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1. Full Text Scavenging Iron: A Novel Mechanism of Plant Immunity Activation by Microbial Siderophores
by Aude Aznar and Nicolas W.G. Chen and Martine Rigault and Nassima Riache and Delphine Joseph and Didier Desmaële and Grégory Mouille and Stéphanie Boutet and Ludivine Soubigou-Taconnat and Jean-Pierre Renou and Sébastien Thomine and Dominique Expert and Alia Dellagi
Plant Physiology, ISSN 0032-0889, 4/2014, Volume 164, Issue 4, pp. 2167 - 2183
Siderophores are specific ferric iron chelators synthesized by virtually all microorganisms in response to iron deficiency. We have previously shown that they... 
Siderophores | Leaves | Up regulation | Genes | Plant roots | Homeostasis | Iron | SIGNALING AND RESPONSE | Plants | Gene expression | Immunity | Genes, Plant | Zinc - metabolism | Arabidopsis - immunology | Plant Roots - genetics | Pseudomonas syringae - drug effects | Plant Diseases - microbiology | Gene Expression Profiling | Water - pharmacology | Plant Roots - drug effects | Arabidopsis Proteins - metabolism | Time Factors | Cation Transport Proteins - metabolism | Cation Transport Proteins - genetics | Plant Immunity - drug effects | Plant Leaves - drug effects | Enterobacteriaceae - physiology | Homeostasis - drug effects | Phosphorylation - drug effects | Pseudomonas syringae - physiology | Deferoxamine - pharmacology | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | Immunity, Innate - drug effects | Up-Regulation - genetics | Iron - metabolism | Siderophores - pharmacology | Arabidopsis - genetics | Up-Regulation - drug effects | Arabidopsis - microbiology | Gene Expression Regulation, Plant - drug effects | Iron Chelating Agents - pharmacology | Plant Leaves - genetics | Models, Biological | Homeostasis - genetics | Arabidopsis thaliana | Botanical research | Plant defenses | Diseases and pests | Nutritional aspects | Genetic research | Genetic aspects | Iron in the body | Genetic transcription | Research | Health aspects | Life Sciences
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2. Full Text Optical and physical mapping with local finishing enables megabase-scale resolution of agronomically important regions in the wheat genome
by Keeble-Gagnère, Gabriel and Rigault, Philippe and Tibbits, Josquin and Pasam, Raj and Hayden, Matthew and Forrest, Kerrie and Frenkel, Zeev and Korol, Abraham and Huang, B.Emma and Cavanagh, Colin and Taylor, Jen and Abrouk, Michael and Sharpe, Andrew and Konkin, David and Sourdille, Pierre and Darrier, Benoît and Choulet, Frédéric and Bernard, Aurélien and Rochfort, Simone and Dimech, Adam and Watson-Haigh, Nathan and Baumann, Ute and Eckermann, Paul and Fleury, Delphine and Juhasz, Angela and Boisvert, Sébastien and Nolin, Marc-Alexandre and Doležel, Jaroslav and Šimková, Hana and Toegelová, Helena and Šafář, Jan and Luo, Ming-Cheng and Câmara, Francisco and Pfeifer, Matthias and Isdale, Don and Nyström-Persson, Johan and Koo, Dal-Hoe and Tinning, Matthew and Cui, Dangqun and Ru, Zhengang and Appels, Rudi and IWGSC
Genome Biology, ISSN 1474-7596, 08/2018, Volume 19, Issue 1, pp. 112 - 18
Background: Numerous scaffold-level sequences for wheat are now being released and, in this context, we report on a strategy for improving the overall assembly... 
