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1. Full Text Circulating branched‐chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents
by McCormack, S. E and Shaham, O and McCarthy, M. A and Deik, A. A and Wang, T. J and Gerszten, R. E and Clish, C. B and Mootha, V. K and Grinspoon, S. K and Fleischman, A
Pediatric obesity, ISSN 2047-6302, 02/2013, Volume 8, Issue 1, pp. 52 - 61
paediatric obesity | metabolomics | insulin resistance | Branched‐chain amino acids | Metabolomics | Insulin resistance | Branched-chain amino acids | Paediatric obesity | Life Sciences & Biomedicine | Pediatrics | Science & Technology | Predictive Value of Tests | Humans | Male | Insulin - blood | Obesity - blood | Diabetes Mellitus, Type 2 - epidemiology | Fasting - blood | Child Nutrition Disorders - prevention & control | Female | Obesity - etiology | Child | Insulin Secretion | Body Mass Index | Isoleucine - blood | Valine - blood | Cross-Sectional Studies | Leucine - blood | Child Nutrition Disorders - blood | Diabetes Mellitus, Type 2 - prevention & control | Insulin Resistance | Biomarkers - blood | Child Nutrition Disorders - epidemiology | Massachusetts - epidemiology | Diabetes Mellitus, Type 2 - blood | Insulin - metabolism | Obesity - epidemiology | Obesity - prevention & control | Adolescent | Amino Acids, Branched-Chain - blood | Blood Glucose - metabolism | Longitudinal Studies | Branched chain amino acids | Obesity in children | Obesity | Body mass index | Diabetes | Insulin | Index Medicus | pediatric obesity | type 2 diabetes | branched-chain amino acids
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2. Full Text MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis
by S. Hani Najafi-Shoushtari and Fjoralba Kristo and Yingxia Li and Toshi Shioda and David E. Cohen and Robert E. Gerszten and Anders M. Näär
Science (American Association for the Advancement of Science), ISSN 0036-8075, 6/2010, Volume 328, Issue 5985, pp. 1566 - 1569
MicroRNA | Genes | HDL lipoproteins | REPORTS | Cell lines | Stem cells | Journalism | Gene expression regulation | Mice | Macrophages | Cholesterols | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cardiology. Vascular system | Biological and medical sciences | Medical sciences | Up-Regulation | Humans | Homeostasis | MicroRNAs - metabolism | Sterol Regulatory Element Binding Proteins - genetics | ATP-Binding Cassette Transporters - genetics | RNA Interference | ATP-Binding Cassette Transporters - metabolism | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | 3' Untranslated Regions | ATP Binding Cassette Transporter 1 | Sterol Regulatory Element Binding Protein 1 - metabolism | Cell Line | Oligonucleotides, Antisense - pharmacology | Introns | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Sterol Regulatory Element Binding Proteins - metabolism | Cholesterol - metabolism | Macrophages - metabolism | Animals | Diet | Sterol Regulatory Element Binding Protein 1 - genetics | Cholesterol, HDL - blood | MicroRNAs - genetics | Physiological aspects | Genetic aspects | Binding proteins | Cholesterol | Biosynthesis | Cellular biology | Ribonucleic acid--RNA | Gene expression | Index Medicus
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3. Full Text The Emerging Role of Metabolomics in the Diagnosis and Prognosis of Cardiovascular Disease
by Ussher, John R and Elmariah, Sammy and Gerszten, Robert E and Dyck, Jason R.B
Journal of the American College of Cardiology, ISSN 0735-1097, 12/2016, Volume 68, Issue 25, pp. 2850 - 2870
ischemic heart disease | heart failure | diagnostics | diabetes mellitus | energy metabolism | obesity | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Biomarkers - metabolism | Prognosis | Cardiovascular Diseases - metabolism | Humans | Energy Metabolism - physiology | Metabolomics - methods | Cardiovascular Diseases - diagnosis | Heart failure | Carbohydrates | Nuclear magnetic resonance--NMR | Dehydrogenases | Pathogenesis | Cardiomyopathy | Cardiovascular disease | Amino acids | Metabolism | Fatty acids | Patients | Chromatography | Signal transduction | Musculoskeletal system | Energy resources | Metabolites | Biopsy | Medical prognosis | Oxidation | Scientific imaging | Diabetes | Mass spectrometry
