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Alcoholism: Clinical and Experimental Research, ISSN 0145-6008, 05/2016, Volume 40, Issue 5, pp. 945 - 954
Journal Article
Psychopharmacology, ISSN 0033-3158, 7/2007, Volume 193, Issue 1, pp. 121 - 136
Data from both preclinical and clinical studies have provided proof of concept that modulation of limbic and forebrain glutamate, via mGlu2/3 receptor... 
Animal models | Biomedicine | mGlu2/3 receptor agonist | Schizophrenia | Antipsychotic | Anxiety | Pharmacology/Toxicology | Psychiatry | Psychiatric disorders | Anxiolytic | Metabotropic glutamate (mGlu) receptors | MGlu2/3 receptor agonist | SINGLY HOUSED MICE | animal models | METABOTROPIC GLUTAMATE-RECEPTOR | RAT | PSYCHIATRY | ACID LY354740 | schizophrenia | metabotropic glutamate (mGlu) receptors | NEUROSCIENCES | NUCLEUS-ACCUMBENS | PHENCYCLIDINE | anxiety | MESSENGER-RNA | MEDIAL PREFRONTAL CORTEX | PHARMACOLOGY & PHARMACY | antipsychotic | anxiolytic | psychiatric disorders | STRESS-INDUCED HYPERTHERMIA | Cyclic S-Oxides - chemistry | Phencyclidine - pharmacology | Rats, Inbred F344 | Motor Activity - drug effects | Male | Amino Acids - pharmacology | Diazepam - pharmacology | Dose-Response Relationship, Drug | Prefrontal Cortex - drug effects | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Behavior, Animal - drug effects | Cyclic S-Oxides - pharmacology | Molecular Structure | Xanthenes - pharmacology | Disease Models, Animal | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Amphetamine - pharmacology | Rats | Rats, Sprague-Dawley | Mental Disorders - psychology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Cyclic S-Oxides - therapeutic use | Animals | Mental Disorders - drug therapy | Prefrontal Cortex - metabolism | Mice | Receptors, Metabotropic Glutamate - agonists | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Neurology | Brain | Pharmacology | Psychology | Rodents | Index Medicus
Journal Article
Neuropharmacology, ISSN 0028-3908, 02/2014, Volume 77, pp. 131 - 144
Journal Article
Frontiers in Neuroscience, ISSN 1662-4548, 2014, Volume 8, Issue 8, pp. 33 - 33
To examine the role of orexin-1 and orexin-2 receptor activity on ethanol self-administration, compounds that differentially target orexin (OX) receptor... 
P rat | Ethanol consumption | Hypocretins/orexins | Operant progressive ratio | C57BL/6J mouse | SYSTEM | ACTIVATION | AROUSAL | ethanol consumption | INVOLVEMENT | REWARD | NEUROSCIENCES | ADDICTION | operant progressive ratio | OREXIN/HYPOCRETIN | ALCOHOL-SEEKING | hypocretins/orexins | NEURONS | PREFERRING P RATS | C57BL6J mouse
Journal Article
Pharmacology & therapeutics, ISSN 0163-7258, 3/2014, Volume 141, Issue 3, pp. 283 - 299
Nociceptin/Orphanin FQ (N/OFQ) is a 17 amino acid peptide that was deorphanized in 1995. The generation of specific agonists, antagonists and receptor... 
Nociceptin | Orphanin FQ | anxiety | stress | alcohol dependence | OFQ | depression | ORL1 | NOP | obesity | drug dependence
Journal Article
Frontiers in Neuroscience, ISSN 1662-4548, 2014, Volume 8, Issue 8, pp. 5 - 5
We describe a novel, potent and selective orexin-2 (OX2)/hypocretin-2 receptor antagonist with in vivo activity in an animal model predictive of... 
Antidepressant | OX2 antagonist | Mouse | Rat | Neuropeptide | Hypocretin | Orexin | DRL | DEPRESSION | SLEEP | rat | INDUCED REINSTATEMENT | neuropeptide | BEHAVIOR | antidepressant | RATS | CEREBROSPINAL-FLUID | KNOCKOUT MICE | NEUROSCIENCES | mouse | hypocretin | NEURONS | orexin | STRESS | RODENT MODEL
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 04/2007, Volume 321, Issue 1, pp. 308 - 317
Journal Article
Pharmacology Research & Perspectives, ISSN 2052-1707, 12/2016, Volume 4, Issue 6, pp. e00275 - n/a
Nociceptin/Orphanin FQ (N/ OFQ ) is a 17 amino acid peptide whose receptor is designated ORL 1 or nociceptin receptor ( NOP ). We utilized a potent, selective,... 
Antidepressant | nociceptin | anxiolytic | LY | 2940094 | LY2940094
Journal Article
International Journal of Neuropsychopharmacology, ISSN 1461-1457, 01/2015, Volume 18, Issue 2, pp. 1 - 11
Journal Article
Journal Article