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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2014, Volume 111, Issue 2, pp. 711 - 716
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2014, Volume 111, Issue 2, pp. 711 - 716
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2008, Volume 105, Issue 24, pp. 8387 - 8392
A subset of gastrointestinal stromal tumors (GISTs) lack gain-of-function mutations in c-KIT and PDGFRα. These so-called wild-type (WT) GISTs tend to be less... 
Pediatrics | Receptors | Gastrointestinal stromal tumors | Somatomedins | Exons | Cell lines | Genetic mutation | Summarization | Tumors | Cancer | Imatinib mesylase | Adult wild-type GIST | Pediatric GIST | NYP-AEW541 | Tyrosine kinase inhibitors | CARCINOMA CELLS | MULTIDISCIPLINARY SCIENCES | adult wild-type GIST | C-KIT | FACTOR-I | ANTITUMOR-ACTIVITY | pediatric GIST | tyrosine kinase inhibitors | BREAST-CANCER | GROWTH-FACTOR RECEPTOR | imatinib mesylase | COPY NUMBER CHANGES | TYROSINE KINASE INHIBITOR | EXPRESSION | IMATINIB MESYLATE | Gastrointestinal Stromal Tumors - enzymology | RNA, Small Interfering - genetics | Receptor, IGF Type 1 - metabolism | Receptor, IGF Type 1 - antagonists & inhibitors | Humans | Gene Expression Regulation, Neoplastic | Antineoplastic Agents - therapeutic use | Mitogen-Activated Protein Kinase Kinases - metabolism | DNA Mutational Analysis | Proto-Oncogene Proteins c-kit - genetics | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Pyrroles - therapeutic use | Gastrointestinal Stromal Tumors - genetics | Signal Transduction | Gene Silencing | Piperazines - therapeutic use | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Receptor, IGF Type 1 - genetics | Pyrroles - pharmacology | Gene Amplification | Gastrointestinal Stromal Tumors - drug therapy | Pyrimidines - therapeutic use | Receptor, Platelet-Derived Growth Factor alpha - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Benzamides | Mutation | Apoptosis | Immunohistochemistry | Prevention | Usage | Care and treatment | Gastrointestinal tumors | Genetic aspects | Research | Insulin-like growth factor 1 | Health aspects | Methods | Risk factors | Ribonucleic acid--RNA | Comparative analysis | Insulin | Cells | Index Medicus | Biological Sciences
Journal Article
Frontiers in Oncology, ISSN 2234-943X, 2013, Volume 3, pp. 117 - 117
Gastrointestinal stromal tumors (GISTs) in adults are generally driven by somatic gain-of-function mutations in KIT or PDGFRA, and biological therapies... 
Insulin-like growth factor receptor | Succinate dehydrogenase | Review | Wild type | Gastrointestinal stromal tumor | wild type | Succinate Dehydrogenase | Gastrointestinal Stromal Tumor | insulin-like growth factor receptor | review
Journal Article
Genes, Chromosomes and Cancer, ISSN 1045-2257, 02/2013, Volume 52, Issue 2, pp. 214 - 224
Approximately 15% of gastrointestinal stromal tumors (GISTs) in adults and 85% in children lack mutations in KIT and PDGFRA and are known as wild‐type GISTs.... 
