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1. Full Text DNA methylation and human disease
by Robertson, Keith D
Nature Reviews Genetics, ISSN 1471-0056, 08/2005, Volume 6, Issue 8, pp. 597 - 610
DNA methylation is a crucial epigenetic modification of the genome that is involved in regulating many cellular processes. These include embryonic development,... 
IMPRINTING CONTROL REGION | SYSTEMIC-LUPUS-ERYTHEMATOSUS | CPG-ISLAND METHYLATION | BECKWITH-WIEDEMANN-SYNDROME | GENETICS & HEREDITY | FRAGILE-X-SYNDROME | FACIAL ANOMALIES SYNDROME | IN-VITRO FERTILIZATION | GROWTH-FACTOR-II | DE-NOVO METHYLATION | PRADER-WILLI-SYNDROME | Genomic Imprinting - genetics | Neoplasms - metabolism | DNA Methylation | Neoplasms - genetics | Humans | Genetic Diseases, Inborn - genetics | Genomic Instability - genetics
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2. Full Text Enhanced and controlled chromatin extraction from FFPE tissues and the application to ChIP-seq
by Zhong, J and Ye, ZQ and Clark, CR and Lenz, SW and Nguyen, JH and Yan, HH and Robertson, KD and Farrugia, G and Zhang, ZG and Ordog, T and Lee, JH
BMC GENOMICS, ISSN 1471-2164, 03/2019, Volume 20, Issue 1, pp. 249 - 11
Background: Epigenetic dysregulation is involved in the etiology and progression of various human diseases. Formalin-fixed paraffin-embedded (FFPE) samples... 
EPIGENETIC MECHANISMS | FFPE tissues | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | Chromatin extraction | GENETICS & HEREDITY | ChIP-seq | HISTONE MODIFICATIONS | IDENTIFICATION | IMMUNOPRECIPITATION | Microbiological assay | Chromatin | Properties | Methods | Paraffins | Disease | Incubation | Genomics | Crosslinking | Genomes | Paraffin | Tissues | Assaying | Pathology | Etiology | Rehydration | Epigenetics | Archiving | Bioinformatics | Deoxyribonucleic acid--DNA
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3. Full Text DNA methyltransferases, DNA damage repair, and cancer
by Jin, Bilian and Robertson, Keith D
Advances in Experimental Medicine and Biology, ISSN 0065-2598, 2013, Volume 754, pp. 3 - 29
Conference Proceeding
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4. Full Text Use of the CRISPR/Cas9‐based epigenetic gene activation system In Vivo: A new potential therapeutic modality
by Ibrahim, Samar H and Robertson, Keith D
Hepatology, ISSN 0270-9139, 09/2018, Volume 68, Issue 3, pp. 1191 - 1193
LIVER-DISEASE | GASTROENTEROLOGY & HEPATOLOGY | Gene Transfer Techniques | Genetic Therapy | Epigenomics | Transcriptional Activation | CRISPR-Cas Systems | CRISPR | epigenetic | Cas9
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5. Full Text Alpha‐1 Antitrypsin Deficiency Liver Disease, Mutational Homogeneity Modulated by Epigenetic Heterogeneity With Links to Obesity
by Wang, Liguo and Marek, George W and Hlady, Ryan A and Wagner, Ryan T and Zhao, Xia and Clark, Virginia C and Fan, Alex Xiucheng and Liu, Chen and Brantly, Mark and Robertson, Keith D
Hepatology, ISSN 0270-9139, 07/2019, Volume 70, Issue 1, pp. 51 - 66
Alpha‐1 antitrypsin deficiency (AATD) liver disease is characterized by marked heterogeneity in presentation and progression, despite a common underlying gene... 
