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Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 9, pp. 8204 - 8205
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 1654 - 1654
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2019, Volume 1877, pp. 111 - 119
Apoptosis, a form of programmed cell death that is important for development and homeostasis, is regulated by the BCL-2 family of proteins. Over twenty BCL-2... 
MOMP | BH3-domain | Mitochondria | BCL-2 family | Liposomal membrane | BAX | BAK | tBID | Apoptosis
Journal Article
Cancer Research, ISSN 0008-5472, 04/2013, Volume 73, Issue 8 Supplement, pp. 2455 - 2455
Journal Article
Nature Cell Biology, ISSN 1465-7392, 10/2015, Volume 17, Issue 10, pp. 1270 - 1281
Multidomain pro-apoptotic BAX and BAK, once activated, permeabilize mitochondria to trigger apoptosis, whereas anti-apoptotic BCL-2 members preserve... 
CYTOCHROME-C | MITOCHONDRIAL APOPTOSIS | ACTIVATION | CONFORMATIONAL-CHANGE | MEMBERS | PROAPOPTOTIC BAX | BH3 DOMAINS | PUMA | BH3-ONLY PROTEINS | MEMBRANE PERMEABILIZATION | CELL BIOLOGY | bcl-2 Homologous Antagonist-Killer Protein - genetics | Immunoblotting | BH3 Interacting Domain Death Agonist Protein - genetics | Cytochromes c - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Embryo, Mammalian - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Mitochondria - genetics | RNA Interference | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cytochromes c - metabolism | Mice, Inbred C57BL | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Intestine, Small - cytology | Embryo, Mammalian - cytology | Models, Biological | Fibroblasts - cytology | Intestine, Small - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Genotype | Genetic aspects | Properties | Cell death | Cellular control mechanisms
Journal Article
Current Opinion in Chemical Biology, ISSN 1367-5931, 08/2017, Volume 39, pp. 133 - 142
Journal Article
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 41, pp. 66326 - 66327
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2016, Volume 64, Issue 2, p. 431
(Molecular Cell 63, 485–497; August 4, 2016) The originally published author list of this paper has now been changed online at the request of the authors. All... 
Journal Article
CANCER DISCOVERY, ISSN 2159-8274, 07/2019, Volume 9, Issue 7, pp. 890 - 909
The BCL2 family plays important roles in acute myeloid leukemia (AML). Veneto-clax, a selective BCL2 inhibitor, has received FDA approval for the treatment of... 
CYTOCHROME-C | APOPTOSIS | ACTIVATION | INHIBITION | CLPB | ONCOLOGY | CRISTAE | MECHANISMS | PROTEINS | BCL-2 FAMILY | EXPRESSION
Journal Article
Oncotarget, ISSN 1949-2553, 01/2019, Volume 10, Issue 4, pp. 494 - 510
Mechanisms of treatment resistance in head and neck squamous cell carcinoma (HNSCC) are not well characterized. In this study, HNSCC tumors from a cohort of... 
A-1210477 | Head | BCL-xL | Navitoclax | MCL-1 | Neck squamous carcinoma
Journal Article
Molecular cell, ISSN 1097-2765, 11/2010, Volume 40, Issue 3, pp. 481 - 492
BAX is a pro-apoptotic BCL-2 family member that lies dormant in the cytosol until converted into a killer protein in response to cellular stress. Having... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2012, Volume 109, Issue 17, p. 6566
The defining event in apoptosis is mitochondrial outer membrane permeabilization (MOMP), allowing apoptogen release. In contrast, the triggering event in... 
Proteins | Heart attacks | Rodents | Gangrene | Apoptosis
Journal Article
Revista Mexicana de Ciencias Farmaceuticas, ISSN 1027-3956, 04/2003, Volume 34, Issue 2, pp. 21 - 26
Journal Article
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