PLoS genetics, ISSN 1553-7390, 07/2005, Volume 1, Issue 1, p. e14
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PLoS genetics, ISSN 1553-7390, 07/2005, Volume 1, Issue 1, p. 3
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American Journal of Human Genetics, ISSN 0002-9297, 03/2016, Volume 98, Issue 3, p. 407
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajhg.2016.02.009 Byline: Neil Risch Author Affiliation: (2)...
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 03/2016, Volume 98, Issue 3, pp. 407 - 416
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 03/2016, Volume 98, Issue 3, pp. 407 - 416
Journal Article
Nature Genetics, ISSN 1061-4036, 03/2003, Volume 33, Issue 3S, pp. 228 - 237
The past two decades have witnessed an explosion in the identification, largely by positional cloning, of genes associated with mendelian diseases. The roughly...
MARIE-TOOTH-DISEASE | HUMAN GENOME | SEQUENCE VARIATION | GENETICS & HEREDITY | FRAGMENT LENGTH POLYMORPHISMS | LINKAGE-DISEQUILIBRIUM | FOUNDER POPULATIONS | FANCONI-ANEMIA | HUNTINGTONS-DISEASE | SINGLE-NUCLEOTIDE POLYMORPHISMS | CYSTIC-FIBROSIS GENE | History, 21st Century | History, 20th Century | Humans | Genetic Diseases, Inborn - genetics | Genotype | Chromosome Mapping | Genomics - history | Genetic Diseases, Inborn - history | Linkage Disequilibrium | Phenotype | Alleles | Cloning, Molecular | Polymorphism, Single Nucleotide | Mutation | Genomics - trends | Physiological aspects | Research | DNA | Human genetics
MARIE-TOOTH-DISEASE | HUMAN GENOME | SEQUENCE VARIATION | GENETICS & HEREDITY | FRAGMENT LENGTH POLYMORPHISMS | LINKAGE-DISEQUILIBRIUM | FOUNDER POPULATIONS | FANCONI-ANEMIA | HUNTINGTONS-DISEASE | SINGLE-NUCLEOTIDE POLYMORPHISMS | CYSTIC-FIBROSIS GENE | History, 21st Century | History, 20th Century | Humans | Genetic Diseases, Inborn - genetics | Genotype | Chromosome Mapping | Genomics - history | Genetic Diseases, Inborn - history | Linkage Disequilibrium | Phenotype | Alleles | Cloning, Molecular | Polymorphism, Single Nucleotide | Mutation | Genomics - trends | Physiological aspects | Research | DNA | Human genetics
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AMERICAN JOURNAL OF HUMAN GENETICS, ISSN 0002-9297, 03/2016, Volume 98, Issue 3, pp. 407 - 416
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Nature, ISSN 0028-0836, 06/2000, Volume 405, Issue 6788, pp. 847 - 856
Human genetics is now at a critical juncture. The molecular methods used successfully to identify the genes underlying rare mendelian syndromes are failing to...
COMPLEX HUMAN-DISEASES | RELATIVE POWER | DEPENDENT DIABETES-MELLITUS | MAPPING GENES | CASE-CONTROL DESIGNS | LINKAGE DISEQUILIBRIUM | MULTIDISCIPLINARY SCIENCES | MARKERS | LOCI | ALLELIC ASSOCIATION | SINGLE-NUCLEOTIDE POLYMORPHISMS | Biotechnology | Genetic Predisposition to Disease | Humans | Computational Biology | Genetic Diseases, Inborn - genetics | Genetics, Medical - trends | Genome, Human | Genetics | Medical disorders | Genes | Genomics
COMPLEX HUMAN-DISEASES | RELATIVE POWER | DEPENDENT DIABETES-MELLITUS | MAPPING GENES | CASE-CONTROL DESIGNS | LINKAGE DISEQUILIBRIUM | MULTIDISCIPLINARY SCIENCES | MARKERS | LOCI | ALLELIC ASSOCIATION | SINGLE-NUCLEOTIDE POLYMORPHISMS | Biotechnology | Genetic Predisposition to Disease | Humans | Computational Biology | Genetic Diseases, Inborn - genetics | Genetics, Medical - trends | Genome, Human | Genetics | Medical disorders | Genes | Genomics
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The New England Journal of Medicine, ISSN 0028-4793, 01/2006, Volume 354, Issue 4, pp. 408 - 411
It is well known that disease does not affect the population equally. Assessing variation in the rates of disease according to demographic factors such as sex...
