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Journal of Cell Science, ISSN 0021-9533, 01/2003, Volume 116, Issue 2, pp. 217 - 224
TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix. A variety of molecules, 'TGFbeta activators,' release TGFbeta... 
Transforming growth factor-β | Activation | Sensor | DOMAIN-SPECIFIC MUTATIONS | EMBRYO FIBROBLASTS | CELL BIOLOGY | transforming growth factor-beta | BINDING-PROTEIN LTBP-1 | GROWTH-FACTOR-BETA | MESSENGER-RNA | 8-CYSTEINE REPEAT | CAMURATI-ENGELMANN-DISEASE | TRANSFORMING GROWTH-FACTOR-BETA-1 | sensor | EXTRACELLULAR-MATRIX | activation | SMOOTH-MUSCLE CELLS
Journal Article
Blood, ISSN 0006-4971, 11/2008, Volume 112, Issue 9, pp. 3650 - 3660
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2017, Volume 482, Issue 4, p. 1387
The four latent transforming growth factor-[beta] (TGF-[beta]) binding proteins LTBP1-4 are extracellular matrix-associated proteins playing a critical role in... 
Medical colleges | Analysis | Amino acids | Bone morphogenetic proteins | Binding proteins | Transforming growth factors | Cells | Biomedical engineering | Protein binding | Estrogen | Progesterone
Journal Article
Matrix Biology, ISSN 0945-053X, 09/2015, Volume 47, p. 44
The LTBPs (or latent transforming growth factor [beta] binding proteins) are important components of the extracellular matrix (ECM) that interact with... 
Proteases | Bone morphogenetic proteins | Chemical properties | Binding proteins | Transforming growth factors | Integrins | Protein binding
Journal Article
Cancer Research, ISSN 0008-5472, 01/2013, Volume 73, Issue 1, pp. 459 - 468
TGF-β and its signaling pathways are important mediators in the suppression of cancers of the gastrointestinal tract. TGF-β is released from cells in a latent... 
Immunohistochemistry | Gastrointestinal Neoplasms - pathology | Animals | Mice, Mutant Strains | Transforming Growth Factor beta1 - metabolism | Immunoblotting | Mice | Real-Time Polymerase Chain Reaction | Gastrointestinal Neoplasms - metabolism
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 12/2007, Volume 179, Issue 6, pp. 1311 - 1323
The conjunctive presence of mechanical stress and active transforming growth factor β1 (TGF-β1) is essential to convert fibroblasts into contractile... 
Lungs | Fibrosis | Fibroblasts | Antibodies | Stress fibers | Actins | Cultured cells | Cytoskeleton | Myofibroblasts | Integrins
Journal Article
Cytokine and Growth Factor Reviews, ISSN 1359-6101, 08/2013, Volume 24, Issue 4, p. 355
TGF[beta] is secreted in a latent state and must be "activated" by molecules that facilitate its release from a latent complex and allow binding to high... 
Transforming growth factors | Cells
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 11/2015, Volume 112, Issue 45, pp. 14012 - 14012
Marfan syndrome (MFS) is an autosomal dominant disorder of connective tissue, caused by mutations of the microfibrillar protein fibrillin-1, that predisposes... 
Journal Article
Journal Article
Journal of Biochemistry, ISSN 0021-924X, 10/2012, Volume 152, Issue 4, pp. 321 - 329
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 01/2015, Volume 230, Issue 1, pp. 226 - 236
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 01/2015, Volume 230, Issue 1, p. 226
  Mice deficient in Latent TGF[beta] Binding Protein 4 (Ltbp4) display a defect in lung septation and elastogenesis. The lung septation defect is normalized by... 
Journal Article
Current Opinion in Cell Biology, ISSN 0955-0674, 2009, Volume 21, Issue 5, pp. 616 - 622
The extracellular matrix plays a key role in organ formation and tissue homeostasis. Recent studies have revealed that fibrillin assemblies (microfibrils)... 
Internal Medicine | MATRIX | ACTIVATES LATENT TGF-BETA-1 | MARFAN-SYNDROME | MOUSE MODEL | FIBRILLIN-1 | BINDING PROTEIN-1 | LUNG DEVELOPMENT | CELL-ADHESION | HEPARAN-SULFATE PROTEOGLYCANS | THORACIC AORTIC-ANEURYSM | CELL BIOLOGY
Journal Article
Journal of Orthopaedic Research, ISSN 0736-0266, 06/2015, Volume 33, Issue 6, pp. 832 - 839
Journal Article