and Nerlov, Claus and Jacobsen, Sten Eirik W
Journal of Experimental Medicine, ISSN 0022-1007, 07/2017, Volume 214, Issue 7, pp. 2005 - 2021
Although previous studies suggested that the expression of FMS-like tyrosine kinase 3 (Flt3) initiates downstream of mouse hematopoietic stem cells (HSCs),... 
PROGENITOR CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | T-SNE | GENE | MULTIPOTENT PROGENITORS | BONE-MARROW NICHE | NECROSIS-FACTOR-ALPHA | ACUTE MYELOID-LEUKEMIA | IMMUNOLOGY | FLT3 LIGAND | DIFFERENTIAL EXPRESSION ANALYSIS | MYELODYSPLASTIC SYNDROMES | Hematopoietic Stem Cells - drug effects | Tumor Necrosis Factor-alpha - metabolism | Cell Proliferation - genetics | Mice, Inbred C57BL | Tumor Necrosis Factor-alpha - genetics | Cells, Cultured | Gene Expression Profiling - methods | Mice, Transgenic | Hematopoietic Stem Cells - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | fms-Like Tyrosine Kinase 3 - genetics | Animals | Single-Cell Analysis - methods | Etanercept - pharmacology | Mesenchymal Stem Cells - drug effects | Bone Marrow Transplantation | Bone Marrow Cells - drug effects | Mutation | Mesenchymal Stem Cells - metabolism | Stem Cell Niche - genetics | Tandem Repeat Sequences - genetics | Bone Marrow Cells - metabolism | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Tyrosine | Mesenchyme | Myeloid leukemia | Leukemia | Stem cell transplantation | Transplantation | Myeloproliferation | Kinases | Gene expression | Hematopoietic stem cells | Tumor necrosis factor | Stromal cells | Interrogation | Stem cells | Bone marrow | Tumor necrosis factor-TNF | Reservoirs | Mice | Flt3 protein | Bone | Acute myeloid leukemia | Protein-tyrosine kinase | 315 | 304 | 308
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9. Full Text Hepcidin is regulated by promoter-associated histone acetylation and HDAC3
by Pasricha, Sant-Rayn and Lim, Pei Jin and Duarte, Tiago L and Casu, Carla and Oosterhuis, Dorenda and Mleczko-Sanecka, Katarzyna and Suciu, Maria and Da Silva, Ana Rita and Al-Hourani, Kinda and Arezes, João and McHugh, Kirsty and Gooding, Sarah and Frost, Joe N and Wray, Katherine and Santos, Ana and Porto, Graça and Repapi, Emmanouela and Gray, Nicki and per, Simon J and Ashley, Neil and Soilleux, Elizabeth and Olinga, Peter and Muckenthaler, Martina U and Hughes, Jim R and Rivella, Stefano and Milne, Thomas A and Armitage, Anew E and kesmith, Hal
Nature Communications, ISSN 2041-1723, 09/2017, Volume 8, Issue 1, pp. 403 - 15
Hepcidin regulates systemic iron homeostasis. Suppression of hepcidin expression occurs physiologically in iron deficiency and increased erythropoiesis but is... 
Journal Article | To be checked by Faculty | DEACETYLASE ACTIVITY | METABOLISM | NUCLEAR RECEPTOR COREPRESSOR | ERYTHROPOIESIS | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | LIVER | DOWN-REGULATION | BETA-THALASSEMIA | EXPRESSION | SYSTEMIC IRON HOMEOSTASIS | Hepcidins - metabolism | Promoter Regions, Genetic | Histone Deacetylases - genetics | Histones - chemistry | Epigenesis, Genetic | Humans | Mice, Inbred C57BL | Gene Expression Regulation | Histone Deacetylases - metabolism | Male | Amino Acid Motifs | Erythropoietin - genetics | Animals | Iron - deficiency | Hepcidins - genetics | Acetylation | Erythropoietin - metabolism | Histones - metabolism | Erythropoiesis | Chromatin | Nutrient deficiency | Intestine | Iron | Hepcidin
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10. Full Text Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease
by Gooding, S and Olechnowicz, SWZ and Morris, EV and Armitage, AE and Arezes, J and Frost, J and Repapi, E and Edwards, JR and Ashley, N and Waugh, C and Gray, N and Martinez-Hackert, E and Lim, PJ and Pasricha, SR and Knowles, H and Mead, AJ and Ramasamy, K and Drakesmith, H and Edwards, CM
NATURE COMMUNICATIONS, ISSN 2041-1723, 10/2019, Volume 10, Issue 1, pp. 1 - 15
Multiple myeloma is an incurable, bone marrow-dwelling malignancy that disrupts bone homeostasis causing skeletal damage and pain. Mechanisms underlying... 
