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Handbook of Experimental Pharmacology, ISSN 0171-2004, 2018, Volume 247, pp. 53 - 70
Very few discoveries in the neurosciences have triggered clinical speculation and experimentation regarding the etiology of psychiatric illness to the same... 
Synthetic opioids | Enkephalinases | Aminopeptidase inhibition | Dopamine | DENKIs, Dual enkephalinase inhibitor | Endogenous opioids peptides | Enkephalin | Depression
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2017, Volume 27, Issue 16, p. 3883
New neprilysin inhibitors containing an [alpha]-mercaptoketone HSC(R.sup.1R.sup.2)CO group, as zinc ligand were designed. Two parameters were explored for... 
Zinc compounds | High performance liquid chromatography
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 02/2001, Volume 306, Issue 3, pp. 443 - 454
Journal Article
Journal Article
Endocrinology, ISSN 0013-7227, 01/2018, Volume 159, Issue 1, pp. 238 - 247
Hyperaldosteronism is associated with hypertension, cardiac hypertrophy, and congestive heart failure. Steroidogenic factors facilitate aldosterone secretion... 
STEROIDOGENESIS | ALDOSTERONE RELEASE | STEROID-SECRETION | ENDOCRINOLOGY & METABOLISM | RAT ADRENALS | AMINOPEPTIDASE | MEDIUM FLOW-RATE | BLOOD-FLOW | RECEPTORS | GLAND | ENDOTHELIAL NITRIC-OXIDE | Endothelium, Vascular - cytology | Gene Expression Regulation, Enzymologic - drug effects | Abattoirs | Muscle, Smooth, Vascular - metabolism | Zona Glomerulosa - drug effects | Adrenal Cortex - metabolism | Endothelium, Vascular - drug effects | Peptide Fragments - pharmacology | Protease Inhibitors - pharmacology | Aldosterone - metabolism | Cattle | Adrenal Cortex - drug effects | Aminopeptidases - metabolism | Arterioles - cytology | Muscle, Smooth, Vascular - drug effects | Aminopeptidases - genetics | Angiotensin II - pharmacology | Peptide Fragments - metabolism | Angiotensin II - metabolism | Cells, Cultured | Zona Glomerulosa - metabolism | Adrenal Cortex - blood supply | Aminopeptidases - antagonists & inhibitors | Angiotensin II - analogs & derivatives | Angiotensin I - metabolism | Muscle, Smooth, Vascular - cytology | Arterioles - drug effects | Zona Glomerulosa - cytology | Angiotensin III - metabolism | Angiotensin II - chemistry | Animals | Arterioles - metabolism | Endothelium, Vascular - metabolism | Peptide Fragments - antagonists & inhibitors | Vasodilation - drug effects | In Vitro Techniques | Angiotensin I - antagonists & inhibitors | Heart | Enzyme activity | Angiotensin III | Adrenal glands | Eicosanoids | Congestive heart failure | Aldosterone | Arteries | Receptors | Enzymatic activity | Metabolites | Adrenal gland | Angiotensin II | Hypertension | Peptidase | Secretion | Cortex | Mass spectroscopy | Liquid chromatography | Metabolism | Blood flow | Angiotensin | Aminopeptidase | Mass spectrometry | Adrenal metabolism | Hypertrophy | Veins & arteries
Journal Article
FASEB Journal, ISSN 0892-6638, 12/2012, Volume 26, Issue 12, pp. 5161 - 5171
Inflammatory pain can be controlled by endogenous opioid peptides. Here we blocked the degradation of opioids in peripheral injured tissue to locally augment... 
Immune cells | Analgesia | Ory nerves | DEGRADING ENZYMES | NEUROGENIC INFLAMMATION | SYNOVIAL-FLUID | CATABOLIZING ENZYMES | BIOCHEMISTRY & MOLECULAR BIOLOGY | analgesia | immune cells | SPINAL-CORD | BETA-ENDORPHIN | sensory nerves | CELL BIOLOGY | RECEPTORS MEDIATING ANTINOCICEPTION | BIOLOGY | INFLAMMATORY PAIN | RAT-BRAIN | NEUTRAL ENDOPEPTIDASE ENKEPHALINASE | Leucine - pharmacology | Opioid Peptides - pharmacology | Rats, Wistar | Thiorphan - pharmacology | Opioid Peptides - immunology | Male | Enkephalin, Methionine - pharmacology | Leukocytes - enzymology | Enkephalin, Methionine - metabolism | Dose-Response Relationship, Drug | Narcotic Antagonists | Alanine - analogs & derivatives | Enkephalin, Methionine - immunology | Hindlimb - physiopathology | Inflammation - complications | Flow Cytometry | Pain - complications | Pain - enzymology | Enkephalin, Leucine - pharmacology | Antibodies - immunology | Pain Threshold - drug effects | Dynorphins - metabolism | Neurons - drug effects | Leucine - analogs & derivatives | Alanine - pharmacology | Receptors, Opioid - metabolism | Amino Acid Sequence | Enkephalin, Leucine - metabolism | Pain - prevention & control | CD13 Antigens - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Hindlimb - innervation | Enkephalin, Leucine - immunology | Neprilysin - metabolism | CD13 Antigens - metabolism | Opioid Peptides - metabolism | Antibodies - pharmacology | Dynorphins - immunology | Animals | Neurons - enzymology | Phosphinic Acids - pharmacology | Neprilysin - antagonists & inhibitors | Hindlimb - drug effects | Leukocytes - drug effects | Dynorphins - pharmacology | Inflammation - prevention & control | Inflammation - enzymology
Journal Article
Pharmacology Research & Perspectives, 03/2015, Volume 3, Issue 2
The peripheral endogenous opioid system is critically involved in neuropathic and inflammatory pain generation as suggested by the modulation of opioid... 