Megabase-scale integration | Yield | Optical/physical maps Grain quality | Wheat sequence finishing | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENES | SIZE | GENETICS & HEREDITY | QTL | CHROMOSOMES | SEGREGATION | CENTROMERES | Chromosomes, Artificial, Bacterial - genetics | Triticum - genetics | Seeds - genetics | Fructans - analysis | Physical Chromosome Mapping - methods | Agriculture | Optical Phenomena | Centromere - metabolism | Genome, Plant | Chromosomes, Plant - genetics | Phenotypes | Nucleotide sequence | Grain | Genes | Chromosome 7 | Genomes | Artificial chromosomes | Bacterial artificial chromosomes | Consortia | Maps | Quality | Gene mapping | Bioinformatics | Physical mapping | Ubiquitin-protein ligase | Life Sciences | Vegetal Biology
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3. Full Text Phasic and tonic mGlu7 receptor activity modulates the thalamocortical network
by Tassin, Valériane and Girard, Benoît and Chotte, Apolline and Fontanaud, Pierre and Rigault, Delphine and Kalinichev, Mikhail and Perroy, Julie and Acher, Francine and Fagni, Laurent and Bertaso, Federica
Frontiers in Neural Circuits, ISSN 1662-5110, 04/2016, Volume 10, p. 31
Mutation of the metabotropic glutamate receptor type 7 (mGlu7) induces absence-like epileptic seizures, but its precise role in the somatosensory... 
Short-term plasticity | Glutamate | EEG | Epilepsy | Thalamic network | Benzoxazoles - pharmacology | Membrane Potentials - genetics | Humans | Synaptic Potentials - drug effects | Channelrhodopsins | Receptors, Metabotropic Glutamate - metabolism | Cerebral Cortex - cytology | Excitatory Postsynaptic Potentials - drug effects | Neural Pathways - physiology | Post-Synaptic Density - genetics | Receptors, Metabotropic Glutamate - genetics | Thalamus - physiology | Excitatory Amino Acid Agents - pharmacology | HEK293 Cells | Neurons - physiology | Post-Synaptic Density - drug effects | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Neurons - drug effects | Excitatory Postsynaptic Potentials - genetics | Membrane Potentials - drug effects | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Synaptic Potentials - genetics | Mice, Transgenic | Mutation - genetics | GABA Agents - pharmacology | Animals | Benzoxazoles - chemistry | Receptors, GABA-A - physiology | Cerebral Cortex - physiology | Mice | In Vitro Techniques | Metabotropic glutamate receptors | Neural transmission | Research | Gene mutations | Analysis | Neurosciences | Oscillations | Optics | Glutamic acid receptors | Mental depression | Proteins | Plasticity (behavioral) | Convulsions & seizures | γ-Aminobutyric acid | Allosteric properties | Synaptic transmission | Genetics | Thalamus | Physiology | Seizures | Firing pattern | Cortex | Mammals | Information processing | Ligands | Mutation | Glutamatergic transmission | Glutamic acid receptors (metabotropic) | Neurotransmission | thalamic network | short-term plasticity
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4. Full Text A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential
by Goudet, Cyril and Vilar, Bruno and Courtiol, Tiphanie and Deltheil, Thierry and Bessiron, Thomas and Brabet, Isabelle and Oueslati, Nadia and Rigault, Delphine and Bertrand, Hugues-Olivier and McLean, Heather and Daniel, Hervé and Amalric, Marianne and Acher, Francine and Pin, Jean-Philippe
FASEB Journal, ISSN 0892-6638, 04/2012, Volume 26, Issue 4, pp. 1682 - 1693
Metabotropic glutamate (mGlu) receptors are promising targets to treat numerous brain disorders. So far, allosteric modulators are the only subtype selective... 
