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1. Full Text Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease
by Philips, Thomas, MSc and Robberecht, Wim, Prof
Lancet Neurology, The, ISSN 1474-4422, 2011, Volume 10, Issue 3, pp. 253 - 263
Summary Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) are characterised by the... 
Neurology | TRANSGENIC-MOUSE MODEL | GLUTAMATE TRANSPORTER EAAT2 | WILD-TYPE MICROGLIA | COLONY-STIMULATING FACTOR | MARROW-DERIVED CELLS | SPINAL-CORD TISSUE | NECROSIS-FACTOR-ALPHA | CENTRAL-NERVOUS-SYSTEM | ALS MODEL | MUTANT SUPEROXIDE-DISMUTASE | CLINICAL NEUROLOGY | Amyotrophic Lateral Sclerosis - immunology | T-Lymphocytes - physiology | Inflammation - metabolism | Motor Neuron Disease - metabolism | Animals | Humans | Amyotrophic Lateral Sclerosis - metabolism | Motor Neuron Disease - immunology | Neuroglia - immunology | Neuroglia - metabolism | Signal Transduction - physiology | Inflammation - immunology | Animal models | Parkinson's disease | Neurodegenerative diseases | Astrocytes | Therapeutic applications | Medical importance | Motor neuron disease | Transgenic mice | Amyotrophic lateral sclerosis | Inflammation | Neuronal-glial interactions | Microglial cells | Alzheimer's disease | Movement disorders
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2. Full Text The changing scene of amyotrophic lateral sclerosis
by Robberecht, Wim and Philips, Thomas
Nature Reviews Neuroscience, ISSN 1471-003X, 04/2013, Volume 14, Issue 4, pp. 248 - 264
Several recent breakthroughs have provided notable insights into the pathogenesis of amyotrophic lateral sclerosis (ALS), with some even shifting our thinking... 
HEXANUCLEOTIDE REPEAT EXPANSION | VALOSIN-CONTAINING PROTEIN | MOTOR-NEURON DEGENERATION | SPINAL MUSCULAR-ATROPHY | MAMMALIAN STRESS GRANULES | NUCLEAR FACTOR TDP-43 | POPULATION-BASED COHORT | FRONTOTEMPORAL LOBAR DEGENERATION | LENGTH POLYGLUTAMINE EXPANSIONS | TRANSGENIC MOUSE MODEL | NEUROSCIENCES | Frontotemporal Dementia - genetics | RNA-Binding Proteins - genetics | Animals | Amyotrophic Lateral Sclerosis - genetics | Humans | Amyotrophic Lateral Sclerosis - diagnosis | Amyotrophic Lateral Sclerosis - etiology | Frontotemporal Dementia - diagnosis | Mutation - genetics | Causes of | Complications and side effects | Amyotrophic lateral sclerosis | Development and progression | Care and treatment | Research
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3. Full Text The phenotypic variability of amyotrophic lateral sclerosis
by Swinnen, Bart and Robberecht, Wim
Nature Reviews Neurology, ISSN 1759-4758, 11/2014, Volume 10, Issue 11, pp. 661 - 670
Classic textbook neurology teaches that amyotrophic lateral sclerosis (ALS) is a degenerative disease that selectively affects upper and lower motor neurons... 
PROGRESSIVE MUSCULAR-ATROPHY | FLAIL ARM SYNDROME | ALS | COGNITIVE IMPAIRMENT | MOTONEURON DISEASE | CLINICAL-FEATURES | FRONTOTEMPORAL LOBAR DEGENERATION | NATURAL-HISTORY | HEXANUCLEOTIDE REPEAT | SUPEROXIDE-DISMUTASE | CLINICAL NEUROLOGY | Frontotemporal Dementia - genetics | Frontotemporal Dementia - physiopathology | Frontotemporal Dementia - complications | Phenotype | Amyotrophic Lateral Sclerosis - physiopathology | Amyotrophic Lateral Sclerosis - genetics | Humans | Frontotemporal Lobar Degeneration - genetics | Frontotemporal Lobar Degeneration - physiopathology | Disease Progression | Frontotemporal Lobar Degeneration - complications | Amyotrophic Lateral Sclerosis - complications | Care and treatment | Gene mutations | Patient outcomes | Analysis | Physiological aspects | Amyotrophic lateral sclerosis | Genetic aspects | Research
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4. Full Text ELP3 Controls Active Zone Morphology by Acetylating the ELKS Family Member Bruchpilot
by Miśkiewicz, Katarzyna and Jose, Liya E and Bento-Abreu, André and Fislage, Marcus and Taes, Ines and Kasprowicz, Jarosław and Swerts, Jef and Sigrist, Stephan and Versées, Wim and Robberecht, Wim and Verstreken, Patrik
Neuron, ISSN 0896-6273, 2011, Volume 72, Issue 5, pp. 776 - 788
Elongator protein 3 (ELP3) acetylates histones in the nucleus but also plays a role in the cytoplasm. Here, we report that in neurons, ELP3 is necessary and... 
