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1. Full Text Fever and the thermal regulation of immunity: The immune system feels the heat
by Evans, Sharon S and Repasky, Elizabeth A and Fisher, Daniel T
Nature Reviews Immunology, ISSN 1474-1733, 06/2015, Volume 15, Issue 6, pp. 335 - 349
Fever is a cardinal response to infection that has been conserved in warm-blooded and cold-blooded vertebrates for more than 600 million years of evolution.... 
SHOCK PROTEINS GP96 | WHOLE-BODY HYPERTHERMIA | CELLULAR STRESS-RESPONSE | DENDRITIC CELLS | MESSENGER-RNA EXPRESSION | L-SELECTIN ADHESION | HOST-DEFENSE | LIPOPOLYSACCHARIDE-INDUCED FEVER | RAT-BRAIN | IMMUNOLOGY | BRAIN ENDOTHELIAL-CELLS | Infection - immunology | Humans | Body Temperature Regulation - immunology | Homeostasis - immunology | Heat-Shock Proteins - immunology | Immunity, Innate - immunology | Animals | Lymphocytes - immunology | Interleukin-6 - immunology | Killer Cells, Natural - immunology | Fever - immunology | Cytokines - biosynthesis | Macrophages - immunology | Stress, Physiological - immunology | Physiological aspects | Medicine, Experimental | Medical research | Immune response | Hyperthermia | Fever
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2. Full Text Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature
by Kathleen M. Kokolus and Maegan L. Capitano and Chen-Ting Lee and Jason W.-L. Eng and Jeremy D. Waight and Bonnie L. Hylander and Sandra Sexton and Chi-Chen Hong and Christopher J. Gordon and Scott I. Abrams and Elizabeth A. Repasky
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2013, Volume 110, Issue 50, pp. 20176 - 20181
We show here that fundamental aspects of antitumor immunity in mice are significantly influenced by ambient housing temperature. Standard housing temperature... 
T lymphocytes | Cell growth | Thermogenesis | Immune response | Ambient temperature | Body temperature | Mice | Housing | Tumors | Cancer | Metabolism | Murine tumor models | INTERLEUKIN-2 | CELLS | MULTIDISCIPLINARY SCIENCES | MOUSE | BROWN ADIPOSE-TISSUE | murine tumor models | CANCER | THERMONEUTRALITY | MODELS | metabolism | TRADE-OFFS | COLD | STRESS | Immunohistochemistry | Immunotherapy - methods | Temperature | Housing, Animal - standards | Linear Models | Blood Cell Count | Animals | Analysis of Variance | Neoplasms - immunology | Cell Line, Tumor | Female | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Stress, Physiological - immunology | Physiological aspects | Research | Growth | Health aspects | Biological Sciences
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3. Full Text Blockade of host β2-adrenergic receptor enhances graft-versus-tumor effect through modulating antigen presenting cells
by Mohammadpour, Hemn and O’Neil, Rachel and Qiu, Jingxin and McCarthy, Philip L and Repasky, Elizabeth A and Cao, Xuefang
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 4/2018, Volume 200, Issue 7, pp. 2479 - 2488
Allogeneic hematopoietic cell transplantation (allo-HCT) is a potential curative therapy for hematologic malignancies. Host antigen presenting cells (APCs) are... 
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4. Full Text Progress in development of biomedical applications of heat shock proteins and thermal stress
by Repasky, Elizabeth A
International Journal of Hyperthermia, ISSN 0265-6736, 8/2013, Volume 29, Issue 5, pp. 359 - 361
HYPERTHERMIA | CELLS | TARGETS | ONCOLOGY | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Heat-Shock Response | Animals | Hot Temperature | Heat-Shock Proteins - physiology | Humans | Hyperthermia, Induced
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5. Full Text The IXth CSSI international symposium on heat shock proteins in biology and medicine: stress responses in health and disease
by Stuart K Calderwood and Elizabeth A Repasky and Len Neckers and Lawrence E Hightower
Cell Stress & Chaperones, ISSN 1355-8145, 01/2019, pp. 1 - 6
The stress response has been studied now for over 50 years and is known to have significance in the survival of organisms in a challenging environment and in... 