Drug development | mGluR | Parkinson's disease | POSITIVE ALLOSTERIC MODULATION | SITE | ACTIVATION | ACID | RECOGNITION | DOCKING | BIOCHEMISTRY & MOLECULAR BIOLOGY | drug development | BINDING DOMAIN | MOLECULAR DETERMINANTS | CELL BIOLOGY | MGLUR4 | BIOLOGY | CHARMM | Antiparkinson Agents - pharmacology | Rats, Wistar | Humans | Male | Structure-Activity Relationship | Dose-Response Relationship, Drug | Receptors, Metabotropic Glutamate - genetics | HEK293 Cells | Antiparkinson Agents - chemistry | Synaptic Transmission - drug effects | Molecular Structure | Receptors, Metabotropic Glutamate - chemistry | Binding Sites | Recombinant Proteins - metabolism | Excitatory Amino Acid Agonists - metabolism | Mutagenesis, Site-Directed | Phosphinic Acids - chemistry | Rats | Excitatory Amino Acid Agonists - pharmacology | Recombinant Proteins - genetics | Mice, Knockout | Patch-Clamp Techniques | Animals | Phosphinic Acids - pharmacology | Phosphinic Acids - metabolism | Ligands | Mice | Receptors, Metabotropic Glutamate - agonists | Antiparkinson Agents - metabolism | Excitatory Amino Acid Agonists - chemistry | Excitatory Amino Acid Agonists | Neurons and Cognition | Neurobiology | Recombinant Proteins | Synaptic Transmission | Life Sciences | Phosphinic Acids | Psychology and behavior | Antiparkinson Agents | Receptors, Metabotropic Glutamate | Cognitive Sciences
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5. Full Text Scavenging Iron: A Novel Mechanism of Plant Immunity Activation by Microbial Siderophores1[C][W]
by Aznar, A and Chen, NWG and Rigault, M and Riache, N and Joseph, D and Desmaele, D and Mouille, G and Boutet, S and Soubigou-Taconnat, L and Renou, JP and Thomine, S and Expert, D and Dellagi, A
PLANT PHYSIOLOGY, ISSN 0032-0889, 04/2014, Volume 164, Issue 4, pp. 2167 - 2183
Siderophores are specific ferric iron chelators synthesized by virtually all microorganisms in response to iron deficiency. We have previously shown that they... 
ARABIDOPSIS-THALIANA | SIGNALING PATHWAYS | OXIDATIVE STRESS | ERWINIA-CHRYSANTHEMI INFECTION | ORGANELLE BIOGENESIS | GLYCINE-RICH PROTEIN | METAL TRANSPORTER | FLUORESCENT PSEUDOMONAS | INDUCED SYSTEMIC RESISTANCE | INTESTINAL EPITHELIAL-CELLS | PLANT SCIENCES
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6. Full Text Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites
by Selvam, Chelliah and Lemasson, Isabelle A and Brabet, Isabelle and Oueslati, Nadia and Karaman, Berin and Cabaye, Alexandre and Tora, Amélie S and Commare, Bruno and Courtiol, Tiphanie and Cesarini, Sara and McCort-Tranchepain, Isabelle and Rigault, Delphine and Mony, Laetitia and Bessiron, Thomas and McLean, Heather and Leroux, Frédéric R and Colobert, Françoise and Daniel, Hervé and Goupil-Lamy, Anne and Bertrand, Hugues-Olivier and Goudet, Cyril and Pin, Jean-Philippe and Acher, Francine C
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2018, Volume 61, Issue 5, pp. 1969 - 1989
A group III metabotropic glutamate (mGlu) receptor agonist (PCEP) was identified by virtual HTS. This orthosteric ligand is composed by an l-AP4-derived... 
MGLU RECEPTOR | NEUROPATHIC PAIN | CHEMISTRY, MEDICINAL | LIGAND-BINDING | CEREBELLAR CORTEX | ANTICONVULSANT ACTIVITY | GABAERGIC SYSTEMS | PHARMACOLOGICAL CHARACTERIZATION | PROTEIN-COUPLED RECEPTORS | ORTHOSTERIC AGONIST | PARKINSONS-DISEASE | Index Medicus | Life Sciences | Cognitive Sciences | Neurons and Cognition | Psychology and behavior | Neurobiology
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7. Full Text Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites
by Selvam, Chelliah and Lemasson, Isabelle and Brabet, Isabelle and Oueslati, Nadia and Karaman, Berin and Cabaye, Alexandre and Tora, Amélie and Commare, Bruno and Courtiol, Tiphanie and Cesarini, Sara and McCort-Tranchepain, Isabelle and Rigault, Delphine and Mony, Laetitia and Bessiron, Thomas and McLean, Heather and Leroux, Frédéric and Colobert, Françoise and Daniel, Hervé and Goupil-Lamy, Anne and Bertrand, Hugues-Olivier and Goudet, Cyril and Pin, Jean-Philippe and Acher, Francine C
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2018, Volume 61, Issue 5, pp. 1969 - 1989
A group III metabotropic glutamate (mGlu) receptor agonist (PCEP) was identified by virtual HTS. This orthosteric ligand is composed by an l-AP4-derived... 
