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index medicus (19) 19
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protein (4) 4
quorum sensing (4) 4
resistance (4) 4
staphylococcus aureus (4) 4
structure-activity relationship (4) 4
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antibacterial agents (3) 3
antibiotic potentiators (3) 3
biofilms (3) 3
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hamamelitannin analogues (3) 3
health aspects (3) 3
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inhibitors (3) 3
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molecules (3) 3
mycobacterium tuberculosis - drug effects (3) 3
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organic chemistry (3) 3
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proteasome (3) 3
research (3) 3
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5f-mdmb-pica (2) 2
aldose-ketose isomerases - antagonists & inhibitors (2) 2
amino acids - chemical synthesis (2) 2
amino acids - chemistry (2) 2
animals (2) 2
anti-bacterial agents - chemistry (2) 2
anti-bacterial agents - pharmacology (2) 2
antimalarials - chemistry (2) 2
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antitubercular agents - chemistry (2) 2
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biofilms - drug effects (2) 2
biological-activity (2) 2
building-blocks (2) 2
care and treatment (2) 2
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cell line, tumor (2) 2
cell survival - drug effects (2) 2
chemical sciences (2) 2
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fosfomycin - analogs & derivatives (2) 2
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glycolipids (2) 2
hexoses - chemistry (2) 2
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1. Full Text Well‐Defined Polymer–Paclitaxel Prodrugs by a Grafting‐from‐Drug Approach
by Louage, Benoit and Nuhn, Lutz and Risseeuw, Martijn D. P and Vanparijs, Nane and De Coen, Ruben and Karalic, Izet and Van Calenbergh, Serge and De Geest, Bruno G
Angewandte Chemie International Edition, ISSN 1433-7851, 09/2016, Volume 55, Issue 39, pp. 11791 - 11796
We report on the design of a polymeric prodrug of the anticancer agent paclitaxel (PTX) by a grafting‐from‐drug approach. A chain transfer agent for reversible... 
nanotechnology | paclitaxel | cancer | RAFT polymerization | prodrugs | CREMOPHOR-FREE | PROTEIN | MICELLES | ANTITUMOR-ACTIVITY | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | NANOPARTICLES | TAXOL | RAFT | Cell Survival - drug effects | Paclitaxel - pharmacology | Paclitaxel - chemical synthesis | Polymers - chemical synthesis | Humans | Paclitaxel - analogs & derivatives | Solubility | Polymerization | Prodrugs - chemistry | Neoplasms - drug therapy | Polymers - pharmacology | Cell Line, Tumor | Hydrophobic and Hydrophilic Interactions | Prodrugs - chemical synthesis | Polymers - chemistry | Prodrugs - pharmacology | Polymer industry | Polymers | Nanotechnology | Paclitaxel
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2. Full Text Novel hamamelitannin analogues for the treatment of biofilm related MRSA infections–A scaffold hopping approach
by Vermote, Arno and Brackman, Gilles and Risseeuw, Martijn D.P and Coenye, Tom and Van Calenbergh, Serge
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2017, Volume 127, pp. 757 - 770
Antimicrobial research is increasingly being focused on the problem of resistance and biofilm formation. Hamamelitannin (HAM) was recently identified as an... 
Scaffold hopping | Antibiotic potentiators | Quorum sensing | Hamamelitannin analogues | MRSA | STAPHYLOCOCCUS-AUREUS PATHOGENESIS | TARGET | ANTIBIOTICS | CHEMISTRY, MEDICINAL | PROTEIN | SUSCEPTIBILITY | QUORUM-SENSING INHIBITOR | DISCOVERY | RIP | POTENTIATORS | Biofilms - drug effects | Methicillin-Resistant Staphylococcus aureus - physiology | User-Computer Interface | Gallic Acid - pharmacology | Methicillin-Resistant Staphylococcus aureus - drug effects | Hexoses - chemical synthesis | Anti-Bacterial Agents - chemical synthesis | Microbial Sensitivity Tests | Anti-Bacterial Agents - chemistry | Drug Design | Gallic Acid - chemical synthesis | Ligands | Anti-Bacterial Agents - pharmacology | Gallic Acid - analogs & derivatives | Drug Evaluation, Preclinical | Gallic Acid - chemistry | Hexoses - chemistry | Hexoses - pharmacology | Care and treatment | Health aspects | Staphylococcus aureus | Staphylococcus aureus infections | Antibacterial agents
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3. Full Text Hamamelitannin Analogues that Modulate Quorum Sensing as Potentiators of Antibiotics against Staphylococcus aureus
by Vermote, Arno and Brackman, Gilles and Risseeuw, Martijn D. P and Vanhoutte, Bieke and Cos, Paul and Van Hecke, Kristof and Breyne, Koen and Meyer, Evelyne and Coenye, Tom and Van Calenbergh, Serge
Angewandte Chemie International Edition, ISSN 1433-7851, 05/2016, Volume 55, Issue 22, pp. 6551 - 6555
The modulation of bacterial communication to potentiate the effect of existing antimicrobial drugs is a promising alternative to the development of novel... 
