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by Lessard, Christopher J and Li, He and Adrianto, Indra and Ice, John A and Rasmussen, Astrid and Grundahl, Kiely M and Kelly, Jennifer A and Dozmorov, Mikhail G and Miceli-Richard, Corinne and Bowman, Simon and Lester, Sue and Eriksson, Per and Eloranta, Maija-Leena and Brun, Johan G and Gøransson, Lasse G and Harboe, Erna and Guthridge, Joel M and Kaufman, Kenneth M and Kvarnström, Marika and Jazebi, Helmi and Graham, Deborah S. Cunninghame and Grandits, Martha E and Nazmul-Hossain, Abu N. M and Patel, Ketan and Adler, Adam J and Maier-Moore, Jacen S and Farris, A. Darise and Brennan, Michael T and Lessard, James A and Chodosh, James and Gopalakrishnan, Rajaram and Hefner, Kimberly S and Houston, Glen D and Huang, Andrew J. W and Hughes, Pamela J and Lewis, David M and Radfar, Lida and Rohrer, Michael D and Stone, Donald U and Wren, Jonathan D and Vyse, Timothy J and Gaffney, Patrick M and James, Judith A and Omdal, Roald and Wahren-Herlenius, Marie and Illei, Gabor G and Witte, Torsten and Jonsson, Roland and Rischmueller, Maureen and Rönnblom, Lars and Nordmark, Gunnel and Ng, Wan-Fai and Mariette, Xavier and Anaya, Juan-Manuel and Rhodus, Nelson L and Segal, Barbara M and Scofield, R. Hal and Montgomery, Courtney G and Harley, John B and Sivils, Kathy L and UK Primary Sjogren's Syndrome Regi and UK Primary Sjögren's Syndrome Registry and for UK Primary Sjögren's Syndrome Registry and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Reumatologiska kliniken i Östergötland and Hjärt- och Medicincentrum and Östergötlands Läns Landsting and Hälsouniversitetet and Reumatologi
Nature Genetics, ISSN 1061-4036, 11/2013, Volume 45, Issue 11, pp. 1284 - 1294
Journal Article
Lancet, The, ISSN 0140-6736, 2017, Volume 390, Issue 10093, pp. 457 - 468
Summary Background Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis. The Oral Rheumatoid Arthritis triaL (ORAL) Strategy... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | MODIFYING ANTIRHEUMATIC DRUGS | NECROSIS-FACTOR | PLACEBO | JANUS KINASE INHIBITOR | INADEQUATE RESPONSE | LONG-TERM SAFETY | PLUS METHOTREXATE | AMERICAN-COLLEGE | OPEN-LABEL | COMBINATION | Antirheumatic Agents - administration & dosage | Humans | Middle Aged | Male | Methotrexate - therapeutic use | Adalimumab - adverse effects | Arthritis, Rheumatoid - drug therapy | Pyrroles - administration & dosage | Antirheumatic Agents - adverse effects | Pyrroles - adverse effects | Adult | Female | Drug Therapy, Combination | Pyrroles - therapeutic use | Antirheumatic Agents - therapeutic use | Severity of Illness Index | Piperidines - administration & dosage | Double-Blind Method | Drug Administration Schedule | Administration, Oral | Pyrimidines - administration & dosage | Treatment Outcome | Methotrexate - adverse effects | Adalimumab - therapeutic use | Adalimumab - administration & dosage | Piperidines - therapeutic use | Pyrimidines - therapeutic use | Piperidines - adverse effects | Pyrimidines - adverse effects | Methotrexate - administration & dosage | Rheumatoid factor | Care and treatment | Analysis | Clinical trials | Arthritis | Pharmaceutical industry | Methotrexate | Rheumatology | Patients | Studies | Rheumatoid arthritis | Monoclonal antibodies | Rheumatism | TNF inhibitors | Janus kinase | Tumor necrosis factor-TNF | Safety | Drug therapy | Drug dosages | Index Medicus | Abridged Index Medicus
Journal Article