Life Sciences | Neurons and Cognition
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8. Full Text A Virtual Screening Hit Reveals New Possibilities for Developing Group III Metabotropic Glutamate Receptor Agonists
by Selvam, Chelliah and Oueslati, Nadia and Lemasson, Isabelle A and Brabet, Isabelle and Rigault, Delphine and Courtiol, Tiphanie and Cesarini, Sara and Triballeau, Nicolas and Bertrand, Hugues-Olivier and Goudet, Cyril and Pin, Jean-Philippe and Acher, Francine C
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2010, Volume 53, Issue 7, pp. 2797 - 2813
(R)-PCEP (3-amino-3-carboxypropyl-2′-carboxyethyl phosphinic acid, 1), a new metabotropic glutamate receptor 4 (mGlu4R) agonist, was discovered in a previously... 
ACTIVATION PROCESS | CHEMISTRY, MEDICINAL | PHOSPHINOTHRICIN | MECHANISM | ANALOGS | PHOSPHINIC ACIDS | PROTEIN-COUPLED RECEPTORS | POSITIVE ALLOSTERIC MODULATORS | SYNTHETASE | GAMMA-GLUTAMATE | POTENT INHIBITORS | Amino Acid Sequence | Cell Line | Drug Evaluation, Preclinical - methods | User-Computer Interface | Phosphinic Acids - chemistry | Stereoisomerism | Molecular Conformation | Models, Molecular | Molecular Sequence Data | Rats | Receptors, Metabotropic Glutamate - metabolism | Structure-Activity Relationship | Dose-Response Relationship, Drug | Animals | Phosphinic Acids - pharmacology | Drug Design | Phosphinic Acids - metabolism | Phosphinic Acids - chemical synthesis | Receptors, Metabotropic Glutamate - agonists | Receptors, Metabotropic Glutamate - chemistry | Binding Sites | Index Medicus
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9. Determination of the absolute configuration of phosphinic analogues of glutamate
Organic & biomolecular chemistry, 01/2015, Volume 13, Issue 4, pp. 1106 - 1112
A series of phosphinic glutamate derivatives (e.g.LSP1-2111) have been proven to be potent agonists of metabotropic glutamate (mGlu) receptors and shown... 
Index Medicus
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10. Full Text Determination of the absolute configuration of phosphinic analogues of glutamate
by Commare, Bruno and Rigault, Delphine and Lemasson, Isabelle A and Deschamps, Patrick and Tomas, Alain and Roussel, Pascal and Brabet, Isabelle and Goudet, Cyril and Pin, Jean-Philippe and Leroux, Frédéric R and Colobert, Françoise and Acher, Francine C
Organic and Biomolecular Chemistry, ISSN 1477-0520, 01/2015, Volume 13, Issue 4, pp. 1106 - 1112
A series of phosphinic glutamate derivatives (e. g. LSP1-2111) have been proven to be potent agonists of metabotropic glutamate (mGlu) receptors and shown... 
AMINOPEPTIDASE INHIBITORS | ASYMMETRIC-SYNTHESIS | ACID | ENANTIOSELECTIVE SYNTHESIS | PHOSPHINOTHRICIN | ENANTIOMERS | CHEMISTRY, ORGANIC | LI-BINOL COMPLEX | ALPHA-HYDROXY PHOSPHONATES | DERIVATIVES | LEUCINE AMINOPEPTIDASE | Glutamic Acid - pharmacology | Humans | Molecular Conformation | HEK293 Cells | Models, Molecular | Organophosphorus Compounds - chemistry | Receptors, Metabotropic Glutamate - agonists | Glutamic Acid - chemistry | Inorganic chemistry | Chemical Sciences
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11. Full Text Identification of Positive Allosteric Modulators VU0155094 (ML397) and VU0422288 (ML396) Reveals New Insights into the Biology of Metabotropic Glutamate Receptor 7
by Jalan-Sakrikar, Nidhi and Field, Julie R and Klar, Rebecca and Mattmann, Margrith E and Gregory, Karen J and Zamorano, Rocio and Engers, Darren W and Bollinger, Sean R and Weaver, C. David and Days, Emily L and Lewis, L. Michelle and Utley, Thomas J and Hurtado, Miguel and Rigault, Delphine and Acher, Francine and Walker, Adam G and Melancon, Bruce J and Wood, Michael R and Lindsley, Craig W and Conn, P. Jeffrey and Xiang, Zixiu and Hopkins, Corey R and Niswender, Colleen M
ACS Chemical Neuroscience, ISSN 1948-7193, 09/2014, Volume 5, Issue 12, pp. 1221 - 1237
Metabotropic glutamate receptor 7 (mGlu7) is a member of the group III mGlu receptors (mGlus), encompassed by mGlu4, mGlu6, mGlu7, and mGlu8. mGlu7 is highly... 