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4. Full Text Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis
by Wagschal, Alexandre and Najafi-Shoushtari, S Hani and Wang, Lifeng and Goedeke, Leigh and Sinha, Sumita and Delemos, Andrew S and Black, Josh C and Ramírez, Cristina M and Li, Yingxia and Tewhey, Ryan and Hatoum, Ida and Shah, Naisha and Lu, Yong and Kristo, Fjoralba and Psychogios, Nikolaos and Vrbanac, Vladimir and Lu, Yi-Chien and Hla, Timothy and De Cabo, Rafael and Tsang, John S and Schadt, Eric and Sabeti, Pardis C and Kathiresan, Sekar and Cohen, David E and Whetstine, Johnathan and Chung, Raymond T and Fernández-Hernando, Carlos and Kaplan, Lee M and Bernards, Andre and Gerszten, Robert E and Näär, Anders M
Nature medicine, ISSN 1078-8956, 11/2015, Volume 21, Issue 11, pp. 1290 - 1297
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Dyslipidemias - genetics | Genome-Wide Association Study | Cholesterol, HDL - metabolism | Humans | Mice, Inbred C57BL | Receptors, LDL - metabolism | Cholesterol - metabolism | ATP Binding Cassette Transporter 1 - metabolism | Mice, Knockout | Triglycerides - metabolism | Animals | Apolipoproteins E - genetics | Diet, High-Fat | Lipoproteins - metabolism | Cholesterol, LDL - metabolism | Mice | MicroRNAs - genetics | Polymorphism, Single Nucleotide | Homeostasis - genetics | Genome-wide association studies | MicroRNA | Analysis | Physiological aspects | Triglycerides | Genetic aspects | Research | Cholesterol | Homeostasis | Genomics | MicroRNAs | Index Medicus
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5. Full Text Early Increases in Multiple Biomarkers Predict Subsequent Cardiotoxicity in Patients With Breast Cancer Treated With Doxorubicin, Taxanes, and Trastuzumab
by Ky, Bonnie and Putt, Mary and Sawaya, Heloisa and French, Benjamin and Januzzi, James L and Sebag, Igal A and Plana, Juan Carlos and Cohen, Victor and Banchs, Jose and Carver, Joseph R and Wiegers, Susan E and Martin, Randolph P and Picard, Michael H and Gerszten, Robert E and Halpern, Elkan F and Passeri, Jonathan and Kuter, Irene and Scherrer-Crosbie, Marielle
Journal of the American College of Cardiology, ISSN 0735-1097, 03/2014, Volume 63, Issue 8, pp. 809 - 816
chemotherapy cardiotoxicity | trastuzumab cardiotoxicity | cardio-oncology | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Predictive Value of Tests | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Troponin I - blood | Antibodies, Monoclonal, Humanized - administration & dosage | Time Factors | Cardiovascular Diseases - blood | Adult | Female | Taxoids - adverse effects | Cardiovascular Diseases - diagnosis | Doxorubicin - administration & dosage | Antibodies, Monoclonal, Humanized - adverse effects | Treatment Outcome | Biomarkers - blood | Breast Neoplasms - drug therapy | Taxoids - administration & dosage | Breast Neoplasms - blood | Breast Neoplasms - diagnosis | Cardiovascular Diseases - chemically induced | Peroxidase - blood | Doxorubicin - adverse effects | Trastuzumab | Cohort Studies | Medical research | Breast cancer | Drug therapy | Cancer therapies | Index Medicus | Abridged Index Medicus
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6. Full Text The search for new cardiovascular biomarkers
by Gerszten, Robert E and Wang, Thomas J
Nature (London), ISSN 0028-0836, 02/2008, Volume 451, Issue 7181, pp. 949 - 952
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cardiovascular System - physiopathology | Cardiovascular System - metabolism | Humans | Risk Factors | Biomarkers - analysis | Proteomics | ROC Curve | Transcription, Genetic | Measurement | Care and treatment | Blood pressure | Research | Cardiovascular diseases | Pharmaceutical industry | Health aspects | Risk factors | Pathology | Medical research | Cardiovascular disease | Index Medicus
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7. Full Text MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions
by Ding, Han A and Rosenzweig, Anthony and Gimbrone, Michael A and Lim, Yaw-Chyn and Gerszten, Robert E and Luster, Andrew D and Luscinskas, Francis W and Garcia-Zepeda, Eduardo A and Yoshida, Masayuki