Proteins | Thermal stress | Posters | Heat shock proteins | Aging | Pharmacology | Protein interaction | Disease control | Environmental impact | Cellular stress response | Heat shock
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6. Full Text Manipulation of ambient housing temperature to study the impact of chronic stress on immunity and cancer in mice
by Hylander, Bonnie L and Gordon, Christopher J and Repasky, Elizabeth A
Journal of Immunology, ISSN 0022-1767, 02/2019, Volume 202, Issue 3, pp. 631 - 636
Mice are the preeminent research organism in which to model human diseases and study the involvement of the immune response. Rapidly accumulating evidence... 
MILD COLD-STRESS | LABORATORY MICE | BREAST-CANCER | RESPONSES | PHYSIOLOGY | PANCREATIC-CANCER | MOUSE MODEL | IMMUNOLOGY | BETA-BLOCKERS | TUMOR-GROWTH | CAGE ENVIRONMENT
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7. Full Text Depression Stresses the Immune Response and Promotes Prostate Cancer Growth
by Mohammadpour, H and Bucsek, MJ and Hylander, BL and Repasky, EA
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 04/2019, Volume 25, Issue 8, pp. 2363 - 2365
Depression induces secretion of neuropeptide Y from prostate cancer cells, which, in turn, recruits myeloid-derived suppressor cells (MDSC) to the tumor; tumor... 
TEMPERATURE | ONCOLOGY | Myeloid-Derived Suppressor Cells - immunology | Prostatic Neoplasms - genetics | Signal Transduction | Humans | Depression | Male | STAT3 Transcription Factor - genetics
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8. Full Text Blockade of host β2-adrenergic receptor enhances graft-versus-tumor effect through modulating APCs
by Mohammadpour, Hemn and O'Neil, Rachel and Qiu, Jingxin and McCarthy, Philip L and Repasky, Elizabeth A and Cao, Xuefang
Journal of Immunology, ISSN 0022-1767, 04/2018, Volume 200, Issue 7, pp. 2479 - 2488
Allogeneic hematopoietic cell transplantation is a potential curative therapy for hematologic malignancies. Host APCs are pivotal to the desired... 
Hematologic Neoplasms - therapy | Cell Proliferation - genetics | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Receptors, Adrenergic, beta-2 - genetics | Dendritic Cells - immunology | Mice, Inbred C57BL | Cell Proliferation - physiology | Cells, Cultured | Hematopoietic Stem Cell Transplantation | Graft vs Tumor Effect - immunology | Receptors, Adrenergic, beta-2 - metabolism | Mice, Knockout | T-Lymphocytes, Regulatory - immunology | Animals | Graft vs Host Disease - prevention & control | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Adrenergic beta-2 Receptor Antagonists - pharmacology | STAT3 Transcription Factor - metabolism | TOR protein | Cell proliferation | Graft-versus-host reaction | CD8 antigen | Transplantation | Lymphocytes T | Grafting | Lymphocytes | Rodents | Bone marrow | Foxp3 protein | Pretreatment | CD11c antigen | Immunological memory | Memory cells | Dendritic cells | Immunoregulation | Stat3 protein | CD4 antigen | Hemopoiesis | Signaling | Immunogenicity | Antigen-presenting cells | Adrenergic receptors
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9. Full Text β2- Adrenergic Signaling Regulates Graft Versus Host Disease after Allogenic Transplantation While Preserving Graft Versus Leukemia Effect
by Mohammadpour, Hemn and Sarow, Joseph L and Chen, George L and MacDonald, Cameron R and Sharma, Umesh and Herr, Megan M and Hahn, Theresa E and Repasky, Elizabeth A and McCarthy, Philip L
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 1915 - 1915
β2 adrenergic receptor signaling is a key regulator of various immune cells, including T cells; however, its role in T cell function in the context of graft... 
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10. Full Text β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells
by Mohammadpour, Hemn and MacDonald, Cameron R and Qiao, Guanxi and Chen, Minhui and Dong, Bowen and Hylander, Bonnie L and McCarthy, Philip L and Abrams, Scott I and Repasky, Elizabeth A
Journal of Clinical Investigation, ISSN 0021-9738, 11/2019
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11. Full Text Housing temperature-induced stress drives therapeutic resistance in murine tumour models through β2-adrenergic receptor activation
by Eng, Jason W.-L and Reed, Chelsey B and Kokolus, Kathleen M and Pitoniak, Rosemarie and Utley, Adam and Bucsek, Mark J and Ma, Wen Wee and Repasky, Elizabeth A and Hylander, Bonnie L
Nature Communications, ISSN 2041-1723, 03/2015, Volume 6, Issue 1, p. 6426
Cancer research relies heavily on murine models for evaluating the anti-tumour efficacy of therapies. Here we show that the sensitivity of several pancreatic... 