Electrophysiology | Allosteric modulator | Hippocampus | Metabotropic glutamate receptor | CHEMISTRY, MEDICINAL | hippocampus | metabotropic glutamate receptor | AMYGDALA PLASTICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCES | PROBE-DEPENDENCE | CHROMOSOME 3 | PHARMACOLOGICAL MODULATION | RODENT MODELS | LU AF21934 | electrophysiology | IN-VIVO | L-DOPA | AGONIST AMN082 | PARKINSONS-DISEASE | Propionates - pharmacology | Glycine - analogs & derivatives | Cricetulus | Calcium - metabolism | Humans | Male | Receptors, Metabotropic Glutamate - metabolism | Structure-Activity Relationship | Thallium - metabolism | Hippocampus - drug effects | Excitatory Postsynaptic Potentials - drug effects | Excitatory Amino Acid Agents - chemistry | Dose-Response Relationship, Drug | Transfection | Receptors, Metabotropic Glutamate - genetics | Excitatory Amino Acid Agents - pharmacology | HEK293 Cells | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Picolinic Acids - chemistry | CHO Cells | Picolinic Acids - pharmacology | Acetanilides - pharmacology | Glutamic Acid - pharmacology | Mice, Inbred C57BL | Rats | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Hippocampus - metabolism | Pyrroles - pharmacology | Animals | Glycine - pharmacology | Acetanilides - chemistry | Benzoates - pharmacology | Pyrroles - chemistry | In Vitro Techniques
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12. Full Text A YAC contig map of the human genome
by Chumakov, Hya M and Rigault, Philippe and Le Gall, Isabelle and Bellanné-Chantelot, Christine and Billault, Alain and Guillou, Sophie and Soularue, Pascal and Guasconi, Ghislaine and Poullier, Eric and Gros, Isabelle and Belova, Maria and Sambucy, Jean-Luc and Susini, Laurent and Gervy, Patricia and Glibert, Fabrice and Beaufils, Sandrine and Bui, Hung and Massart, Catherine and De Tand, Marie-France and Dukasz, Frédérique and Lecoulant, Sandrine and Ougen, Pierre and Perrot, Virginie and Saumier, Martial and Soravito, Catherine and Bahouayila, Rita and Cohen-Akenine, Annick and Barillot, Emmanuel and Bertrand, Stéphane and Codani, Jean-Jacques and Caterina, Dominique and Georges, Isabelle and Lacroix, Bruno and Lucotte, Georges and Sahbatou, Mourad and Schmit, Christian and Sangouard, Muriel and Tubacher, Emmanuel and Dib, Colette and Fauré, Sabine and Fizames, Cécile and Gyapay, Gabor and Millasseau, Philippe and Nguyen, Simon and Muselet, Delphine and Vignal, Alain and Morissette, Jean and Menninger, Joan and Lieman, Jonathan and Desal, Trushna and Banks, Amy and Bray-Ward, Patricia and Ward, David and Hudson, Thomas and Gerety, Sebastian and Foote, Simon and Stein, Lincoln and Page, David C and Lander, Eric S and Weissenbach, Jean and Le Paslier, Denis and Cohen, Daniel
Nature, ISSN 0028-0836, 09/1995, Volume 377, Issue 6547, pp. 175 - 183
A yeast artificial chromosome library containing 33,000 clones with an average insert size of one megabase of human genomic DNA was extensively analysed by... 
