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by Kähönen, Mika and Albrecht, Eva and Obeidat, Ma'en and Mustelin, Linda and Froguel, Philippe and Burton, Paul R and Johansson, Åsa and Jankovic, Stipan and Grallert, Harald and Imboden, Medea and Hartikainen, Anna-Liisa and Delplanque, Jérôme and Porteous, David J and Olin, Anna-Carin and Schnabel, Eva and Holloway, John W and Ebrahim, Shah and Zgaga, Lina and MacLeod, Andrew K and Sayers, Ian and Rudan, Igor and Tobin, Martin D and Ripatti, Samuli and Wain, Louise V and McArdle, Wendy L and Evans, David M and Cooper, Matthew N and Smith, George Davey and Spector, Tim D and Völzke, Henry and Deloukas, Panos and Jarvelin, Marjo-Riitta and Blakey, John D and Strachan, David P and Cooper, Cyrus and Schulz, Holger and Campbell, Harry and Huffman, Jennifer E and Hall, Ian P and Rudnicka, Alicja R and James, Alan L and Rantanen, Taina and Lawlor, Debbie A and Morris, Andrew D and Nyberg, Fredrik and Ramasamy, Adaikalavan and Wright, Alan F and Karrasch, Stefan and Palmer, Lyle J and Wild, Sarah H and Repapi, Emmanouela and Hui, Jennie and Morris, Richard W and Elliott, Paul and Polašek, Ozren and Shaheen, Seif and Britton, John R and Igl, Wilmar and Heliövaara, Markku and Johnson, Toby and Bouatia-Naji, Nabila and Homuth, Georg and Dennison, Elaine and McKeever, Tricia M and Granell, Raquel and Pouta, Anneli and Gyllensten, Ulf and Zaboli, Ghazal and Soranzo, Nicole and Hingorani, Aroon D and Vitart, Veronique and Koch, Beate and Zhao, Jing Hua and Barroso, Inês and Wilson, James F and Kaprio, Jaakko and Jackson, Cathy and Wareham, Nicholas J and Loos, Ruth J F and Grkovic, Ivica and Peltonen, Leena and Torén, Kjell and Probst-Hensch, Nicole M and Wannamethee, S Goya and Pavord, Ian D and Gläser, Sven and Naluai, Åsa Torinsson and Henderson, John and Wichmann, H Erich and Surakka, Ida and Mangino, Massimo and Whincup, Peter H and Zhai, Guangju and Hayward, Caroline and Wellcome Trust Case Control Consor and NSHD Resp Study Team and Wellcome Trust Case Control Consortium and NSHD Respiratory Study Team and The NSHD Respiratory Study Team and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för genetik och patologi and Uppsala universitet
Nature Genetics, ISSN 1061-4036, 01/2010, Volume 42, Issue 1, pp. 36 - 44
Journal Article
Thorax, ISSN 0040-6376, 12/2016, Volume 71, Issue 12, pp. 1161 - 1163
BackgroundA major gap in the management of sarcoidosis is the lack of accessible and objective methods to measure disease activity. Since 90% of patients have... 