MULTIPLE-MYELOMA | CELLS | OSTEOLYTIC LESIONS | RNA-SEQ | TUMOR BURDEN | MULTIDISCIPLINARY SCIENCES | OSTEOBLASTS | MASS | IA RECEPTOR BMPRIA | MORPHOGENETIC PROTEINS | INDUCE APOPTOSIS | Profiling | Multiple myeloma | Homeostasis | SOST protein | Malignancy | Bone diseases | Bone (trabecular) | Osteoblasts | Signal transduction | Bone growth | Biomedical materials | Pain | Bone marrow | Bone morphogenetic proteins | Inhibition | Bone loss | Bone (cortical) | Bone turnover | Progenitor cells | Osteoclastogenesis | Signaling | Bone mass | Stem cells | Cells (biology) | Osteogenesis | Tumors
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11. Full Text MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia
by Kerry, Jon and Godfrey, Laura and Repapi, Emmanouela and Tapia, Marta and Blackledge, Neil P and Ma, Helen and Ballabio, Erica and O’Byrne, Sorcha and Ponthan, Frida and Heidenreich, Olaf and Roy, Anindita and Roberts, Irene and Konopleva, Marina and Klose, Robert J and Geng, Huimin and Milne, Thomas A
Cell Reports, ISSN 2211-1247, 01/2017, Volume 18, Issue 2, pp. 482 - 495
Understanding the underlying molecular mechanisms of defined cancers is crucial for effective personalized therapies. Translocations of the mixed-lineage... 
leukemia | epigenetic spreading | DOT1L | H3K79me2 | MLL-AF4 | MLL | drug combination therapy | epigenetic therapy | H3K79 METHYLATION | TARGET GENES | DOMAIN | CHROMATIN | MENIN | DNA | ACUTE LYMPHOBLASTIC-LEUKEMIA | CELL IDENTITY | MLL-FUSION PROTEINS | MIXED-LINEAGE LEUKEMIA | CELL BIOLOGY | Proto-Oncogene Proteins - metabolism | Myeloid-Lymphoid Leukemia Protein - metabolism | Oncogene Proteins, Fusion - metabolism | Leukemia - pathology | Prognosis | Humans | Methyltransferases - metabolism | DNA Methylation - genetics | Gene Expression Regulation, Leukemic | Intercellular Signaling Peptides and Proteins - metabolism | Methyltransferases - antagonists & inhibitors | Cell Line, Tumor | CpG Islands - genetics | Protein Binding | Enhancer Elements, Genetic - genetics | Lysine - metabolism | Histones - metabolism | Genome, Human | Binding Sites | Leukemia - genetics
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12. Full Text Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells
by Monteiro, Rui and Pinheiro, Philip and Joseph, Nicola and Peterkin, Tessa and Koth, Jana and Repapi, Emmanouela and Bonkhofer, Florian and Kirmizitas, Arif and Patient, Roger
Developmental Cell, ISSN 1534-5807, 08/2016, Volume 38, Issue 4, pp. 358 - 370
Hematopoietic stem cells (HSCs) are self-renewing multipotent stem cells that generate mature blood lineages throughout life. They, together with hematopoietic... 
EHT | TGFβ | hematopoietic stem cell | notch | jag1a | zebrafish | ZEBRAFISH EMBRYOS | VASCULAR DEVELOPMENT | TRANSGENIC ZEBRAFISH | TGF-BETA | PATHWAY | IN-VIVO | GENE-EXPRESSION | NOTCH | DEVELOPMENTAL BIOLOGY | DORSAL AORTA | AORTIC ENDOTHELIUM | CELL BIOLOGY | Zebrafish Proteins - biosynthesis | Morpholinos - genetics | Signal Transduction | Transforming Growth Factor beta3 - genetics | Animals, Genetically Modified | Transforming Growth Factor beta2 - metabolism | Zebrafish Proteins - metabolism