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1. Full Text Improving the human hazard characterization of chemicals: A Tox21 update
by Tice, Raymond R and Austin, Christopher P and Kavlock, Robert J and Bucher, John R
Environmental health perspectives, ISSN 0091-6765, 07/2013, Volume 121, Issue 7, pp. 756 - 765
In vitro models | Chemical hazard characterization | Systems biology | High throughput testing | Computational biology | Tox21 | Public, Environmental & Occupational Health | Environmental Sciences & Ecology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | National Institute of Environmental Health Sciences (U.S.) | Computational Biology - methods | United States | Humans | Hazardous Substances - toxicity | National Institutes of Health (U.S.) | Animals | Toxicity Tests - methods | Environmental Pollutants - toxicity | Toxicology - methods | Genomics - methods | United States Environmental Protection Agency | United States Food and Drug Administration | Environmental aspects | Health aspects | Analysis | Chemicals | Public health | Working groups | Collaboration | Gene expression | Informatics | Methods | Molecular weight | Index Medicus | Human | Drugs | Health | Toxicity | Hazards | Biological | Assessments | Computation | In vitro testing | Biology | computational biology | high throughput testing | systems biology | in vitro models | Review | chemical hazard characterization
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2. Full Text Profiling Chemicals Based on Chronic Toxicity Results from the U.S. EPA ToxRef Database
by Matthew T. Martin and Richard S. Judson and David M. Reif and Robert J. Kavlock and David J. Dix
Environmental health perspectives, ISSN 0091-6765, 3/2009, Volume 117, Issue 3, pp. 392 - 399
Chemical hazards | Pathology | Toxicology | Kidneys | Databases | Liver | Rats | Environmental agencies | Research | Lesions | Tumors | Toxicity profile | Chronic toxicity | Pesticides | Relational database | Cancer | Public, Environmental & Occupational Health | Environmental Sciences & Ecology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Computational Biology - methods | Ecotoxicology - methods | Pesticides - toxicity | United States | Pesticides - classification | Environmental Pollutants - toxicity | Environmental Pollutants - classification | United States Environmental Protection Agency | Databases, Factual | Environmental aspects | Health aspects | Risk factors | Chemicals | Index Medicus | Spleen | Surgical implants | Bioassay | Profiling | Toxicity | Health | Meetings | Incidence | Biomedical materials | Classification | Biocompatibility | Mathematical models | Signatures | Laboratory animals | Anchoring | cancer | toxicity profile | relational database | pesticides | chronic toxicity
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3. Full Text In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project
by Richard S. Judson and Keith A. Houck and Robert J. Kavlock and Thomas B. Knudsen and Matthew T. Martin and Holly M. Mortensen and David M. Reif and Daniel M. Rotroff and Imran Shah and Ann M. Richard and David J. Dix
Environmental health perspectives, ISSN 0091-6765, 4/2010, Volume 118, Issue 4, pp. 485 - 492
Chemical hazards | Human umbilical vein endothelial cells | Hepatocytes | Liver | Environmental health | Materials | Rats | Environmental agencies | Research | Lesions | Tumors | Liver tumors | Toxcast | Liver proliferative lesions | Pathways | In vitro screening | Public, Environmental & Occupational Health | Environmental Sciences & Ecology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Public health. Hygiene-occupational medicine | Public health. Hygiene | Environment. Living conditions | Biological and medical sciences | Medical sciences | General aspects. Methods | Cell Line | Animals | United States | Computer Simulation | Humans | Cells, Cultured | Toxicity Tests - methods | Environmental Pollutants - toxicity | United States Environmental Protection Agency | Usage | Genes | Toxicity testing | Environmental aspects | Physiological aspects | Health aspects | Chemicals | Index Medicus | in vitro screening | liver proliferative lesions | liver tumors | pathways | ToxCast
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4. Full Text Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data
by David M. Reif and Matthew T. Martin and Shirlee W. Tan and Keith A. Houck and Richard S. Judson and Ann M. Richard and Thomas B. Knudsen and David J. Dix and Robert J. Kavlock
Environmental health perspectives, ISSN 0091-6765, 12/2010, Volume 118, Issue 12, pp. 1714 - 1720
