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The New England Journal of Medicine, ISSN 0028-4793, 01/2009, Volume 360, Issue 4, pp. 354 - 362
The antiplatelet drug clopidogrel requires activation by cytochrome P-450 (CYP) enzymes. This study shows that CYP polymorphisms that reduce clopidogrel... 
MEDICINE, GENERAL & INTERNAL | MYOCARDIAL-INFARCTION | STENT THROMBOSIS | HEALTHY-SUBJECTS | INCREASED RISK | PLATELET INHIBITION | ACUTE CORONARY SYNDROMES | PRASUGREL | ST-SEGMENT ELEVATION | INDIVIDUAL RESPONSIVENESS | ATHEROTHROMBOTIC EVENTS | Ticlopidine - pharmacology | Ticlopidine - therapeutic use | Area Under Curve | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Male | Cardiovascular Diseases - genetics | Angioplasty, Balloon, Coronary | Ticlopidine - adverse effects | Ticlopidine - metabolism | Cardiovascular Diseases - epidemiology | Platelet Aggregation Inhibitors - pharmacology | Adult | Female | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - metabolism | Platelet Aggregation Inhibitors - therapeutic use | Stents | Platelet Aggregation Inhibitors - adverse effects | Genotype | Thrombosis - epidemiology | Combined Modality Therapy | Ticlopidine - analogs & derivatives | Polymorphism, Genetic | Randomized Controlled Trials as Topic | Cytochrome P-450 CYP2C19 | Acute Coronary Syndrome - therapy | Heterozygote | Thrombosis - genetics | Mutation | Usage | Genetic variation | Cytochrome P-450 | Physiological aspects | Causes of | Clopidogrel | Cardiovascular diseases | Health aspects | Risk factors | Studies | Cardiovascular disease | Heart attacks | Drug therapy | Index Medicus | Abridged Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 05/2009, Volume 119, Issue 19, pp. 2553 - 2560
Background-Both clopidogrel and prasugrel require biotransformation to active metabolites by cytochrome P450 (CYP) enzymes. Among persons treated with... 
Drugs | Cardiovascular diseases | Genetics | 2007 FOCUSED UPDATE | CARDIAC & CARDIOVASCULAR SYSTEMS | drugs | STENT THROMBOSIS | OF-FUNCTION POLYMORPHISM | cardiovascular diseases | PERCUTANEOUS CORONARY INTERVENTION | genetics | PLATELET INHIBITION | ASSOCIATION TASK-FORCE | PERIPHERAL VASCULAR DISEASE | ELEVATION MYOCARDIAL-INFARCTION | THIENOPYRIDINE ANTIPLATELET AGENT | CLOPIDOGREL RESPONSIVENESS | ACTIVE METABOLITE | Prasugrel Hydrochloride | Thiophenes - therapeutic use | Myocardial Infarction - mortality | Cardiovascular Diseases - drug therapy | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Biotransformation - genetics | Cytochrome P-450 Enzyme System - metabolism | Male | Young Adult | Receptors, Purinergic P2Y12 | Cardiovascular Diseases - mortality | Platelet Aggregation Inhibitors - pharmacology | Adult | Female | Microsomes, Liver - enzymology | Platelet Aggregation - drug effects | Platelet Aggregation Inhibitors - pharmacokinetics | Piperazines - pharmacokinetics | Stroke - mortality | Platelet Aggregation Inhibitors - therapeutic use | Stroke - prevention & control | Purinergic P2 Receptor Antagonists | Thiophenes - pharmacology | Genotype | Treatment Outcome | Piperazines - therapeutic use | Piperazines - pharmacology | Aryl Hydrocarbon Hydroxylases - metabolism | Polymorphism, Genetic | Thiophenes - pharmacokinetics | Prodrugs - pharmacokinetics | Cytochrome P-450 CYP2C19 | Cytochrome P-450 Enzyme System - genetics | Aged | Myocardial Infarction - prevention & control | Prodrugs - therapeutic use | Prodrugs - pharmacology | Care and treatment | Demographic aspects | Patient outcomes | Cytochrome P-450 | Genetic aspects | Research | Genetic polymorphisms | Heart attack | Index Medicus | Abridged Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 02/2006, Volume 12, Issue 3, pp. 832 - 838
Journal Article
Nature Methods, ISSN 1548-7091, 10/2005, Volume 2, Issue 10, pp. 731 - 734
Standard controls and best practice guidelines advance acceptance of data from research, preclinical and clinical Laboratories by providing a means for... 
DNA AMPLIFICATION | PCR | BIOCHEMICAL RESEARCH METHODS | Guidelines as Topic | Animals | Oligonucleotide Array Sequence Analysis - standards | Humans | RNA, Messenger - analysis | Rats | Mice | Gene Expression Profiling - standards | Quality Control
Journal Article
Journal Article
Infection and Immunity, ISSN 0019-9567, 02/1998, Volume 66, Issue 2, pp. 608 - 614
Journal Article
Pharmacogenomics, ISSN 1462-2416, 2009, Volume 10, Issue 1, pp. 111 - 115
The 4th US FDA/Industry workshop, in a series on Pharmacogenomics, was on 'Biomarkers and Pharmacogenomics in Drug Development and Regulatory Decision Making'... 
Biomarkers | Drug development | Regulatory decision making | drug development | PHARMACOLOGY & PHARMACY | regulatory decision making | biomarkers | Biomarkers, Pharmacological - analysis | Pharmacogenetics | Animals | United States | Humans | Drug Design | United States Food and Drug Administration
Journal Article
The Journal of Immunology, ISSN 0022-1767, 04/2001, Volume 166, Issue 7, pp. 4534 - 4542
Inducible expression of Fas ligand (CD95 ligand) by activated T cells and the resulting apoptosis of CD95-bearing cells is a critical component of peripheral T... 
TUMOR-NECROSIS-FACTOR | CYCLOSPORINE-A | NGFI-A | INDUCED APOPTOSIS | CD95 LIGAND | MONOCLONAL-ANTIBODY | ACTIVATION-INDUCED CELL | IMMUNOLOGY | PROMOTER | TRANSCRIPTION FACTOR | T-CELLS | Cell Nucleus - immunology | Sequence Deletion | Cyclosporine - pharmacology | Humans | Membrane Glycoproteins - biosynthesis | Molecular Sequence Data | Th2 Cells - immunology | Promoter Regions, Genetic - drug effects | Th1 Cells - immunology | fas Receptor - metabolism | Promoter Regions, Genetic - genetics | Th2 Cells - drug effects | Immediate-Early Proteins | Th1 Cells - metabolism | RNA, Messenger - biosynthesis | Lymphocyte Activation - genetics | Cell Nucleus - metabolism | Transfection | Early Growth Response Protein 3 | Base Sequence | Early Growth Response Protein 1 | Cell Line | Th1 Cells - drug effects | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Gene Expression Regulation - immunology | Mice, Transgenic | Transcription Factors - biosynthesis | NFATC Transcription Factors | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Th2 Cells - metabolism | Membrane Glycoproteins - genetics | Nuclear Proteins | Fas Ligand Protein | Gene Expression Regulation - drug effects | Animals | Sp1 Transcription Factor - genetics | Hybridomas | Ligands | Mice | Mice, Inbred BALB C | Promoter Regions, Genetic - immunology | Multigene Family - immunology | DNA-Binding Proteins - biosynthesis | Egr3 protein | Egr1 protein | FasL protein | Egr2 protein | NF-AT protein | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article