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1. Full Text Selective inhibition of FLT3 by gilteritinib in relapsed or refractory acute myeloid leukaemia: a multicentre, first-in-human, open-label, phase 1–2 study
by Perl, Alexander E, MD and Altman, Jessica K, MD and Cortes, Jorge, MD and Smith, Catherine, MD and Litzow, Mark, MD and Baer, Maria R, MD and Claxton, David, Prof and Erba, Harry P, Prof and Gill, Stan, PhD and Goldberg, Stuart, MD and Jurcic, Joseph G, Prof and Larson, Richard A, Prof and Liu, Chaofeng, PhD and Ritchie, Ellen, MD and Schiller, Gary, MD and Spira, Alexander I, MD and Strickland, Stephen A, MD and Tibes, Raoul, MD and Ustun, Celalettin, MD and Wang, Eunice S, Prof and Stuart, Robert, Prof and Röllig, Christoph, MD and Neubauer, Andreas, Prof and Martinelli, Giovanni, Prof and Bahceci, Erkut, MD and Levis, Mark, Dr
Lancet Oncology, The, ISSN 1470-2045, 2017, Volume 18, Issue 8, pp. 1061 - 1075
Summary Background Internal tandem duplication mutations in FLT3 are common in acute myeloid leukaemia and are associated with rapid relapse and short overall... 
Hematology, Oncology and Palliative Medicine | AML | INTERNAL TANDEM DUPLICATION | CONTROLLED-TRIAL | ONCOLOGY | MIDOSTAURIN PKC412 | ACUTE MYELOGENOUS LEUKEMIA | THERAPEUTIC TARGET | MUTATIONS | SORAFENIB | MYELODYSPLASTIC SYNDROME | RECEPTOR TYROSINE KINASE | fms-Like Tyrosine Kinase 3 - antagonists & inhibitors | Recurrence | Aniline Compounds - pharmacology | Aniline Compounds - blood | Humans | Middle Aged | Blood Platelets | Male | Antineoplastic Agents - therapeutic use | Pyrazines - therapeutic use | fms-Like Tyrosine Kinase 3 - metabolism | fms-Like Tyrosine Kinase 3 - genetics | Retreatment | Maximum Tolerated Dose | Antineoplastic Agents - blood | Leukemia, Myeloid, Acute - drug therapy | Female | Aged | Antineoplastic Agents - pharmacology | Aniline Compounds - therapeutic use | Phosphorylation - drug effects | Pyrazines - pharmacology | Pyrazines - blood | Leukemia, Myeloid, Acute - genetics | Relapse | Diseases | Analysis | Index Medicus
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2. Full Text Vosaroxin plus cytarabine versus placebo plus cytarabine in patients with first relapsed or refractory acute myeloid leukaemia (VALOR): a randomised, controlled, double-blind, multinational, phase 3 study
by Ravandi, Farhad, Prof and Ritchie, Ellen K, MD and Sayar, Hamid, MD and Lancet, Jeffrey E, MD and Craig, Michael D, MD and Vey, Norbert, Prof and Strickland, Stephen A, MD and Schiller, Gary J, Prof and Jabbour, Elias, MD and Erba, Harry P, Prof and Pigneux, Arnaud, Prof and Horst, Heinz-August, Prof and Recher, Christian, Prof and Klimek, Virginia M, MD and Cortes, Jorge, Prof and Roboz, Gail J, MD and Odenike, Olatoyosi, MD and Thomas, Xavier, MD and Havelange, Violaine, MD and Maertens, Johan, Prof and Derigs, Hans-Günter, Prof and Heuser, Michael, MD and Damon, Lloyd, Prof and Powell, Bayard L, Prof and Gaidano, Gianluca, Prof and Carella, Angelo-Michele, MD and Wei, Andrew, MBBS and Hogge, Donna, Prof and Craig, Adam R, MD and Fox, Judith A, PhD and Ward, Renee, MD and Smith, Jennifer A, PhD and Acton, Gary, MD and Mehta, Cyrus, Prof and Stuart, Robert K, MD and Kantarjian, Hagop M, Prof
Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 9, pp. 1025 - 1036
Summary Background Safe and effective treatments are urgently needed for patients with relapsed or refractory acute myeloid leukaemia. We investigated the... 
