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SCIENTIFIC REPORTS, ISSN 2045-2322, 10/2019, Volume 9, Issue 1, pp. 15469 - 16
The nucleus pulposus (NP) cells adapt to their physiologically hyperosmotic microenvironment through Tonicity-responsive enhancer binding protein... 
TRANSLOCATION | MUTANT MICE | EPITHELIAL-CELLS | DISEASE GENE | TRANSACTIVATION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | INTERVERTEBRAL DISC | OSMOTIC RESPONSE | INTRAFLAGELLAR TRANSPORT | EXPRESSION | Osmolarity | Transcription | Osmoregulation | Embryo fibroblasts | Nucleus pulposus | Intervertebral discs | Embryos | Kinesin | Cilia
Journal Article
Journal Article
Developmental Biology, ISSN 0012-1606, 11/2019, Volume 455, Issue 2, pp. 369 - 381
High osmolarity, bound water, and hydrostatic pressure contribute to notochord mechanics and its morphogenesis into the nucleus pulposus (NP) compartment of... 
Brachyury | NFAT5 transcription factor | Sonic hedgehog | Extracellular matrix | Notochord | Intervertebral disc | NUCLEUS PULPOSUS | CELLS | NFAT5 | PROTEIN | EXTRACELLULAR OSMOLARITY | DEVELOPMENTAL BIOLOGY | IDENTIFICATION | TONEBP | INTRAFLAGELLAR TRANSPORT | TRANSCRIPTION FACTOR | EXPRESSION
Journal Article
Matrix biology : journal of the International Society for Matrix Biology, ISSN 0945-053X, 10/2018, Volume 71-72, pp. 368 - 379
Few human tissues have functions as closely linked to the composition of their extracellular matrices as the intervertebral disc. In fact, the hallmark of... 
intervertebral disc degeneration | proteoglycans | GAG synthesis | Intervertebral disc | extracellular matrix
Journal Article
Matrix Biology, ISSN 0945-053X, 09/2019, Volume 82, p. 54
Intervertebral disc degeneration is an important contributor to chronic low back and neck pain. Although many environmental and genetic factors are known to... 
Analysis | Homeostasis | Genetic aspects | Gene expression | Cells
Journal Article
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, ISSN 0884-0431, 11/2019
Maintenance of glycolytic metabolism is postulated to be required for health of the spinal column. In the hypoxic tissues of the intervertebral disc and... 
Journal Article
JOURNAL OF BONE AND MINERAL RESEARCH, ISSN 0884-0431, 06/2016, Volume 31, Issue 6, pp. 1287 - 1299
The objective of this study was to determine the role of histone deacetylases (HDACs) in regulating HIF-1 protein stability and activity in nucleus pulposus... 
NUCLEUS PULPOSUS | HYPOXIA-INDUCIBLE FACTOR | COMPLEX | HYPOXIA | LYSINE ACETYLATION | HDAC6 | HIF-1 | FACTOR-1-ALPHA | TRANSACTIVATION | ENDOCRINOLOGY & METABOLISM | INTERVERTEBRAL DISC | DEGRADATION | HIF-1-ALPHA | HISTONE DEACETYLASE INHIBITORS | TRANSCRIPTION FACTOR | EXPRESSION | BINDING | Heat shock proteins | Genetic aspects | Genetic transcription
Journal Article
Matrix Biology, ISSN 0945-053X, 09/2019, Volume 82, pp. 54 - 70
Intervertebral disc degeneration is an important contributor to chronic low back and neck pain. Although many environmental and genetic factors are known to... 
Senescence | p16 | Mouse models | Intervertebral disc degeneration | Aging | p19 | Extracellular matrix | Ink4a | Aggrecan | Nucleus pulposus | SASP | Index Medicus
Journal Article
Journal of Orthopaedic Research, ISSN 0736-0266, 01/2017, Volume 35, Issue 1, pp. 5 - 7
Journal Article
Journal of Orthopaedic Research, ISSN 0736-0266, 08/2016, Volume 34, Issue 8, pp. 1287 - 1288
Journal Article
Matrix biology : journal of the International Society for Matrix Biology, ISSN 0945-053X, 11/2019
The tonicity-responsive enhancer binding protein (TonEBP) plays an important role in intervertebral disc and axial skeleton embryogenesis. However, the... 
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 05/2010, Volume 25, Issue 5, pp. 1179 - 1190
The goal of the study was to investigate bone morphogenetic protein 2 (BMP‐2) and transforming growth factor β (TGF‐β) control of the expression of... 
TGF‐β | GlcAT‐1 | glycosaminoglycan | BMP‐2 | nucleus pulposus | TonEBP | Glycosaminoglycan | TGF-β | Nucleus pulposus | BMP-2 | GLCAT-1 | GlcAT-1 | Original
Journal Article