quorum sensing | antibiotics | biofilms | potentiators | MRSA | INFECTIONS | SUSCEPTIBILITY | RESISTANCE | INHIBITOR | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | Antibiotics | Analysis | Staphylococcus aureus | Genes | Drugs | Chemical communication | Toxicity | Analogue | Cytotoxicity | Infections | Drug development | Antiinfectives and antibacterials | Inhibitors | Modulation | Bacteria | Mammary gland | Detection
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4. Full Text Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors
by Song, Lijun and Merceron, Romain and Gracia, Begoña and Quintana, Ainhoa Lucía and Risseeuw, Martijn D. P and Hulpia, Fabian and Cos, Paul and Aínsa, José A and Munier-Lehmann, Hélène and Savvides, Savvas N and Van Calenbergh, Serge
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 7, pp. 2753 - 2775
In recent years, thymidylate kinase (TMPK), an enzyme indispensable for bacterial DNA biosynthesis, has been pursued for the development of new antibacterial... 
Medicinal Chemistry | Life Sciences | Microbiology and Parasitology | Biomolecules | Biochemistry, Molecular Biology | Chemical Sciences
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5. Full Text Design, synthesis and biological evaluation of novel hamamelitannin analogues as potentiators for vancomycin in the treatment of biofilm related Staphylococcus aureus infections
by Vermote, Arno and Brackman, Gilles and Risseeuw, Martijn D.P and Coenye, Tom and Van Calenbergh, Serge
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 10/2016, Volume 24, Issue 19, pp. 4563 - 4575
is a frequent cause of biofilm-related infections. Bacterial cells within a biofilm are protected from attack by the immune system and conventional antibiotics... 
Antibiotic potentiators | Quorum sensing | Biofilms | Hamamelitannin analogues | Staphylococcus aureus | ANTIBIOTICS | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUSCEPTIBILITY | CHEMISTRY, ORGANIC | DISCOVERY | RESISTANCE | AGENTS | Biofilms - drug effects | Staphylococcal Infections - drug therapy | Gallic Acid - pharmacology | Quorum Sensing - drug effects | Staphylococcus aureus - physiology | Humans | Structure-Activity Relationship | Microbial Sensitivity Tests | Anti-Bacterial Agents - chemistry | Vancomycin - pharmacology | Drug Design | Anti-Bacterial Agents - pharmacology | Gallic Acid - analogs & derivatives | Staphylococcus aureus - drug effects | Gallic Acid - chemistry | Hexoses - chemistry | Hexoses - pharmacology | Care and treatment | Health aspects | Antibacterial agents | Analysis | Staphylococcus aureus infections
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6. Full Text Identification and characterization of 4-chloromethamphetamine (4-CMA) in seized ecstacy — a risk to public health
by Blanckaert, Peter and Vanquekelberghe, Stijn and Coopman, Vera and Risseeuw, Martijn D.P and Van Calenbergh, Serge and Cordonnier, Jan
Forensic Science International, ISSN 0379-0738, 07/2018, Volume 288, pp. 173 - 180
This paper reports the structure elucidation and full characterization of 4-chloromethamphetamine (4-CMA), a compound which was never reported previously... 