Pain | Nuclear magnetic resonance--NMR | Narcotics | Analgesics | Spectrum analysis | Physiology | Inflammation | Chromatography
Journal Article
Hypertension, ISSN 0194-911X, 08/2012, Volume 60, Issue 2, pp. 411 - 418
Brain renin-angiotensin system hyperactivity has been implicated in the development and maintenance of hypertension. We reported previously in the brain that... 
blood pressure | brain renin-Angiotensin system | aminopeptidase A inhibitors | hypertension | spontaneously hypertensive rats | brain renin-angiotensin system | BRAIN ANGIOTENSIN | IDENTIFICATION | BLOOD-PRESSURE | VASOPRESSIN RELEASE | SALT HYPERTENSION | SARALASIN | NUCLEI | RENIN-ANGIOTENSIN SYSTEM | PERIPHERAL VASCULAR DISEASE | EXPRESSION | CONVERTING-ENZYME | Antihypertensive Agents - pharmacology | Antihypertensive Agents - administration & dosage | Rats, Inbred WKY | Hypertension - drug therapy | Male | Sulfonic Acids - administration & dosage | Enalapril - therapeutic use | Brain - metabolism | Dose-Response Relationship, Drug | Enzyme Inhibitors - administration & dosage | Heart Rate - drug effects | Disulfides - therapeutic use | Glutamyl Aminopeptidase - antagonists & inhibitors | Heart Rate - physiology | Disulfides - pharmacology | Blood Pressure - drug effects | Blood Pressure - physiology | Enalapril - administration & dosage | Disease Models, Animal | Rats, Inbred SHR | Administration, Oral | Enzyme Inhibitors - pharmacology | Glutamyl Aminopeptidase - metabolism | Rats | Renin-Angiotensin System - physiology | Antihypertensive Agents - therapeutic use | Sulfonic Acids - pharmacology | Enzyme Inhibitors - therapeutic use | Hypertension - physiopathology | Animals | Enalapril - pharmacology | Sulfonic Acids - therapeutic use | Renin-Angiotensin System - drug effects | Disulfides - administration & dosage
Journal Article
Medecine/Sciences, ISSN 0767-0974, 05/2012, Volume 28, Issue 5, pp. 476 - 478
Journal Article
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 04/2009, Volume 109, Issue 1, pp. 248 - 256
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2008, Volume 383, Issue 5, pp. 1112 - 1128
The human immunodeficiency virus type 1 nucleocapsid protein (NCp7) plays an important role in the second strand transfer during reverse transcription. It... 
HIV-1 | nuclear Overhauser enhancement | Rh6G | stem–loop | TOCSY | nuclear Overhauser enhancement spectroscopy | human immunodeficiency virus type 1 | isothermal titration calorimetry | fluorescence correlation spectroscopy | nuclear magnetic resonance (NMR) | 6-carboxyrhodamine | PBS | NOE | ROESY | human immunodeficiency virus type 1 (HIV-1) | DABCYL | rotating frame Overhauser effect spectroscopy | primer binding site (PBS) | exchange spectroscopy | FCS | ITC | EXSY | nucleocapsid protein (NCp7) | NOESY | total correlated spectroscopy | exchange | primer-binding site | 4-(4′-dimethylaminophenylazo)benzoic acid | stem-loop | TERMINAL ZINC-FINGER | NMR-SPECTROSCOPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACID CHAPERONE FUNCTION | COMPLEMENTARY SEQUENCE | DNA-SYNTHESIS | HUMAN-IMMUNODEFICIENCY-VIRUS | NUCLEIC-ACIDS | STEM-LOOP SL2 | primer bixiding site (PBS) | RNA PACKAGING SIGNAL | PLUS-STRAND TRANSFER | Amino Acid Sequence | Sequence Deletion | Magnetic Resonance Spectroscopy | Protein Structure, Secondary | RNA, Transfer - metabolism | Molecular Sequence Data | Spectrometry, Fluorescence | Nucleocapsid Proteins - chemistry | gag Gene Products, Human Immunodeficiency Virus - chemistry | DNA Primers - genetics | DNA Primers - chemistry | Reverse Transcription | gag Gene Products, Human Immunodeficiency Virus - metabolism | Nucleocapsid Proteins - metabolism | HIV-1 - chemistry | Base Sequence | DNA Primers - metabolism | Protein Binding | Titrimetry | Nucleic Acid Conformation | Binding Sites | Dimerization
Journal Article