GENETIC-STRUCTURE | MEDICINE, GENERAL & INTERNAL | CYP2A6 | METABOLISM | NICOTINE | RACE | POPULATIONS | HEALTH DISPARITIES | Lung Neoplasms - genetics | Smoking - adverse effects | Lung Neoplasms - ethnology | United States - epidemiology | European Continental Ancestry Group - genetics | Gene Frequency | Humans | Hispanic Americans | African Americans - genetics | Hawaii | Male | Risk | Incidence | Smoking - ethnology | Asian Americans - genetics | Lung Neoplasms - etiology | Female | Oceanic Ancestry Group
GENETIC-STRUCTURE | MEDICINE, GENERAL & INTERNAL | CYP2A6 | METABOLISM | NICOTINE | RACE | POPULATIONS | HEALTH DISPARITIES | Lung Neoplasms - genetics | Smoking - adverse effects | Lung Neoplasms - ethnology | United States - epidemiology | European Continental Ancestry Group - genetics | Gene Frequency | Humans | Hispanic Americans | African Americans - genetics | Hawaii | Male | Risk | Incidence | Smoking - ethnology | Asian Americans - genetics | Lung Neoplasms - etiology | Female | Oceanic Ancestry Group
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PLoS Genetics, ISSN 1553-7390, 04/2017, Volume 13, Issue 4, p. e1006655
Genetic similarity of spouses can reflect factors influencing mate choice, such as physical/behavioral characteristics, and patterns of social endogamy. Spouse...
HEART | HUMAN HEIGHT | POPULATION STRATIFICATION | GENETICS & HEREDITY | SPOUSAL CONCORDANCE | EUROPEAN AMERICANS | TRAITS | SELECTION | ASSOCIATION | ANCESTRY | HERITABILITY | European Continental Ancestry Group - genetics | Genome-Wide Association Study | Phenotype | Humans | Female | Genotype | Male | Spouses | Polymorphism, Single Nucleotide | Genome, Human | Jews - genetics | Linkage Disequilibrium | Single nucleotide polymorphisms | Research | Health aspects | Chromosomes | Genomics | Married people | Heart | Assortative mating | Clines | Linkage disequilibrium | Principal components analysis | Cardiovascular disease | Genomes | Single-nucleotide polymorphism | Mate selection | Mating | Studies | Progeny | Genotype & phenotype | Population | Heritability | Health risk assessment | Public health | Polymorphism
HEART | HUMAN HEIGHT | POPULATION STRATIFICATION | GENETICS & HEREDITY | SPOUSAL CONCORDANCE | EUROPEAN AMERICANS | TRAITS | SELECTION | ASSOCIATION | ANCESTRY | HERITABILITY | European Continental Ancestry Group - genetics | Genome-Wide Association Study | Phenotype | Humans | Female | Genotype | Male | Spouses | Polymorphism, Single Nucleotide | Genome, Human | Jews - genetics | Linkage Disequilibrium | Single nucleotide polymorphisms | Research | Health aspects | Chromosomes | Genomics | Married people | Heart | Assortative mating | Clines | Linkage disequilibrium | Principal components analysis | Cardiovascular disease | Genomes | Single-nucleotide polymorphism | Mate selection | Mating | Studies | Progeny | Genotype & phenotype | Population | Heritability | Health risk assessment | Public health | Polymorphism
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JAMA, ISSN 0098-7484, 06/2009, Volume 301, Issue 23, pp. 2462 - 2471
CONTEXT Substantial resources are being devoted to identify candidate genes for complex mental and behavioral disorders through inclusion of environmental...
REGION 5-HTTLPR | SOCIAL SUPPORTS | MEDICINE, GENERAL & INTERNAL | POLYMORPHISM 5-HTTLPR | PSYCHIATRIC-DISORDERS | PROMOTER POLYMORPHISM | MALTREATED CHILDREN | HUMAN-DISEASES | MAJOR DEPRESSION | THREATENING EXPERIENCES | X ENVIRONMENT INTERACTION | Stress, Psychological - genetics | Serotonin Plasma Membrane Transport Proteins - genetics | Depressive Disorder, Major - genetics | Humans | Life Change Events | Risk Factors | Female | Genotype | Male | Studies | Genotype & phenotype | Mental depression | Stress | Meta-analysis | Depressive Disorders | Neurotransmitters | Multiple Traumatic Events | Predisposition | Survivors | Genetic Markers | Meta Analysis | Females | Males | Stressors
REGION 5-HTTLPR | SOCIAL SUPPORTS | MEDICINE, GENERAL & INTERNAL | POLYMORPHISM 5-HTTLPR | PSYCHIATRIC-DISORDERS | PROMOTER POLYMORPHISM | MALTREATED CHILDREN | HUMAN-DISEASES | MAJOR DEPRESSION | THREATENING EXPERIENCES | X ENVIRONMENT INTERACTION | Stress, Psychological - genetics | Serotonin Plasma Membrane Transport Proteins - genetics | Depressive Disorder, Major - genetics | Humans | Life Change Events | Risk Factors | Female | Genotype | Male | Studies | Genotype & phenotype | Mental depression | Stress | Meta-analysis | Depressive Disorders | Neurotransmitters | Multiple Traumatic Events | Predisposition | Survivors | Genetic Markers | Meta Analysis | Females | Males | Stressors
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Nature, ISSN 0028-0836, 03/2018, Volume 555, Issue 7695, pp. 190 - 196
From around 2750 to 2500 bc, Bell Beaker pottery became widespread across western and central Europe, before it disappeared between 2200 and 1800 bc. The...
