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1. Full Text High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
by Fu, Yanfang and Foden, Jennifer A and Khayter, Cyd and Maeder, Morgan L and Reyon, Deepak and Joung, J Keith and Sander, Jeffry D
Nature biotechnology, ISSN 1087-0156, 09/2013, Volume 31, Issue 9, pp. 822 - 826
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Genetic Engineering - methods | Endonucleases - genetics | CRISPR-Associated Proteins - genetics | Base Sequence | Humans | HEK293 Cells | K562 Cells | Mutagenesis - genetics | Molecular Sequence Data | Physiological aspects | Nucleases | Research | Mutagenesis | Gene expression | Enzymes | Cellular biology | Ribonucleic acid--RNA | Index Medicus
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2. Full Text Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
by Fu, Yanfang and Sander, Jeffry D and Reyon, Deepak and Cascio, Vincent M and Joung, J Keith
Nature biotechnology, ISSN 1087-0156, 2014, Volume 32, Issue 3, pp. 279 - 284
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Genetic research | Nucleases | Genetic engineering | Research | RNA | Methods | Enzymes | Mutation | Ribonucleic acid--RNA | Genomics | Index Medicus
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3. Full Text FLASH assembly of TALENs for high-throughput genome editing
by Reyon, Deepak and Tsai, Shengdar Q and Khgayter, Cyd and Foden, Jennifer A and Sander, Jeffry D and Joung, J Keith
Nature biotechnology, ISSN 1087-0156, 05/2012, Volume 30, Issue 5, pp. 460 - 465
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Biotechnology | Biological and medical sciences | Diverse techniques | Molecular and cellular biology | Gene Targeting - methods | Green Fluorescent Proteins - metabolism | Automation | Computational Biology - methods | Endonucleases - genetics | Biotinylation | DNA Restriction Enzymes - genetics | Epigenesis, Genetic | Humans | Molecular Sequence Data | Genetic Techniques | Sequence Homology, Nucleic Acid | Sequence Analysis, DNA - instrumentation | Neoplasms - genetics | Base Sequence | Transcription, Genetic | Mutation | Genome, Human | Sequence Analysis, DNA - methods | Physiological aspects | Nucleases | DNA binding proteins | Research | Genetic transcription | Proteins | Genomics | Binding sites | Biomedical engineering | Index Medicus
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4. Full Text Efficient genome editing in zebrafish using a CRISPR-Cas system
by Hwang, Woong Y and Fu, Yanfang and Reyon, Deepak and Maeder, Morgan L and Tsai, Shengdar Q and Sander, Jeffry D and Peterson, Randall T and Yeh, J-R Joanna and Joung, J Keith
Nature biotechnology, ISSN 1087-0156, 03/2013, Volume 31, Issue 3, pp. 227 - 229
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Endonucleases - genetics | RNA, Guide - genetics | RNA Editing | Molecular Sequence Data | Zebrafish - genetics | DNA - genetics | Animals | Genetic Engineering | Base Sequence | CRISPR-Cas Systems | Embryo, Nonmammalian | Mutation | Genome | Nucleic Acid Conformation | DNA Cleavage | Inverted Repeat Sequences | Physiological aspects | Genetic aspects | Restriction enzymes, DNA | Restriction-modification system | Zebra fish | Biotechnology | Zebrafish | Genetic engineering | Mutagenesis | Ribonucleic acid--RNA | Index Medicus
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5. Full Text Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
by Tsai, Shengdar Q and Wyvekens, Nicolas and Khayter, Cyd and Foden, Jennifer A and Thapar, Vishal and Reyon, Deepak and Goodwin, Mathew J and Aryee, Martin J and Joung, J. Keith
Nature biotechnology, ISSN 1087-0156, 2014, Volume 32, Issue 6, pp. 569 - 576
Genetic research | Nucleases | Genetic aspects | Genetic engineering | Zinc finger proteins | Research | Biotechnology | Enzymes | Mutation | Genomics | Index Medicus
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6. Full Text Locus-specific editing of histone modifications at endogenous enhancers
by Mendenhall, Eric M and Williamson, Kaylyn E and Reyon, Deepak and Zou, James Y and Ram, Oren and Joung, J Keith and Bernstein, Bradley E
Nature biotechnology, ISSN 1087-0156, 12/2013, Volume 31, Issue 12, pp. 1133 - 1136
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Histones - genetics | Polymorphism, Single Nucleotide - genetics | Mutagenesis, Site-Directed - methods | Enhancer Elements, Genetic - genetics | Chromatin - genetics | Promoter Regions, Genetic - genetics | Regulatory Elements, Transcriptional - genetics | Physiological aspects | Histones | Genetic aspects | Research | Genetic regulation | Proteins | Chromatin | Cellular biology | Gene expression | Index Medicus
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7. Full Text Targeted gene disruption in somatic zebrafish cells using engineered TALENs
by Sander, Jeffry D and Cade, Lindsay and Khayter, Cyd and Reyon, Deepak and Peterson, Randall T and Joung, J Keith and Yeh, Jing-Ruey J