V600E BRAF MUTATIONS | CARNEY TRIAD | SUCCINATE-DEHYDROGENASE | ONCOLOGY | COPY NUMBER | GENETICS & HEREDITY | GERMLINE MUTATIONS | DEHYDROGENASE-DEFICIENT GISTS | POTENTIAL THERAPEUTIC TARGET | OF-FUNCTION MUTATIONS | INVERSION PROBE ASSAY | PULMONARY CHONDROMA | Immunohistochemistry | Receptor, IGF Type 1 - metabolism | Gastrointestinal Neoplasms - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Molecular Sequence Data | Male | Proto-Oncogene Proteins c-kit - metabolism | Young Adult | DNA Mutational Analysis | Base Sequence | Aged, 80 and over | Adult | Female | Proto-Oncogene Proteins c-kit - genetics | Gastrointestinal Stromal Tumors - genetics | Proto-Oncogene Proteins B-raf - metabolism | Gastrointestinal Neoplasms - metabolism | Electron Transport Complex II - genetics | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Receptor, IGF Type 1 - genetics | Succinate Dehydrogenase - genetics | Electron Transport Complex II - metabolism | Proto-Oncogene Proteins B-raf - genetics | Receptor, Platelet-Derived Growth Factor alpha - genetics | Adolescent | Gastrointestinal Stromal Tumors - metabolism | Succinate Dehydrogenase - metabolism | Aged | Mutation | Platelet-derived growth factor | Gene mutations | Genes | Genomics | Genetic aspects | Tumors | Index Medicus
Journal Article
Journal Article
World Journal of Surgical Oncology, ISSN 1477-7819, 07/2014, Volume 12, Issue 1, pp. 231 - 231
Background: The insulin-like growth factor (IGF) pathway is implicated in the pathogenesis of hepatocellular carcinoma (HCC) and may be important in... 
nonalcoholic fatty liver disease | insulin-like growth factor | hepatocellular carcinoma | SURGERY | DIFFERENTIAL EXPRESSION | INSULIN-LIKE-GROWTH-FACTOR-2 | FACTOR-II | FATTY LIVER-DISEASE | POTENTIAL THERAPEUTIC TARGET | MECHANISMS | CANCER | OBESITY | ONCOLOGY | CIRRHOSIS | GASTROINTESTINAL STROMAL TUMORS | Non-alcoholic Fatty Liver Disease - pathology | Receptor, IGF Type 1 - metabolism | Carcinoma, Hepatocellular - mortality | Liver - pathology | Prognosis | Follow-Up Studies | Tissue Array Analysis | Humans | Middle Aged | Male | Liver Neoplasms - mortality | Immunoenzyme Techniques | Receptor, IGF Type 2 - metabolism | Liver Neoplasms - etiology | Non-alcoholic Fatty Liver Disease - complications | Neoplasm Grading | Aged, 80 and over | Biomarkers, Tumor - metabolism | Adult | Female | Hepacivirus - physiology | Hepatitis C - complications | Liver Neoplasms - pathology | Carcinoma, Hepatocellular - etiology | Retrospective Studies | Liver Cirrhosis - complications | Liver - metabolism | Risk Factors | Survival Rate | Insulin-Like Growth Factor II - metabolism | Liver Cirrhosis - virology | Carcinoma, Hepatocellular - pathology | Hepatitis C - virology | Liver Neoplasms - metabolism | Liver Cirrhosis - pathology | Non-alcoholic Fatty Liver Disease - virology | Aged | Hepatitis C - pathology | Neoplasm Staging | Insulin-Like Growth Factor I - metabolism | Carcinoma, Hepatocellular - metabolism | Type 2 diabetes | Viral antibodies | Antibodies | Liver | Insulin-like growth factors | Kinases | Insulin | Rodents | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, pp. e54477 - e54477
Although imatinib mesylate (IM) has transformed the treatment of gastrointestinal stromal tumors (GIST), many patients experience primary/secondary drug... 
