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humans (88) 88
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physiological aspects (11) 11
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1. Full Text Metabolic response to amylose-rich wheat-based rusks in overweight individuals
by Vetrani, Claudia and Sestili, Francesco and Vitale, Marilena and Botticella, Ermelinda and Giacco, Rosalba and Griffo, Ettore and Costabile, Giuseppina and Cipriano, Paola and Tura, Andrea and Pacini, Giovanni and Rivellese, Angela A and Lafiandra, Domenico and Riccardi, Gabriele
European Journal of Clinical Nutrition, ISSN 0954-3007, 06/2018, Volume 72, Issue 6, pp. 904 - 912
Background/objectives The amylose-amylopectin ratio influences starch properties. A higher amylose content is associated with slower starch digestion thus... 
AMYLOPECTIN STARCH | GLYCEMIC INDEX | NUTRITION & DIETETICS | PLASMA | DURUM-WHEAT | RESISTANT STARCH | APPETITE | INSULIN SENSITIVITY | CANCER | GLUCOSE-TOLERANCE | CONSUMPTION | Carbohydrates | Starch | Amylopectin | Body weight | Diabetes mellitus | Flour | Glucose | Metabolism | Fermentation | Insulin | Metabolic response | Glucose tolerance | Glucose metabolism | Amylose | Intestine | Computer applications | Satiety | Mathematical models | Meals | Wheat
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2. Diets rich in whole grains increase betainized compounds associated with glucose metabolism
by Olli Kärkkäinen and Maria A Lankinen and Marilena Vitale and Jenna Jokkala and Jukka Leppänen and Ville Koistinen and Marko Lehtonen and Rosalba Giacco and Natalia Rosa-Sibakov and Valérie Micard and Angela AA Rivellese and Ursula Schwab and Hannu Mykkänen and Matti Uusitupa and Marjukka Kolehmainen and Gabriele Riccardi and Kaisa Poutanen and Seppo Auriola and Kati Hanhineva
The American Journal of Clinical Nutrition, ISSN 0002-9165, 11/2018, Volume 108, Issue 5, p. 971
Epidemiologic evidence suggests that diets rich in whole grains are associated with a reduced risk of developing chronic diseases and all-cause mortality.... 
Enrichment | Intervention | Correlation | Grain | Proline | Glucose | Glycine | Epidemiology | High fat diet | Glucose metabolism | Betaine | Glycine betaine | Chemical synthesis | Rye | Spectroscopy | Secretion | Health risks | Risk reduction | Mass spectroscopy | Liquid chromatography | Metabolism | Insulin | Feeding | Glucose tolerance | Organic chemistry | Molecular modelling | Diet | Valine | Insulin resistance | Mice | Risk management | Mass spectrometry | Wheat | Metabolic disorders | Betaines
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3. Full Text Role of glycemic index and glycemic load in the healthy state, in prediabetes, and in diabetes
by Riccardi, Gabriele and Rivellese, Angela A and Giacco, Rosalba
American Journal of Clinical Nutrition, ISSN 0002-9165, 01/2008, Volume 87, Issue 1, pp. 269S - 274S
The choice of carbohydrate-rich foods in the habitual diet should take into account not only their chemical composition but also their ability to influence... 
Prevention | Cardiovascular disease | Glycemic index | Dietary carbohydrates | Dietary fiber | Diabetes mellitus | dietary carbohydrates | cardiovascular disease | glycemic index | HIGH-CARBOHYDRATE DIET | BLOOD-GLUCOSE | POSTPRANDIAL GLUCOSE | WEIGHT-LOSS | RISK | diabetes mellitus | MELLITUS | INSULIN SENSITIVITY | FIBER | NUTRITION & DIETETICS | LIPID PROFILE | LIFE-STYLE | dietary fiber | prevention | Glucose Intolerance - metabolism | Area Under Curve | Glycemic Index | Humans | Dietary Fiber - metabolism | Diabetes Mellitus, Type 2 - diet therapy | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Diet, Diabetic | Glucose Intolerance - diet therapy | Triglycerides - blood | Blood Glucose - metabolism | Health Status | High-carbohydrate diet | Analysis | High-fiber diet | Diabetes | Health aspects | Risk factors
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4. Full Text Relationship between adherence to a Mediterranean Dietary Pattern and cardiometabolic risk factors profile in People with Type 2 Diabetes
by Calabrese, Ilaria and Vitale, Marilena and Masulli, Maria and Albarosa Rivellese, Angela and Riccardi, Gabriele and Vaccaro, Olga
Nutrition, Metabolism and Cardiovascular Diseases, ISSN 0939-4753, 08/2019, Volume 29, Issue 8, pp. 880 - 880
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5. Full Text Effects of a diet naturally rich in polyphenols on lipid composition of postprandial lipoproteins in high cardiometabolic risk individuals: an ancillary analysis of a randomized controlled trial
by Della Pepa, Giuseppe and Vetrani, Claudia and Vitale, Marilena and Bozzetto, Lutgarda and Costabile, Giuseppina and Cipriano, Paola and Mangione, Anna and Patti, Lidia and Riccardi, Gabriele and Rivellese, Angela Albarosa and Annuzzi, Giovanni
European journal of clinical nutrition, ISSN 0954-3007, 06/2019
Plasma lipoprotein composition, especially in the postprandial state, could be relevant for cardiovascular risk and could be influenced by eating habits. This... 
