Viruses, ISSN 1999-4915, 10/2019, Volume 11, Issue 10, p. 926
Human respiratory syncytial virus (HRSV) is a major cause of pediatric infection and also causes disease in the elderly and those with underlying respiratory...
host response | proteomics | respiratory disease | clinical sample | nasopharyngeal aspirate | respiratory syncytial virus | rnaseq | quasispecies
host response | proteomics | respiratory disease | clinical sample | nasopharyngeal aspirate | respiratory syncytial virus | rnaseq | quasispecies
Journal Article
Nature, ISSN 0028-0836, 02/2016, Volume 530, Issue 7589, pp. 228 - 232
The Ebola virus disease epidemic in West Africa is the largest on record, responsible for over 28,599 cases and more than 11,299 deaths(1). Genome sequencing...
TRANSMISSION | VIRUS | EVOLUTION | DNA | MULTIDISCIPLINARY SCIENCES | SIERRA-LEONE | DYNAMICS | OUTBREAK | NANOPORE SEQUENCER | Ebolavirus - classification | Genome, Viral - genetics | Humans | Mutagenesis - genetics | Ebolavirus - pathogenicity | Mutation Rate | Disease Outbreaks - statistics & numerical data | Ebolavirus - genetics | Guinea - epidemiology | Hemorrhagic Fever, Ebola - epidemiology | Sequence Analysis, DNA - instrumentation | Epidemiological Monitoring | Time Factors | Hemorrhagic Fever, Ebola - virology | Aircraft | Sequence Analysis, DNA - methods | Ebola virus | Distribution | Genetic aspects | Nucleotide sequencing | Methods | DNA sequencing | Prevalence studies (Epidemiology) | Electrical currents | Pathogens | Surveillance | Laboratories | Phylogenetics | Universal Serial Bus | Genomes | Bioinformatics | Deoxyribonucleic acid--DNA
TRANSMISSION | VIRUS | EVOLUTION | DNA | MULTIDISCIPLINARY SCIENCES | SIERRA-LEONE | DYNAMICS | OUTBREAK | NANOPORE SEQUENCER | Ebolavirus - classification | Genome, Viral - genetics | Humans | Mutagenesis - genetics | Ebolavirus - pathogenicity | Mutation Rate | Disease Outbreaks - statistics & numerical data | Ebolavirus - genetics | Guinea - epidemiology | Hemorrhagic Fever, Ebola - epidemiology | Sequence Analysis, DNA - instrumentation | Epidemiological Monitoring | Time Factors | Hemorrhagic Fever, Ebola - virology | Aircraft | Sequence Analysis, DNA - methods | Ebola virus | Distribution | Genetic aspects | Nucleotide sequencing | Methods | DNA sequencing | Prevalence studies (Epidemiology) | Electrical currents | Pathogens | Surveillance | Laboratories | Phylogenetics | Universal Serial Bus | Genomes | Bioinformatics | Deoxyribonucleic acid--DNA
Journal Article
Nature, ISSN 0028-0836, 08/2015, Volume 524, Issue 7563, pp. 97 - 101
West Africa is currently witnessing the most extensive Ebola virus (EBOV) outbreak so far recorded(1-3). Until now, there have been 27,013 reported cases and...
