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Science, ISSN 0036-8075, 03/2012, Volume 335, Issue 6075, pp. 1503 - 1506
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2011, Volume 108, Issue 36, pp. 14968 - 14973
Aggregation of amyloid-β (Aβ) as toxic oligomers and amyloid plaques within the brain appears to be the pathogenic event that initiates Alzheimer's disease... 
Receptors | Antidepressants | Neurons | Imaging | Amyloids | Physiological regulation | Alzheimers disease | Depressive disorders | Hippocampus | Vehicles | Late-life depression | Microdialysis | Selective serotonin reuptake inhibitor antidepressants | late-life depression | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | INTERSTITIAL FLUID | DEPRESSIVE SYMPTOMS | MILD COGNITIVE IMPAIRMENT | CEREBROSPINAL-FLUID | MUSCARINIC ACETYLCHOLINE-RECEPTORS | PITTSBURGH COMPOUND-B | REGULATED KINASE | microdialysis | IN-VIVO | PRECURSOR PROTEIN SECRETION | selective serotonin reuptake inhibitor antidepressants | Brain - diagnostic imaging | Humans | Alzheimer Disease - drug therapy | Male | Mice, Transgenic | Thiazoles - administration & dosage | Positron-Emission Tomography | Antidepressive Agents, Second-Generation - administration & dosage | Brain - metabolism | Radiography | Animals | Citalopram - administration & dosage | Signal Transduction - drug effects | Time Factors | Amyloid beta-Peptides - genetics | Serotonin - metabolism | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Female | Mice | Alzheimer Disease - diagnostic imaging | Alzheimer Disease - genetics | Aniline Compounds - administration & dosage | Drugs | Neuroimaging | Brain | Animal models | Neurodegenerative diseases | Transgenic mice | Extracellular signal-regulated kinase | Data processing | Serotonin uptake inhibitors | beta -Amyloid | Metabolism | Amyloid | Alzheimer's disease | Positron emission tomography | citalopram | Plaques | Geriatrics | Index Medicus | Biological Sciences
Journal Article
FASEB Journal, ISSN 0892-6638, 01/2013, Volume 27, Issue 1, pp. 187 - 198
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2016, Volume 213, Issue 5, pp. 677 - 685
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 08/2011, Volume 31, Issue 31, pp. 11328 - 11337
The concentration of amyloid-beta (A beta) within the brain extracellular space is one determinant of whether the peptide will aggregate into toxic species... 
ALPHA-SECRETASE | RAT HIPPOCAMPAL-NEURONS | ALZHEIMERS-DISEASE | INTERSTITIAL FLUID | A-BETA | PRECURSOR PROTEIN | CEREBROSPINAL-FLUID | NEUROSCIENCES | METHYL-D-ASPARTATE | GENE-TRANSCRIPTION | TRANSGENIC MICE | Enzyme-Linked Immunosorbent Assay - methods | Action Potentials - genetics | Calcium - metabolism | Humans | Extracellular Space - drug effects | Receptors, N-Methyl-D-Aspartate - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Synapses - pathology | Serotonin - pharmacology | N-Methylaspartate - pharmacology | Dose-Response Relationship, Drug | Extracellular Space - metabolism | Synapses - metabolism | Piperidines - pharmacology | Amyloid beta-Peptides - metabolism | Egtazic Acid - analogs & derivatives | Brain Waves - drug effects | Tetrodotoxin - pharmacology | Action Potentials - drug effects | Flavones - pharmacology | Synapses - drug effects | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Presenilin-1 - genetics | Mice, Transgenic | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Chelating Agents - pharmacology | Mutation - genetics | Electroencephalography - methods | Piperazines - pharmacology | Amyloid beta-Protein Precursor - genetics | Animals | Egtazic Acid - pharmacology | Pregnanolone - pharmacology | Analysis of Variance | Presenilin-1 - metabolism | Mice | Index Medicus
Journal Article
The Journal of Experimental Medicine, ISSN 0022-1007, 05/2016, Volume 213, Issue 5, pp. 677 - 685
Accumulation of β-amyloid peptide is a key step in Alzheimer’s disease pathogenesis. Yuede et al. propose a novel method to track β-amyloid levels in vivo.... 
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Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 04/2016, Volume 213, Issue 2, p. 2132
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 01/2016, Volume 85, p. 218
Physical activity has long been hypothesized to influence the risk and pathology of Alzheimer's disease. However, the amount of physical activity necessary for... 
Heat shock proteins | Brain | Alzheimer's disease | Proteins
Journal Article
Journal Article
MOLECULAR NEURODEGENERATION, ISSN 1750-1326, 12/2009, Volume 4, Issue 1, pp. 51 - 51
Background: Recent reports suggest that latrepirdine (Dimebon T, dimebolin), a retired Russian antihistamine, improves cognitive function in aged rodents and... 
HUMAN BRAIN | SYNAPSES | DISEASE | A-BETA | PRECURSOR PROTEIN | ACCUMULATION | SYNAPTIC PLASTICITY | NEUROSCIENCES | OLIGOMERS | COGNITIVE DEFICITS | TRANSGENIC MICE
Journal Article
Science, ISSN 0036-8075, 3/2012, Volume 335, Issue 6075, pp. 1503 - 1506
Alzheimer's disease (AD) is associated with impaired clearance of ß-amyloid (Aß) from the brain, a process normally facilitated by apolipoprotein E (apoE).... 
Receptors | Odors | REPORTS | Mice | Alzheimers disease | Behavioral neuroscience | T tests | Hippocampus | Vehicles | Neural conduction | Microglia
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 09/2011, Volume 108, Issue 36, pp. 14968 - 14973
microdialysis | selective serotonin reuptake inhibitor antidepressants | late-life depression 
Physiological aspects | Genetic aspects | Serotonin | Health aspects | Alzheimer's disease | Amyloid beta-protein | Human subjects | Signal transduction | Alzheimers disease | Rodents
Journal Article
Science, ISSN 0036-8075, 03/2012, Volume 335, Issue 6075, pp. 1503 - 1506
Alzheirner's disease (AD) is associated with impaired clearance of [beta]-amyloid (A[beta]) from the brain, a process normally facilitated by apolipoprotein E... 
Physiological aspects | Research | Apolipoproteins | Alzheimer's disease | Amyloid beta-protein
Journal Article
Functional Neurology, ISSN 0393-5264, 2009, Volume 24, Issue 3, pp. 159 - 162
Journal Article