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science & technology (24) 24
life sciences & biomedicine (23) 23
humans (22) 22
animals (17) 17
chemistry (14) 14
pharmacology & pharmacy (14) 14
biological and medical sciences (12) 12
prostaglandin-e synthases (11) 11
inflammation (10) 10
medical sciences (10) 10
microsomes - enzymology (10) 10
pharmacology. drug treatments (10) 10
chemistry, medicinal (9) 9
chemistry, organic (9) 9
physical sciences (9) 9
bones, joints and connective tissue. antiinflammatory agents (8) 8
cyclooxygenase inhibitors - pharmacology (8) 8
intramolecular oxidoreductases - antagonists & inhibitors (8) 8
cyclooxygenase 2 (6) 6
membrane proteins (6) 6
prostaglandin-endoperoxide synthases - metabolism (6) 6
rats (6) 6
structure-activity relationship (6) 6
beer (5) 5
biochemistry (5) 5
biochemistry & molecular biology (5) 5
cell line (5) 5
compositions or test papers therefor (5) 5
compositions thereof (5) 5
condition-responsive control in microbiological orenzymological processes (5) 5
culture media (5) 5
cyclooxygenase 2 inhibitors (5) 5
dinoprostone - biosynthesis (5) 5
enzymology (5) 5
female (5) 5
male (5) 5
measuring or testing processes involving enzymes, nucleicacids or microorganisms (5) 5
metallurgy (5) 5
microbiology (5) 5
microorganisms or enzymes (5) 5
mpges-1 (5) 5
mutation or genetic engineering (5) 5
processes of preparing such compositions (5) 5
propagating, preserving or maintaining microorganisms (5) 5
recombinant proteins - metabolism (5) 5
spirits (5) 5
vinegar (5) 5
wine (5) 5
anti-inflammatory agents, non-steroidal - pharmacology (4) 4
cho cells (4) 4
cricetinae (4) 4
cyclooxygenase inhibitors - chemistry (4) 4
intramolecular oxidoreductases - metabolism (4) 4
molecular sequence data (4) 4
prostaglandins (4) 4
aged (3) 3
amino acid sequence (3) 3
analgesics (3) 3
arachidonic acid - metabolism (3) 3
automobile driver examination (3) 3
base sequence (3) 3
basic electric elements (3) 3
cyclooxygenase 1 (3) 3
disease models, animal (3) 3
electric switches (3) 3
electricity (3) 3
emergency protective devices (3) 3
guinea pigs (3) 3
imidazoles - chemistry (3) 3
imidazoles - pharmacology (3) 3
intramolecular oxidoreductases - biosynthesis (3) 3
intramolecular oxidoreductases - genetics (3) 3
isoenzymes - metabolism (3) 3
mice (3) 3
pge synthase (3) 3
phenanthrenes - chemistry (3) 3
prostaglandin e (3) 3
prostaglandin synthase (3) 3
prostaglandin-endoperoxide synthases - genetics (3) 3
rats, sprague-dawley (3) 3
relays (3) 3
selectors (3) 3
spodoptera (3) 3
task performance and analysis (3) 3
adult (2) 2
aged, 80 and over (2) 2
arachidonate (2) 2
arginine (2) 2
arthritis, experimental - enzymology (2) 2
automobile drivers (2) 2
automobile driving (2) 2
automobile driving simulators (2) 2
biarylimidazole (2) 2
cell line, tumor (2) 2
cells, cultured (2) 2
computer simulation (2) 2
cyclooxygenase inhibitors - chemical synthesis (2) 2
cyclooxygenase inhibitors - metabolism (2) 2
dinoprostone - antagonists & inhibitors (2) 2
dinoprostone - metabolism (2) 2
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1. Full Text Phase I clinical trial of temozolomide and methoxyamine (TRC-102), an inhibitor of base excision repair, in patients with advanced solid tumors
by Eads, Jennifer R and Krishnamurthi, Smitha S and Saltzman, Joel and Bokar, Joseph A and Savvides, Panos and Meropol, Neal J and Gibbons, Joseph and Koon, Henry and Sharma, Neelesh and Rogers, Lisa and Pink, John J and Xu, Yan and Beumer, Jan H and Riendeau, John and Fu, Pingfu and Gerson, Stanton L and Dowlati, Afshin
Investigational new drugs, ISSN 0167-6997, 02/2021, Volume 39, Issue 1, pp. 142 - 151