by Liu, Ke and Kurien, Biji T and Zimmerman, Sarah L and Kaufman, Kenneth M and Taft, Diana H and Kottyan, Leah C and Lazaro, Sara and Weaver, Carrie A and Ice, John A and Adler, Adam J and Chodosh, James and Radfar, Lida and Rasmussen, Astrid and Stone, Donald U and Lewis, David M and Li, Shibo and Koelsch, Kristi A and Igoe, Ann and Talsania, Mitali and Kumar, Jay and Maier‐Moore, Jacen S and Harris, Valerie M and Gopalakrishnan, Rajaram and Jonsson, Roland and Lessard, James A and Lu, Xianglan and Gottenberg, Jacques‐Eric and Anaya, Juan‐Manuel and Cunninghame‐Graham, Deborah S and Huang, Andrew J. W and Brennan, Michael T and Hughes, Pamela and Illei, Gabor G and Miceli‐Richard, Corinne and Keystone, Edward C and Bykerk, Vivian P and Hirschfield, Gideon and Xie, Gang and Ng, Wan‐Fai and Nordmark, Gunnel and Eriksson, Per and Omdal, Roald and Rhodus, Nelson L and Rischmueller, Maureen and Rohrer, Michael and Segal, Barbara M and Vyse, Timothy J and Wahren‐Herlenius, Marie and Witte, Torsten and Pons‐Estel, Bernardo and Alarcón‐Riquelme, Marta E and Guthridge, Joel M and James, Judith A and Lessard, Christopher J and Kelly, Jennifer A and Thompson, Susan D and Gaffney, Patrick M and Montgomery, Courtney G and Edberg, Jeffrey C and Kimberly, Robert P and Alarcón, Graciela S and Langefeld, Carl L and Gilkeson, Gary S and Kamen, Diane L and Tsao, Betty P and Joseph McCune, W and Salmon, Jane E and Merrill, Joan T and Weisman, Michael H and Wallace, Daniel J and Utset, Tammy O and Bottinger, Erwin P and Amos, Christopher I and Siminovitch, Katherine A and Mariette, Xavier and Sivils, Kathy L and Harley, John B and Hal Scofield, R
Arthritis & Rheumatology, ISSN 2326-5191, 05/2016, Volume 68, Issue 5, pp. 1290 - 1300
Journal Article
ARTHRITIS & RHEUMATOLOGY, ISSN 2326-5191, 05/2016, Volume 68, Issue 5, pp. 1290 - 1300
Objective. More than 80% of autoimmune disease predominantly affects females, but the mechanism for this female bias is poorly understood. We suspected that an... 
RHEUMATOID-ARTHRITIS | WOMEN | SYSTEMIC-LUPUS-ERYTHEMATOSUS | REVISED CRITERIA | PRIMARY BILIARY-CIRRHOSIS | JUVENILE IDIOPATHIC ARTHRITIS | TURNERS-SYNDROME | SJOGRENS-SYNDROME | CLASSIFICATION | PREMATURE OVARIAN FAILURE | RHEUMATOLOGY | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
Journal Article
by Li, He and Reksten, Tove Ragna and Ice, John A and Kelly, Jennifer A and Adrianto, Indra and Rasmussen, Astrid and Wang, Shaofeng and He, Bo and Grundahl, Kiely M and Glenn, Stuart B and Miceli-Richard, Corinne and Bowman, Simon and Lester, Sue and Eriksson, Per and Eloranta, Maija-Leena and Brun, Johan G and Gøransson, Lasse G and Harboe, Erna and Guthridge, Joel M and Kaufman, Kenneth M and Kvarnström, Marika and Cunninghame Graham, Deborah S and Patel, Ketan and Adler, Adam J and Farris, A. Darise and Brennan, Michael T and Chodosh, James and Gopalakrishnan, Rajaram and Weisman, Michael H and Venuturupalli, Swamy and Wallace, Daniel J and Hefner, Kimberly S and Houston, Glen D and Huang, Andrew J. W and Hughes, Pamela J and Lewis, David M and Radfar, Lida and Vista, Evan S and Edgar, Contessa E and Rohrer, Michael D and Stone, Donald U and Vyse, Timothy J and Harley, John B and Gaffney, Patrick M and James, Judith A and Turner, Sean and Alevizos, Ilias and Anaya, Juan-Manuel and Rhodus, Nelson L and Segal, Barbara M and Montgomery, Courtney G and Scofield, R. Hal and Kovats, Susan and Mariette, Xavier and Rönnblom, Lars and Witte, Torsten and Rischmueller, Maureen and Wahren-Herlenius, Marie and Omdal, Roald and Jonsson, Roland and Ng, Wan-Fai and Nordmark, Gunnel and Lessard, Christopher J and Sivils, Kathy L and UK Primary Sjoegren's Syndrome and for UK Primary Sjögren's Syndrome Registry and Avdelningen för neuro- och inflammationsvetenskap and Region Östergötland and Medicinska fakulteten and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Reumatologiska kliniken i Östergötland and Hjärt- och Medicincentrum
PLoS Genetics, ISSN 1553-7390, 2017, Volume 13, Issue 6, pp. e1006820 - e1006820
Sjogren's syndrome (SS) is a common, autoimmune exocrinopathy distinguished by keratoconjunctivitis sicca and xerostomia. Patients frequently develop serious... 
