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NEW ENGLAND JOURNAL OF MEDICINE, ISSN 0028-4793, 03/2004, Volume 350, Issue 10, pp. 1013 - 1022
  The single most common cause of the withdrawal or restriction of the use of marketed drugs has been QT-interval prolongation associated with polymorphic... 
ANTIARRHYTHMIC DRUGS | MEDICINE, GENERAL & INTERNAL | TORSADES-DE-POINTES | TRIGGERED ACTIVITY | CARDIAC-ARRHYTHMIA | M-CELLS | CLINICAL-FEATURES | VENTRICULAR ARRHYTHMIAS | ACUTE PROMYELOCYTIC LEUKEMIA | POTASSIUM CHANNEL | ATRIAL-FIBRILLATION | Side effects | Drug therapy | Health risk assessment | Toxicity | Decision making
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 09/2019
Journal Article
1999, Clinical pharmacology, ISBN 9783886036844, Volume 19., v, 52
Book
Circulation, ISSN 0009-7322, 09/2018, Volume 138, Issue 12, pp. 1206 - 1209
Over half a century ago, heart specialists – there were no board certified cardiologists yet – began to report unusual phenotypes like very long QT intervals... 
Editorials | PERIPHERAL VASCULAR DISEASE | CARDIAC & CARDIOVASCULAR SYSTEMS | VARIANTS | ASSOCIATION | DISEASE
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 09/2008, Volume 118, Issue 10, pp. 981 - 982
Journal Article
Cardiovascular Research, ISSN 0008-6363, 04/2019, Volume 115, Issue 5, pp. 895 - 903
Abstract The QT interval, a global index of ventricular repolarization, varies among individuals and is influenced by diverse physiologic and pathophysiologic... 
Cardio-oncology | PI3 Kinase | Arrhythmia | Torsades de pointes | QT Prolongation | TORSADES-DE-POINTES | INTERVAL PROLONGATION | CARDIAC & CARDIOVASCULAR SYSTEMS | CARDIAC REPOLARIZATION | MECHANISM | RISK | POLYMORPHISM | I-KS | POTASSIUM | INHIBITORS | ASSOCIATION
Journal Article
The Lancet, ISSN 0140-6736, 08/2019, Volume 394, Issue 10197, pp. 533 - 540
One of the primary goals of genomic medicine is to improve diagnosis through identification of genomic conditions, which could improve clinical management,... 
STATEMENT | ISSUES | MEDICINE, GENERAL & INTERNAL | RARE | GENETICS | FAMILIES | AMERICAN-COLLEGE | SECONDARY FINDINGS | UTILITY | CLINICAL EXOME | Pregnant women | Genomics | Research institutes | Medicine | Proteins | Genotype & phenotype | Surveillance | Laboratories | Health promotion | Complications | Genomes | Patients | Age | Gene sequencing | Diseases
Journal Article
The Journal of Physiology, ISSN 0022-3751, 06/2017, Volume 595, Issue 12, pp. 4109 - 4115
Journal Article
The Lancet, ISSN 0140-6736, 08/2019, Volume 394, Issue 10198, pp. 604 - 610
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 10/2019, Volume 74, Issue 13, pp. 1667 - 1678
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 03/2004, Volume 350, Issue 10, pp. 1013 - 1022
Journal Article
Heart Rhythm, ISSN 1547-5271, 07/2019, Volume 16, Issue 7, pp. 1091 - 1097
We recently reported a quantitative relationship between the degree of functional perturbation reported in the literature for 356 variants in the cardiac... 
Genetics | hiPSC-CMs | SCN5A/NaV1.5 | Late/persistent current | Human-induced pluripotent stem cell cardiomyocytes | LQT3 | INACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | VARIANTS | LONG QT SYNDROME | CHANNEL MUTATIONS | SCN5A/Na(V)1.5 | ANEMONIA-SULCATA | Medicine, Experimental | Medical research | Analysis | Stem cells
Journal Article
Pediatric Research, ISSN 0031-3998, 04/2019, Volume 85, Issue 5, pp. 602 - 606
BACKGROUND: There are few and conflicting data on the role of cytochrome P450 2D6 (CYP2D6) polymorphisms in relation to risperidone adverse events (AEs) in... 
DRUG-REACTIONS | ANTIPSYCHOTICS | POLYMORPHISMS | PHARMACOKINETICS | SAFETY | TOLERABILITY | PEDIATRICS | WEIGHT-GAIN | PHARMACOGENETICS | PHARMACODYNAMICS | CODEINE THERAPY
Journal Article
The Journal of Physiology, ISSN 0022-3751, 05/2016, Volume 594, Issue 9, pp. 2459 - 2468
Journal Article