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Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2018, Volume 200, Issue 8, pp. 3020 - 3021
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 11/2014, Volume 12, Issue 11 Supplement, pp. PR02 - PR02
Journal Article
Nature Genetics, ISSN 1061-4036, 2014, Volume 46, Issue 4, pp. 364 - 370
The identification of activating NOTCH1 mutations in T cell acute lymphoblastic leukemia (T-ALL) led to clinical testing of g-secretase inhibitors (GSIs) that... 
NOTCH1 | INHIBITION | CHROMATIN | PATHWAY | GENES | GENETICS & HEREDITY | C-MYC | ACUTE MYELOID-LEUKEMIA | CANCER | LENTIVIRAL RNAI LIBRARY | GENOME | Chromatin - metabolism | Humans | Flow Cytometry | Chromatin Immunoprecipitation | Gene Expression Regulation, Neoplastic - drug effects | Indoles | Nuclear Proteins - genetics | Real-Time Polymerase Chain Reaction | Gene Expression Regulation, Neoplastic - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Enzyme-Linked Immunosorbent Assay | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Signal Transduction - genetics | Transcription Factors - genetics | Enzyme Inhibitors - therapeutic use | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Epigenesis, Genetic - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Histones - metabolism | Receptor, Notch1 - antagonists & inhibitors | Receptor, Notch1 - genetics | Chromatin - genetics | Care and treatment | Pharmacology, Experimental | Acute lymphocytic leukemia | Research | Drug resistance | Proteins | Genotype & phenotype | Leukemia | Epigenetics | Genomes | Kinases | Gene expression | Cancer therapies | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7516, pp. 65 - 70
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2014, Volume 111, Issue 40, pp. 14436 - 14441
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is recruited to the TNF receptor 1 to mediate proinflammatory signaling and to regulate... 
Cytokines | Cell death | Bone marrow | Inflammation | Gene expression regulation | Bone marrow cells | Liver cells | Progenitor cells | Apoptosis | Necrosis | Tumor necrosis factor | Programmed necrosis | Hematopoietic failure | PROGENITOR CELLS | KAPPA-B ACTIVATION | DOMAIN KINASE RIP | MULTIDISCIPLINARY SCIENCES | NECROSIS-FACTOR-ALPHA | hematopoietic failure | CELL-DEATH | programmed necrosis | tumor necrosis factor | RECEPTOR-INTERACTING PROTEIN | FANCONI-ANEMIA PATIENTS | TNF-ALPHA | APLASTIC-ANEMIA | Intestinal Mucosa - metabolism | Epithelial Cells - metabolism | Apoptosis - drug effects | Apoptosis - genetics | Estrogen Antagonists - pharmacology | Intestinal Mucosa - cytology | Flow Cytometry | Bone Marrow - metabolism | Epithelial Cells - cytology | Thymus Gland - metabolism | Cytokines - blood | Mice, Inbred C57BL | Cells, Cultured | Inflammation Mediators - blood | Thymus Gland - cytology | Mice, Transgenic | Hematopoietic Stem Cells - metabolism | Spleen - cytology | Mice, Knockout | Tumor Necrosis Factor-alpha - pharmacology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Spleen - metabolism | Bone Marrow - pathology | Hematopoietic Stem Cells - cytology | Tamoxifen - pharmacology | Receptor-Interacting Protein Serine-Threonine Kinases - deficiency | Apoptosis - physiology | Protein research | Physiological aspects | Research | Protein kinases | Health aspects | Diseases | Signal transduction | T cell receptors | Kinases | Rodents | Index Medicus | Biological Sciences
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2017, Volume 67, Issue 1, pp. 5 - 18.e19
Processive elongation of RNA Polymerase II from a proximal promoter paused state is a rate-limiting event in human gene control. A small number of regulatory... 
