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1. Climate change science and policy
by Schneider, Stephen Henry
2010, ISBN 9781597265669, xix, 522
International cooperation | Environmental policy | Environmental aspects | Climatic changes | Science and state | Greenhouse gases | Government policy
Book
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2. Full Text Systematic RNA interference reveals that oncogenic KRAS -driven cancers require TBK1
by Kim, So Young and Sabatini, David M and Michel, Kathrin and Tamayo, Pablo and Weir, Barbara A and Le, Hanh and Mermel, Craig and Gupta, Piyush B and Meyerson, Matthew and Hahn, William C and Schinzel, Anna C and Hoersch, Sebastian and Lander, Eric S and Sandy, Peter and Mesirov, Jill P and Sheng, Qing and Boehm, Jesse S and Meylan, Etienne and Gilliland, D. Gary and Barbie, David A and Sos, Martin L and Fröhling, Stefan and Chan, Edmond M and Wittner, Ben S and Ramaswamy, Sridhar and Livingston, David M and Root, David E and Reiling, Jan H and Wadlow, Raymond C and Dunn, Ian F and Thomas, Roman K and Scholl, Claudia and Moody, Susan E and Silver, Serena J and Jacks, Tyler
Nature (London), ISSN 0028-0836, 11/2009, Volume 462, Issue 7269, pp. 108 - 112
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Biological and medical sciences | General aspects | Carcinogenesis, carcinogens and anticarcinogens | Medical sciences | Tumors | Lung Neoplasms - genetics | Neoplasms - metabolism | Signal Transduction | Cell Survival | Humans | Lung Neoplasms - metabolism | Proto-Oncogene Proteins c-rel - metabolism | Lung Neoplasms - pathology | Gene Expression Profiling | Oncogene Protein p21(ras) - metabolism | Genes, Lethal | Neoplasms - genetics | RNA Interference | Alleles | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Line, Tumor | Neoplasms - pathology | bcl-X Protein - metabolism | Protein-Serine-Threonine Kinases - metabolism | Apoptosis | Genes, ras - genetics | Oncogene Protein p21(ras) - genetics | Cancer patients | Care and treatment | Genetic aspects | Research | Cancer | Proteins | Genes | Kinases | Cells | Methods | Index Medicus
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3. A Search for Belonging: David Foster Wallace's Fictional Communities
by Root, Colbert
2018, Volume 79, Issue 5
prose | Television and U.S. Fiction | Wallace, David Foster | "E Unibus Pluram | consumer society | postmodernist fiction | national culture | television viewing | 1900-1999 | community | Infinite Jest | American literature
Dissertation
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4. Full Text Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
by Ophir Shalem and Neville E. Sanjana and Ella Hartenian and Xi Shi and David A. Scott and Tarjei S. Mikkelsen and Dirk Heckl and Benjamin L. Ebert and David E. Root and John G. Doench and Feng Zhang
Science (American Association for the Advancement of Science), ISSN 0036-8075, 1/2014, Volume 343, Issue 6166, pp. 84 - 87
T lymphocytes | HEK293 cells | Genetic vectors | Genomics | REPORTS | Cell lines | Stem cells | Melanoma | Genetic loci | Genetic mutation | Genetic screening | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Genome-Wide Association Study | Gene Library | raf Kinases - antagonists & inhibitors | Humans | Selection, Genetic | Cell Survival - genetics | Mediator Complex - genetics | Genetic Loci | Transcription Factors - genetics | Gene Knockout Techniques | Genes, Neurofibromatosis 1 | Genes, Neurofibromatosis 2 | Genetic Testing - methods | Lentivirus | Cullin Proteins - genetics | Pluripotent Stem Cells - metabolism | Drug Resistance, Neoplasm - genetics | Sulfonamides - therapeutic use | Melanoma - genetics | Protein Kinase Inhibitors - therapeutic use | Melanoma - drug therapy | Adaptor Proteins, Signal Transducing - genetics | Clustered Regularly Interspaced Short Palindromic Repeats | Indoles - therapeutic use | RNA sequencing | Genome-wide association studies | Research | Studies | Genetic engineering | Pharmaceutical sciences | Index Medicus
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5. Full Text COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
by Emery, Caroline M and Hieronymus, Haley and Zhao, Jean J and Boehm, Jesse S and Golub, Todd and Yang, Xiaoping and Root, David E and Roberts, Thomas M and Hahn, William C and Hill, David E and Wilson, Christopher J and Weber, Barbara L and Garraway, Levi A and Johnson, Laura A and Kim, Sungjoon and Harris, Jennifer L and Kim, So Young and Vidal, Marc and Finan, Peter M and Myer, Vic E and Sellers, William R and Barretina, Jordi and Alkan, Ozan and Thomas, Sapana R and Wardwell, Leslie and Cogdill, Alexandria P and Dummer, Reinhard and Schlegel, Robert and Stransky, Nicolas and Flaherty, Keith T and Wargo, Jennifer A and Murray, Ryan R and Johannessen, Cory M and Salehi-Ashtiani, Kourosh and Caponigro, Giordano
Nature (London), ISSN 0028-0836, 12/2010, Volume 468, Issue 7326, pp. 968 - 972
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Allosteric Regulation | Humans | Gene Expression Regulation, Neoplastic | Melanoma - enzymology | Gene Expression Profiling | MAP Kinase Signaling System | Mitogen-Activated Protein Kinase Kinases - metabolism | Melanoma - genetics | Indoles - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Gene Library | Proto-Oncogene Proteins c-raf - genetics | MAP Kinase Kinase Kinases - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | Clinical Trials as Topic | MAP Kinase Kinase Kinases - metabolism | Enzyme Activation - drug effects | Open Reading Frames - genetics | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Indoles - therapeutic use | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinases - metabolism | Protein research | Research | Properties | Protein kinases | Cancer cells | Cell lines | Biochemistry | Mutation | Kinases | Genes | Cancer | Index Medicus