Temperature | Paclitaxel - pharmacology | Pancreatic Neoplasms - metabolism | Apoptosis - drug effects | Humans | Gene Expression Regulation, Neoplastic | Stress, Physiological | bcl-X Protein - genetics | Pancreatic Neoplasms - drug therapy | Proto-Oncogene Proteins c-bcl-2 - metabolism | TNF-Related Apoptosis-Inducing Ligand - pharmacology | Antineoplastic Agents - pharmacology | Signal Transduction | Receptors, Adrenergic, beta-2 - genetics | Mice, Inbred C57BL | Pancreatic Neoplasms - pathology | Adrenergic beta-Agonists - pharmacology | Pancreatic Neoplasms - genetics | Cisplatin - pharmacology | Mice, SCID | Receptors, Adrenergic, beta-2 - metabolism | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Albumins - pharmacology | Animals | Isoproterenol - pharmacology | Cell Line, Tumor | Mice | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics
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12. Full Text Systemic Endocrine Instigation of Indolent Tumor Growth Requires Osteopontin
by McAllister, Sandra S and Gifford, Ann M and Greiner, Ashley L and Kelleher, Stephen P and Saelzler, Matthew P and Ince, Tan A and Reinhardt, Ferenc and Harris, Lyndsay N and Hylander, Bonnie L and Repasky, Elizabeth A and Weinberg, Robert A
Cell, ISSN 0092-8674, 2008, Volume 133, Issue 6, pp. 994 - 1005
The effects of primary tumors on the host systemic environment and resulting contributions of the host to tumor growth are poorly understood. Here, we find... 
CELLCYCLE | PROGENITOR CELLS | IN-VITRO | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEMATOPOIETIC STEM-CELLS | BONE-MARROW | GENE-EXPRESSION | STROMAL FIBROBLASTS | HUMAN BREAST-CANCER | MYELOID CELLS | TRANSGENIC MICE | CELL BIOLOGY | Neoplasm Transplantation | Bone Marrow Cells - cytology | Humans | Transplantation, Heterologous | Osteopontin - metabolism | Colonic Neoplasms - metabolism | Breast Neoplasms - metabolism | Neoplasm Metastasis | Adenocarcinoma - metabolism | Animals | Mice, Nude | Cell Division | Cell Line, Tumor | Mice | Bone Marrow Cells - metabolism | Cell Movement | Growth | Tumors
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13. The impact of housing temperature-induced chronic stress on preclinical mouse tumor models and therapeutic responses: An important role for the nervous system
by Hylander, Bonnie L and Eng, Jason W.-L and Repasky, Elizabeth A
Advances in Experimental Medicine and Biology, ISSN 0065-2598, 2017, Volume 1036, pp. 173 - 189
In the last 10-15 years, there has been a recognition that the catecholamines (norepinephrine, NE, and epinephrine, Epi) released by the sympathetic nervous... 
Thermoregulation | Immunosuppression | Tumor microenvironment | Metabolism | Therapeutic resistance | Neoplasms, Experimental - pathology | Stress, Psychological - pathology | Stress, Psychological - therapy | Animals | Nervous System - pathology | Humans | Neoplasms, Experimental - immunology | Neoplasms, Experimental - therapy | Mice | Chronic Disease | Nervous System - immunology | Stress, Psychological - immunology
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14. Full Text IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells
by Fisher, Daniel T and Chen, Qing and Skitzki, Joseph J and Muhitch, Jason B and Zhou, Lei and Appenheimer, Michelle M and Vardam, Trupti D and Weis, Emily L and Passanese, Jessica and Wang, Wan-Chao and Gollnick, Sandra O and Dewhirst, Mark W and Rose-John, Stefan and Repasky, Elizabeth A and Baumann, Heinz and Evans, Sharon S
Journal of Clinical Investigation, ISSN 0021-9738, 10/2011, Volume 121, Issue 10, pp. 3846 - 3859
Immune cells are key regulators of neoplastic progression, which is often mediated through their release of cytokines. Inflammatory cytokines such as IL-6... 