Nature biotechnology, ISSN 1087-0156, 08/2011, Volume 29, Issue 8, pp. 697 - 698
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Combinatorial Chemistry Techniques - methods | Transcription Factors - metabolism | Mutagenesis, Site-Directed - methods | Genetic Engineering | Transcription Factors - genetics | Humans | Nucleases | Usage | Zebra fish | Physiological aspects | Genetic engineering | Genetic aspects | Research | Zinc finger proteins | Index Medicus
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8. Full Text Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins
by Maeder, Morgan L and Angstman, James F and Richardson, Marcy E and Linder, Samantha J and Cascio, Vincent M and Tsai, Shengdar Q and Ho, Quan H and Sander, Jeffry D and Reyon, Deepak and Bernstein, Bradley E and Costello, Joseph F and Wilkinson, Miles F and Joung, J. Keith
Nature biotechnology, ISSN 1087-0156, 12/2013, Volume 31, Issue 12, pp. 1137 - 1142
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Mixed Function Oxygenases | Gene Targeting - methods | Humans | Recombinant Fusion Proteins - genetics | Proto-Oncogene Proteins - genetics | Up-Regulation - genetics | DNA Methylation - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Promoter Regions, Genetic - genetics | Usage | Genomics | Physiological aspects | Genetic aspects | Research | Methylation | Gene fusion | Methods | Proteins | DNA methylation | Cellular biology | Gene expression | Index Medicus
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9. Full Text Toddler: An Embryonic Signal That Promotes Cell Movement via Apelin Receptors
by Andrea Pauli and Megan L. Norris and Eivind Valen and Guo-Liang Chew and James A. Gagnon and Steven Zimmerman and Andrew Mitchell and Jiao Ma and Julien Dubrulle and Deepak Reyon and Shengdar Q. Tsai and J. Keith Joung and Alan Saghatelian and Alexander F. Schier
Science (American Association for the Advancement of Science), ISSN 0036-8075, 2/2014, Volume 343, Issue 6172, pp. 746 - 746
RESEARCH ARTICLE SUMMARY | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Amino Acid Sequence | Frameshift Mutation | Receptors, G-Protein-Coupled - metabolism | Signal Transduction | Zebrafish Proteins - metabolism | Molecular Sequence Data | Zebrafish - embryology | Zebrafish - genetics | Gastrulation - physiology | Animals | Chemokine CXCL12 - metabolism | Gastrulation - genetics | Apelin Receptors | Zebrafish - metabolism | Receptors, G-Protein-Coupled - genetics | Zebrafish Proteins - genetics | Cell Movement | Biological research | Embryonic development | Cell receptors | Gastrulation | Motility | Research | Properties | Cells | Biology, Experimental | Index Medicus
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10. Full Text Robust, synergistic regulation of human gene expression using TALE activators
by Maeder, Morgan L and Linder, Samantha J and Reyon, Deepak and Angstman, James F and Fu, Yanfang and Sander, Jeffry D and Joung, J. Keith
Nature methods, ISSN 1548-7091, 03/2013, Volume 10, Issue 3, pp. 243 - 245
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Genetic Engineering - methods | Promoter Regions, Genetic | Humans | Transcriptional Activation | Tandem Repeat Sequences | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Vascular Endothelial Growth Factor A - genetics | Xanthomonas | Transfection | Plasmids | HEK293 Cells | Zinc Fingers - genetics | MicroRNAs - genetics | Cell Culture Techniques | Binding Sites | Fibroblasts - metabolism | Physiological aspects | Genetic aspects | Research | DNA binding proteins | Gene expression | Protein binding | Biotechnology | Genetic engineering | Protein synthesis | Index Medicus
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11. Full Text Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells
by Liao, Jing and Karnik, Rahul and Gu, Hongcang and Ziller, Michael J and Clement, Kendell and Tsankov, Alexander M and Akopian, Veronika and Gifford, Casey A and Donaghey, Julie and Galonska, Christina and Pop, Ramona and Reyon, Deepak and Tsai, Shengdar Q and Mallard, William and Joung, J Keith and Rinn, John L and Gnirke, Andreas and Meissner, Alexander
Nature genetics, ISSN 1061-4036, 05/2015, Volume 47, Issue 5, pp. 469 - 478
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Catalytic Domain | Gene Expression | Cell Proliferation | Cell Survival | DNA (Cytosine-5-)-Methyltransferase 1 | Coculture Techniques | Epigenesis, Genetic | Humans | Cells, Cultured | Embryonic Stem Cells - enzymology | Gene Knockout Techniques | Embryonic Stem Cells - physiology | DNA (Cytosine-5-)-Methyltransferases - genetics | DNA Methylation | Animals | Base Sequence | CpG Islands | Cell Differentiation | Mice | Apoptosis | Genetic aspects | Methyltransferases | Embryonic stem cells | Gene expression | Properties | Health aspects | Studies | DNA methylation | Mutation | Stem cells | Index Medicus
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