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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2018, Volume 115, Issue 41, p. E9687
Two of the most predominant features of the Alzheimer’s disease (AD) brain are deposition of β-amyloid (Aβ) plaques and inflammation. The mechanism behind... 
Brain | Pathogenesis | Liver | Activation | Mental depression | Blood | Plasmin | Risk factors | Proteins | Cell activation | Rodents | Atherosclerosis | Aging | Alzheimer's disease | Deposition | Plaques | Brain diseases | Immune system | Obesity | Immune response | Wound healing | Diabetes mellitus | Health risks | Antisense oligonucleotides | Inflammation | Risk analysis | Fibrinolysis | Studies | Pathology | Arteriosclerosis | β-Amyloid | Alzheimers disease
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 10/2018, Volume 115, Issue 41, pp. E9687 - E9696
Two of the most predominant features of the Alzheimer’s disease (AD) brain are deposition of β-amyloid (Aβ) plaques and inflammation. The mechanism behind... 
plasminogen | Biological Sciences | PNAS Plus | Alzheimer’s disease | neuroinflammation
Journal Article
Cancer Research, ISSN 0008-5472, 04/2009, Volume 69, Issue 8, pp. 3339 - 3346
Journal Article
Journal Article
Haematologica, ISSN 0390-6078, 07/2019, p. haematol.2019.223545
Sepsis causes an activation of the human contact system, an inflammatory response mechanism against foreign surfaces, proteins and pathogens. The serine... 
Journal Article
Journal Article
American Journal of Physiology, ISSN 1040-0605, 03/2018, Volume 314, Issue 3, p. L397
High-molecular-weight kininogen (HK), together with factor XI, factor XII and prekallikrein, is part of the contact system that has proinflammatory,... 
Klebsiella | Pneumonia | Antisense oligonucleotides | Activation | Inflammation | Infections | Endothelium | Proenzymes | Proteins | Coagulation factors | Cell activation | Kininogen | Depletion | Lungs | Vasoactive agents | Rodents | Sepsis | Genetics | Mice | Peroxidase | Gram-negative bacteria | Kininogens
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 04/2018, Volume 46, Issue 7, pp. 3579 - 3594
Abstract Chemically modified antisense oligonucleotides (ASOs) with phosphorothioate (PS) linkages have been extensively studied as research and therapeutic... 
HEPATOCYTES | PROTEIN | RNA | PHARMACOKINETICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | A431 CELLS | TRAFFICKING | ENDOCYTOSIS | BINDING | EGF RECEPTOR | TARGETED DELIVERY | Molecular Biology
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 5095 - 5095
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2013, Volume 33, Issue 7, pp. 1670 - 1678
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 11/2010, Volume 30, Issue 22, pp. 5260 - 5272
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 05/2019, Volume 47, Issue 9, pp. 4375 - 4392
Abstract Antisense oligonucleotides (ASOs) modulate cellular target gene expression through direct binding to complementary RNA. Advances in ASO chemistry have... 
LYSOSOMES | EXTRACELLULAR VESICLES | UPSTREAM | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXOSOMES | SIRNA | TRANSLATION | ENDOCYTOSIS | RECEPTORS | MOLECULAR-MECHANISMS | DELIVERY | Chemical Biology and Nucleic Acid Chemistry
Journal Article
Journal Article