Nature (London), ISSN 0028-0836, 04/1999, Volume 398, Issue 6729, pp. 718 - 723
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Molecular and cellular biology | Cell interactions, adhesion | Gene Transfer Techniques | Receptors, Leukocyte-Adhesion - physiology | Humans | Cells, Cultured | Interleukin-8 - physiology | Vascular Cell Adhesion Molecule-1 - physiology | Chemotaxis, Leukocyte - physiology | Endothelium, Vascular - physiology | Cell Adhesion - physiology | Chemokine CCL2 - physiology | Vascular Cell Adhesion Molecule-1 - genetics | E-Selectin - physiology | Monocytes - physiology | Umbilical Veins - cytology | Chemoreceptors | Monocytes | Research | Proteins | Rodents | Anatomy & physiology | Index Medicus
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8. Full Text β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors
by Roberts, Lee D and Boström, Pontus and O’Sullivan, John F and Schinzel, Robert T and Lewis, Gregory D and Dejam, Andre and Lee, Youn-Kyoung and Palma, Melinda J and Calhoun, Sondra and Georgiadi, Anastasia and Chen, Ming-Huei and Ramachandran, Vasan S and Larson, Martin G and Bouchard, Claude and Rankinen, Tuomo and Souza, Amanda L and Clish, Clary B and Wang, Thomas J and Estall, Jennifer L and Soukas, Alexander A and Cowan, Chad A and Spiegelman, Bruce M and Gerszten, Robert E
Cell metabolism, ISSN 1550-4131, 01/2014, Volume 19, Issue 1, pp. 96 - 108
Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Organ Specificity - drug effects | Transcription, Genetic - drug effects | Metabolic Diseases - pathology | Adipocytes, Brown - metabolism | Humans | Adipose Tissue, White - metabolism | Cardiovascular Diseases - pathology | Organ Specificity - genetics | Adipocytes, White - drug effects | Adipose Tissue, White - cytology | Exercise | Liver - drug effects | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Oxidation-Reduction - drug effects | Weight Gain - drug effects | Physical Conditioning, Animal | Aminoisobutyric Acids - pharmacology | Induced Pluripotent Stem Cells - metabolism | Adipocytes, Brown - pathology | Glucose Tolerance Test | Cardiovascular Diseases - metabolism | Induced Pluripotent Stem Cells - drug effects | Adipocytes, Brown - drug effects | Liver - metabolism | Risk Factors | Aminoisobutyric Acids - blood | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Adipose Tissue, Brown - cytology | Phenotype | Adipocytes, White - pathology | Animals | Metabolic Diseases - metabolism | Cell Differentiation - drug effects | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Mice | PPAR alpha - metabolism | Adipocytes, White - metabolism | Adipose Tissue, White - drug effects | Index Medicus | Medicin och hälsovetenskap
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9. Full Text Early Detection and Prediction of Cardiotoxicity in Chemotherapy-Treated Patients
by Sawaya, Heloisa, MD, PhD and Sebag, Igal A., MD and Plana, Juan Carlos, MD and Januzzi, James L., MD and Ky, Bonnie, MD and Cohen, Victor, MD and Gosavi, Sucheta, MD and Carver, Joseph R., MD and Wiegers, Susan E., MD and Martin, Randolph P., MD and Picard, Michael H., MD and Gerszten, Robert E., MD and Halpern, Elkan F., PhD and Passeri, Jonathan, MD and Kuter, Irene, MD and Scherrer-Crosbie, Marielle, MD, PhD
The American journal of cardiology, ISSN 0002-9149, 2011, Volume 107, Issue 9, pp. 1375 - 1380
Cardiovascular | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiology. Vascular system | Biological and medical sciences | Medical sciences | Antibodies, Monoclonal - toxicity | Echocardiography | Anthracyclines - toxicity | Humans | Treatment Outcome | Troponin C - blood | Breast Neoplasms - drug therapy | Ventricular Dysfunction, Left - chemically induced | Antineoplastic Agents - toxicity | Antineoplastic Combined Chemotherapy Protocols - toxicity | Stroke Volume | Antibodies, Monoclonal, Humanized | Ventricular Dysfunction, Left - blood | Adult | Female | Natriuretic Peptide, Brain - blood | Trastuzumab | Chemotherapy | Ultrasonic imaging | Toxicity | Mortality | Biomarkers | Breast cancer | Medical diagnosis | Index Medicus | Abridged Index Medicus
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