LUNG | METHYLATION | SIGNATURES | PROGNOSIS | DNA | GENE-EXPRESSION | MODEL | GASTROENTEROLOGY & HEPATOLOGY | Phenotypes | Liver diseases | Immune response | Phenotypic variations | Hepatocellular carcinoma | Genomes | Cirrhosis | Liver cancer | Hepatocytes | Fibrosis | Point mutation | Cell cycle | DNA methylation | Epigenetics | Degeneration | Deoxyribonucleic acid--DNA | Genotypes
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6. Full Text Abstract LB-235: DNA methylation of individual repetitive elements in HCV infection-induced HCC
by Zheng, Yinan and Ren, Jimmy and Hlady, Ryan A and Robertson, Keith D and Murphy, Robert L and Roberts, Lewis R and Hou, Lifang
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. LB-235 - LB-235
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7. Full Text Genome-wide DNA methylomic differences between dorsolateral prefrontal and temporal pole cortices of bipolar disorder
by Ho, Ada M.-C and Winham, Stacey J and Armasu, Sebastian M and Blacker, Caren J and Millischer, Vincent and Lavebratt, Catharina and Overholser, James C and Jurjus, George J and Dieter, Lesa and Mahajan, Gouri and Rajkowska, Grazyna and Vallender, Eric J and Stockmeier, Craig A and Robertson, Keith D and Frye, Mark A and Choi, Doo-Sup and Veldic, Marin
Journal of Psychiatric Research, ISSN 0022-3956, 10/2019, Volume 117, pp. 45 - 54
Dorsolateral prefrontal cortex (DLPFC) and temporal pole (TP) are brain regions that display abnormalities in bipolar disorder (BD) patients. DNA methylation —... 
PERCEPTION | DEPRESSION | METHYLATION | CORTEX | PSYCHIATRY | GENE-EXPRESSION | SCHIZOPHRENIA | FASCICULI | DEFICITS | HYPOMETHYLATION | Epigenetic inheritance | Genomics | DNA | Genetic research | GABA | Bipolar disorder | Genomes | Methylation | Gene expression
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8. Full Text DNA Methyltransferases, DNA Damage Repair, and Cancer
by Jin, Bilian and Robertson, Keith D
2013, 2013, Advances in Experimental Medicine and Biology, ISBN 9781441999665, Volume 754, 27
The maintenance DNA methyltransferase (DNMT) 1 and the de novo methyltransferases DNMT3A and DNMT3B are all essential for mammalian development. DNA... 
Human Genetics | Cancer Research | Oncology | Biomedicine | BASE-EXCISION-REPAIR | PROMOTER HYPERMETHYLATION | ONCOLOGY | GENE O-6-METHYLGUANINE-DNA METHYLTRANSFERASE | EMBRYONIC STEM-CELLS | GENETICS & HEREDITY | SQUAMOUS-CELL CARCINOMA | TUMOR-SUPPRESSOR GENE | MISMATCH REPAIR | ACUTE MYELOID-LEUKEMIA | DE-NOVO METHYLATION | WERNER-SYNDROME PROTEIN | DNA Methylation | Animals | DNA Modification Methylases - metabolism | Neoplasms - genetics | Humans | DNA Damage - genetics | Neoplasms - enzymology | DNA Repair - genetics | Neoplasms - pathology | Index Medicus
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9. Full Text Indoleamine 2,3-Dioxygenase-1 Expressing Dendritic Cell Populations Are Associated with Tumor-Induced Immune Tolerance & Aggressive Disease Biology in Chronic Myelomonocytic Leukemia
by Mangaonkar, Abhishek A and Reichard, Kaaren K and Chiu, April and Howard, Matthew T and King, Rebecca L and Carr, Ryan M and Alver, Bonnie M and Robertson, Keith D and Cousin, Margot and Villasboas, Jose C and Fernandez-Zapico, Martin E and Lasho, Terra L and Gangat, Naseema and Al-Kali, Aref and Elliott, Michelle A and Hogan, William J and Litzow, Mark R and Pardanani, Animesh and Solary, Eric and Tefferi, Ayalew and Patnaik, Mrinal M
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 4344 - 4344
Abstract Introduction: Chronic myelomonocytic leukemia (CMML) is a chronic myeloid malignancy associated with monocytosis, autoimmunity (~30%) & an inherent... 
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10. Full Text DNA methylation and chromatin - Unraveling the tangled web
by Robertson, Keith D
Oncogene, ISSN 0950-9232, 08/2002, Volume 21, Issue 35, pp. 5361 - 5379
Methylation of cytosines within the CpG dinucleotide by DNA methyltransferases is involved in regulating transcription and chromatin structure, controlling the... 