NPS | Ecstasy | Identification | 4-Chloromethamphetamine (4-CMA) | (Neuro)toxic | Elucidation | BRAIN-SEROTONIN | METABOLISM | RAT | MEDICINE, LEGAL | PARA-CHLOROAMPHETAMINE | Forensic toxicology | Methamphetamine | Ecstasy (Drug) | Research | Identification and classification | Chloromethane | Methods | Neurotoxic agents | Nuclear magnetic resonance--NMR | Tablets | Laboratories | Quantitation | Trifluoroacetyl | Magnetic resonance spectroscopy | Literature reviews | Hydrochloric acid | Neurotoxicity | Drug dosages | Pattern analysis | Public health | Seizing | Serotonin | Health risks | Mass spectroscopy | Liquid chromatography | High-performance liquid chromatography | Gas chromatography | Amphetamines | Dance | Mass spectrometry | High performance liquid chromatography | Structural analysis | Index Medicus
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7. Full Text Kinase Substrate Sensor (KISS), a mammalian in situ protein interaction sensor
by Lievens, Sam and Gerlo, Sarah and Lemmens, Irma and De Clercq, Dries J. H and Risseeuw, Martijn D. P and Vanderroost, Nele and De Smet, Anne-Sophie and Ruyssinck, Elien and Chevet, Eric and Van Calenbergh, Serge and Tavernier, Jan
Molecular and Cellular Proteomics, ISSN 1535-9476, 12/2014, Volume 13, Issue 12, pp. 3332 - 3342
Probably every cellular process is governed by protein-protein interaction (PPIs), which are often highly dynamic in nature being modulated by in-or external... 
YEAST 2-HYBRID SYSTEM | HUMAN-CELLS | DRUG DISCOVERY | REVERSE-TRANSCRIPTASE | BIOCHEMICAL RESEARCH METHODS | DYNAMICS | RECEPTOR | BINDING | INTERACTION TRAP | STRATEGIES | REVEALS | Endoribonucleases - genetics | Phosphorylation | Humans | TYK2 Kinase - metabolism | Arrestins - genetics | Endoplasmic Reticulum Stress - genetics | Arrestins - metabolism | Receptors, Somatostatin - genetics | Receptor, Angiotensin, Type 1 - genetics | Sensitivity and Specificity | HEK293 Cells | Receptors, Somatostatin - metabolism | Protein-Serine-Threonine Kinases - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Endoribonucleases - metabolism | Signal Transduction | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Benchmarking | Protein Interaction Mapping - methods | Two-Hybrid System Techniques | beta-Arrestins | Receptor, Angiotensin, Type 1 - metabolism | Biosensing Techniques - methods | TYK2 Kinase - genetics | Research
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8. Full Text Erratum: Corrigenda to “Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents” (Bioorganic & Medicinal Chemistry (2016) 24(21) (5172–5182) (S0968089616306496) (10.1016/j.bmc.2016.08.041)
by Song, Lijun and Risseeuw, Martijn D.P and Froeyen, Matheus and Karalic, Izet and Goeman, Jan and Cappoen, Davie and Van der Eycken, Johan and Cos, Paul and Munier-Lehmann, Hélène and Van Calenbergh, Serge
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 10/2017, Volume 25, Issue 20, p. 5889
An error is present on page 5175 of the above mentioned published paper. Since we were unable to reproduce the in vitro activity of compound 5 against M.... 
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9. Full Text Identification of a new tert -leucinate class synthetic cannabinoid in powder and “spice-like” herbal incenses: methyl 2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethyl-butanoate (5F-MDMB-PICA)
by Risseeuw, Martijn D.P and Blankaert, Peter and Coopman, Vera and Quekelberghe, Stijn Van and Calenbergh, Serge Van and Cordonnier, Jan
Forensic Science International, ISSN 0379-0738, 2017, Volume 273, pp. 45 - 52
Highlights • characterization of a new tert -leucinate class synthetic cannabinoid. • GC-EI-MS, HPLC-PDA, LCMS, ESI-HRMS and NMR data for 5F-MDMB-PICA. • First... 
Pathology | 5F-MDMB-PICA | Synthetic cannabinoid | GC–MS | NMR | HPLC–PDA | ESI-HRMS | LC–MS
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10. Full Text Corrigenda to “Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents” [Bioorg Med Chem 24 (2016) 5172–5182]
by Song, Lijun and Risseeuw, Martijn D.P and Froeyen, Matheus and Karalic, Izet and Goeman, Jan and Cappoen, Davie and Van der Eycken, Johan and Cos, Paul and Munier-Lehmann, Hélène and Van Calenbergh, Serge
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 10/2017, Volume 25, Issue 20, pp. 5889 - 5889
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11. Full Text Synthetic fosmidomycin analogues with altered chelating moieties do not inhibit 1-deoxy-d-xylulose 5-phosphate reductoisomerase or Plasmodium falciparum growth in vitro
by Chofor, René and Risseeuw, Martijn D.P and Pouyez, Jenny and Johny, Chinchu and Wouters, Johan and Dowd, Cynthia S and Couch, Robin D and Van Calenbergh, Serge
Molecules, ISSN 1420-3049, 02/2014, Volume 19, Issue 2, pp. 2571 - 2587
Fourteen new fosmidomycin analogues with altered metal chelating groups were prepared and evaluated for inhibition of E. coli Dxr, M. tuberculosis Dxr and the... 
