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Heart, ISSN 1355-6037, 05/2019, Volume 105, Issue Suppl 4, p. A3
Atherosclerotic plaque formation is the result of lipid accumulation in the arterial intima leading to foam cell formation and is exacerbated by high fat diet... 
Proteins | Liver | Rodents | Atherosclerosis | Lipids | Adipocytes | Gene expression | Metabolism
Journal Article
Heart, ISSN 1355-6037, 06/2018, Volume 104, Issue Suppl 6, p. A94
Atherosclerotic plaque formation is the result of lipid accumulation in the arterial intima leading to foam cell formation and is exacerbated by high fat diet... 
Journal Article
CELLS, ISSN 2073-4409, 03/2019, Volume 8, Issue 3, p. 268
Seipin (BSCL2/SPG17) is a key factor in lipid droplet (LD) biology, and its dysfunction results in severe pathologies, including the fat storage disease... 
seipin | lipid droplet | SPG17 | CONGENITAL LIPODYSTROPHY | SIZE | CHROMOSOME 11Q12-Q14 | IDENTIFICATION | promethin | CELL BIOLOGY | BSCL2 | adipogenesis | TMEM159 | LDO | GENES | BSCL2/SEIPIN | lipodystrophy
Journal Article
Journal of Cell Science, ISSN 0021-9533, 11/2011, Volume 124, Issue 21, pp. 3726 - 3726
Journal Article
Journal Article
Science, ISSN 0036-8075, 5/2004, Volume 304, Issue 5675, pp. 1325 - 1328
Inherited defects in signaling pathways downstream of the insulin receptor have long been suggested to contribute to human type 2 diabetes mellitus. Here we... 
Hep G2 cells | Genetic inheritance | Diabetes mellitus | Liver | Insulin resistance | Reports | Type 2 diabetes mellitus | Adipocytes | Diabetes | Genetic mutation | Insulin | STRUCTURAL BASIS | GENETICS | PKB | MULTIDISCIPLINARY SCIENCES | KINASE | MELLITUS | HYPERTENSION | MICE LACKING | BETA | Phosphorylation | Diabetes Mellitus - genetics | Humans | Middle Aged | Molecular Sequence Data | Adipocytes - cytology | Male | Proto-Oncogene Proteins - chemistry | Mutation, Missense | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | Genes, Dominant | Hyperinsulinism - genetics | Adult | Female | Cell Differentiation | Active Transport, Cell Nucleus | Protein-Serine-Threonine Kinases - metabolism | Hyperinsulinism - metabolism | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Cell Line | Catalytic Domain | Hepatocyte Nuclear Factor 3-beta | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Diabetes Mellitus - metabolism | Lipid Metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Amino Acid Motifs | Proto-Oncogene Proteins c-akt | Insulin - metabolism | Pedigree | Adipocytes - metabolism | Insulin Resistance - genetics | Cytosol - metabolism | Aged | Protein-Serine-Threonine Kinases - chemistry | Transcription Factors | Amino Acid Substitution | Research | Families & family life | Mutation | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Scientific reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 17863 - 11
Mutations affecting the BSCL2 gene cause the most severe form of congenital generalised lipodystrophy. Affected individuals almost completely lack adipose... 
THERMOGENESIS | MULTIDISCIPLINARY SCIENCES | GENERALIZED LIPODYSTROPHY | MUTATIONS | SEIP CONGENITAL LIPODYSTROPHY | INSULIN SENSITIVITY | GENDER-DIFFERENCES | HEPATIC STEATOSIS | PROTEIN SEIPIN | EXPRESSION | DEFICIENCY | Glucose tolerance | Intolerance | Adipose tissue | Diabetes mellitus | Rodents | Homeostasis | Sex differences | Lipodystrophy | Housing | Metabolism | Age | High fat diet
Journal Article
Journal Article
Molecular Metabolism, ISSN 2212-8778, 2015, Volume 4, Issue 3, pp. 199 - 209
Abstract Objective Disruption of the genes encoding either seipin or 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) causes severe congenital... 