MIGRATION | EARLY FARMERS | ORIGIN | DNA | PERSISTENCE | MULTIDISCIPLINARY SCIENCES | SEQUENCE | DIVERSITY | ANCIENT BONES | ADMIXTURE | HISTORY | Haplotypes | Genetics, Population | History, Ancient | Europe | Gene Pool | Genomics | Humans | Male | Cultural Evolution - history | Genome, Human - genetics | Human Migration - history | Chromosomes, Human, Y - genetics | DNA, Ancient | Spatio-Temporal Analysis | Europeans | Genetic aspects | Genetic transformation | Research | Transformation | Migration | Gene pool | Principal components analysis | Genomes | Ceramics | Neolithic | Artifacts | Archaeology | S gene | Artefacts | Pottery | Stone Age | Copper | Bioinformatics | Deoxyribonucleic acid--DNA | Geography | Environmental Engineering | Humanities and Social Sciences | Biodiversity and Ecology | Environmental and Society | Environmental Sciences | Global Changes | Arkeologi | admixture | 1st farmers | Science & Technology - Other Topics | history | Genetik | ancient bones | dna | migration | Genetics | persistence | eurasia | populations | early farmers
MIGRATION | EARLY FARMERS | ORIGIN | DNA | PERSISTENCE | MULTIDISCIPLINARY SCIENCES | SEQUENCE | DIVERSITY | ANCIENT BONES | ADMIXTURE | HISTORY | Haplotypes | Genetics, Population | History, Ancient | Europe | Gene Pool | Genomics | Humans | Male | Cultural Evolution - history | Genome, Human - genetics | Human Migration - history | Chromosomes, Human, Y - genetics | DNA, Ancient | Spatio-Temporal Analysis | Europeans | Genetic aspects | Genetic transformation | Research | Transformation | Migration | Gene pool | Principal components analysis | Genomes | Ceramics | Neolithic | Artifacts | Archaeology | S gene | Artefacts | Pottery | Stone Age | Copper | Bioinformatics | Deoxyribonucleic acid--DNA | Geography | Environmental Engineering | Humanities and Social Sciences | Biodiversity and Ecology | Environmental and Society | Environmental Sciences | Global Changes | Arkeologi | admixture | 1st farmers | Science & Technology - Other Topics | history | Genetik | ancient bones | dna | migration | Genetics | persistence | eurasia | populations | early farmers
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Nature Genetics, ISSN 1061-4036, 01/2017, Volume 49, Issue 1, pp. 54 - 64
Longitudinal electronic health records on 99,785 Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort individuals provided 1,342,814 systolic...
MEAN ARTERIAL | INDIVIDUALS | METAANALYSIS | VARIANTS | GENETICS & HEREDITY | COMMON | GENETIC-LOCI | AFRICAN | PULSE PRESSURE | TRAITS | HYPERTENSION | Genetic Predisposition to Disease | Genome-Wide Association Study | Meta-Analysis as Topic | Prevalence | Blood Pressure - genetics | Humans | Middle Aged | Genetic Loci - genetics | Male | Phenotype | Ethnic Groups - genetics | Polymorphism, Single Nucleotide - genetics | Adult | Female | Hypertension - epidemiology | Hypertension - genetics | Electronic Health Records | Longitudinal Studies | Cohort Studies | Medical records | Genome-wide association studies | Blood pressure | Management | Analysis | Studies | Body mass index | Genotype & phenotype | Genealogy | Hispanic Americans | African Americans | Genomes | Research | Electronic health records | Age | blood pressure | electronic health records | hypertension | genome-wide association study
MEAN ARTERIAL | INDIVIDUALS | METAANALYSIS | VARIANTS | GENETICS & HEREDITY | COMMON | GENETIC-LOCI | AFRICAN | PULSE PRESSURE | TRAITS | HYPERTENSION | Genetic Predisposition to Disease | Genome-Wide Association Study | Meta-Analysis as Topic | Prevalence | Blood Pressure - genetics | Humans | Middle Aged | Genetic Loci - genetics | Male | Phenotype | Ethnic Groups - genetics | Polymorphism, Single Nucleotide - genetics | Adult | Female | Hypertension - epidemiology | Hypertension - genetics | Electronic Health Records | Longitudinal Studies | Cohort Studies | Medical records | Genome-wide association studies | Blood pressure | Management | Analysis | Studies | Body mass index | Genotype & phenotype | Genealogy | Hispanic Americans | African Americans | Genomes | Research | Electronic health records | Age | blood pressure | electronic health records | hypertension | genome-wide association study
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Science, ISSN 0036-8075, 9/1996, Volume 273, Issue 5281, pp. 1516 - 1517
Risch and Merikangas argue that the method that linkage analysis has limited power to detect genes of modest effect, but association studies, which utilize...