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6. Full Text Polyphenol-rich diets improve glucose metabolism in people at high cardiometabolic risk: a controlled randomised intervention trial
by Bozzetto, Lutgarda and Annuzzi, Giovanni and Pacini, Giovanni and Costabile, Giuseppina and Vetrani, Claudia and Vitale, Marilena and Griffo, Ettore and Giacco, Angela and De Natale, Claudia and Cocozza, Sara and Della Pepa, Giuseppe and Tura, Andrea and Riccardi, Gabriele and Rivellese, Angela A
Diabetologia, ISSN 0012-186X, 7/2015, Volume 58, Issue 7, pp. 1551 - 1560
Dietary polyphenols and long chain n-3 polyunsaturated fatty acids (LCn3) are associated with lower cardiovascular risk. This may relate to their influence on... 
GLP-1 | Human Physiology | Insulin sensitivity | Metabolic Diseases | Internal Medicine | Beta cell function | Oral glucose insulin sensitivity | Insulin secretion | Glucose metabolism | Medicine & Public Health | Diet | Polyphenols | Long chain n -3 polyunsaturated fatty acids | OGTT | Long chain n-3 polyunsaturated fatty acids | EVENTS | TOLERANCE | N-3 FATTY-ACIDS | HUMANS | INGESTION | IN-VIVO | DISEASE | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELL | SECRETION | Obesity - diet therapy | Cardiovascular Diseases - diet therapy | Glucose Tolerance Test | Metabolic Diseases - diet therapy | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Insulin Resistance | Polyphenols - pharmacology | Glucagon-Like Peptide 1 - blood | Male | Insulin - blood | Insulin-Secreting Cells - metabolism | Waist Circumference | Fatty Acids, Omega-3 - pharmacology | Glucose - metabolism | Adult | Female | Aged | Metabolic Diseases - prevention & control | Patient Compliance | Blood Glucose - metabolism | Physiological aspects | Evaluation | Unsaturated fatty acids | Blood sugar | Glucose tolerance tests
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7. Full Text Extra-virgin olive oil reduces glycemic response to a high-glycemic index meal in patients with type 1 diabetes: A randomized controlled trial
by Bozzetto, Lutgarda and Alderisio, Antonio and Giorgini, Marisa and Barone, Francesca and Giacco, Angela and Riccardi, Gabriele and Rivellese, Angela A and Annuzzi, Giovanni
Diabetes Care, ISSN 0149-5992, 04/2016, Volume 39, Issue 4, pp. 518 - 524
OBJECTIVE To evaluate whether fat quality, in the context of meals with high- (HGI) or low-glycemic index (LGI), influences postprandial blood glucose (PPG)... 
REQUIREMENTS | INSULIN BOLUS CALCULATION | DIETARY-PROTEIN | LOAD | BLOOD-GLUCOSE | ENDOCRINOLOGY & METABOLISM | POSTPRANDIAL GLUCOSE | CARBOHYDRATE | FATTY-ACIDS | PUMP | CHILDREN | Body Mass Index | Glycemic Index | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Diabetes Mellitus, Type 1 - metabolism | Insulin - administration & dosage | Male | Treatment Outcome | Olive Oil - administration & dosage | Insulin - blood | Diabetes Mellitus, Type 1 - drug therapy | Cross-Over Studies | Sample Size | Postprandial Period | Adult | Female | Blood Glucose - metabolism | Meals | Care and treatment | Usage | Type 1 diabetes | Analysis | Clinical trials | Glycemic index | Dosage and administration | Olive oil | Health aspects | Insulin
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8. Full Text Dietary fibre as a unifying remedy for the whole spectrum of obesity-associated cardiovascular risk
by Bozzetto, Lutgarda and Costabile, Giuseppina and Della Pepa, Giuseppe and Ciciola, Paola and Vetrani, Claudia and Vitale, Marilena and Rivellese, Angela A and Annuzzi, Giovanni
Nutrients, ISSN 2072-6643, 07/2018, Volume 10, Issue 7, p. 943
Obesity is a pandemic carrying the heavy burden of multiple and serious co-morbidities including metabolic syndrome, type 2 diabetes and cardiovascular... 