Endocrinology & Metabolism | BSCL2 | Lipid synthesis | Adipocyte | Atomic force microscopy (AFM) | Lipin | Lipodystrophy | Seipin | AGPAT2 | Adipogenesis | ACTIVATED RECEPTOR-GAMMA | PHOSPHATASE-ACTIVITY | CONGENITAL LIPODYSTROPHY | LIPODYSTROPHY PROTEIN SEIPIN | YEAST | ATOMIC-FORCE MICROSCOPY | IN-VIVO | ENDOCRINOLOGY & METABOLISM | ADIPOCYTE DIFFERENTIATION | PPAR-GAMMA
Journal Article
Journal Article
Cell Metabolism, ISSN 1550-4131, 11/2007, Volume 6, Issue 5, pp. 398 - 405
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2008, Volume 283, Issue 43, pp. 29166 - 29174
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 06/2009, Volume 106, Issue 23, pp. 9350 - 9355
Journal Article
Cell Metabolism, ISSN 1550-4131, 10/2018, Volume 28, Issue 4, pp. 619 - 630.e5
To meet the challenge to human health posed by obesity, a better understanding of the regulation of feeding is essential. Medications targeting... 
lorcaserin | serotonin | 5-HT2CR | nucleus of the solitary tract | obesity | food intake | R | 5-HT | 5-HT(2C)R | GLUCOSE-HOMEOSTASIS | REGULATE ENERGY | OBESITY | PROOPIOMELANOCORTIN NEURONS | FEEDING-BEHAVIOR | ENDOCRINOLOGY & METABOLISM | BRAIN-STEM | PHYSICAL-ACTIVITY | MICE | 2C RECEPTORS | HYPOTHALAMIC POMC NEURONS | CELL BIOLOGY
Journal Article
The Journal of Biological Chemistry, ISSN 0021-9258, 10/2008, Volume 283, Issue 43, pp. 29166 - 29174
Lipins are the founding members of a novel family of Mg 2+ -dependent phosphatidate phosphatases (PAP1 enzymes) that play key roles in fat metabolism and lipid... 
Lipids and Lipoproteins | Metabolism, Regulation, and Signaling
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, pp. e45790 - e45790
Journal Article
Cell Metabolism, ISSN 1550-4131, 10/2018, Volume 28, Issue 4, p. 619
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.cmet.2018.07.017 
Serotonin | Neurons | Physiological aspects | Phenols | Intermedin
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2010, Volume 425, Issue 1, pp. 215 - 223
The transcription factor SREBP1c (sterol-regulatory-element-binding protein 1c) is highly expressed in adipose tissue and plays a central role in several... 
Adipocyte | CCAAT/enhancer-binding protein(C/EBP) | Sterol-regulatory-element-binding protein 1c(SREBP1c) | Transcription | Lipid | Adipogenesis | transcription | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELEMENT-BINDING PROTEIN-1C | ALPHA | sterol-regulatory-element-binding protein 1c (SREBP1c) | lipid | BETA | adipogenesis | INSULIN-RESISTANCE | adipocyte | LIPODYSTROPHY | ADIPOCYTE DIFFERENTIATION | PPAR-GAMMA | ADD1/SREBP1 | CCAAT/enhancer-binding protein (C/EBP) | MICE | ADIPOSE-TISSUE | CCAAT-Enhancer-Binding Protein-alpha - metabolism | Humans | Adipocytes - cytology | DNA-Binding Proteins - metabolism | Chromatin Immunoprecipitation | RNA Interference | CCAAT-Enhancer-Binding Protein-delta - metabolism | CCAAT-Enhancer-Binding Proteins - genetics | Sterol Regulatory Element Binding Protein 1 - metabolism | CCAAT-Enhancer-Binding Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Promoter Regions, Genetic | CCAAT-Enhancer-Binding Protein-beta - genetics | Cells, Cultured | Gene Expression Regulation | Proto-Oncogene Proteins - genetics | Transcription Factors - genetics | 3T3-L1 Cells | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | CCAAT-Enhancer-Binding Protein-beta - metabolism | RUNX1 Translocation Partner 1 Protein | Transcription Factors - metabolism | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | CCAAT-Enhancer-Binding Protein-delta - genetics | Adipocytes - metabolism | CCAAT-Enhancer-Binding Protein-alpha - genetics | Protein Binding | Mice | Index Medicus
Journal Article
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