Pharmacology & Pharmacy | Oncology | Life Sciences & Biomedicine | Science & Technology | Intravenous administration | Mental disorders | Toxicity | Leukocytes (mononuclear) | AP endonuclease | Allergic reactions | Base excision repair | DNA repair | Psychosis | N3-Methyladenine | Peripheral blood mononuclear cells | Pancreas | Repair | Constipation | Deoxyribonucleic acid--DNA | Adducts | Neutropenia | Thrombocytopenia | Bioassay | Leukopenia | Anemia | Methylguanine | Hypersensitivity | Patients | Damage detection | Lymphopenia | Solid tumors | DNA adducts | Temozolomide | Endonuclease | Pharmacokinetics | Tumors | Neuroendocrine tumors | Index Medicus
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2. Full Text Carrageenan-induced Paw Edema in Rat Elicits a Predominant Prostaglandin E2 (PGE2) Response in the Central Nervous System Associated with the Induction of Microsomal PGE2 Synthase-1
by Jocelyne Guay and Kevin Bateman and Robert Gordon and Joseph Mancini and Denis Riendeau
The Journal of biological chemistry, ISSN 0021-9258, 06/2004, Volume 279, Issue 23, pp. 24866 - 24872
Microsomes - metabolism | Up-Regulation | Brain - embryology | Thromboxane B2 - metabolism | Spinal Cord - metabolism | Rats | Extremities - pathology | Inflammation | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Blotting, Western | Dinoprostone - metabolism | Animals | Time Factors | Carrageenan - pharmacology | Prostaglandin-E Synthases | Polymerase Chain Reaction | Central Nervous System - drug effects | Chromatography, Liquid | Cytosol - metabolism | Edema - chemically induced | Intramolecular Oxidoreductases - metabolism | RNA - metabolism | Index Medicus
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3. MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation
by Xu, Daigen and Rowland, Steven E and Clark, Patsy and Giroux, André and Côté, Bernard and Guiral, Sébastien and Salem, Myriam and Ducharme, Yves and Friesen, Richard W and Méthot, Nathalie and Mancini, Joseph and Audoly, Laurent and Riendeau, Denis
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 09/2008, Volume 326, Issue 3, pp. 754 - 763
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Intramolecular Oxidoreductases - biosynthesis | Humans | Imidazoles - chemistry | Intramolecular Oxidoreductases - antagonists & inhibitors | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Dose-Response Relationship, Drug | Microsomes - drug effects | Phenanthrenes - chemistry | Pain - enzymology | Pain - genetics | Pain - drug therapy | Female | Prostaglandin Antagonists - pharmacology | Imidazoles - therapeutic use | Prostaglandin Antagonists - chemistry | Drug Evaluation, Preclinical - methods | Phenanthrenes - therapeutic use | Guinea Pigs | Mice, Inbred C57BL | Rats | Saimiri | Mice, Transgenic | Microsomes - enzymology | Imidazoles - pharmacology | Prostaglandin Antagonists - therapeutic use | Phenanthrenes - pharmacology | Fever - enzymology | Animals | Intramolecular Oxidoreductases - genetics | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Prostaglandin-E Synthases | Fever - genetics | Mice | Fever - drug therapy | Index Medicus
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4. Full Text Multiple healing effect of thermally activated self-healing composites based on Diels–Alder reaction
by Park, Jong Se and Darlington, Thomas and Starr, Anthony F and Takahashi, Kosuke and Riendeau, Joseph and Thomas Hahn, H
Composites science and technology, ISSN 0266-3538, 2010, Volume 70, Issue 15, pp. 2154 - 2159