RESPIRATORY SYSTEM | HRCT | Severity of Illness Index | Young Adult | Humans | Middle Aged | Sarcoidosis, Pulmonary - diagnostic imaging | Vital Capacity - physiology | Tomography, X-Ray Computed - methods | Adult | Female | Male | Aged | CT imaging | Usage | Care and treatment | Sarcoidosis | Radiologists | Practice | Diagnosis | Health risk assessment | Medical imaging
Journal Article
by Artigas, María Soler and Wain, Louise V and Repapi, Emmanouela and Obeidat, Ma'en and Sayers, Ian and Burton, Paul R and Johnson, Toby and Zhao, Jing Hua and Albrecht, Eva and Dominiczak, Anna F and Kerr, Shona M and Smith, Blair H and Cadby, Gemma and Hui, Jennie and Palmer, Lyle J and Hingorani, Aroon D and Wannamethee, S. Goya and Whincup, Peter H and Ebrahim, Shah and Smith, George Davey and Barroso, Inês and Loos, Ruth J. F and Wareham, Nicholas J and Cooper, Cyrus and Dennison, Elaine and Shaheen, Seif O and Liu, Jason Z and Marchini, Jonathan and Dahgam, Santosh and Naluai, Torinsson and Olin, Anna-Carin and Karrasch, Stefan and Heinrich, Joachim and Schulz, Holger and McKeever, Tricia M and Pavord, Ian D and Heliövaara, Markku and Ripatti, Samuli and Surakka, Ida and Blakey, John D and Kähönen, Mika and Britton, John R and Nyberg, Fredrik and Holloway, John W and Lawlor, Debbie A and Morris, Richard W and James, Alan L and Jackson, Cathy M and Hall, Ian P and Tobin, Martin D and SpiroMeta Consortium and Med Res Council Natl Survey Hlth D and Medical Research Council National Survey of Health and Development (NSHD) Respiratory Study Team and the SpiroMeta Consortium and Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy and Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi and Sahlgrenska akademin and Institute of Biomedicine, Department of Microbiology and Immunology and Institute of Medicine, Department of Public Health and Community Medicine
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 10/2011, Volume 184, Issue 7, pp. 786 - 795
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 2803 - 15
Enhancer elements are a key regulatory feature of many important genes. Several general features including the presence of specific histone modifications are... 
SUPER-ENHANCERS | CHROMATIN | SIGNATURES | MULTIDISCIPLINARY SCIENCES | CELL IDENTITY | TRANSCRIPTION | MLL-FUSION PROTEINS | GENE-EXPRESSION | LEUKEMIA | HISTONE MODIFICATIONS | LOCUS | Enhancers | Chromatin | Lysine | Leukemia | DNA methylation | Histones | Acetylation | Methylation
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5375 - 17
During development, it is unclear if lineage-fated cells derive from multilineage-primed progenitors and whether active mechanisms operate to restrict cell... 
MESODERMAL CELLS | PROGENITORS | DEFINITIVE HEMATOPOIESIS | RYBP | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | MOUSE | COMPLEXES | DIFFERENTIATION | EXPRESSION | SCL | Heart | Gene silencing | Polycomb group proteins | Phenotypes | Transcription factors | Cell fate | Specifications | Mesoderm | Genomes | Gene expression | Blood | Hemopoiesis
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 07/2017, Volume 214, Issue 7, pp. 2005 - 2021
Although previous studies suggested that the expression of FMS-like tyrosine kinase 3 (Flt3) initiates downstream of mouse hematopoietic stem cells (HSCs),... 
PROGENITOR CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | T-SNE | GENE | MULTIPOTENT PROGENITORS | BONE-MARROW NICHE | NECROSIS-FACTOR-ALPHA | ACUTE MYELOID-LEUKEMIA | IMMUNOLOGY | FLT3 LIGAND | DIFFERENTIAL EXPRESSION ANALYSIS | MYELODYSPLASTIC SYNDROMES | Hematopoietic Stem Cells - drug effects | Tumor Necrosis Factor-alpha - metabolism | Cell Proliferation - genetics | Mice, Inbred C57BL | Tumor Necrosis Factor-alpha - genetics | Cells, Cultured | Gene Expression Profiling - methods | Mice, Transgenic | Hematopoietic Stem Cells - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | fms-Like Tyrosine Kinase 3 - genetics | Animals | Single-Cell Analysis - methods | Etanercept - pharmacology | Mesenchymal Stem Cells - drug effects | Bone Marrow Transplantation | Bone Marrow Cells - drug effects | Mutation | Mesenchymal Stem Cells - metabolism | Stem Cell Niche - genetics | Tandem Repeat Sequences - genetics | Bone Marrow Cells - metabolism | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Tyrosine | Mesenchyme | Myeloid leukemia | Leukemia | Stem cell transplantation | Transplantation | Myeloproliferation | Kinases | Gene expression | Hematopoietic stem cells | Tumor necrosis factor | Stromal cells | Interrogation | Stem cells | Bone marrow | Tumor necrosis factor-TNF | Reservoirs | Mice | Flt3 protein | Bone | Acute myeloid leukemia | Protein-tyrosine kinase | 315 | 304 | 308
Journal Article
Nature Communications, ISSN 2041-1723, 09/2017, Volume 8, Issue 1, pp. 403 - 15
Journal Article
Journal Article