Chemical hazards | Endocrine disruptors | Toxicology | Screening tests | Pesticides | Environmental health | Materials | Prioritization | Environmental agencies | Chemical properties | Research | Public, Environmental & Occupational Health | Environmental Sciences & Ecology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Public health. Hygiene-occupational medicine | Public health. Hygiene | Environment. Living conditions | Biological and medical sciences | Medical sciences | General aspects. Methods | Endocrine Disruptors - classification | Signal Transduction - drug effects | Decision Support Techniques | Endocrine System - drug effects | Toxicity Tests - methods | Environmental Pollutants - toxicity | Environmental Pollutants - classification | Endocrine Disruptors - toxicity | Endocrine gland diseases | Health aspects | Risk factors | Priorities | Screening | Visualization | Ranking | Pathways | Focusing | In vitro testing | Assaying | Data sources | Index Medicus | androgen | estrogen | screening | toxicity profile | ToxPi | chemical prioritization | ToxCast | data integration | endocrine disruption
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5. Full Text Informing Selection of Nanomaterial Concentrations for ToxCast in Vitro Testing Based on Occupational Exposure Potential
by Sumit Gangwal and James S. Brown and Amy Wang and Keith A. Houck and David J. Dix and Robert J. Kavlock and Elaine A. Cohen Hubal
Environmental health perspectives, ISSN 0091-6765, 11/2011, Volume 119, Issue 11, pp. 1539 - 1546
Chemical hazards | Pulmonary alveoli | Reviews | Lungs | Surface areas | Aerosols | Particle mass | Environmental agencies | Breathing | Aspect ratio | Inhalation | Human particle deposition and retention | Multiple-path particle dosimetry (MPPD) | In vitro nanomaterial concentration | Occupational exposure | ToxCast | ExpoCast | Public, Environmental & Occupational Health | Environmental Sciences & Ecology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Environment. Living conditions | Public health. Hygiene-occupational medicine | Public health. Hygiene | Biological and medical sciences | Medical sciences | Air Pollutants, Occupational - toxicity | United States | Humans | Occupational Exposure | Nanotubes | Nanoparticles - toxicity | Aerosols - toxicity | Titanium - toxicity | Animals | Models, Biological | Computer Simulation | Inhalation Exposure | Sensitivity and Specificity | Pulmonary Alveoli - drug effects | Silver - toxicity | Toxicity Tests - methods | United States Environmental Protection Agency | Carbon - toxicity | Nanoparticles | Environmental aspects | Research | Titanium dioxide | Health aspects | Index Medicus | multiple-path particle dosimetry (MPPD) | Review | human particle deposition and retention | in vitro nanomaterial concentration | occupational exposure
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6. Full Text The Toxicity Data Landscape for Environmental Chemicals
by Richard Judson and Ann Richard and David J. Dix and Keith Houck and Matthew Martin and Robert Kavlock and Vicki Dellarco and Tala Henry and Todd Holderman and Philip Sayre and Shirlee Tan and Thomas Carpenter and Edwin Smith
Environmental health perspectives, ISSN 0091-6765, 5/2009, Volume 117, Issue 5, pp. 685 - 695
Chemical hazards | Toxicology | Databases | Reviews | Molecular structure | Pesticides | Environmental health | Prioritization | Toxins | Environmental agencies | Chemicals | Developmental | MPV | Reproductive | Pesticide | Toxicity | ACToR | Database | Carcinogenicity | Hazard | Public, Environmental & Occupational Health | Environmental Sciences & Ecology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Environmental Monitoring | United States | Humans | United States Government Agencies | United States Environmental Protection Agency | Environmental Pollutants - analysis | Databases, Factual | Environmental aspects | Hazardous substances | Usage | Research | Online databases | Index Medicus | Drinking water | Health | In vivo testing | Ingredients | Summaries | In vitro testing | Screening | Landscapes | Synthesis | Computation | Copyrights | Biocompatibility | Links | Inert | Catalogs | toxicity | developmental | database | hazard | pesticide | Review | carcinogenicity | HPV | reproductive
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7. Full Text Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis
by Smith, Martyn T and Guyton, Kathryn Z and Gibbons, Catherine F and Fritz, Jason M and Portier, Christopher J and Rusyn, Ivan and DeMarini, David M and Caldwell, Jane C and Kavlock, Robert J and Lambert, Paul F and Hecht, Stephen S and Bucher, John R and Stewart, Bernard W and Baan, Robert A and Cogliano, Vincent J and Straif, Kurt