SEQUENCES | CLONING | DNA | MULTIDISCIPLINARY SCIENCES | GENES | LIBRARY | POLYMERASE CHAIN-REACTION | YEAST ARTIFICIAL CHROMOSOMES | VECTORS | REPEATS | CLONES | Nucleic Acid Hybridization | Chromosomes, Artificial, Yeast | DNA Fingerprinting | Chromosome Mapping - methods | Humans | In Situ Hybridization, Fluorescence | Genetic Markers | Genome, Human | Sequence Tagged Sites
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13. Full Text A new Selective Metabotropic Glutamate Receptor type 4 Agonist Reveals New ways to Develop Subtype Selective Orthosteric Ligands with Potential Therapeutic Effects
by Goudet, Cyril and Vilar, Bruno and Courtiol, Tiphanie and Deltheil, Thierry and Bessiron, Thomas and Brabet, Isabelle and Oueslati, Nadia and Rigault, Delphine and Bertrand, Hugues-Olivier and McLean, Heather and Daniel, Hervé and Amalric, Marianne and Acher, Francine C and Pin, Jean-Philippe
Current Neuropharmacology, ISSN 1570-159X, 2011, Volume 9, Issue 1, p. 26
Neuroscience | Cognitive science
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14. Hypophosphorous acid derivatives having antihyperalgic activity and biological applications thereof
by ACHER FRANCINE and ESCHALIER ALAIN and PIN JEAN-PHILIPPE and LEMASSON ISABELLE and COMMARE BRUNO and RIGAULT DELPHINE and CESARINI SARA and BUSSEROLLES JÉRÔME and GOUDET CYRIL
12/2015
The invention relates to hypophosphorous acid derivatives of formula (I) wherein -X is H or OH, -R represents one or several radicals R1-R5, identical or... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
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15. HYPOPHOSPHOROUS ACID DERIVATIVES HAVING ANTIHYPERALGIC ACTIVITY AND BIOLOGICAL APPLICATIONS THEREOF
by ACHER FRANCINE and ESCHALIER ALAIN and COMMARE BRONO and PIN JEAN-PHILIPPE and LEMASSON ISABELLE and RIGAULT DELPHINE and CESARINI SARA and BUSSEROLLES JÉRÔME and GOUDET CYRIL
04/2014
The invention relates to hypophosphorous acid derivatives of formula (I) wherein -X is H or OH, -R represents one or several radicals R1-R5, identical or... 
METALLURGY | ORGANIC CHEMISTRY | CHEMISTRY | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
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16. Full Text Biotin biosynthetic pathway in recombinant strains of Escherichia coli overexpressing bio genes: Evidence for a limiting step upstream from KAPA
by Levy-Schil, S and Lévy-Schil, Sophie and Mayaux, J.-F and Debussche, Laurent and Rigault, Sylvie and Debussche, L and Rigault, S and Soubrier, Fabienne and Soubrier, F and Bacchetta, Fabrice and Bacchetta, F and Lagneaux, Delphine and Schleuniger, Josiane and Lagneaux, D and Schleuniger, J and Blanche, Francis and Blanche, F and Crouzet, Joël and Crouzet, J and Mayaux, Jean-François
Applied Microbiology and Biotechnology, ISSN 0175-7598, 1993, Volume 38, Issue 6, pp. 755 - 762
The effect of the overexpression of the bioABFCD operon on the biotin biosynthetic pathway was investigated in an Escherichia coli K12 bioR mutant with a... 
PERFORMANCE LIQUID-CHROMATOGRAPHY | DETHIOBIOTIN | VERSATILE CLONING | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PRODUCT | PURIFICATION | BACILLUS-SPHAERICUS | UVRB-GENE | OPERON | VECTORS | NUCLEOTIDE-SEQUENCE
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17. HYPOPHOSPHOROUS ACID DERIVATIVES HAVING ANTIHYPERALGIC ACTIVITY AND BIOLOGICAL APPLICATIONS THEREOF
by ESCHALIER, ALAIN and BUSSEROLLES, JEROME and GOUDET, CYRIL and COMMARE, BRUNO and ACHER, FRANCINE and PIN, JEAN-PHILIPPE and RIGAULT, DELPHINE and LEMASSON, ISABELLE and CESARINI, SARA
11/2012
The invention relates to hypophosphorous acid derivatives of formula (I) wherein - X is H or OH, - R represents one or several radicals R1-R5, identical or... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
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