MEDICINE, RESEARCH & EXPERIMENTAL | STAT3 ACTIVATION | LEUKOCYTE RECRUITMENT | WHOLE-BODY HYPERTHERMIA | DESIGNER CYTOKINE | RANGE THERMAL-STRESS | IMMUNE SURVEILLANCE | PANCREATIC-CANCER | HIGH ENDOTHELIAL VENULES | INTESTINAL EPITHELIAL-CELLS | LYMPHOCYTE TRAFFICKING | T-Lymphocytes, Cytotoxic - immunology | Signal Transduction | P-Selectin - metabolism | Humans | E-Selectin - metabolism | Neoplasms - blood supply | Microvessels - immunology | Cell Movement - immunology | Tumor Microenvironment - immunology | Intercellular Adhesion Molecule-1 - metabolism | Models, Immunological | Neoplasms - therapy | Animals | Neoplasms - immunology | Hyperthermia, Induced | Cell Line, Tumor | Mice | Neoplasms - pathology | Interleukin-6 - metabolism | Apoptosis | Physiological aspects | Development and progression | Research | T cells | Tumors | Interleukin-6
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15. Full Text β-Adrenergic signaling in mice housed at standard temperatures suppresses an effector phenotype in CD8+ T cells and undermines checkpoint inhibitor therapy
by Bucsek, Mark J and Qiao, Guanxi and MacDonald, Cameron R and Giridharan, Thejaswini and Evans, Lauren and Niedzwecki, Brian and Liu, Haichao and Kokolus, Kathleen M and Eng, Jason W.-L and Messmer, Michelle N and Attwood, Kristopher and Abrams, Scott I and Hylander, Bonnie L and Repasky, Elizabeth A
Cancer Research, ISSN 0008-5472, 10/2017, Volume 77, Issue 20, pp. 5639 - 5651
The immune context of tumors has significant prognostic value and is predictive of responsiveness to several forms of therapy, including immunotherapy. We... 
LABORATORY MICE | LUNG-CANCER | ALTERNATIVELY ACTIVATED MACROPHAGES | HOUSING TEMPERATURE | ONCOLOGY | ADAPTIVE THERMOGENESIS | LYMPH-NODES | OVARIAN-CANCER | REGULATORY T | STRESS | TUMOR MICROENVIRONMENT | Mammary Neoplasms, Experimental - immunology | Immunotherapy - methods | Temperature | Melanoma, Experimental - therapy | Mice, Inbred C57BL | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Receptors, Adrenergic, beta-2 - immunology | Random Allocation | Mammary Neoplasms, Experimental - therapy | Mice, Knockout | Signal Transduction - immunology | Phenotype | Animals | Melanoma, Experimental - immunology | Female | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Adrenergic beta-2 Receptor Antagonists - pharmacology | Stresses | Therapy | Animal models | PD-1 protein | CD8 antigen | Effector cells | Lymphocytes T | Pharmacology | Immune status | Conversion | CD4 antigen | Environmental stress | Signaling | Immune checkpoint | Lymphocytes | Immunotherapy | γ-Interferon | Antitumor activity | Norepinephrine | Adrenergic receptors | Tumors | Cancer | Apoptosis | Immune system | Checkpoint inhibitors | Chronic stress | Breast cancer | Animal models of cancer | Adrenergic signaling | Melanoma
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16. Full Text A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response
by Eng, Jason W.-L and Kokolus, Kathleen M and Reed, Chelsey B and Hylander, Bonnie L and Ma, Wen W and Repasky, Elizabeth A
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 11/2014, Volume 63, Issue 11, pp. 1115 - 1128
Long conserved mechanisms maintain homeostasis in living creatures in response to a variety of stresses. However, continuous exposure to stress can result in... 
Immunosuppression | Immunology | Medicine & Public Health | Immunotherapies | Oncology | Cancer Research | Catecholamines | Nervous system | Stress | LABORATORY MICE | PLASMA IL-12 LEVELS | REGULATORY T | IMMUNOLOGY | BREAST-CANCER | ONCOLOGY | PROSTATE-CANCER | IN-VIVO SUPPRESSION | BETA-BLOCKER USE | NF-KAPPA-B | T-CELLS | ADOPTIVE IMMUNOTHERAPY | Immunosuppression - methods | Receptors, Adrenergic - metabolism | Humans | Immunosuppressive Agents - therapeutic use | Homeostasis | Immune Tolerance | Tumor Microenvironment | Neoplasms - psychology | Disease Progression | Disease-Free Survival | Fear | Animals | Norepinephrine - metabolism | Anxiety - complications | Stress, Psychological | Sympathetic Nervous System | Mice | Neoplasms - pathology | Epinephrine - metabolism | Epinephrine | Development and progression | Stress (Psychology) | Immunotherapy | Cancer | Nervous System
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