DROSOPHILA NEUROMUSCULAR-JUNCTION | IN-VIVO | SYNAPTIC-TRANSMISSION | CALCIUM INDICATORS | NEURAL ACTIVITY | QUANTAL CONTENT | RELEASE SITES | HISTONE ACETYLATION | NEUROSCIENCES | ACETYLTRANSFERASE | PLASTICITY | Embryo, Mammalian | Neuromuscular Junction - metabolism | Humans | Histone Acetyltransferases - genetics | Green Fluorescent Proteins - genetics | Presynaptic Terminals - ultrastructure | Drosophila Proteins - metabolism | Tubulin - metabolism | Transfection - methods | Histone Acetyltransferases - metabolism | Acetylation | Acetyltransferases | Microscopy, Electron, Transmission | Animals, Genetically Modified | Drosophila | Zebrafish | Presynaptic Terminals - physiology | Mutation - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Patch-Clamp Techniques | Animals | Larva | Drosophila Proteins - genetics | Cell Line, Transformed | Neuromuscular Junction - physiology | Histones | Neurons | DNA binding proteins | Proteins | Mutation | Grants | Insects | Cytoplasm
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5. Full Text Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
by Jovičič, Ana and Mertens, Jerome and Boeynaems, Steven and Bogaert, Elke and Chai, Noori and Yamada, Shizuka B and Paul, Joseph W and Sun, Shuying and Herdy, Joseph R and Bieri, Gregor and Kramer, Nicholas J and Gage, Fred H and Van Den Bosch, Ludo and Robberecht, Wim and Gitler, Aaron D
Nature Neuroscience, ISSN 1097-6256, 08/2015, Volume 18, Issue 9, pp. 1226 - 1229
C9orf72 mutations are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Dipeptide repeat proteins (DPRs) produced... 
HUMAN NEURONS | IN-VITRO | C9FTD/ALS | EXPANSIONS | ALS | FUS MUTATIONS | PATHOLOGY | PROTEINS | HEXANUCLEOTIDE REPEAT | NEUROSCIENCES | RNA FOCI | Frontotemporal Dementia - genetics | Yeasts | DNA Repeat Expansion - physiology | Active Transport, Cell Nucleus - physiology | Amyotrophic Lateral Sclerosis - genetics | Humans | Cells, Cultured | Frontotemporal Dementia - metabolism | Proteins - genetics | Animals | Cell Nucleus - metabolism | Proteins - metabolism | Cell Nucleus - genetics | Gene Deletion | Amyotrophic Lateral Sclerosis - metabolism | C9orf72 Protein | Mice | Dipeptides - metabolism | Dipeptides - genetics | Gene mutations | Amyotrophic lateral sclerosis | Genetic aspects | Research | Frontotemporal dementia | Health aspects | Risk factors | Index Medicus
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6. Full Text Modelling amyotrophic lateral sclerosis: Progress and possibilities
by Van Damme, Philip and Robberecht, Wim and Van Den Bosch, Ludo
DMM Disease Models and Mechanisms, ISSN 1754-8403, 05/2017, Volume 10, Issue 5, pp. 537 - 549
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that primarily affects the motor system and presents with progressive muscle weakness. Most... 
Zebrafish | C. elegans | Fruit fly | Motor neuron | Neurodegeneration | IPSCs | DROSOPHILA MODEL | MOTOR-NEURON DISEASE | PATHOLOGY | FRONTOTEMPORAL LOBAR DEGENERATION | FAMILIAL ALS | CELL BIOLOGY | iPSCs | RODENT MODELS | DIPEPTIDE-REPEAT PROTEINS | MUTANT SOD1 | SUPEROXIDE-DISMUTASE | GENOME-WIDE ASSOCIATION | NUCLEOCYTOPLASMIC TRANSPORT | Amyotrophic Lateral Sclerosis - pathology | Genetic Predisposition to Disease | Animals | Amyotrophic Lateral Sclerosis - genetics | Humans | Mutation | Disease Models, Animal | 302 | Review
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7. Full Text Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study
by Shatunov, Aleksey, PhD and Mok, Kin, MSc and Newhouse, Stephen, PhD and Weale, Michael E, PhD and Smith, Bradley, PhD and Vance, Caroline, PhD and Johnson, Lauren, PhD and Veldink, Jan H, MD and van Es, Michael A, MD and van den Berg, Leonard H, Prof and Robberecht, Wim, Prof and Van Damme, Philip, MD and Hardiman, Orla, Prof and Farmer, Anne E, Prof and Lewis, Cathryn M, Prof and Butler, Amy W, PhD and Abel, Olubunmi, MSc and Andersen, Peter M, Prof and Fogh, Isabella, PhD and Silani, Vincenzo, Prof and Chiò, Adriano, MD and Traynor, Bryan J, MD and Melki, Judith, Prof and Meininger, Vincent, Prof and Landers, John E, PhD and McGuffin, Peter, Prof and Glass, Jonathan D, MD and Pall, Hardev, MD and Leigh, P Nigel, Prof and Hardy, John, Prof and Brown, Robert H, Prof and Powell, John F, DPhil and Orrell, Richard W, MD and Morrison, Karen E, Prof and Shaw, Pamela J, Prof and Shaw, Christopher E, Prof and Al-Chalabi, Ammar, Prof and Medicinska fakulteten and Institutionen för farmakologi och klinisk neurovetenskap and Neurologi and Umeå universitet
Lancet Neurology, The, ISSN 1474-4422, 2010, Volume 9, Issue 10, pp. 986 - 994
Summary Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motor neurons that results in progressive weakness and death from... 