A. Functional composites | Thermally activated self-healing composites | B. Delamination | A. Smart materials | D. Non-destructive testing | Materials Science | Technology | Materials Science, Composites | Science & Technology | Applied sciences | Technology of polymers | Laminates | Exact sciences and technology | Polymer industry, paints, wood | Forms of application and semi-finished materials | Furans | Composite materials industry | Diels-Alder reaction | Mechanical engineering | Laminated materials | Aerospace engineering | Diels-Alder reactions | Deformation | Heating | Shape memory effect | Delaminating | Bending | Injection molding | Healing
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5. Full Text Cloning, Expression, and Up-regulation of Inducible Rat Prostaglandin E Synthase during Lipopolysaccharide-induced Pyresis and Adjuvant-induced Arthritis
by Joseph A. Mancini and Katherine Blood and Jocelyne Guay and Robert Gordon and David Claveau and Chi-Chung Chan and Denis Riendeau
The Journal of biological chemistry, ISSN 0021-9258, 02/2001, Volume 276, Issue 6, pp. 4469 - 4475
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Prostaglandin-Endoperoxide Synthases - biosynthesis | Prostaglandin-Endoperoxide Synthases - genetics | Amino Acid Sequence | Up-Regulation | Cricetinae | Humans | Enzyme Induction | Molecular Sequence Data | Rats | Fever - chemically induced | Rats, Sprague-Dawley | Sequence Homology, Amino Acid | Fever - enzymology | Animals | Prostaglandin-Endoperoxide Synthases - chemistry | Prostaglandin-Endoperoxide Synthases - metabolism | Base Sequence | Cloning, Molecular | Lipopolysaccharides - pharmacology | Arthritis, Experimental - enzymology | CHO Cells | DNA, Complementary | prostaglandin E | lipopolysaccharides | CHO-K1 cells | Index Medicus
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6. Full Text Deletion of Microsomal Prostaglandin E2 (PGE2) Synthase-1 Reduces Inducible and Basal PGE2 Production and Alters the Gastric Prostanoid Profile
by Louise Boulet and Marc Ouellet and Kevin P. Bateman and Diane Ethier and M. David Percival and Denis Riendeau and Joseph A. Mancini and Nathalie Méthot
The Journal of biological chemistry, ISSN 0021-9258, 05/2004, Volume 279, Issue 22, pp. 23229 - 23237
Intramolecular Oxidoreductases - biosynthesis | Dinoprostone - biosynthesis | Cyclooxygenase 1 | Intramolecular Oxidoreductases - antagonists & inhibitors | Microsomes - enzymology | Gastric Mucosa - metabolism | Organ Specificity | Gene Expression Regulation, Enzymologic | Membrane Proteins | Animals | Intramolecular Oxidoreductases - genetics | Isoenzymes - metabolism | Prostaglandin-Endoperoxide Synthases - metabolism | Gene Deletion | Prostaglandin-E Synthases | Mice | Prostaglandins - metabolism | Index Medicus
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7. Full Text Phase I clinical trial of temozolomide and methoxyamine (TRC-102) in patients with advanced solid tumors
by Eads, Jennifer Rachel and Krishnamurthi, Smitha S and Saltzman, Joel N and Meropol, Neal J and Bokar, Joseph A and Gibbons, Joseph and Koon, Henry B and Sharma, Neelesh and Savvides, Panayiotis and Pink, John and Xu, Yan and Beumer, Jan Hendrik and Fu, Pingfu and Beatty, Kristi and Kane, Donna and Rodal, Mary Beth and Czalkiewicz, Julianne and Riendeau, John and Gerson, Stanton L and Dowlati, Afshin
Journal of clinical oncology, ISSN 0732-183X, 05/2015, Volume 33, Issue 15_suppl, pp. 2558 - 2558
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8. Full Text Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model
by Claveau, David and Sirinyan, Mirna and Guay, Jocelyne and Gordon, Robert and Chan, Chi-Chung and Bureau, Yves and Riendeau, Denis and Mancini, Joseph A
The Journal of immunology (1950), ISSN 0022-1767, 05/2003, Volume 170, Issue 9, pp. 4738 - 4744