MODEL | VP24 | INFERENCE | MULTIDISCIPLINARY SCIENCES | Sierra Leone - epidemiology | Humans | Molecular Sequence Data | Hemorrhagic Fever, Ebola - transmission | Male | Disease Outbreaks - statistics & numerical data | Phylogeny | Ebolavirus - genetics | Guinea - epidemiology | Hemorrhagic Fever, Ebola - epidemiology | Mali - epidemiology | Ebolavirus - isolation & purification | Hemorrhagic Fever, Ebola - virology | Amino Acid Substitution - genetics | Female | Spatio-Temporal Analysis | High-Throughput Nucleotide Sequencing | Liberia - epidemiology | Evolution, Molecular | Ebola virus | Ebola virus infections | Distribution | Proteins | Epidemics | Phylogenetics | Evolution | Infections | Genomes | Epidemiology
MODEL | VP24 | INFERENCE | MULTIDISCIPLINARY SCIENCES | Sierra Leone - epidemiology | Humans | Molecular Sequence Data | Hemorrhagic Fever, Ebola - transmission | Male | Disease Outbreaks - statistics & numerical data | Phylogeny | Ebolavirus - genetics | Guinea - epidemiology | Hemorrhagic Fever, Ebola - epidemiology | Mali - epidemiology | Ebolavirus - isolation & purification | Hemorrhagic Fever, Ebola - virology | Amino Acid Substitution - genetics | Female | Spatio-Temporal Analysis | High-Throughput Nucleotide Sequencing | Liberia - epidemiology | Evolution, Molecular | Ebola virus | Ebola virus infections | Distribution | Proteins | Epidemics | Phylogenetics | Evolution | Infections | Genomes | Epidemiology
Journal Article
Genome Biology, ISSN 1474-7596, 01/2017, Volume 18, Issue 1, p. 4
Background: In 2014, Western Africa experienced an unanticipated explosion of Ebola virus infections. What distinguishes fatal from non-fatal outcomes remains...
NONHUMAN-PRIMATES | ACTIVATION | WEST-AFRICA | MANAGEMENT | DENDRITIC CELLS | HEMORRHAGIC-FEVER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SIERRA-LEONE | DISEASE | GENETICS & HEREDITY | CYNOMOLGUS MACAQUES | EXPRESSION | T-Lymphocyte Subsets - immunology | Coinfection | Guinea | Humans | Transcriptome | Disease Resistance - immunology | Gene Expression Profiling | Viral Load | Host-Pathogen Interactions - immunology | Hemorrhagic Fever, Ebola - virology | Killer Cells, Natural - immunology | Hemorrhagic Fever, Ebola - immunology | Disease Resistance - genetics | Ebolavirus | Computational Biology - methods | Signal Transduction | Patient Outcome Assessment | Host-Pathogen Interactions - genetics | T-Lymphocyte Subsets - metabolism | Interferons - metabolism | ROC Curve | Hemorrhagic Fever, Ebola - genetics | Killer Cells, Natural - metabolism | Hemorrhagic Fever, Ebola - metabolism | Cluster Analysis | Dendritic cells | Outbreaks | Infections | Gene expression | Patients | Ebola virus | Immunology | Hepatocytes | Medical prognosis | Peripheral blood | Fibrinogen | Biomarkers | Fatalities | Interferon | Bioinformatics | Viral infections
NONHUMAN-PRIMATES | ACTIVATION | WEST-AFRICA | MANAGEMENT | DENDRITIC CELLS | HEMORRHAGIC-FEVER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SIERRA-LEONE | DISEASE | GENETICS & HEREDITY | CYNOMOLGUS MACAQUES | EXPRESSION | T-Lymphocyte Subsets - immunology | Coinfection | Guinea | Humans | Transcriptome | Disease Resistance - immunology | Gene Expression Profiling | Viral Load | Host-Pathogen Interactions - immunology | Hemorrhagic Fever, Ebola - virology | Killer Cells, Natural - immunology | Hemorrhagic Fever, Ebola - immunology | Disease Resistance - genetics | Ebolavirus | Computational Biology - methods | Signal Transduction | Patient Outcome Assessment | Host-Pathogen Interactions - genetics | T-Lymphocyte Subsets - metabolism | Interferons - metabolism | ROC Curve | Hemorrhagic Fever, Ebola - genetics | Killer Cells, Natural - metabolism | Hemorrhagic Fever, Ebola - metabolism | Cluster Analysis | Dendritic cells | Outbreaks | Infections | Gene expression | Patients | Ebola virus | Immunology | Hepatocytes | Medical prognosis | Peripheral blood | Fibrinogen | Biomarkers | Fatalities | Interferon | Bioinformatics | Viral infections
Journal Article
Lancet Global Health, ISSN 2214-109X, 2017, Volume 5, Issue 1, pp. e80 - e88
Summary Background By January, 2016, all known transmission chains of the Ebola virus disease (EVD) outbreak in west Africa had been stopped. However, there is...