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6. Full Text Identification of an oncogenic RAB protein
by Douglas B. Wheeler and Roberto Zoncu and David E. Root and David M. Sabatini and Charles L. Sawyers
Science (American Association for the Advancement of Science), ISSN 0036-8075, 10/2015, Volume 350, Issue 6257, pp. 211 - 217
REPORTS | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Neoplasms - metabolism | Oncogene Proteins - genetics | RNA, Small Interfering - genetics | Immunoprecipitation | TOR Serine-Threonine Kinases - metabolism | Humans | rab GTP-Binding Proteins - genetics | Phosphatidylinositol 3-Kinases - metabolism | Mechanistic Target of Rapamycin Complex 2 | Multiprotein Complexes - metabolism | Phosphorylation - genetics | Neoplasms - genetics | RNA Interference | Gene Deletion | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | rab GTP-Binding Proteins - metabolism | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Oncogene Proteins - metabolism | Protein Transport | Alleles | Cell Line, Tumor | Mutation | Neoplasms - pathology | Lysosomal-Associated Membrane Protein 2 - metabolism | G proteins | Identification and classification | Health aspects | Oncogenes | Proteins | Cellular biology | Ribonucleic acid--RNA | Genes | Index Medicus | Mutations | Phosphorylation | Regulators | Receptors | Pathways | Kinases | Tumors
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7. Full Text Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities
by Sanson, Kendall R and Hanna, Ruth E and Hegde, Mudra and Donovan, Katherine F and Strand, Christine and Sullender, Meagan E and Vaimberg, Emma W and Goodale, Amy and Root, David E and Piccioni, Federica and Doench, John G
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5416 - 15
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Genomic Library | Streptococcus pyogenes | CRISPR-Associated Protein 9 | CRISPR-Cas Systems | CRISPR | RNA-mediated interference | Genes | Positive selection | Interrogation | Libraries | Genomes | Negative selection | Open reading frames | Perturbation | Genetic screening | Geckos | Index Medicus
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8. Full Text A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles
by Subramanian, Aravind and Narayan, Rajiv and Corsello, Steven M and Peck, David D and Natoli, Ted E and Lu, Xiaodong and Gould, Joshua and Davis, John F and Tubelli, Andrew A and Asiedu, Jacob K and Lahr, David L and Hirschman, Jodi E and Liu, Zihan and Donahue, Melanie and Julian, Bina and Khan, Mariya and Wadden, David and Smith, Ian C and Lam, Daniel and Liberzon, Arthur and Toder, Courtney and Bagul, Mukta and Orzechowski, Marek and Enache, Oana M and Piccioni, Federica and Johnson, Sarah A and Lyons, Nicholas J and Berger, Alice H and Shamji, Alykhan F and Brooks, Angela N and Vrcic, Anita and Flynn, Corey and Rosains, Jacqueline and Takeda, David Y and Hu, Roger and Davison, Desiree and Lamb, Justin and Ardlie, Kristin and Hogstrom, Larson and Greenside, Peyton and Gray, Nathanael S and Clemons, Paul A and Silver, Serena and Wu, Xiaoyun and Zhao, Wen-Ning and Read-Button, Willis and Wu, Xiaohua and Haggarty, Stephen J and Ronco, Lucienne V and Boehm, Jesse S and Schreiber, Stuart L and Doench, John G and Bittker, Joshua A and Root, David E and Wong, Bang and Golub, Todd R
Cell (Cambridge), ISSN 0092-8674, 11/2017, Volume 171, Issue 6, pp. 1437 - 1452.e17
chemical biology | gene expression profiling | Functional genomics | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Sequence Analysis, RNA - methods | Pharmaceutical Preparations - metabolism | Small Molecule Libraries | Humans | Cell Line, Tumor | Drug Resistance, Neoplasm | Gene Expression Profiling - economics | Gene Expression Profiling - methods | Sequence Analysis, RNA - economics | Organ Specificity | Neoplasms - drug therapy | RNA sequencing | Gene expression | Genes | Index Medicus
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9. Nonlinear transistor model parameter extraction techniques
by Rudolph, Matthias and Fager, Christian and Root, David E
2011, The Cambridge RF and microwave engineering series, ISBN 0521762103, xiv, 352
Transistors | Mathematical models | Electronic circuit design | Elektroteknik och elektronik | Other Electrical Engineering, Electronic Engineering, Information Engineering | Control Engineering | Electrical Engineering, Electronic Engineering, Information Engineering | Reglerteknik | Annan elektroteknik och elektronik
Book
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10. Full Text The bromodomain protein Brd4 insulates chromatin from DNA damage signalling
by Floyd, Scott R and Pacold, Michael E and Huang, Qiuying and Clarke, Scott M and Lam, Fred C and Cannell, Ian G and Bryson, Bryan D and Rameseder, Jonathan and Lee, Michael J and Blake, Emily J and Fydrych, Anna and Ho, Richard and Greenberger, Benjamin A and Chen, Grace C and Maffa, Amanda and Del Rosario, Amanda M and Root, David E and Carpenter, Anne E and Hahn, William C and Sabatini, David M and Chen, Clark C and White, Forest M and Bradner, James E and Yaffe, Michael B
Nature (London), ISSN 0028-0836, 2013, Volume 498, Issue 7453, pp. 246 - 250
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Chromatin - metabolism | Transcription Factors - chemistry | Histones - chemistry | Humans | Transcription Factors - deficiency | DNA Repair - radiation effects | Positive Transcriptional Elongation Factor B - metabolism | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | Protein Isoforms - metabolism | Chromatin Assembly and Disassembly - radiation effects |