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Biomedicines, ISSN 2227-9059, 03/2019, Volume 7, Issue 1, p. 1
Few immunotoxins or targeted toxins have become mainline cancer therapies. Still immunotoxins continue to be of major interest and subject of research and... 
Immunotoxin | Pseudomonas exotoxin | Immunogenicity | CD19 | Deimmunized | Diphtheria toxin | CD22 | Chemo-immunosuppression | B-cell malignancies | chemo-immunosuppression | pseudomonas exotoxin | diphtheria toxin | immunotoxin | immunogenicity | deimmunized
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 04/2011, Volume 22, Issue 4, p. 736
Recombinant immunotoxins BL22 (CAT-3888) and LMB-2, composed of Fv fragments of anti-CD22 and CD25 MAbs, respectively, have produced major responses in... 
Proteins | Urine | Plasma | Toxicity | Bacteria | Toxins | Chromatography
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 06/2015, Volume 26, Issue 6, p. 1120
  Recombinant immunotoxins (RITs) are fusion proteins that join antibodies to protein toxins for targeted cell killing. RITs armed with Pseudomonas exotoxin A... 
Proteins | Polypeptides | Cytotoxicity | Toxins | Gram-negative bacteria | Immune system
Journal Article
Leukemia & Lymphoma, ISSN 1042-8194, 10/2019, Volume 60, Issue 12, pp. 2869 - 2879
Hairy cell leukemia (HCL) is an indolent B-cell malignancy, with long-term responses to purine analogs, but with decreasing efficacy and increasing toxicity... 
cladribine | vemurafenib | moxetumomab pasudotox | BRAF | trametinib | Hairy cell leukemia | MEK | pentostatin | Lumoxiti | BTK | recombinant immunotoxin | dabrafenib | bendamustine | purine analog | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 29, pp. 11782 - 11787
Journal Article
The Oncologist, ISSN 1083-7159, 10/2019, p. theoncologist.2019-0370
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 23, pp. 8571 - 8576
Nonhuman proteins have valuable therapeutic properties, but their efficacy is limited by neutralizing antibodies. Recombinant immunotoxins (RITs) are potent... 
T lymphocytes | Immunotoxins | Hairy cell leukemia | Immune response | Cell lines | Antibodies | T lymphocyte epitopes | B lymphocyte epitopes | Epitopes | Tumors | Protein engineering | Deimmunization | IMMUNODOMINANCE | ANTIGENICITY | MOXETUMOMAB PASUDOTOX | DETERMINANTS | PROTEIN THERAPEUTICS | MULTIDISCIPLINARY SCIENCES | ELIMINATION | deimmunization | TOXICITY | protein engineering | PHASE-I TRIAL | PSEUDOMONAS-AERUGINOSA | EXOTOXIN-A | Recombinant Fusion Proteins - immunology | Epitope Mapping | Immunotherapy - methods | Virulence Factors - genetics | Humans | Recombinant Fusion Proteins - therapeutic use | Amino Acids - immunology | Peptides - genetics | Virulence Factors - immunology | Amino Acids - genetics | Lymphocyte Activation - immunology | Neoplasms - therapy | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Bacterial Toxins - genetics | Female | Epitopes, T-Lymphocyte - immunology | Protein Structure, Tertiary | ADP Ribose Transferases - immunology | Cell Survival - drug effects | Antibody Formation - immunology | Immunotoxins - immunology | Bacterial Toxins - immunology | Electrophoresis, Polyacrylamide Gel | Exotoxins - immunology | Peptides - immunology | Models, Molecular | Recombinant Fusion Proteins - chemistry | Cell Survival - immunology | Mice, SCID | Xenograft Model Antitumor Assays | ADP Ribose Transferases - genetics | Point Mutation | Immunotoxins - genetics | Animals | Immunotoxins - therapeutic use | Lymphocyte Activation - drug effects | Neoplasms - immunology | Exotoxins - genetics | Cell Line, Tumor | T-Lymphocytes - immunology | Mice | Neoplasms - pathology | Care and treatment | Oncology, Experimental | Research | T cells | Recombinant proteins | Health aspects | Cancer | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2011, Volume 108, Issue 14, pp. 5742 - 5747
Many nonhuman proteins have useful pharmacological activities, but are infrequently effective in humans because of their high immunogenicity. A recombinant... 
Immunotoxins | Immune response | Reactivity | Cell lines | Antibodies | B lymphocyte epitopes | Amino acids | Toxins | Epitopes | Inhibitory concentration 50 | Protein engineering | SS1P | Passive immunotherapy | Target therapy/cancer therapeutics | ANIMAL TOXICITY | MULTIDISCIPLINARY SCIENCES | STAPHYLOKINASE VARIANTS | ANTITUMOR-ACTIVITY | passive immunotherapy | CYTOTOXIC ACTIVITY | target therapy/cancer therapeutics | protein engineering | PHASE-I TRIAL | RFB4(DSFV)-PE38 BL22 | LEUKEMIA | PSEUDOMONAS EXOTOXIN | ALTERED IMMUNOREACTIVITY | Recombinant Fusion Proteins - immunology | Virulence Factors - genetics | Protein Engineering - methods | Recombinant Fusion Proteins - therapeutic use | Molecular Sequence Data | Exotoxins - metabolism | Epitopes, B-Lymphocyte - genetics | Statistics, Nonparametric | Bacterial Toxins - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | ADP Ribose Transferases - metabolism | Recombinant Fusion Proteins - biosynthesis | Amino Acid Sequence | Immunization, Passive - methods | Enzyme-Linked Immunosorbent Assay | Models, Molecular | Antibodies, Monoclonal | ADP Ribose Transferases - genetics | Bacterial Toxins - metabolism | Animals | Mutagenesis | Exotoxins - genetics | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Virulence Factors - metabolism | Mice | Mice, Inbred BALB C | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Physiological aspects | B cells | Research | Properties | Antibody-toxin conjugates | Antigenic determinants | cancer therapeutics | Biological Sciences | target therapy
Journal Article
Leukemia, ISSN 0887-6924, 08/2018, Volume 32, Issue 8, pp. 1768 - 1777
Journal Article