Internal Medicine | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | HEMORRHAGIC-FEVER | SEXUAL TRANSMISSION | KIKWIT | CONGO | Hemorrhagic Fever, Ebola - prevention & control | RNA | Guinea | Semen | Humans | Middle Aged | Survivors | Hemorrhagic Fever, Ebola - transmission | Male | Models, Statistical | Ebolavirus - genetics | Hemorrhagic Fever, Ebola - epidemiology | Ebolavirus - isolation & purification | Time Factors | Hemorrhagic Fever, Ebola - virology | Adult | Longitudinal Studies
Internal Medicine | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | HEMORRHAGIC-FEVER | SEXUAL TRANSMISSION | KIKWIT | CONGO | Hemorrhagic Fever, Ebola - prevention & control | RNA | Guinea | Semen | Humans | Middle Aged | Survivors | Hemorrhagic Fever, Ebola - transmission | Male | Models, Statistical | Ebolavirus - genetics | Hemorrhagic Fever, Ebola - epidemiology | Ebolavirus - isolation & purification | Time Factors | Hemorrhagic Fever, Ebola - virology | Adult | Longitudinal Studies
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2017, Volume 7, Issue 1, p. 43144
The Ebola virus (EBOV) variant Makona (which emerged in 2013) was the causative agent of the largest outbreak of Ebola Virus Disease recorded. Differences in...
NIEMANN-PICK C1 | ENTRY | REPLICATION | DENDRITIC CELLS | VP35 | CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | INTERFERON REGULATORY FACTOR-3 | MEDIATED APOPTOSIS | RESPIRATORY SYNCYTIAL VIRUS | REVEALS | Host-Pathogen Interactions | A549 Cells | Respiratory Syncytial Virus, Human - growth & development | Sequence Analysis, RNA | Humans | Transcriptome | Ebolavirus - growth & development | Gene Expression Profiling | Ebola virus | Cell proliferation | Disease transmission | Extravasation | Outbreaks | Interferon | Genomes | Inflammation | Gene expression | Cholesterol
NIEMANN-PICK C1 | ENTRY | REPLICATION | DENDRITIC CELLS | VP35 | CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | INTERFERON REGULATORY FACTOR-3 | MEDIATED APOPTOSIS | RESPIRATORY SYNCYTIAL VIRUS | REVEALS | Host-Pathogen Interactions | A549 Cells | Respiratory Syncytial Virus, Human - growth & development | Sequence Analysis, RNA | Humans | Transcriptome | Ebolavirus - growth & development | Gene Expression Profiling | Ebola virus | Cell proliferation | Disease transmission | Extravasation | Outbreaks | Interferon | Genomes | Inflammation | Gene expression | Cholesterol
Journal Article
JOURNAL OF INFECTIOUS DISEASES, ISSN 0022-1899, 07/2019, Volume 220, Issue 2, pp. 195 - 202
Background. In 2015, the laboratory at the Ebola treatment center in Coyah, Guinea, confirmed Ebola virus disease (EVD) in 286 patients. The cycle threshold...
VIRAL LOAD | DIAGNOSIS | INFECTIOUS DISEASES | Guinea | epidemic | SIERRA-LEONE | MICROBIOLOGY | IMMUNOLOGY | mobile laboratory | Favipiravir | CHEMISTRY | Filovirus | Ebola virus disease | Major and Brief Reports
VIRAL LOAD | DIAGNOSIS | INFECTIOUS DISEASES | Guinea | epidemic | SIERRA-LEONE | MICROBIOLOGY | IMMUNOLOGY | mobile laboratory | Favipiravir | CHEMISTRY | Filovirus | Ebola virus disease | Major and Brief Reports
Journal Article
mSphere, 07/2017, Volume 2, Issue 4
Journal Article
mSphere, ISSN 2379-5042, 03/2018, Volume 3, Issue 2, p. e00120-18
Zika virus (ZIKV) has reemerged in the population and caused unprecedented global outbreaks. Here, the transcriptomic consequences of ZIKV infection were...