Fosmidomycin | Non-mevalonate pathway | Isoprenoid biosynthesis | Coordination chemistry | DOXP reductoisomerase | Fosfomycin - chemical synthesis | Humans | Plasmodium falciparum - drug effects | Erythrocytes - drug effects | Enzyme Inhibitors - administration & dosage | Antimalarials - administration & dosage | Fosfomycin - administration & dosage | Enzyme Inhibitors - chemistry | Antimalarials - chemistry | Drug Design | Plasmodium falciparum - growth & development | Aldose-Ketose Isomerases - antagonists & inhibitors | Antimalarials - chemical synthesis | Fosfomycin - analogs & derivatives | isoprenoid biosynthesis | non-mevalonate pathway | fosmidomycin | coordination chemistry
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12. Full Text Identification of a new tert-leucinate class synthetic cannabinoid in powder and "spice-like" herbal incenses: Methyl 2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethyl-butanoate (5F-MDMB-PICA)
by Risseeuw, MDP and Blanckaert, P and Coopman, V and Van Quekelberghe, S and Van Calenbergh, S and Cordonnier, J
FORENSIC SCIENCE INTERNATIONAL, ISSN 0379-0738, 04/2017, Volume 273, pp. 45 - 52
A brown powder and different product packages of "spice-like" herbal incenses were analyzed using a systematic identification approach based on liquid... 
GC-MS | 5F-MDMB-PICA | Synthetic cannabinoid | HPLC-PDA | LC-MS | NMR | MEDICINE, LEGAL | ESI-HRMS | MDMB-CHMICA | Cannabinoids | Identification | Research | Identification and classification | Designer drugs | Methods | Drugs | Laboratories | Fatalities | Marijuana | Scientific imaging | Mass spectrometry | Emergency communications systems
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13. Full Text Synthesis and Bioactivity of β-Substituted Fosmidomycin Analogues Targeting 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase
by Chofor, René and Sooriyaarachchi, Sanjeewani and Risseeuw, Martijn D.P and Bergfors, Terese and Pouyez, Jenny and Johny, Chinchu and Haymond, Amanda and Everaert, Annelien and Dowd, Cynthia S and Maes, Louis and Coenye, Tom and Alex, Alexander and Couch, Robin D and Jones, T. Alwyn and Wouters, Johan and Mowbray, Sherry L and Van Calenbergh, Serge and Science for Life Laboratory, SciLifeLab and Teknisk-naturvetenskapliga vetenskapsområdet and Struktur- och molekylärbiologi and Biologiska sektionen and Uppsala universitet and Institutionen för cell- och molekylärbiologi
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2015, Volume 58, Issue 7, pp. 2988 - 3001
Blocking the 2-C-methyl-d-erythrithol-4-phosphate (MEP) pathway for isoprenoid biosynthesis offers interesting prospects for inhibiting Plasmodium or... 
MYCOBACTERIUM-TUBERCULOSIS | ANTIMALARIAL-DRUG | DXR INHIBITION | CLINDAMYCIN | CHEMISTRY, MEDICINAL | METHYLERYTHRITOL PHOSPHATE-PATHWAY | ISOPRENOID BIOSYNTHESIS | RESISTANCE | OXA ISOSTERES | 5-PHOSPHATE REDUCTOISOMERASE | NONMEVALONATE PATHWAY | Aldose-Ketose Isomerases - chemistry | Chemistry Techniques, Synthetic | Fosfomycin - chemistry | Escherichia coli - drug effects | Enzyme Inhibitors - pharmacology | Models, Molecular | Crystallography, X-Ray | Structure-Activity Relationship | Plasmodium falciparum - drug effects | Enzyme Inhibitors - chemical synthesis | Molecular Targeted Therapy | Mycobacterium tuberculosis - drug effects | Antimalarials - pharmacology | Microbial Sensitivity Tests | Enzyme Inhibitors - chemistry | Mycobacterium tuberculosis - enzymology | Antimalarials - chemistry | Inhibitory Concentration 50 | Protein Conformation | Aldose-Ketose Isomerases - genetics | Aldose-Ketose Isomerases - antagonists & inhibitors | Aldose-Ketose Isomerases - metabolism | Fosfomycin - analogs & derivatives | Medicinal Chemistry | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Läkemedelskemi | Medicinska och farmaceutiska grundvetenskaper
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14. Full Text Galactosylsphingamides: New α-GalCer analogues to probe the F'-pocket of CD1d
by Guillaume, Joren and Wang, Jing and Janssens, Jonas and Remesh, Soumya G and Risseeuw, Martijn D. P and Decruy, Tine and Froeyen, Mathy and Elewaut, DIrk and Zajonc, DIrk M and Calenbergh, Serge Van
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 4276 - 18
Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a... 
