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Methods in Molecular Biology, ISSN 1064-3745, 2019, Volume 1878, pp. 125 - 137
Journal Article
Nature Biotechnology, ISSN 1087-0156, 03/2018, Volume 36, Issue 3, pp. 265 - 271
Despite the utility of CRISPR-Cas9 nucleases for genome editing, the potential for off-target activity limits their application, especially for therapeutic... 
CRISPR-CAS SYSTEMS | MUTAGENESIS | RNA | GENOME MODIFICATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | HUMAN-CELLS | GENE DISRUPTION | ZINC-FINGER NUCLEASES | SACCHAROMYCES-CEREVISIAE | SEQ | DELIVERY | Genetic variation | Streptococcus pyogenes | Genetic aspects | Nucleotide sequencing | Observations | Methods | DNA sequencing | CRISPR | Yeast | Therapeutic applications | Editing | Cleavage | Genomes | Mutation | Kinases
Journal Article
Nature Communications, ISSN 2041-1723, 05/2017, Volume 8, Issue 1, p. 15334
In vivo application of the CRISPR-Cas9 technology is still limited by unwanted Cas9 genomic cleavages. Long-term expression of Cas9 increases the number of... 
SYSTEM | STAPHYLOCOCCUS-AUREUS CAS9 | HUMAN GENOME | SPECIFICITY | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | RNA-GUIDED ENDONUCLEASE | CRISPR-CAS9 | PROTEINS | MODULATION | NUCLEASES
Journal Article
Bioinformatics, ISSN 1367-4803, 08/2017, Volume 33, Issue 15, pp. 2402 - 2404
Whole exome sequencing (WES) is widely utilized both in translational cancer genomics studies and in the setting of precision medicine. Stratification of... 
SNP DATA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | Applications Notes
Journal Article
Journal Article
Cell, ISSN 0092-8674, 04/2013, Volume 153, Issue 3, pp. 666 - 677
Journal Article
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2017, Volume 35, Issue 15_suppl, pp. 5011 - 5011
Journal Article
Journal of experimental & clinical cancer research : CR, ISSN 1756-9966, 05/2019, Volume 38, Issue 1, pp. 222 - 12
The third generation Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI) osimertinib has been initially approved for T790M positive... 
Chemotherapy | Epidermal growth factor | Lung cancer | Cloning | Mutation | Kinases | Tumors | Apoptosis | Resistance | Osimertinib | Epidermal Growth Factor Receptor | Non-Small Cell Lung Cancer | Pemetrexed | Cisplatin
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, p. e29716
Journal Article