Epoprostenol - genetics | Intramolecular Oxidoreductases - biosynthesis | Hindlimb | Adjuvants, Immunologic - administration & dosage | Intracellular Membranes - enzymology | Dinoprostone - biosynthesis | Epoprostenol - biosynthesis | Cyclooxygenase 2 | Cytosol - drug effects | Arthritis, Experimental - pathology | Microsomes - drug effects | Cytosol - enzymology | RNA, Messenger - biosynthesis | Prostaglandin Antagonists - biosynthesis | Indoles - pharmacology | Prostaglandin Antagonists - pharmacology | Disease Models, Animal | Injections, Intradermal | Isoenzymes - physiology | Prostaglandin-Endoperoxide Synthases - genetics | Mycobacterium - immunology | Dinoprostone - genetics | Isoenzymes - genetics | Rats | Edema - enzymology | Microsomes - enzymology | Up-Regulation - genetics | Antigens, Bacterial - administration & dosage | Arthritis, Experimental - immunology | Rats, Sprague-Dawley | Animals | Intramolecular Oxidoreductases - genetics | Up-Regulation - immunology | Prostaglandin-E Synthases | Intracellular Membranes - drug effects | Arthritis, Experimental - enzymology | Edema - pathology | Prostaglandin-Endoperoxide Synthases - physiology | Index Medicus | Abridged Index Medicus
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9. Full Text Inhibition of inducible prostaglandin E2 synthase by 15-deoxy-Δ12,14-prostaglandin J2 and polyunsaturated fatty acids
by Quraishi, Omar and Mancini, Joseph A and Riendeau, Denis
Biochemical pharmacology, ISSN 0006-2952, 03/2002, Volume 63, Issue 6, pp. 1183 - 1189
Arachidonate | Prostaglandins | 15-Deoxy-prostaglandin J | Inflammation | MAPEG | PGE synthase | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents
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10. Full Text Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors
by Côté, Bernard and Boulet, Louise and Brideau, Christine and Claveau, David and Ethier, Diane and Frenette, Richard and Gagnon, Marc and Giroux, André and Guay, Jocelyne and Guiral, Sébastien and Mancini, Joseph and Martins, Evelyn and Massé, Frédéric and Méthot, Nathalie and Riendeau, Denis and Rubin, Joel and Xu, Daigen and Yu, Hongping and Ducharme, Yves and Friesen, Richard W
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 2007, Volume 17, Issue 24, pp. 6816 - 6820
PGE 2 | mPGES-1 | Inflammation | Prostanoid | PGE | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | Neuropharmacology | Analgesics | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Hyperalgesia - chemically induced | Analgesics, Non-Narcotic - blood | Guinea Pigs | Humans | Analgesics, Non-Narcotic - pharmacology | Imidazoles - chemistry | Intramolecular Oxidoreductases - antagonists & inhibitors | Rats | Imidazoles - pharmacology | Structure-Activity Relationship | Phenanthrenes - blood | Imidazoles - blood | Phenanthrenes - chemistry | Phenanthrenes - pharmacology | Animals | Phenanthrenes - chemical synthesis | Prostaglandin-E Synthases | Drug Design | Inhibitory Concentration 50 | Molecular Structure | Analgesics, Non-Narcotic - chemical synthesis | Imidazoles - chemical synthesis | Analgesics, Non-Narcotic - chemistry | Disease Models, Animal | Index Medicus
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11. Full Text Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886
by Riendeau, Denis and Aspiotis, Renee and Ethier, Diane and Gareau, Yves and Grimm, Erich L and Guay, Jocelyne and Guiral, Sébastien and Juteau, Hélène and Mancini, Joseph A and Méthot, Nathalie and Rubin, Joel and Friesen, Richard W
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 07/2005, Volume 15, Issue 14, pp. 3352 - 3355