BREAST-CANCER | KIT MUTATIONS | MULTIDISCIPLINARY SCIENCES | GROWTH | POTENTIAL THERAPEUTIC TARGET | CAS-L | EXPRESSION | PERIOSTIN | PROMOTES | OVARIAN-CARCINOMA | INTERSTITIAL-CELLS | RNA, Small Interfering - genetics | Cell Adhesion Molecules - genetics | Transforming Growth Factor beta3 - genetics | Humans | Cell Adhesion Molecules - antagonists & inhibitors | Gene Expression Profiling | Phosphoproteins - antagonists & inhibitors | Genetic Loci | Phosphoproteins - metabolism | Transforming Growth Factor beta3 - metabolism | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Gastrointestinal Stromal Tumors - pathology | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Gastrointestinal Stromal Tumors - genetics | Gene Library | Transforming Growth Factor beta3 - antagonists & inhibitors | Phosphoproteins - genetics | Pyrimidines - pharmacology | Cell Adhesion Molecules - metabolism | Imatinib Mesylate | Piperazines - pharmacology | Drug Resistance, Neoplasm - genetics | Pyrroles - pharmacology | Gastrointestinal Stromal Tumors - drug therapy | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Gastrointestinal Stromal Tumors - metabolism | Zinc Fingers - genetics | Protein Kinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Drug Resistance, Neoplasm - drug effects | RNA, Small Interfering - metabolism | Medical research | Care and treatment | Genes | Medicine, Experimental | Genetic transcription | DNA binding proteins | Drug resistance | Tumors | Transcription factors | Substance abuse treatment | Transcription | Laboratories | Clinical trials | Oncology | Metastasis | Kinases | Repressors | Ischemia | Zinc finger proteins | Growth factors | Protein-tyrosine kinase | Kruppel protein | Sensitizing | Tyrosine | Imatinib | RNA-mediated interference | siRNA | Gene expression | Screens | Zinc | Gene silencing | Silence | Stem cells | Hypoxia | Mutation | Cancer | Index Medicus
Journal Article
Journal of the American College of Surgeons, ISSN 1072-7515, 2013, Volume 217, Issue 3, pp. S32 - S32
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 04/2012, Volume 53, Issue 4, pp. 567 - 574
We investigated the correlation between metabolic response by (18)F-FDG PET and objective response, glucose transporter type 4 (GLUT4) expression, and... 
FDG-PET | Therapeutic response | Genotype | GIST | GLUT4 | Gastrointestinal Neoplasms - genetics | Gastrointestinal Neoplasms - drug therapy | Humans | Middle Aged | Gastrointestinal Stromal Tumors - diagnostic imaging | Gene Expression Regulation, Neoplastic | Fluorodeoxyglucose F18 - metabolism | Male | Positron-Emission Tomography | Young Adult | Biological Transport | Time Factors | Aged, 80 and over | Adult | Female | Proto-Oncogene Proteins c-kit - genetics | Gastrointestinal Stromal Tumors - genetics | Gastrointestinal Stromal Tumors - surgery | Glucose Transporter Type 4 - genetics | Gastrointestinal Neoplasms - surgery | Treatment Outcome | Piperazines - therapeutic use | Imatinib Mesylate | Piperazines - adverse effects | Gastrointestinal Neoplasms - diagnostic imaging | Image Processing, Computer-Assisted | Gastrointestinal Stromal Tumors - drug therapy | Neoadjuvant Therapy - adverse effects | Pyrimidines - therapeutic use | Neoadjuvant Therapy - methods | Pyrimidines - adverse effects | Aged | Benzamides | Mutation | Signal transduction | Genotype & phenotype | Surgery | Kinases | Binding sites | Cancer | Glucose transporter | Immunohistochemistry | Nuclear medicine | Imatinib | Exons | Clinical trials | Data processing | Metabolic response | Glycolysis | Solid tumors | Positron emission tomography | Genotypes | Metabolic disorders | Tumors | Index Medicus | therapeutic response | genotype
Journal Article
Cancer Research, ISSN 0008-5472, 04/2013, Volume 73, Issue 8 Supplement, pp. 3927 - 3927
Journal Article
Current oncology reports, ISSN 1523-3790, 7/2009, Volume 11, Issue 4, p. 314
Gastrointestinal stromal tumors (GISTs) typically occur late in life; however, there are also reports of these tumors in pediatric patients and young adults.... 
young adult | GISTs | imatinib mesylate | pediatric
Journal Article
Cell Cycle, ISSN 1538-4101, 05/2006, Volume 5, Issue 9, pp. 994 - 1000
Journal Article