Alleles | Medical genetics | Parents | Disease risk | Genetic loci | Perspectives | Genetic diseases | Alzheimers disease | Epidemiology | Human genetics | Siblings | TRAITS | MULTIDISCIPLINARY SCIENCES | Genetic Predisposition to Disease | Humans | Genetic Diseases, Inborn - genetics | Probability | Genotype | Heterozygote | Genetic Techniques | Genome, Human | Genetic Linkage | Polymorphism, Genetic | Genetic disorders | Research | Methods | Genetics | Statistical analysis | Disease | Genes
Alleles | Medical genetics | Parents | Disease risk | Genetic loci | Perspectives | Genetic diseases | Alzheimers disease | Epidemiology | Human genetics | Siblings | TRAITS | MULTIDISCIPLINARY SCIENCES | Genetic Predisposition to Disease | Humans | Genetic Diseases, Inborn - genetics | Probability | Genotype | Heterozygote | Genetic Techniques | Genome, Human | Genetic Linkage | Polymorphism, Genetic | Genetic disorders | Research | Methods | Genetics | Statistical analysis | Disease | Genes
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PLoS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 3, p. e0173339
Introduction Gene-set analysis (GSA) is an approach using the results of single-marker genome-wide association studies when investigating pathways as a whole...
RISK-FACTORS | POLYMORPHISMS | VARIANTS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | POOLED ANALYSIS | SUSCEPTIBILITY LOCUS | NEVER-SMOKERS | 15Q25 | DNA-REPAIR | ASSOCIATION | Lung Neoplasms - genetics | Computational Biology - methods | Gene Expression | Genetic Predisposition to Disease | Genome-Wide Association Study | Signal Transduction | Humans | Lupus Erythematosus, Systemic - metabolism | Chromosome Mapping | Gene Expression Profiling | Case-Control Studies | Lupus Erythematosus, Systemic - genetics | Polymorphism, Single Nucleotide | Quantitative Trait Loci | Genetic aspects | Systemic lupus erythematosus | Analysis | Lung cancer | Risk factors | Genes | Linkage disequilibrium | Encyclopedias | Genomes | Epidemiology | DNA repair | Consortia | Pathways | Cell cycle | Genetics | Public health | Deoxyribonucleic acid--DNA | Lupus | Medical research | Rheumatic diseases | Chromosome 6 | Lung carcinoma | Studies | Pleiotropy | Chronic conditions | Information processing | Autoimmune diseases | Cancer | Deoxyribonucleic acid | DNA
RISK-FACTORS | POLYMORPHISMS | VARIANTS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | POOLED ANALYSIS | SUSCEPTIBILITY LOCUS | NEVER-SMOKERS | 15Q25 | DNA-REPAIR | ASSOCIATION | Lung Neoplasms - genetics | Computational Biology - methods | Gene Expression | Genetic Predisposition to Disease | Genome-Wide Association Study | Signal Transduction | Humans | Lupus Erythematosus, Systemic - metabolism | Chromosome Mapping | Gene Expression Profiling | Case-Control Studies | Lupus Erythematosus, Systemic - genetics | Polymorphism, Single Nucleotide | Quantitative Trait Loci | Genetic aspects | Systemic lupus erythematosus | Analysis | Lung cancer | Risk factors | Genes | Linkage disequilibrium | Encyclopedias | Genomes | Epidemiology | DNA repair | Consortia | Pathways | Cell cycle | Genetics | Public health | Deoxyribonucleic acid--DNA | Lupus | Medical research | Rheumatic diseases | Chromosome 6 | Lung carcinoma | Studies | Pleiotropy | Chronic conditions | Information processing | Autoimmune diseases | Cancer | Deoxyribonucleic acid | DNA
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