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Journal Article
Human Genetics, ISSN 0340-6717, 8/2006, Volume 120, Issue 1, pp. 101 - 110
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 2013, Volume 19, Issue 28, pp. 5093 - 5104
Among hereditary diseases, the group of motor neuron diseases (MNDs) includes some of the most devastating and rapidly progressive lethal conditions. Although... 
SAHA | Spinal and bulbar muscular atrophy | HDAC inhibitor | Amyotrophic lateral sclerosis | Trichostatin A | Valproic acid | HSP1 | Spinal muscular atrophy | MARIE-TOOTH-DISEASE | trichostatin A | spinal and bulbar muscular atrophy | valproic acid | AMYOTROPHIC-LATERAL-SCLEROSIS | FRONTOTEMPORAL LOBAR DEGENERATION | VALPROIC ACID INCREASES | PLURIPOTENT STEM-CELLS | SPINAL MUSCULAR-ATROPHY | DEACETYLASE INHIBITORS | PHARMACOLOGY & PHARMACY | spinal muscular atrophy | INCREASES SMN EXPRESSION | TRANSGENIC MOUSE MODEL | ANDROGEN RECEPTOR-GENE | Neuroprotective Agents - therapeutic use | Humans | Muscular Atrophy, Spinal - enzymology | Molecular Targeted Therapy | Amyotrophic Lateral Sclerosis - drug therapy | Motor Neuron Disease - metabolism | Protein Processing, Post-Translational - drug effects | Motor Neuron Disease - enzymology | Bulbo-Spinal Atrophy, X-Linked - enzymology | Motor Neuron Disease - drug therapy | Amyotrophic Lateral Sclerosis - enzymology | Motor Neurons - drug effects | Disease Models, Animal | Nerve Tissue Proteins - antagonists & inhibitors | Muscular Atrophy, Spinal - metabolism | Bulbo-Spinal Atrophy, X-Linked - metabolism | Motor Neurons - enzymology | Bulbo-Spinal Atrophy, X-Linked - drug therapy | Motor Neurons - metabolism | Nerve Tissue Proteins - metabolism | Acetylation - drug effects | Animals | Amyotrophic Lateral Sclerosis - metabolism | Muscular Atrophy, Spinal - drug therapy | Histone Deacetylase Inhibitors - therapeutic use | Mice | Histones - metabolism
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 10/2013, Volume 369, Issue 16, pp. 1529 - 1536
Journal Article
Biochemistry, ISSN 0006-2960, 12/2017, Volume 56, Issue 49, pp. 6409 - 6410
Journal Article
European journal of human genetics : EJHG, ISSN 1018-4813, 06/2013, Volume 21, Issue 6, pp. 643 - 652
Spinal muscular atrophy (SMA) is the leading genetic cause of early childhood death worldwide and no therapy is available today. Many drugs, especially histone... 
SMN2 | neuromuscular disease | spinal muscular atrophy | therapy HDAC inhibitors | JNJ-26481585 | VPA | SURVIVAL | HISTONE DEACETYLASE INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | SPINAL-MUSCULAR-ATROPHY | PATHOLOGY | CARDIAC DEFECTS | IDENTIFICATION | VALPROIC ACID INCREASES | SKELETAL-MUSCLE | MOUSE MODEL | GENETICS & HEREDITY | NEUROMUSCULAR-JUNCTION | Organ Specificity - drug effects | Spinal Cord - drug effects | Spinal Cord - metabolism | Neuromuscular Junction - drug effects | Neuromuscular Junction - metabolism | Humans | Hydroxamic Acids - adverse effects | Body Weight - drug effects | Motor Activity - drug effects | Brain - metabolism | Dose-Response Relationship, Drug | Spinal Cord - pathology | Muscle, Skeletal - drug effects | Hydroxamic Acids - pharmacology | Neuromuscular Junction - pathology | Fibroblasts - metabolism | Muscle, Skeletal - blood supply | SMN Complex Proteins - metabolism | Muscular Atrophy, Spinal - metabolism | Cells, Cultured | Treatment Outcome | Fibroblasts - pathology | Muscular Atrophy, Spinal - pathology | Brain - drug effects | Up-Regulation - drug effects | Phenotype | Animals | Fibroblasts - drug effects | Survival Analysis | Brain - pathology | Histone Deacetylase Inhibitors - pharmacology | Hydroxamic Acids - therapeutic use | Muscular Atrophy, Spinal - drug therapy | Histone Deacetylase Inhibitors - therapeutic use | Mice | Muscle, Skeletal - pathology | Histone deacetylase | Disease | Genes | SMN protein | Clinical trials | Drug screening | Spinal muscular atrophy | Proteins | Genotype & phenotype | Autopsy | Intestine | Genetics | Children | Myelin P0 protein | Heart failure | Phenotypes | Cardiac muscle | Limiting factors | Valproic acid | Patients | Skeletal muscle | Musculoskeletal system | Ostomy | Life span | Cell lines | Death | Mutation | Cancer
Journal Article
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 04/2013, Volume 19, Issue 28, pp. 5093 - 5104
Among hereditary diseases, the group of motor neuron diseases (MNDs) includes some of the most devastating and rapidly progressive lethal conditions. Although... 
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 07/2006, Volume 98, Issue 1, pp. 193 - 202
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2014, Volume 124, Issue 4, pp. 1821 - 1834
Journal Article