Prostaglandin E2 | FLAP inhibitors | Inflammation | MK-886 | Prostaglandin synthase | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Humans | Indoles - chemical synthesis | Intramolecular Oxidoreductases - antagonists & inhibitors | Microsomes - enzymology | Cyclooxygenase Inhibitors - chemistry | Structure-Activity Relationship | Cyclooxygenase Inhibitors - pharmacology | Prostaglandin-E Synthases | Cyclooxygenase Inhibitors - chemical synthesis | Cell Line, Tumor | Indoles - pharmacology | Cell Proliferation - drug effects | Indoles - chemistry | Index Medicus
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12. Full Text Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors
by Giroux, André and Boulet, Louise and Brideau, Christine and Chau, Anh and Claveau, David and Côté, Bernard and Ethier, Diane and Frenette, Richard and Gagnon, Marc and Guay, Jocelyne and Guiral, Sébastien and Mancini, Joseph and Martins, Evelyn and Massé, Frédéric and Méthot, Nathalie and Riendeau, Denis and Rubin, Joel and Xu, Daigen and Yu, Hongping and Ducharme, Yves and Friesen, Richard W
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 2009, Volume 19, Issue 20, pp. 5837 - 5841
Phenanthrene imidazole | Activity | mPGES-1 | Inhibitors | Pharmacokinetic | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | Neuropharmacology | Analgesics | Pharmacology. Drug treatments | Humans | Intramolecular Oxidoreductases - antagonists & inhibitors | Nitriles - chemical synthesis | Structure-Activity Relationship | Benzimidazoles - chemistry | Enzyme Inhibitors - chemical synthesis | Nitriles - pharmacokinetics | Phenanthrenes - chemistry | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | Drug Design | Intramolecular Oxidoreductases - metabolism | Disease Models, Animal | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Guinea Pigs | Administration, Oral | Benzimidazoles - chemical synthesis | Phenanthrenes - pharmacokinetics | Benzimidazoles - pharmacokinetics | Animals | Phenanthrenes - chemical synthesis | Hyperalgesia - drug therapy | Prostaglandin-E Synthases | Nitriles - chemistry | Index Medicus
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13. Full Text Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1
by Wu, Tom Y.H and Juteau, Hélne and Ducharme, Yves and Friesen, Richard W and Guiral, Sébastien and Dufresne, Lynn and Poirier, Hugo and Salem, Myriam and Riendeau, Denis and Mancini, Joseph and Brideau, Christine
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 12/2010, Volume 20, Issue 23, pp. 6978 - 6982
PGE2 | Inflammation | Inhibitor | MPGES-1 | Biarylimidazole | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Cell Line | Anti-Inflammatory Agents - pharmacology | Dinoprostone - biosynthesis | Imidazoles - chemistry | Intramolecular Oxidoreductases - antagonists & inhibitors | Microsomes - enzymology | Imidazoles - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | High-Throughput Screening Assays | Prostaglandin-E Synthases | Mice | Dinoprostone - antagonists & inhibitors | Index Medicus
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14. Full Text Conversion of Prostaglandin G/H Synthase-1 into an Enzyme Sensitive to PGHS-2-selective Inhibitors by a Double His513 → Arg and Ile523 → Val Mutation
by Elizabeth Wong and Christopher Bayly and Heather L. Waterman and Denis Riendeau and Joseph A. Mancini
The Journal of biological chemistry, ISSN 0021-9258, 04/1997, Volume 272, Issue 14, pp. 9280 - 9286
Amino Acid Sequence | Mutagenesis, Site-Directed | Dinoprostone - biosynthesis | Cyclooxygenase 2 | Humans | Models, Molecular | Molecular Sequence Data | Thiophenes - pharmacology | Cyclooxygenase Inhibitors - chemistry | Structure-Activity Relationship | Nitrobenzenes - pharmacology | Sulfonamides - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Membrane Proteins | Cyclooxygenase 2 Inhibitors | Histidine | Arginine | Isoenzymes - metabolism | Prostaglandin-Endoperoxide Synthases - metabolism | Valine | Binding Sites | Isoleucine | Index Medicus
