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JAMA, ISSN 0098-7484, 10/2011, Volume 306, Issue 15, pp. 1711 - 1713
Journal Article
Survey of ophthalmology, ISSN 0039-6257, 07/2019
Corneal melt, an ophthalmological condition in which corneal epithelium is lost accompanied by thinning of the corneal stroma, can lead to corneal perforation... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/1998, Volume 95, Issue 26, pp. 15327 - 15332
Fourier-transform IR (FT-IR) spectra of pelleted exfoliated cervical cells from patients with cervical cancer or dysplasia differ from those from normal women.... 
Statistical significance | Infrared spectroscopy | Epithelial cells | Glycogen | Spectral bands | Infrared radiation | Spectroscopic analysis | Calibration | Neoplasia | Carcinogenesis | LEAST-SQUARES METHODS | SPECTRAL ANALYSES | INFRARED-SPECTROSCOPY | TISSUES | MULTIDISCIPLINARY SCIENCES | Usage | Fourier transform infrared spectroscopy | Research | Cervical cancer | Cancer cells | Tumors
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2005, Volume 102, Issue 47, pp. 17207 - 17212
Nitric oxide-donating aspirin (NO-ASA) is a promising chemoprevention agent against colon cancer and other cancers. It consists of traditional ASA to which a... 
T lymphocytes | Oxidative stress | Biological Sciences | Cell growth | Reactive oxygen species | Cell death | Colorectal cancer | Cadherins | Adherens junctions | Cyclins | Apoptosis | NO-aspirin | Wnt signaling | Chemoprevention | POLY(ADP-RIBOSE) POLYMERASE | cell death | MULTIDISCIPLINARY SCIENCES | BETA-CATENIN | CLEAVAGE | ADHESION | chemoprevention | CARCINOGENESIS | INHIBITION | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | TRANSACTIVATION | NF-KAPPA-B | ASSOCIATION | Caspases - physiology | Cyclin D1 - metabolism | Adenocarcinoma - pathology | Apoptosis - drug effects | Colonic Neoplasms - drug therapy | Humans | Antineoplastic Agents - administration & dosage | Adherens Junctions - metabolism | Colonic Neoplasms - metabolism | Aspirin - administration & dosage | Genes, APC | Antineoplastic Agents - metabolism | Adenocarcinoma - metabolism | Aspirin - metabolism | Caspases - biosynthesis | Caspase 3 | Mice, Inbred C57BL | Nitric Oxide Donors - metabolism | Down-Regulation - drug effects | Adenocarcinoma - drug therapy | beta Catenin - metabolism | Hydrolysis | Nitric Oxide Donors - administration & dosage | Animals | Signal Transduction - drug effects | Colonic Neoplasms - pathology | Adherens Junctions - drug effects | Cell Line, Tumor | Mice | Oxidative Stress - drug effects | Aspirin | Care and treatment | Dosage and administration | Colon cancer | Research
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e61532
New agents are needed to treat pancreatic cancer, one of the most lethal human malignancies. We synthesized phosphovalproic acid, a novel valproic acid... 
COLON-CANCER | CELLS | ACTIVATOR | MULTIDISCIPLINARY SCIENCES | SULINDAC OXT-328 | RECEPTOR | INDUCTION | TUMOR-GROWTH | HISTONE DEACETYLASE | PROGRESSION | SIGNAL TRANSDUCER | Reactive Oxygen Species - metabolism | Humans | Protein Transport - drug effects | Membrane Potential, Mitochondrial - drug effects | Molecular Targeted Therapy | Valproic Acid - analogs & derivatives | Valproic Acid - pharmacology | Pancreatic Neoplasms - drug therapy | Female | Antineoplastic Agents - pharmacology | Pancreatic Neoplasms - prevention & control | STAT3 Transcription Factor - metabolism | Pancreatic Neoplasms - pathology | Mitochondria - metabolism | Mitochondria - drug effects | Drug Synergism | Organophosphates - pharmacology | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Mice, Nude | Cell Line, Tumor | Cimetidine - pharmacology | Mice | Mice, Inbred BALB C | Apoptosis | Divalproex | Molecular targeted therapy | Transcription factors | Care and treatment | Pancreatic cancer | Innovations | Development and progression | Genetic aspects | Valproic acid | Health aspects | Flow cytometry | Hsp90 protein | Phosphorylation | Reactive oxygen species | Cancer therapies | Cytosol | Anticancer properties | Proteins | Mitochondria | Cell growth | Bcl-x protein | Ischemia | Rodents | Janus kinase 2 | Cell cycle | Xenografts | Inhibition | Translocation | Stat3 protein | Cimetidine | Survivin | Mcl-1 protein | Disease prevention | Medicine | Acids | Microscopy | Cancer | Pharmaceuticals
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 04/2015, Volume 353, Issue 1, pp. 1 - 8
Journal Article
Trends in Molecular Medicine, ISSN 1471-4914, 07/2004, Volume 10, Issue 7, pp. 324 - 330
Journal Article
Current Pharmacology Reports, ISSN 2198-641X, 10/2018, Volume 4, Issue 5, pp. 414 - 414
The article The Chemoprevention of Ovarian Cancer: the Need and the Options, written by Rishil J. Kathawala, Andrzej Kudelka and Basil Rigas, was originally... 