Transcriptomes | Monocytes | NK cells | Zika virus | Immune response | RNA-seq | STRAINS | monocytes | NATURAL-KILLER-CELLS | ACTIVATION | IMMUNE CELLS | transcriptomes | MICROBIOLOGY | immune response | GENE-EXPRESSION | CHEMOATTRACTANT PROTEIN-1 | MICE | OUTBREAK | CYTOTOXICITY | MACROPHAGE HETEROGENEITY | Zika Virus - immunology | Genome, Viral | Zika Virus - genetics | Killer Cells, Natural - virology | Lymphocyte Activation | Humans | Cells, Cultured | Transcriptome | Monocytes - immunology | Lymphocyte Depletion | Host-Pathogen Interactions | Monocytes - virology | Macrophages - virology | RNA, Viral - genetics | Sequence Analysis, RNA | Virus Replication | Interferon-gamma - immunology | Lysosomal-Associated Membrane Protein 1 - immunology | Proteomics | Killer Cells, Natural - immunology | Zika Virus Infection - immunology | Macrophages - immunology | Neonates | Disease | Guillain-Barre syndrome | Fetuses | Blood cells | Outbreaks | Infections | Genomes | Genetic diversity | Macrophages | Gene expression | CD14 antigen | Medicine | Disease transmission | Neurological complications | γ-Interferon | Peripheral blood | Natural killer cells
Transcriptomes | Monocytes | NK cells | Zika virus | Immune response | RNA-seq | STRAINS | monocytes | NATURAL-KILLER-CELLS | ACTIVATION | IMMUNE CELLS | transcriptomes | MICROBIOLOGY | immune response | GENE-EXPRESSION | CHEMOATTRACTANT PROTEIN-1 | MICE | OUTBREAK | CYTOTOXICITY | MACROPHAGE HETEROGENEITY | Zika Virus - immunology | Genome, Viral | Zika Virus - genetics | Killer Cells, Natural - virology | Lymphocyte Activation | Humans | Cells, Cultured | Transcriptome | Monocytes - immunology | Lymphocyte Depletion | Host-Pathogen Interactions | Monocytes - virology | Macrophages - virology | RNA, Viral - genetics | Sequence Analysis, RNA | Virus Replication | Interferon-gamma - immunology | Lysosomal-Associated Membrane Protein 1 - immunology | Proteomics | Killer Cells, Natural - immunology | Zika Virus Infection - immunology | Macrophages - immunology | Neonates | Disease | Guillain-Barre syndrome | Fetuses | Blood cells | Outbreaks | Infections | Genomes | Genetic diversity | Macrophages | Gene expression | CD14 antigen | Medicine | Disease transmission | Neurological complications | γ-Interferon | Peripheral blood | Natural killer cells
Journal Article
MSPHERE, ISSN 2379-5042, 07/2017, Volume 2, Issue 4, p. e00325-17
In this study, samples from the 2013-2016 West African Ebola virus outbreak from patients in Guinea with Ebola virus disease (EVD) were analyzed to discover...
intracellular parasites | WEST-AFRICA | MANAGEMENT | SIERRA-LEONE | POLYMERASE | PATTERNS | MICROBIOLOGY | informatics | malaria | filovirus | GASTROENTERITIS | ROTAVIRUS | CHILDREN | Plasmodium falciparum | host-pathogen interactions | RNA-seq | bioinformatics | GENERATION | Ebola | coinfection | gene expression | Ebola virus disease | Outbreaks | Nucleic acids
intracellular parasites | WEST-AFRICA | MANAGEMENT | SIERRA-LEONE | POLYMERASE | PATTERNS | MICROBIOLOGY | informatics | malaria | filovirus | GASTROENTERITIS | ROTAVIRUS | CHILDREN | Plasmodium falciparum | host-pathogen interactions | RNA-seq | bioinformatics | GENERATION | Ebola | coinfection | gene expression | Ebola virus disease | Outbreaks | Nucleic acids
Journal Article
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