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Thorax, ISSN 0040-6376, 2017, Volume 72, Issue 5, pp. 359 - 390
Journal Article
Cytokine, ISSN 1043-4666, 09/2013, Volume 63, Issue 3, p. 268
The 2',5'-oligoadenylate (2-5A) synthetase (OAS)-RNase L system is an interferon inducible pathway that blocks virus infections by cleaving viral and cellular... 
Virus diseases | Ribonuclease
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 04/2012, Volume 109, Issue 15, pp. E869 - E878
IRE1 couples endoplasmic reticulum unfolded protein load to RNA cleavage events that culminate in the sequence-specific splicing of the Xbp1 mRNA and in the... 
High-throughput screening | 8-formyl-umbelliferone | Aldehydes | Reversible covalent inhibitor | Unfolded protein response | reversible covalent inhibitor | ACTIVATION | UNFOLDED-PROTEIN RESPONSE | ER-STRESS | MULTIDISCIPLINARY SCIENCES | high-throughput screening | KINASE | IRE1-ALPHA | TRANSCRIPTION FACTOR XBP-1 | ENDOPLASMIC-RETICULUM STRESS | CELL-SURVIVAL | unfolded protein response | aldehydes | IRE1 | TRANSMEMBRANE PROTEIN | Humans | Coumarins - chemistry | Endoribonucleases - antagonists & inhibitors | RNA, Messenger - metabolism | Ribonucleases - metabolism | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Ribonucleases - antagonists & inhibitors | Proteolysis - drug effects | Protein Binding - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Membrane Proteins - metabolism | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | RNA Splicing - drug effects | Endoribonucleases - metabolism | RNA, Messenger - genetics | Regulatory Factor X Transcription Factors | Coumarins - pharmacology | Transcription Factors - metabolism | Secretory Pathway - drug effects | Animals | Membrane Proteins - antagonists & inhibitors | Endoplasmic Reticulum Stress | Schiff Bases - chemistry | Mice | Schiff Bases - metabolism | Proteins | Molecules | Membranes | Ribonucleic acid--RNA | Cells | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Science, ISSN 0036-8075, 10/2009, Volume 326, Issue 5952, pp. 585 - 589
Chronic fatigue syndrome (CFS) is a debilitating disease of unknown etiology that is estimated to affect 17 million people worldwide. Studying peripheral blood... 
T lymphocytes | Cell culture techniques | Disease transmission | B lymphocytes | Lymphocytes | Cell lines | Retroviridae | Viruses | Reports | Prostate cancer | Chronic fatigue syndrome | GENE | RNASE-L | FOCUS-FORMING VIRUS | MULTIDISCIPLINARY SCIENCES | LYMPHOMA | MURINE LEUKEMIA-VIRUS | CENTRIFUGAL ENHANCEMENT | GROWTH-FACTOR | REGION | Gene Products, gag - analysis | Gammaretrovirus - physiology | Retroviridae Infections - virology | Tumor Virus Infections - virology | Coculture Techniques | Humans | Molecular Sequence Data | Retroviridae Infections - transmission | Male | Antibodies, Viral - blood | Leukocytes, Mononuclear - virology | Prostatic Neoplasms - virology | T-Lymphocytes - virology | Tumor Virus Infections - transmission | Base Sequence | B-Lymphocytes - virology | Gammaretrovirus - immunology | Tumor Virus Infections - epidemiology | Cell Line | Genome, Viral | Lymphocyte Activation | DNA - genetics | Animals | B-Lymphocytes - immunology | Gammaretrovirus - genetics | Fatigue Syndrome, Chronic - virology | Cell Line, Tumor | Gammaretrovirus - isolation & purification | T-Lymphocytes - immunology | Mice | Retroviridae Infections - epidemiology | Gene Products, env - analysis | Complications and side effects | Retrovirus infections | Development and progression | Research | Diagnosis | Risk factors | Pathology | Cellular biology | Immune system | Blood cells | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2016, Volume 113, Issue 8, pp. 2241 - 2246
The 2′,5′-oligoadenylate (2-5A) synthetase (OAS)–RNase L system is an IFN-induced antiviral pathway. RNase L activity depends on 2-5A, synthesized by OAS.... 