Biomedicine, general | Cancer Research | Molecular Medicine | Biomedicine | Pharmacology/Toxicology
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 11, p. e111720
Phospho-aspirin (PA-2) is a novel aspirin derivative that exhibits promising anticancer properties and is considerably safer than conventional aspirin. In this... 
SURVIVAL | MDC-917 | OXIDATIVE STRESS | THERAPY | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | ASPIRIN INTAKE | PIK3CA MUTATION | ANTIINFLAMMATORY DRUGS | P53 | Apoptosis - drug effects | Humans | Tumor Suppressor Protein p53 - metabolism | Receptors, Estrogen - analysis | Antineoplastic Agents - chemistry | Breast - metabolism | Breast Neoplasms - drug therapy | Breast Neoplasms - metabolism | Acetylation - drug effects | Animals | MCF-7 Cells | Aspirin - analogs & derivatives | Breast - drug effects | Breast Neoplasms - pathology | Oxidation-Reduction - drug effects | Female | Antineoplastic Agents - pharmacology | Aspirin - therapeutic use | Cell Proliferation - drug effects | Mice | Oxidative Stress - drug effects | Breast - pathology | Cell proliferation | Flow cytometry | Oxidative stress | Cell culture | Reactive oxygen species | Animal models | Transcription | Estrogens | p53 Protein | Estrogen | Estrogen receptors | Acetylcysteine | Mitochondrial DNA | Drug resistance | Cancer therapies | Anticancer properties | Skin cancer | Mitochondria | Xenografts | Cell cycle | Tumorigenesis | Membrane potential | Inhibition | Acetylation | Nonsteroidal anti-inflammatory drugs | Translocation | MDM2 protein | Aspirin | RNA-mediated interference | Breast cancer | Medicine | Studies | Disease prevention | Signaling | Overexpression | Medical prognosis | Breast | Apoptosis | Tumors | Cancer | Pharmaceuticals
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 05/2015, Volume 32, Issue 5, pp. 1663 - 1675
The purpose of the study was to evaluate the metabolism, pharmacokinetics and efficacy of phospho-NSAIDs in Ces1c-knockout mice. Hydrolysis of phospho-NSAIDs... 
carboxylesterase | pharmacokinetics | non-steroidal anti-inflammatory drugs | xenografts | CPT-11 | CHEMISTRY, MULTIDISCIPLINARY | COLON-CANCER | CAPECITABINE | IN-VITRO | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | 5'-DEOXY-5-FLUOROCYTIDINE | SULINDAC OXT-328 | GROWTH | PHARMACOLOGY & PHARMACY | HUMAN LIVER | IBUPROFEN MDC-917 | Organophosphates - metabolism | Sulindac - pharmacokinetics | Ibuprofen - therapeutic use | Organophosphates - therapeutic use | Aspirin - pharmacokinetics | Male | Antineoplastic Agents - therapeutic use | Organophosphorus Compounds - metabolism | Ibuprofen - analogs & derivatives | Sulindac - metabolism | Antineoplastic Agents - metabolism | Carboxylic Ester Hydrolases - blood | Aspirin - metabolism | Antineoplastic Agents - pharmacokinetics | Aspirin - therapeutic use | Carboxylic Ester Hydrolases - genetics | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Organophosphates - pharmacokinetics | Ibuprofen - pharmacokinetics | Mice, Inbred C57BL | Organophosphorus Compounds - therapeutic use | Sulindac - therapeutic use | Carcinoma, Lewis Lung - metabolism | Ibuprofen - metabolism | Carcinoma, Lewis Lung - drug therapy | Mice, Knockout | Sulindac - analogs & derivatives | Animals | Carcinoma, Lewis Lung - genetics | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Aspirin - analogs & derivatives | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Mice | Organophosphorus Compounds - pharmacokinetics | Physiological aspects | Nonsteroidal anti-inflammatory drugs | Fluocinolone acetonide | Pancreatic cancer | Clinical trials | Plasma | Pharmacology | Metabolism | Rodents | Carboxylesterase | Pharmacokinetics | Xenografts | Non-steroidal anti-inflammatory drugs
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2003, Volume 100, Issue 22, pp. 12584 - 12589
Dysregulation of the Wnt pathway and altered β-catenin expression are central early events in colorectal carcinogenesis. We studied the ortho, meta, and para... 
T lymphocytes | Biological Sciences | Cell growth | Cell nucleus | Genes | Colorectal cancer | Cell lines |