Hematology, Oncology and Palliative Medicine | TRIALS | CELLS | MITOXANTRONE | ONCOLOGY | VORELOXIN | RISK | OUTCOMES | DOSE CYTOSINE-ARABINOSIDE | SAMPLE-SIZE | COMBINATION | CHEMOTHERAPY | Double-Blind Method | Leukemia, Myeloid, Acute - pathology | Humans | Middle Aged | Kaplan-Meier Estimate | Antineoplastic Combined Chemotherapy Protocols | Neoplasm Recurrence, Local - drug therapy | Male | Thiazoles - administration & dosage | Treatment Outcome | Remission Induction | Cytarabine - administration & dosage | Neoplasm Recurrence, Local - pathology | Disease-Free Survival | Aged, 80 and over | Leukemia, Myeloid, Acute - drug therapy | Adult | Female | Aged | Naphthyridines - administration & dosage | Relapse | Care and treatment | Diseases | Analysis
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3. Full Text Enlarged Spleen Prior to Allogeneic Transplantation for Myelofibrosis Is Associated with Poor Engraftment and Increased Non-Relapse Mortality
by Gergis, Usama, MD and van Besien, Koen, MD and Shore, Tsiporah B., MD, FRCPC, FACP and Mayer, Sebastian, MD and Feldman, Eric, MD and Roboz, Gail, MD and Ritchie, Ellen, MD and Silver, Richard, MD and Wang, Hanhan and Zhou, Xi Kathy, PhD and Kuriakose, Emil, MD
Biology of Blood and Marrow Transplantation, ISSN 1083-8791, 2015, Volume 21, Issue 2, pp. S285 - S285
Hematology, Oncology and Palliative Medicine | Health aspects | Leukemia | Mortality
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4. Full Text Phase 1/2, dose-escalation study of oral NS-018 in patients with primary myelofibrosis (PMF), post-polycythemia vera MF (post-PV MF), or post-essential thrombocythemia MF(post-ET MF)
by Verstovsek, Srdan, MD, PhD and Talpaz, Moshe, MD and Ritchie, Ellen, MD and Wadleigh, Martha, MD and Odenike, Olatoyosi M., MD and Jamieson, Catriona, MD, PhD and Stein, Brady, MD and Uno, Tomonori, PhD and Mesa, Ruben A., MD
Clinical Lymphoma, Myeloma & Leukemia, ISSN 2152-2650, 2015, Volume 15, pp. S58 - S58
Hematology, Oncology and Palliative Medicine
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5. Full Text Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
by Habre, Walid, Prof and Disma, Nicola, MD and Virag, Katalin, MSc and Becke, Karin, MD and Hansen, Tom G, MD and Jöhr, Martin, MD and Leva, Brigitte, MT and Morton, Neil S, MD and Vermeulen, Petronella M, PhD and Zielinska, Marzena, MD and Boda, Krisztina, Prof and Veyckemans, Francis, MD and APRICOT Grp European Soc Anaesthes and APRICOT Group of the European Society of Anaesthesiology Clinical Trial Network
Lancet Respiratory Medicine, The, ISSN 2213-2600, 2017, Volume 5, Issue 5, pp. 412 - 425
Summary Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the... 
Pulmonary/Respiratory | RESPIRATORY ADVERSE EVENTS | SYSTEM | AUDIT | RISK-FACTORS | OPERATING-ROOM | CARDIAC-ARREST | MORBIDITY | RESPIRATORY SYSTEM | REGIONAL ANESTHESIA | COMPLICATIONS | CHILDREN | CRITICAL CARE MEDICINE | Postoperative Complications - etiology | Prospective Studies | Age Factors | Humans | Child, Preschool | Infant | Male | Anesthesia, General - adverse effects | Incidence | Nervous System Diseases - epidemiology | Hospitals - statistics & numerical data | Cardiovascular Diseases - epidemiology | Female | Child | Infant, Newborn | Drug Hypersensitivity - etiology | Cardiovascular Diseases - etiology | Clinical Competence | Intraoperative Complications - epidemiology | Europe - epidemiology | Postoperative Complications - epidemiology | Respiratory Tract Diseases - etiology | Drug Hypersensitivity - epidemiology | Respiratory Tract Diseases - epidemiology | Intraoperative Complications - etiology | Adolescent | Nervous System Diseases - etiology | Health Status | Dosage and administration | Research | Children | Management | Pediatric anesthesia | Health aspects
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6. Full Text Genetic studies of body mass index yield new insights for obesity biology