Neurology | POPULATION | DEMENTIA | GENE | SUSCEPTIBILITY | ALS | LOCI | FRONTOTEMPORAL LOBAR DEGENERATION | COPY NUMBER VARIATION | LINKAGE | IRISH | CLINICAL NEUROLOGY | Frontotemporal Dementia - genetics | United States - epidemiology | Amyotrophic Lateral Sclerosis - genetics | Humans | Middle Aged | Europe - epidemiology | Case-Control Studies | Chromosomes, Human, Pair 9 - genetics | Internationality | Aged, 80 and over | Polymorphism, Single Nucleotide - genetics | Aged | Genome-Wide Association Study - methods | Frontotemporal Dementia - epidemiology | United Kingdom - epidemiology | Amyotrophic Lateral Sclerosis - epidemiology | Cohort Studies | Genetic research | Amyotrophic lateral sclerosis | Analysis | Genomics | Risk factors | Fast track
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8. Full Text HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease
by D'Ydewalle, Constantin and Krishnan, Jyothsna and Chiheb, Driss M and Van Damme, Philip and Irobi, Joy and Kozikowski, Alan P and Berghe, Pieter Vanden and Timmerman, Vincent and Robberecht, Wim and Van Den Bosch, Ludo
Nature Medicine, ISSN 1078-8956, 08/2011, Volume 17, Issue 8, pp. 968 - 974
Charcot-Marie-Tooth disease (CMT) is the most common inherited disorder of the peripheral nervous system. Mutations in the 27-kDa small heat-shock protein gene... 
MEDICINE, RESEARCH & EXPERIMENTAL | NERVOUS-SYSTEM | NEUROFILAMENT NETWORK | MITOFUSIN 2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUBULIN ACETYLATION | HEREDITARY MOTOR NEUROPATHY | CELL BIOLOGY | MITOCHONDRIAL TRANSPORT | HEAT-SHOCK PROTEINS | GAIT ANALYSIS | CELLULAR FUNCTIONS | TRANSGENIC MICE | Immunohistochemistry | Age Factors | Enzyme-Linked Immunosorbent Assay | Histone Deacetylase 6 | Axons - drug effects | Histone Deacetylases - metabolism | Mice, Transgenic | Charcot-Marie-Tooth Disease - drug therapy | Blotting, Western | Mutation, Missense - genetics | Action Potentials - physiology | Heat-Shock Proteins - genetics | Acetylation - drug effects | Rotarod Performance Test | Tubulin - metabolism | Animals | Analysis of Variance | Histone Deacetylase Inhibitors - pharmacology | Mice | Charcot-Marie-Tooth Disease - physiopathology | Neoplasm Proteins - genetics | Gait - genetics | Neuromuscular Junction - pathology | Gene mutations | Charcot-Marie-Tooth disease | Heat shock proteins | Physiological aspects | Genetic aspects | Research | Tubulins | Proteins | Nervous system | Mutation | Transgenic animals | Genes | Rodents
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9. Full Text Progressive Multifocal Leukoencephalopathy after Natalizumab Therapy for Crohn's Disease
by Van Assche, Gert and Van Ranst, Marc and Sciot, Raf and Dubois, Bénédicte and Vermeire, Séverine and Noman, Maja and Verbeeck, Jannick and Geboes, Karel and Robberecht, Wim and Rutgeerts, Paul
The New England Journal of Medicine, ISSN 0028-4793, 07/2005, Volume 353, Issue 4, pp. 362 - 368
In a man with Crohn's disease who was treated with natalizumab and subsequently died, reexamination showed that the fatal lesion was progressive multifocal... 
Natalizumab | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Brain - virology | Antibodies, Monoclonal - therapeutic use | Male | Opportunistic Infections - chemically induced | Viral Load | Antibodies, Monoclonal, Humanized | Leukoencephalopathy, Progressive Multifocal - chemically induced | Diagnostic Errors | Fatal Outcome | Leukocyte Count | Astrocytoma - diagnosis | JC Virus - genetics | Brain Neoplasms - diagnosis | Genotype | Integrin alpha4 - immunology | DNA, Viral - blood | Magnetic Resonance Imaging | Crohn Disease - drug therapy | JC Virus - isolation & purification | Brain - pathology | Leukoencephalopathy, Progressive Multifocal - pathology | Opportunistic Infections - pathology | Case studies | Crohn's disease | Drug therapy | Leukoencephalopathy, Progressive multifocal | Monoclonal antibodies | Leukemia | Neurological disorders | Crohns disease
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