Hypertension | Obesity | Cardiovascular risk | Dyslipidemia | Insulin resistance | Dietary fibre | Metabolic syndrome | Diabetes type 2 | IMPROVES INSULIN SENSITIVITY | APPARENTLY HEALTHY-ADULTS | BETA-GLUCAN | FATTY LIVER-DISEASE | GRAIN INTAKE | BLOOD-PRESSURE | metabolic syndrome | BODY-WEIGHT | HIGH-GLYCEMIC INDEX | NUTRITION & DIETETICS | dietary fibre | diabetes type 2 | cardiovascular risk | dyslipidemia | hypertension | insulin resistance | TYPE-2 DIABETES-MELLITUS | obesity | ADIPOSE-TISSUE | Cardiovascular Diseases - etiology | Dietary Fiber - pharmacology | Obesity - complications | Cardiovascular Diseases - prevention & control | Humans | Risk Factors | Dietary Fiber - administration & dosage | Pressure effects | Body fat | Liver | Clinical trials | Body weight loss | Glucose | Epidemiology | Blood | Accumulation | Risk factors | Fibers | Glucose metabolism | Fatty liver | Renin | Polyphenols | Blood pressure | Lipid metabolism | Diabetes mellitus (non-insulin dependent) | Heart diseases | Medical research | Liver diseases | Statistical analysis | Diabetes mellitus | Weight loss | Health risks | Risk analysis | Metabolism | Insulin | Cholesterol | Weight control | Diet | Angiotensin | Health risk assessment | Dietary fiber | Cardiovascular diseases | Metabolic disorders | Cardiovascular disease | Lipids
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9. Full Text Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber
by Vitaglione, P and Mennella, I and Ferracane, R and Rivellese, A.A and Giacco, R and Ercolini, D and Gibbons, S.M and Storia, la, A and Gilbert, A.J and Jonnalagadda, S and Thielecke, F and Gallo, M.A and Scalfi, L and Fogliano, V
American Journal of Clinical Nutrition, ISSN 0002-9165, 2015, Volume 101, Issue 2, pp. 251 - 261
Background: Epidemiology associates whole-grain (WG) consumption with several health benefits. Mounting evidence suggests that WG wheat polyphenols play a role... 
Obesity | Inflammation | Bioavailability | Wholegrain wheat | Ferulic acid | METABOLIC SYNDROME | PHENOLIC-ACIDS | COFFEE CONSUMPTION | wholegrain wheat | ARABINOXYLAN FRACTIONS | MICROBIAL COMMUNITY | ferulic acid | NUTRITION & DIETETICS | bioavailability | inflammation | CARDIOVASCULAR-DISEASE | HYDROLASE ACTIVITY | HEMOSTATIC FACTORS | HUMAN GUT | obesity | Body Composition | Obesity - diet therapy | Life Style | Cholesterol - blood | Humans | Middle Aged | Tumor Necrosis Factor-alpha - blood | Dietary Fiber - administration & dosage | Interleukin-10 - blood | Male | Overweight - diet therapy | Inflammation - blood | Young Adult | Feces - microbiology | Inflammation - diet therapy | Triticum | Adult | Female | Edible Grain | Plasminogen Activator Inhibitor 1 - genetics | Polyphenols - blood | Body Mass Index | Polyphenols - urine | Feeding Behavior | Biomarkers - blood | Plasminogen Activator Inhibitor 1 - blood | Feces - chemistry | Diet | Triglycerides - blood | Polyphenols - administration & dosage | Food Quality and Design | VLAG
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10. Full Text Diets rich in whole grains increase betainized compounds associated with glucose metabolism
by Kärkkäinen, Olli and Lankinen, Maria A and Vitale, Marilena and Jokkala, Jenna and Leppänen, Jukka and Koistinen, Ville and Lehtonen, Marko and Giacco, Rosalba and Rosa-Sibakov, Natalia and Micard, Valérie and Rivellese, Angela A A and Schwab, Ursula and Mykkänen, Hannu and Uusitupa, Matti and Kolehmainen, Marjukka and Riccardi, Gabriele and Poutanen, Kaisa and Auriola, Seppo and Hanhineva, Kati
The American Journal of Clinical Nutrition, ISSN 0002-9165, 11/2018, Volume 108, Issue 5, pp. 971 - 979
ABSTRACT Background Epidemiologic evidence suggests that diets rich in whole grains are associated with a reduced risk of developing chronic diseases and... 