NKT CELLS | RECOGNITION | INKT CELLS | KRN7000 | MULTIDISCIPLINARY SCIENCES | KILLER T-CELLS | BIOLOGICAL EVALUATION | SPHINGOSINE BACKBONE | C-GALACTOSYLCERAMIDE | RECEPTOR | GLYCOLIPIDS | T-cell receptor | CD1d antigen | Immune response | Cytokines | Immunomodulation | Lymphocytes T | Natural killer cells | Galactosylceramide
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15. Full Text A compendium of sugar amino acids (SAA): scaffolds, peptide- and glyco-mimetics
by Risseeuw, Martijn D.P and Overhand, Mark and Fleet, George W.J and Simone, Michela I
Tetrahedron: Asymmetry, ISSN 0957-4166, 2007, Volume 18, Issue 17, pp. 2001 - 2010
Sugar amino acids (SAAs) are carbohydrate derivatives bearing both amino and carboxylic acid functionalities. SAAs are very versatile conformationally biased... 
N-LINKED GLYCOPEPTIDES | DIPEPTIDE ISOSTERES | VASOACTIVE-INTESTINAL-PEPTIDE | L-RHAMNOSE | SOLID-PHASE SYNTHESIS | ADENOSINE A RECEPTOR | BUILDING-BLOCKS | CHEMISTRY, PHYSICAL | EFFICIENT S(N)2 REACTIONS | CONFORMATIONAL-ANALYSIS | RECEPTOR-BINDING INHIBITOR
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16. Full Text Nature of pharmacophore influences active site specificity of proteasome inhibitors
by Screen, Michael and Britton, Matthew and Downey, Sondra L and Verdoes, Martijn and Voges, Mathias J and Blom, Annet E. M and Geurink, Paul P and Risseeuw, Martijn D. P and Florea, Bogdan I and Van Der Linden, Wouter A and Pletnev, Alexandre A and Overkleeft, Herman S and Kisselev, Alexei F
Journal of Biological Chemistry, ISSN 0021-9258, 12/2010, Volume 285, Issue 51, pp. 40125 - 40134
Proteasomes degrade most proteins in mammalian cells and are established targets of anti-cancer drugs. The majority of proteasome inhibitors are composed of... 
20S PROTEASOME | YEAST | CELLS | SELECTIVE INHIBITOR | PROTEIN | MECHANISM | SUBSTRATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BORTEZOMIB | PEPTIDE | Rabbits | Catalytic Domain | Oligopeptides | Humans | Protease Inhibitors - chemistry | Proteasome Endopeptidase Complex - chemistry | Antineoplastic Agents - chemistry | Sulfones - pharmacology | Protease Inhibitors - pharmacology | Animals | Cytotoxins - pharmacology | Sulfones - chemistry | Cytotoxins - chemistry | HEK293 Cells | Antineoplastic Agents - pharmacology | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | Proteasome Inhibitors | Index Medicus | Ubiquitin | Cysteine Protease | Protease Inhibitor | Protein Degradation | Protein Synthesis and Degradation | Proteasome
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17. Full Text Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents
by Song, Lijun and Risseeuw, Martijn D.P and Froeyen, Matheus and Karalic, Izet and Goeman, Jan and Cappoen, Davie and Van der Eycken, Johan and Cos, Paul and Munier-Lehmann, Hélène and Van Calenbergh, Serge
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2016, Volume 24, Issue 21, pp. 5172 - 5182
We report the design and synthesis of a series of non-nucleoside TMPK inhibitors ( – ) based on the gram-positive bacterial TMPK inhibitor hit compound . A... 