transcription elongation | core regulatory circuitry | CRBN | targeted degradation | T-ALL | RNA polymerase II | BRD4 | P-TEFb | RNA-POLYMERASE-II | PAUSE | CELLS | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | CEREBLON | E3 UBIQUITIN LIGASE | CELL BIOLOGY | Peptide Hydrolases - genetics | Humans | Multiprotein Complexes | RNA Polymerase II - metabolism | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Transfection | Time Factors | Proteolysis | HEK293 Cells | Female | Antineoplastic Agents - pharmacology | Protein Stability | Nuclear Proteins - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Peptide Hydrolases - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Cyclin-Dependent Kinase 9 - genetics | Jurkat Cells | HCT116 Cells | Mice, Transgenic | Nuclear Proteins - metabolism | Gene Expression Regulation, Leukemic | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mice, SCID | Transcription Elongation, Genetic - drug effects | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Animals | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Mice, Inbred NOD | Cyclin-Dependent Kinase 9 - metabolism | Proteins | Promoters (Genetics) | RNA | Analysis | Leukemia | Genetic transcription | Research institutes | T cells | Index Medicus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2016, Volume 113, Issue 52, pp. 15024 - 15029
The p53 tumor suppressor acts as a guardian of the genome by preventing the propagation of DNA damage-induced breaks and mutations to subsequent generations of... 
Mdm2 | Tumorigenesis | C-Abl | DNA damage | P53 | ACTIVATION | INDUCED APOPTOSIS | DNA-DAMAGE RESPONSE | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | c-Abl | RADIATION | p53 | LYMPHOMAGENESIS | IN-VIVO | ATM | SENESCENCE | tumorigenesis | STRESS | Physiological aspects | Phosphorylation | Observations | Tumor proteins | Phosphotransferases | Rodents | Mutation | Cells | Tumors | Apoptosis | Index Medicus | Biological Sciences
Journal Article
by Townsend, Elizabeth C and Murakami, Mark A and Murakami, Masato and Christodoulou, Alexandra and Christie, Amanda L and Köster, Johannes and DeSouza, Tiffany A and Morgan, Elizabeth A and Kallgren, Scott P and Liu, Huiyun and Wu, Shuo-Chieh and Plana, Olivia and Montero, Joan and Stevenson, Kristen E and Rao, Prakash and Vadhi, Raga and Andreeff, Michael and Armand, Philippe and Ballen, Karen K and Barzaghi-Rinaudo, Patrizia and Cahill, Sarah and Clark, Rachael A and Cooke, Vesselina G and Davids, Matthew S and DeAngelo, Daniel J and Dorfman, David M and Eaton, Hilary and Ebert, Benjamin L and Etchin, Julia and Firestone, Brant and Fisher, David C and Freedman, Arnold S and Galinsky, Ilene A and Gao, Hui and Garcia, Jacqueline S and Garnache-Ottou, Francine and Graubert, Timothy A and Gutierrez, Alejandro and Halilovic, Ensar and Harris, Marian H and Herbert, Zachary T and Horwitz, Steven M and Inghirami, Giorgio and Intlekofer, Andrew M and Ito, Moriko and Izraeli, Shai and Jacobsen, Eric D and Jacobson, Caron A and Jeay, Sébastien and Jeremias, Irmela and Kelliher, Michelle A and Koch, Raphael and Konopleva, Marina and Kopp, Nadja and Kornblau, Steven M and Kung, Andrew L and Kupper, Thomas S and LeBoeuf, Nicole R and LaCasce, Ann S and Lees, Emma and Li, Loretta S and Look, A. Thomas and Muschen, Markus and Neuberg, Donna and Ng, Samuel Y and Odejide, Oreofe O and Orkin, Stuart H and Paquette, Rachel R and Place, Andrew E and Roderick, Justine E and Ryan, Jeremy A and Sallan, Stephen E and Shoji, Brent and Silverman, Lewis B and Soiffer, Robert J and Steensma, David P and Stegmaier, Kimberly and Stone, Richard M and Tamburini, Jerome and Thorner, Aaron R and van Hummelen, Paul and Wadleigh, Martha and Wiesmann, Marion and Weng, Andrew P and Wuerthner, Jens U and Williams, David A and Wollison, Bruce M and Lane, Andrew A and Letai, Anthony and Bertagnolli, Monica M and Ritz, Jerome and Brown, Myles and Long, Henry and Aster, Jon C and Shipp, Margaret A and Griffin, James D and Weinstock, David M
Cancer Cell, ISSN 1535-6108, 04/2016, Volume 29, Issue 4, pp. 574 - 586
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 04/2018, Volume 200, Issue 8, pp. 3020 - 3021
Journal Article