INSULIN | NUTRITION & DIETETICS | WHEAT ALEURONE | INFLAMMATION | MARKERS | FAT DIET | RANDOMIZED CONTROLLED-TRIAL | HEALTHY | ONE-CARBON METABOLISM | CARDIOVASCULAR RISK | CONSUMPTION | Glucose metabolism | Insulin resistance | Diet therapy | Chemical properties | Health aspects | Grain | Life Sciences | Food engineering
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11. Full Text Effects of a Plant-Based High-Carbohydrate/High-Fiber Diet Versus High–Monounsaturated Fat/Low-Carbohydrate Diet on Postprandial Lipids in Type 2 Diabetic Patients
by Claudia De Natale and Giovanni Annuzzi and Lutgarda Bozzetto and Raffaella Mazzarella and Giuseppina Costabile and Ornella Ciano and Gabriele Riccardi and Angela A. Rivellese
Diabetes Care, ISSN 0149-5992, 12/2009, Volume 32, Issue 12, pp. 2168 - 2173
Effects of a Plant-Based High-Carbohydrate/High-Fiber Diet Versus High–Monounsaturated Fat/Low-Carbohydrate Diet on Postprandial Lipids in Type 2 Diabetic... 
LIPEMIA | GLYCEMIC INDEX | METABOLISM | NONFASTING TRIGLYCERIDES | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | RISK | MELLITUS | SATURATED FAT | BLOOD-GLUCOSE CONTROL | ADIPOSE-TISSUE | Dietary Carbohydrates | Area Under Curve | Fatty Acids, Monounsaturated - administration & dosage | Humans | Middle Aged | Lipoproteins - blood | Energy Intake | Cross-Over Studies | Diabetes Mellitus, Type 2 - blood | Diet, Diabetic | Dietary Proteins | Lipids - blood | Postprandial Period | Triglycerides - blood | Chylomicrons - blood | Dietary Fiber | Lipoprotein Lipase - blood | Diet, Carbohydrate-Restricted | Diabetics | Diet therapy | Low-carbohydrate diet | Blood sugar | Analysis | Lipids | Diabetes | Research | Food and nutrition | Cholesterol | Diet | Dietary fiber | Disease control | Original Research
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12. Full Text Effects of whole-grain cereal foods on plasma short chain fatty acid concentrations in individuals with the metabolic syndrome
by Vetrani, Claudia, R.D and Costabile, Giuseppina, Ph.D and Luongo, Delia, B.Sc and Naviglio, Daniele, B.Sc and Rivellese, Angela A., M.D and Riccardi, Gabriele, M.D and Giacco, Rosalba, M.D
Nutrition, ISSN 0899-9007, 2016, Volume 32, Issue 2, pp. 217 - 221
Abstract Objective Short chain fatty acids (SCFAs) derived from dietary fiber fermentation by gut microbiota have been identified as one of the mechanisms... 
Gastroenterology and Hepatology | Propionate | Fiber fermentation | Cardiometabolic diseases | Inflammation | Postprandial insulin | Whole-grains | HEALTHY-SUBJECTS | ORGANIC-ACIDS | WHEAT | INSULIN SENSITIVITY | FIBER | NUTRITION & DIETETICS | GLUCOSE-METABOLISM | RESISTANT STARCH | CARDIOVASCULAR-DISEASE | GASTRIC-EMPTYING RATE | RYE | Acetates - blood | Humans | Middle Aged | Tumor Necrosis Factor-alpha - blood | Dietary Fiber - administration & dosage | Male | Butyrates - blood | Insulin - blood | Obesity - blood | Metabolic Syndrome - blood | C-Reactive Protein - metabolism | Interleukin-6 - blood | Postprandial Period | Whole Grains | Cholesterol, LDL - blood | Female | Body Mass Index | Biomarkers - blood | Energy Intake | Interleukin-1alpha - blood | Propionates - blood | Diet | Overweight - blood | Triglycerides - blood | Cholesterol, HDL - blood | Patient Compliance | Blood Glucose - metabolism | Fatty Acids, Volatile - blood | Microbiota (Symbiotic organisms) | Fermentation | Fatty acids | Analysis | Correlation | Fasting | Cytokines | Grain | Health risks | Triglycerides | Metabolism | Metabolic syndrome | Insulin | Metabolites | Dietary fiber | Wheat | Metabolic disorders
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13. Full Text Cardiovascular effects of pioglitazone or sulphonylureas according to pretreatment risk: moving towards personalized care