Histone methylase | DNA methylation | Histone deacetylase | DNA methyltransferase | Chromatin | Transcriptional repression | DE-NOVO | SATELLITE DNA | MESSENGER-RNA EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECOMBINANT HUMAN DNA | MAMMALIAN DEVELOPMENT | chromatin | histone methylase | histone deacetylase | REPLICATION FOCI | CELL BIOLOGY | transcriptional repression | ONCOLOGY | ICF SYNDROME | CYTOSINE-5 METHYLTRANSFERASE | EMBRYONIC STEM-CELLS | GENETICS & HEREDITY | Humans | Methyltransferases - metabolism | Gene Expression Regulation | Gene Silencing | Histone Deacetylases - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Syndrome | Nuclear Proteins | DNA Helicases | DNA Methylation | Animals | Transcription, Genetic | Adenosine Triphosphatases - genetics | Acetylation | Histones - metabolism | Chromatin - genetics | Disease Models, Animal
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11. Full Text Number and Type of TET2 Mutations in Chronic Myelomonocytic Leukemia: Clinical and Prognostic Correlates
by Patnaik, Mrinal M and Zahid, Mohammad Faizan and Lasho, Terra L and Tolosa, Ezequiel and Finke, Christy and Hanson, Curtis A and Ketterling, Rhett P and Solary, Eric and Robertson, Keith D and Gangat, Naseema and Fernandez-Zapico, Martin E and Tefferi, Ayalew
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 4343 - 4343
Abstract Background : TET2, located on chromosome 4q24, is frequently mutated in the majority of patients with chronic myelomonocytic leukemia (CMML). TET2 has... 
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12. Full Text Association of Clinical Epidemiologic Exposures and Overall Survival with Genome-Wide DNA Methylation Profiles in Acute Myeloid Leukemia: Analysis of the Mayo Clinic AML Epidemiology Cohort
by Torres-Gutierrez, César J and Heckman, Michael G and Hlady, Ryan A and Ketterling, Rhett P and Sproat, Lisa Z and Pearce, Kathryn E and Lesser, Elizabeth R and Diehl, Nancy N and Finn, Laura E and Jiang, Liuyan Jennifer and Robertson, Keith D and Cerhan, James R and Foran, James M
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 3987 - 3987
Abstract Background: We previously demonstrated that putative clinical epidemiologic exposures associated with leukemia risk are prevalent among AML patients,... 
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13. Full Text Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes
by Green, Jennifer B and Bethel, M. Angelyn and Armstrong, Paul W and Buse, John B and Engel, Samuel S and Garg, Jyotsna and Josse, Robert and Kaufman, Keith D and Koglin, Joerg and Korn, Scott and Lachin, John M and McGuire, Darren K and Pencina, Michael J and Standl, Eberhard and Stein, Peter P and Suryawanshi, Shailaja and Van de Werf, Frans and Peterson, Eric D and Holman, Rury R and TECOS Study Grp and TECOS Study Group
The New England Journal of Medicine, ISSN 0028-4793, 07/2015, Volume 373, Issue 3, pp. 232 - 242
The addition of sitagliptin to usual care in patients with type 2 diabetes and cardiovascular disease was not associated with any change in the risk of major... 
TRIAL | MEDICINE, GENERAL & INTERNAL | RISK | GLUCOSE-LOWERING DRUGS | STRATEGIES | Glycated Hemoglobin A - analysis | Hypoglycemic Agents - therapeutic use | Triazoles - adverse effects | Double-Blind Method | Follow-Up Studies | Administration, Oral | Humans | Kaplan-Meier Estimate | Hospitalization - statistics & numerical data | Pyrazines - therapeutic use | Cardiovascular Diseases - complications | Diabetes Mellitus, Type 2 - blood | Heart Diseases - etiology | Heart Diseases - epidemiology | Pyrazines - adverse effects | Cardiovascular Diseases - mortality | Sitagliptin Phosphate | Diabetes Mellitus, Type 2 - drug therapy | Drug Therapy, Combination | Heart Failure - etiology | Hypoglycemic Agents - adverse effects | Diabetes Mellitus, Type 2 - complications | Triazoles - therapeutic use | Type 2 diabetes | Care and treatment | Usage | Clinical trials | Influence | Sitagliptin | Dosage and administration | Cardiovascular diseases | Myocardial infarction | Cerebral infarction | Stroke | Inhibitor drugs | Peptidase | Diabetes mellitus | Pancreatitis | Cardiovascular disease | Angina | Side effects | Pancreatic cancer | Hemoglobin | Diabetes | Health risk assessment | Drug therapy | Diabetes mellitus (non-insulin dependent) | Heart diseases
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