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1994, Volume 23, no. 1., xvii, 233
Book
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 02/2010, Volume 28, Issue 5, pp. 767 - 772
Purpose There is no effective therapy for patients with distant metastasis of medullary thyroid carcinoma (MTC). Activating mutations in the RET proto-oncogene... 
MALIGNANT-TUMORS | ANGIOGENESIS | ONCOLOGY | GROWTH | MUTATIONS | INHIBITOR | CARCINOMA | EXPRESSION | RET PROTOONCOGENE | ZD6474 | KINASES | Carcinoembryonic Antigen - blood | United States | Humans | Middle Aged | Carcinoma, Medullary - metabolism | Male | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Young Adult | Carcinoma, Medullary - drug therapy | Carcinoma, Medullary - secondary | Time Factors | Antineoplastic Agents - adverse effects | Germ-Line Mutation | Adult | Female | Quinazolines - administration & dosage | France | Proto-Oncogene Proteins c-ret - antagonists & inhibitors | Calcitonin - blood | Genetic Predisposition to Disease | Piperidines - administration & dosage | Thyroid Neoplasms - mortality | Carcinoma, Medullary - mortality | Drug Administration Schedule | Administration, Oral | Carcinoma, Medullary - genetics | Risk Factors | Kaplan-Meier Estimate | Treatment Outcome | Biomarkers, Tumor - blood | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Thyroid Neoplasms - genetics | Thyroid Neoplasms - drug therapy | Pedigree | Piperidines - adverse effects | Quinazolines - adverse effects | Aged | Proto-Oncogene Proteins c-ret - genetics | Thyroid Neoplasms - metabolism | Thyroid Neoplasms - pathology | Index Medicus | Hnc7 | Original Reports | Endo7 | To8
Journal Article
Journal Article
Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, 03/2017, Volume 102, Issue 3, pp. 933 - 941
Context: Medullary thyroid cancer (MTC) is an aggressive tumor that harbors activating mutations of the RET proto-oncogene. We previously reported that RET... 
APOPTOSIS | ONCOGENE | 2A MUTATION | ENDOCRINOLOGY & METABOLISM | RECEPTOR | CARCINOMA | PROTOONCOGENE | TRANSGENIC MICE | CELL-DEATH | Immunohistochemistry | Proto-Oncogene Proteins c-ret - metabolism | Apoptosis - drug effects | Humans | Middle Aged | Cell Survival - genetics | Apoptosis - genetics | Male | Young Adult | Ubiquitination - drug effects | HEK293 Cells | Aged, 80 and over | Adult | Female | Indoles - pharmacology | Thyroid Gland - cytology | Genes, Tumor Suppressor | Real-Time Polymerase Chain Reaction | Thyroid Gland - drug effects | Carcinoma, Neuroendocrine - metabolism | Cell Survival - drug effects | Cell Proliferation - genetics | Kaplan-Meier Estimate | Activating Transcription Factor 4 - genetics | Carcinoma, Neuroendocrine - genetics | Blotting, Western | Mice, Knockout | Thyroid Neoplasms - genetics | Pyrroles - pharmacology | Animals | Activating Transcription Factor 4 - metabolism | Adolescent | Anilides - pharmacology | Aged | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Thyroid Gland - metabolism | Ubiquitination - genetics | Thyroid Neoplasms - metabolism | Prognosis | Transcription | Hyperplasia | AKT protein | Thyroid gland | Gene deletion | Kinases | Western blotting | Degradation | Proteins | Ubiquitination | Ret protein | Clonal deletion | Deletion | Protein-tyrosine kinase | Thyroid | Expression vectors | Tyrosine | Cell survival | Activating transcription factor 4 | Extracellular signal-regulated kinase | Patients | Survival | Signaling | Thyroid cancer | Cell death | Medical prognosis | Tumor suppressor genes | Mutation | Cellular stress response | Tumors | Cancer | Apoptosis
Journal Article
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 08/2017, Volume 102, Issue 8, pp. 2807 - 2813
Journal Article
Journal Article
Endocrine-related cancer, ISSN 1351-0088, 02/2019, Volume 26, Issue 2, pp. 241 - 250
Vandetanib is an oral tyrosine kinase inhibitor approved for treatment of advanced symptomatic or progressive medullary thyroid cancer (MTC). The current study... 
medullary thyroid cancer | vandetanib | safety | efficacy | SURVIVAL | MANAGEMENT | ONCOLOGY | GUIDELINES | ENDOCRINOLOGY & METABOLISM | CARCINOMA | ZD6474
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, p. e0180547
Journal Article