by Vaccaro, Olga and Lucisano, Giuseppe and Masulli, Maria and Bonora, Enzo and Del Prato, Stefano and Rivellese, Angela A and Giorda, Carlo B and Mocarelli, Paolo and Squatrito, Sebastiano and Maggioni, Aldo P and Riccardi, Gabriele and Nicolucci, Antonio
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 05/2019
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14. Full Text Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial
by Vaccaro, Olga and Masulli, Maria and Nicolucci, Antonio and Bonora, Enzo and Del Prato, Stefano and Maggioni, Aldo Pietro and Maggioni, Aldo P and Rivellese, Angela A and Rivellese, Angela Albarosa and Squatrito, Sebastiano and Giorda, Carlo B and Sesti, Giorgio and Mocarelli, Paolo and Lucisano, Giuseppe and Sacco, Michele and Signorini, Stefano and Cappellini, Fabrizio and Perriello, Gabriele and Babini, Massimiliano and Babini, Anna Carla and Lapolla, Annunziata and Gregori, Giovanna and Giordano, Carla and Corsi, Simona and Corsi, Laura and Corsi, Anna and Buzzetti, Raffaella and Clemente, Gennaro and Di Cianni, Graziano and Iannarelli, Rossella and Cordera, Renzo and La Macchia, Olga and Zamboni, Chiara and Scaranna, Cristiana and Boemi, Massimo and Iovine, Ciro and Lauro, Davide and Leotta, Sergio and Dall'Aglio, Elisabetta and Cannarsa, Emanuela and Tonutti, Laura and Pugliese, Giuseppe and Bossi, Antonio C and Bossi, Antonio Carlo and Anichini, Roberto and Dotta, Francesco and Di Benedetto, Antonino and Citro, Giuseppe and Antenucci, Daniela and Ricci, Lucia and Giorgino, Francesco and Santini, Costanza and Gnasso, Agostino and De Cosmo, Salvatore and Zavaroni, Donatella and Vedovato, Monica and Consoli, Agostino and Calabrese, Maria and di Bartolo, Paolo and Fornengo, Paolo and Riccardi, Gabriele and D'Angelo, Federica and D'Angelo, Paola and Giansanti, Roberto and Tanase, Laura and Lanari, Luigi and Testa, Ivano and Pancani, Francesca and Ranchelli, Anna and Vagheggi, Paolo and Scatona, Alessia and Fontana, Lucia and Laviola, Luigi and Tarantino, Lucia and Ippolito, Claudia and Ippolito, Giulio and Gigantelli, Vittoria and Manicone, Mariangela and Conte, Eleonora and Trevisan, Roberto and Rota, Giuseppe and Rota, Rossella and Dodesini, Alessandro R and Reggiani, Giulio Marchesini and Montesi, Luca and Mazzella, Natalia and Forlani, Gabriele and Caselli, Chiara and Di Luzio, Raffaella and Mazzotti, Arianna and Aiello, Antimo and Barrea, Angelina and Musto, Antonio and D'Amico, Fiorentina and Sinagra, Tiziana and Longhitano, Sara and Trowpea, Vanessa and Sparti, Maria and Italia, Salvatore and Lisi, Enrico and ... and Thizolidinediones Sulfonylureas Ca and Italian Diabetes Society and Thiazolidinediones Or Sulfonylureas Cardiovascular Accidents Intervention Trial (TOSCA.IT) study group
The Lancet Diabetes & Endocrinology, ISSN 2213-8587, 11/2017, Volume 5, Issue 11, pp. 887 - 897
The best treatment option for patients with type 2 diabetes in whom treatment with metformin alone fails to achieve adequate glycaemic control is debated. We... 
MORTALITY | INSULIN | GLYCEMIC CONTROL | IMPACT | METAANALYSIS | GLUCOSE-LOWERING DRUGS | ENDOCRINOLOGY & METABOLISM | FOLLOW-UP | RISK | GLIMEPIRIDE | Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - etiology | Metformin - therapeutic use | Cardiovascular Diseases - drug therapy | Humans | Middle Aged | Pioglitazone | Sulfonylurea Compounds - therapeutic use | Male | Treatment Outcome | Diabetes Mellitus, Type 2 - epidemiology | Incidence | Thiazolidinediones - therapeutic use | Cardiovascular Diseases - epidemiology | Female | Aged | Drug Therapy, Combination | Diabetes Mellitus, Type 2 - complications
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