by Locke, A.E and Kahali, B and Berndt, S.I and Justice, A.E and Pers, T.H and Day, F.R and Powell, C and Vedantam, S and Buchkovich, M.L and Yang, J and Croteau-Chonka, D.C and Esko, T and Fall, T and Ferreira, T and Gustafsson, S and Kutalik, Z and Luan, J and Magi, R and Randall, J.C and Winkler, T.W and Wood, A.R and Workalemahu, T and Faul, J.D and Smith, J.A and Zhao, J and Zhao, W and Chen, J and Fehrmann, R and Hedman, A.K and Karjalainen, J and Schmidt, E.M and Absher, D and Amin, N and Anderson, D and Beekman, M and Bolton, J.L and Bragg-Gresham, J.L and Buyske, S and Demirkan, A and Deng, G and Ehret, G.B and Feenstra, B and Feitosa, M.F and Fischer, K and Goel, A and Gong, J and Jackson, A.U and Kanoni, S and Kleber, M.E and Kristiansson, K and Lim, U and Lotay, V and Mangino, M and Leach, I. Mateo and Medina-Gomez, C and Medland, S.E and Nalls, M.A and Palmer, C.D and Pasko, D and Pechlivanis, S and Peters, M.J.W and Prokopenko, I and Shungin, D and Stancakova, A and Strawbridge, R.J and Sung, Y. Ju and Tanaka, T and Teumer, A and Trompet, S and Laan, S.W. van der and Setten, J. van and Vliet-Ostaptchouk, J.V. Van and Wang, Z and Yengo, L and Zhang, W and Isaacs, A and Albrecht, E and Arnlov, J and Arscott, G.M and Attwood, A.P and Bandinelli, S and Barrett, A and Bas, I.N and Bellis, C and Bennett, A.J and Berne, C and Blagieva, R and Bluher, M and Bohringer, S and Bonnycastle, L.L and Bottcher, Y and Boyd, H.A and Bruinenberg, M and Caspersen, I.H and Chen, Y.D and Clarke, R and Daw, E.W and Craen, A.J. de and Delgado, G and Dimitriou, M and ... and ADIPOGen Consortium and PAGE Consortium and LifeLines Cohort Study and MIGen Consortium and CARDIOGRAMplusC4D Consortium and MuTHER Consortium and ICBP and CKDGen Consortium and Int Endogene Consortium and GENIE Consortium and MAGIC Investigators and ReproGen Consortium and AGEN-BMI Working Grp and GLGC and International Endogene Consortium and AGEN-BMI Working Group and The PAGE Consortium and The International Endogene Consortium and The MAGIC Investigators and The ReproGen Consortium and The CKDGen Consortium and The ADIPOGen Consortium and The ICBP and The CARDIOGRAMplusC4D Consortium and The GLGC and The GENIE Consortium and The AGEN-BMI Working Group and The MIGen Consortium and The MuTHER Consortium and The LifeLines Cohort Study and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Medicinsk genetik och genomik and Geriatrik and Uppsala universitet and Klinisk diabetologi och metabolism and Institutionen för immunologi, genetik och patologi and Molekylär medicin and Kardiovaskulär epidemiologi and Institutionen för medicinska vetenskaper and Molekylär epidemiologi and Institutionen för folkhälso- och vårdvetenskap
Nature, ISSN 0028-0836, 2015, Volume 518, Issue 7538, pp. 197 - 206
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and... 
INDIVIDUALS | PROVIDES INSIGHTS | METAANALYSIS | VARIANTS | MULTIDISCIPLINARY SCIENCES | HIPPOCAMPAL | GLYCEMIC TRAITS | ARCHITECTURE | TOPIRAMATE | LOCI | GENOME-WIDE ASSOCIATION | Body Mass Index | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Age Factors | Humans | Male | Continental Population Groups - genetics | Adiposity - genetics | Obesity - genetics | Europe - ethnology | Obesity - metabolism | Insulin - metabolism | Synapses - metabolism | Polymorphism, Single Nucleotide - genetics | Female | Glutamic Acid - metabolism | Energy Metabolism - genetics | Adipogenesis - genetics | Insulin Secretion | Quantitative Trait Loci - genetics | Body mass index | Obesity | Genetic research | Genetic aspects | Research | Diabetes | Gene expression | Health aspects | Studies | Genomics | Genetics | Biology | Genomes | Metabolic disorders | Meta-analysis | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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