Inhibitors | XDR-TB | Thymine derivatives | Mycobacterium tuberculosis | extensively drug-resistant tuberculosis | Thymidine monophosphate kinase | MYCOBACTERIUM-TUBERCULOSIS | SYSTEM | DESIGN | CHEMISTRY, MEDICINAL | NUCLEOSIDE ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | CHIMERA | POTENT INHIBITORS | DISCOVERY | TMK | ANTIBACTERIAL INHIBITORS | Antitubercular Agents - chemical synthesis | Protein Kinase Inhibitors - chemical synthesis | Piperidines - chemistry | Antitubercular Agents - chemistry | Humans | Nucleoside-Phosphate Kinase - antagonists & inhibitors | Antitubercular Agents - pharmacology | Models, Molecular | Structure-Activity Relationship | Piperidines - chemical synthesis | Mycobacterium tuberculosis - drug effects | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Protein Kinase Inhibitors - chemistry | Piperidines - pharmacology | Mycobacterium tuberculosis - enzymology | Molecular Structure | Protein Kinase Inhibitors - pharmacology | Nucleoside-Phosphate Kinase - metabolism | Tuberculosis | Nucleosides | Drug resistance in microorganisms | Health aspects | Immunodeficiency | Nucleoside-Phosphate Kinase | Chemical Sciences | Life Sciences | Protein Kinase Inhibitors | Antitubercular Agents | Piperidines
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18. Full Text Micellar Paclitaxel-Initiated RAFT Polymer Conjugates with Acid-Sensitive Behavior
by Louage, Benoit and van Steenbergen, Mies J and Nuhn, Lutz and Risseeuw, Martijn D. P and Karalic, Izet and Winne, Johan and Van Calenbergh, Serge and Hennink, Wim E and De Geest, Bruno G
ACS Macro Letters, ISSN 2161-1653, 03/2017, Volume 6, Issue 3, pp. 272 - 276
Acid-sensitive paclitaxel (PTX)–polymer conjugates were designed by applying a grafting-from-drug RAFT approach. PTX was linked through either a cyclic or a... 
ACTIVATION | POLYMER SCIENCE | VEHICLES | EFFICACY | DRUG-DELIVERY | PRODRUGS | CREMOPHOR-EL | ACETALS | FORMULATION
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19. Full Text Synthesis of extended uridine phosphonates derived from an allosteric p2y2 receptor ligand
by Song, Lijun and Risseeuw, Martijn D. P and Karalic, Izet and Barrett, Matthew O and Brown, Kyle A and Harden, T. Kendall and Van Calenbergh, Serge
Molecules, ISSN 1420-3049, 2014, Volume 19, Issue 4, pp. 4313 - 4325
In this study we report the synthesis of C5/C6-fused uridine phosphonates that are structurally related to earlier reported allosteric P2Y2 receptor ligands. A... 
Extended uridine | Nucleoside phosphonates | Astrocytes - cytology | Astrocytes - drug effects | Purinergic P2Y Receptor Agonists - chemical synthesis | Allosteric Regulation | Humans | Uridine - analogs & derivatives | Uridine - pharmacology | Purinergic P2Y Receptor Agonists - pharmacology | Organophosphonates - chemical synthesis | Organophosphonates - pharmacology | Cell Line, Tumor | Receptors, Purinergic P2Y2 - metabolism | Ligands | Quinazolines - chemistry | Uridine - chemical synthesis | Astrocytes - metabolism | nucleoside phosphonates | extended uridine | P2Y2 receptor
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20. Full Text Novel Potentiators for Vancomycin in the Treatment of Biofilm-Related MRSA Infections via a Mix and Match Approach
by Vermote, Arno and Brackman, Gilles and Risseeuw, Martijn D. P and Cappoen, Davie and Cos, Paul and Coenye, Tom and Van Calenbergh, Serge
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 01/2017, Volume 8, Issue 1, pp. 38 - 42
A library of 52 hamamelitannin analogues was synthesized and investigated for its ability to potentiate the effect of vancomycin toward Staphylococcus aureus... 
Antibiotic potentiators | Quorum sensing | Biofilms | Hamamelitannin analogues | Staphylococcus aureus | ANTIBIOTICS | CHEMISTRY, MEDICINAL | quorum sensing | SUSCEPTIBILITY | QUORUM-SENSING INHIBITOR | HAMAMELITANNIN ANALOGS | BACTERIAL BIOFILMS | hamamelitannin analogues | STAPHYLOCOCCUS-AUREUS INFECTIONS | RESISTANCE | biofilms
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