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15. Full Text Identification and Characterization of a Novel Microsomal Enzyme with Glutathione-dependent Transferase and Peroxidase Activities
by Per-Johan Jakobsson and Joseph A. Mancini and Denis Riendeau and Anthony W. Ford-Hutchinson
The Journal of biological chemistry, ISSN 0021-9258, 09/1997, Volume 272, Issue 36, pp. 22934 - 22939
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Cell Line | Glutathione Peroxidase - metabolism | Humans | Glutathione Transferase - metabolism | Molecular Sequence Data | Baculoviridae - genetics | Microsomes - enzymology | Chromosome Mapping | Chromosomes, Human, Pair 4 | Glutathione Peroxidase - genetics | Spodoptera | Sequence Homology, Amino Acid | Animals | Glutathione Transferase - genetics | Base Sequence | DNA, Recombinant | Index Medicus
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16. Full Text Trisubstituted ureas as potent and selective mPGES-1 inhibitors
by Chiasson, Jean-François and Boulet, Louise and Brideau, Christine and Chau, Anh and Claveau, David and Côté, Bernard and Ethier, Diane and Giroux, André and Guay, Jocelyne and Guiral, Sébastien and Mancini, Joseph and Massé, Frédéric and Méthot, Nathalie and Riendeau, Denis and Roy, Patrick and Rubin, Joel and Xu, Daigen and Yu, Hongping and Ducharme, Yves and Friesen, Richard W
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 2011, Volume 21, Issue 5, pp. 1488 - 1492
Trisubstituted urea | mPGES-1 | Prostaglandins | Inflammation | PGE synthase | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Humans | Prostaglandin-E Synthases | Cell Line, Tumor | Intramolecular Oxidoreductases - antagonists & inhibitors | Microsomes - enzymology | Structure-Activity Relationship | Urea - chemical synthesis | Urea - chemistry | Urea - pharmacology | Index Medicus
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17. Full Text Biarylimidazoles as inhibitors of microsomal prostaglandin E sub(2) synthase-1
by Wu, Tom YH and Juteau, Helene and Ducharme, Yves and Friesen, Richard W and Guiral, Sebastien and Dufresne, Lynn and Poirier, Hugo and Salem, Myriam and Riendeau, Denis and Mancini, Joseph and Brideau, Christine
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 12/2010, Volume 20, Issue 23, pp. 6978 - 6982
Analgesics
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18. Full Text Arginine 120 of Prostaglandin G/H Synthase-1 Is Required for the Inhibition by Nonsteroidal Anti-inflammatory Drugs Containing a Carboxylic Acid Moiety
by Joseph A. Mancini and Denis Riendeau and Jean-Pierre Falgueyret and Philip J. Vickers and Gary P. O'Neill
The Journal of biological chemistry, ISSN 0021-9258, 12/1995, Volume 270, Issue 49, pp. 29372 - 29377
Arachidonic Acid - metabolism | Animals | Arginine | Oxidation-Reduction | Prostaglandin-Endoperoxide Synthases - chemistry | Base Sequence | Cells, Cultured | Molecular Sequence Data | Structure-Activity Relationship | Mutation | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Index Medicus
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19. Full Text Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs and selective COX-2 inhibitors, using sensitive microsomal and platelet assays
by Riendeau, D and Charleson, S and Cromlish, W and Mancini, J A and Wong, E and Guay, J
Canadian journal of physiology and pharmacology, ISSN 0008-4212, 09/1997, Volume 75, Issue 9, pp. 1088 - 1095
Gastrointestinal toxicity | COS-2 inhibitors | Cyclooxygenase | Nonsteroidal anti-inflammatory drugs | Platelets | Prostaglandin synthase
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