RHEUMATOID-ARTHRITIS | QUANTITATIVE TRAIT LOCI | SYSTEMIC-LUPUS-ERYTHEMATOSUS | SPLICE-SITE POLYMORPHISM | MULTIPLE-SCLEROSIS | 2'-5'-OLIGOADENYLATE SYNTHETASE | GENETICS & HEREDITY | GENE-EXPRESSION | MOLECULAR MIMICRY | CLASSIFICATION CRITERIA | GENOME-WIDE ASSOCIATION | 2',5'-Oligoadenylate Synthetase - biosynthesis | Genetic Predisposition to Disease | Sjogren's Syndrome - pathology | Genetic Association Studies | Alternative Splicing - genetics | Humans | Gene Expression Regulation | Male | Virus Diseases - virology | Sjogren's Syndrome - metabolism | 2',5'-Oligoadenylate Synthetase - genetics | Alleles | Interferon Type I - genetics | Interferon Type I - metabolism | Female | Virus Diseases - genetics | Sjogren's Syndrome - genetics | Quantitative Trait Loci - genetics | Haplotypes | Health sciences | Visualization | Alternative splicing | Sjogren's syndrome | Profiling | Transcription | Laboratories | Physicians | Genomics | Risk | Stimulation | Genomes | Arthritis | Neuropathy | Xerostomia | Maxillofacial surgery | Confidence intervals | Keratoconjunctivitis | Vasculitis | Immunology | Enzymatic activity | Surgery | Bioinformatics | Medical research | Autoantibodies | Internal medicine | Splicing | Susceptibility | Rheumatology | Principal components analysis | Fatigue | Dentistry | Gene expression | Patients | Lymphoma | Switching | Quantitative trait loci | Medicine | Pathology | Hospitals | Isoforms | Interferon | Index Medicus | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article
by Kottyan, Leah C and Zoller, Erin E and Bene, Jessica and Lu, Xiaoming and Kelly, Jennifer A and Rupert, Andrew M and Lessard, Christopher J and Vaughn, Samuel E and Marion, Miranda and Weirauch, Matthew T and Namjou, Bahram and Adler, Adam and Rasmussen, Astrid and Glenn, Stuart and Montgomery, Courtney G and Hirschfield, Gideon M and Xie, Gang and Coltescu, Catalina and Amos, Chris and Li, He and Ice, John A and Nath, Swapan K and Mariette, Xavier and Bowman, Simon and Rischmueller, Maureen and Lester, Sue and Brun, Johan G and Gøransson, Lasse G and Harboe, Erna and Omdal, Roald and Cunninghame-Graham, Deborah S and Vyse, Tim and Miceli-Richard, Corinne and Brennan, Michael T and Lessard, James A and Wahren-Herlenius, Marie and Kvarnström, Marika and Illei, Gabor G and Witte, Torsten and Jonsson, Roland and Eriksson, Per and Nordmark, Gunnel and Ng, Wan-Fai and Anaya, Juan-Manuel and Rhodus, Nelson L and Segal, Barbara M and Merrill, Joan T and James, Judith A and Guthridge, Joel M and Scofield, R. Hal and Alarcon-Riquelme, Marta and Bae, Sang-Cheol and Boackle, Susan A and Criswell, Lindsey A and Gilkeson, Gary and Kamen, Diane L and Jacob, Chaim O and Kimberly, Robert and Brown, Elizabeth and Edberg, Jeffrey and Alarcón, Graciela S and Reveille, John D and Vilá, Luis M and Petri, Michelle and Ramsey-Goldman, Rosalind and Freedman, Barry I and Niewold, Timothy and Stevens, Anne M and Tsao, Betty P and Ying, Jun and Mayes, Maureen D and Gorlova, Olga Y and Wakeland, Ward and Radstake, Timothy and Martin, Ezequiel and Martin, Javier and Siminovitch, Katherine and Moser Sivils, Kathy L and Gaffney, Patrick M and Langefeld, Carl D and Harley, John B and Kaufman, Kenneth M and UK Primary Sjogrens Syndrome Regis and UK Primary Sjögren's Syndrome Registry and for UK Primary Sjögren's Syndrome Registry and Avdelningen för neuro- och inflammationsvetenskap and Medicinska fakulteten and Region Östergötland and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Reumatologiska kliniken i Östergötland and Hjärt- och Medicincentrum
Human Molecular Genetics, ISSN 0964-6906, 01/2015, Volume 24, Issue 2, pp. 582 - 596
Journal Article