Environmental health perspectives, ISSN 0091-6765, 06/2016, Volume 124, Issue 6, pp. 713 - 721
Public, Environmental & Occupational Health | Environmental Sciences & Ecology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Risk Assessment - methods | Animals | Polychlorinated Biphenyls - toxicity | Carcinogenicity Tests - methods | Humans | Carcinogenicity Tests - standards | Carcinogens - standards | Benzene - toxicity | Carcinogenesis | Carcinogens - toxicity | Risk Assessment - standards | Monographs | Hydrocarbons | Gene expression | Epidemiology | Chemicals | Studies | Carcinogens | Databases | Polychlorinated biphenyls--PCB | Tumors | Cancer | Index Medicus | Review
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8. Full Text Environmental Impact on Vascular Development Predicted by High-Throughput Screening
by Nicole C. Kleinstreuer and Richard S. Judson and David M. Reif and Nisha S. Sipes and Amar V. Singh and Kelly J. Chandler and Rob DeWoskin and David J. Dix and Robert J. Kavlock and Thomas B. Knudsen
Environmental health perspectives, ISSN 0091-6765, 11/2011, Volume 119, Issue 11, pp. 1596 - 1603
Chemical hazards | Pregnancy | Angiogenesis | Environmental health | Rats | Environmental agencies | Research | Signatures | Embryos | Endothelial cells | Chemicals | High-throughput screening (HTS) | Developmental toxicity | Vascular development | Thalidomide | Public, Environmental & Occupational Health | Environmental Sciences & Ecology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Fundamental and applied biological sciences. Psychology | Public health. Hygiene-occupational medicine | Public health. Hygiene | Embryology: invertebrates and vertebrates. Teratology | Environment. Living conditions | Biological and medical sciences | Medical sciences | Teratology. Teratogens | Multivariate Analysis | Species Specificity | United States | Humans | Male | Maternal Exposure | Environmental Pollutants - immunology | Small Molecule Libraries - toxicity | Female | Models, Animal | Environmental Pollutants - toxicity | Toxicology - methods | Environmental Pollutants - classification | United States Environmental Protection Agency | Cardiovascular System - embryology | Databases, Factual | Small Molecule Libraries - classification | Rabbits | Small Molecule Libraries - analysis | Risk Assessment | Computational Biology | Cardiovascular System - drug effects | Animals | High-Throughput Screening Assays | Mice | Environmental Pollutants - analysis | Index Medicus | high-throughput screening (HTS) | vascular development | thalidomide | developmental toxicity | angiogenesis
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9. Full Text Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment
by Kavlock, Robert J and Austin, Christopher P and Tice, Raymond R
Risk analysis, ISSN 0272-4332, 04/2009, Volume 29, Issue 4, pp. 485 - 487
Mathematics, Interdisciplinary Applications | Physical Sciences | Social Sciences | Life Sciences & Biomedicine | Social Sciences, Mathematical Methods | Public, Environmental & Occupational Health | Mathematics | Mathematical Methods In Social Sciences | Science & Technology | National Institutes of Health (U.S.) | Animals | History, 21st Century | Risk Assessment | United States | Humans | Toxicity Tests - methods | Health Status | United States Environmental Protection Agency | Health | Health aspects | Risk assessment | Index Medicus
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10. Full Text Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms
by Kleinstreuer, Nicole C and Yang, Jian and Berg, Ellen L and Knudsen, Thomas B and Richard, Ann M and Martin, Matthew T and Reif, David M and Judson, Richard S and Polokoff, Mark and Dix, David J and Kavlock, Robert J and Houck, Keith A
Nature biotechnology, ISSN 1087-0156, 2014, Volume 32, Issue 6, pp. 583 - 591
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Animal Testing Alternatives - methods | United States | Humans | Rats | Phenotype | Animals | Models, Biological | Small Molecule Libraries | Computer Simulation | Toxicity Tests - methods | Mice | United States Environmental Protection Agency | High-Throughput Screening Assays - methods | Toxicity testing | Chemical research | Toxicological chemistry | Research | Identification and classification | Chemicals | Testing | Genotype & phenotype | Toxicology | Pharmacology | Index Medicus
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