2-5A | Oligoadenylate synthetase 3 | Antiviral response | Type I interferon | Ribonuclease L | ENCEPHALOMYOCARDITIS VIRUS | L PATHWAY | HUMAN 2',5'-OLIGOADENYLATE SYNTHETASE | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | HUMAN OLIGOADENYLATE SYNTHETASE | CRISPR-CAS9 SYSTEM | RIG-I | oligoadenylate synthetase 3 | VACCINIA VIRUS | antiviral response | type I interferon | MURINE CORONAVIRUS | ribonuclease L | ANTIVIRAL ACTIVITY | Endoribonucleases - genetics | Humans | 2',5'-Oligoadenylate Synthetase - antagonists & inhibitors | Endoribonucleases - antagonists & inhibitors | RNA, Ribosomal - genetics | Alphavirus Infections - genetics | Sindbis Virus | RNA, Viral - genetics | Alphavirus Infections - metabolism | RNA, Viral - metabolism | Virus Diseases - genetics | Vaccinia - metabolism | 2',5'-Oligoadenylate Synthetase - metabolism | Cell Line | Influenza, Human - metabolism | West Nile Fever - genetics | Endoribonucleases - metabolism | RNA, Ribosomal - metabolism | West Nile Fever - metabolism | Virus Diseases - metabolism | Gene Knockout Techniques | Vaccinia - genetics | 2',5'-Oligoadenylate Synthetase - genetics | Models, Biological | Influenza, Human - genetics | CRISPR-Cas Systems | Enzyme Activation | Genetic aspects | Interferon | Host-virus relationships | Gene expression | Observations | Health aspects | RNA polymerases | Bioengineering | RNA-protein interactions | Viruses | Biosynthesis | Antiviral drugs | Binding sites | Index Medicus | Biological Sciences
Journal Article
Retrovirology, ISSN 1742-4690, 12/2011, Volume 8, Issue S1, pp. A241 - A241
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2013, Volume 110, Issue 32, pp. 13114 - 13119
Efficient and productive virus infection often requires viral countermeasures that block innate immunity. The IFN-inducible 2',5'-oligoadenylate (2-5A)... 
Coronavirus | Rotavirus | RNA | Liver | Antivirals | Viruses | Amino acids | Mice | Infections | Murine hepatitis virus | Interferon-stiumulated gene | RNA capping enzyme | Nidovirales | Reoviridae | ROTAVIRUS OPEN CORES | PROTEIN | MOUSE HEPATITIS-VIRUS | 2',5'-OLIGOADENYLATE SYNTHETASE | MULTIDISCIPLINARY SCIENCES | interferon-stiumulated gene | 2-5A-DEPENDENT RNASE | MURINE CORONAVIRUS | INTERFERON | PROSTATE-CANCER | INFECTED-CELLS | STRAIN A59 | Endoribonucleases - genetics | Humans | Rotavirus - physiology | Rotavirus - immunology | Molecular Sequence Data | RNA Viruses - physiology | Immunoblotting | Murine hepatitis virus - physiology | Host-Pathogen Interactions - immunology | Murine hepatitis virus - immunology | Rotavirus - metabolism | Macrophages - virology | Oligoribonucleotides - metabolism | RNA Viruses - immunology | Binding Sites - immunology | Capsid Proteins - immunology | RNA Virus Infections - immunology | Macrophages - immunology | Viral Nonstructural Proteins - immunology | 2',5'-Oligoadenylate Synthetase - metabolism | Amino Acid Sequence | Cell Line | Phosphoric Diester Hydrolases - metabolism | Endoribonucleases - metabolism | Capsid Proteins - metabolism | Murine hepatitis virus - metabolism | Cells, Cultured | Viral Nonstructural Proteins - genetics | Phosphoric Diester Hydrolases - genetics | RNA Virus Infections - virology | RNA Viruses - metabolism | Binding Sites - genetics | Mice, Knockout | Phosphoric Diester Hydrolases - immunology | Sequence Homology, Amino Acid | Immunity, Innate - immunology | Macrophages - metabolism | Animals | 2',5'-Oligoadenylate Synthetase - immunology | Adenine Nucleotides - metabolism | Viral Nonstructural Proteins - metabolism | Mutation | Capsid Proteins - genetics | Endoribonucleases - immunology | RNA viruses | Antiviral agents | Immune response | Physiological aspects | Dosage and administration | Research | Phosphodiesterases | Health aspects | Proteins | Ribonucleic acid--RNA | Rodents | Cells | Index Medicus | Biological Sciences
Journal Article
Journal Article