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Nature, ISSN 0028-0836, 03/2010, Volume 464, Issue 7287, pp. 427 - 430
Tumours with mutant BRAF are dependent on the RAF–MEK–ERK signalling pathway for their growth. We found that ATP-competitive RAF inhibitors inhibit ERK... 
SELECTIVE INHIBITOR | ACTIVATION | MELANOMA | MECHANISM | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | HETERODIMERIZATION | KINASE INHIBITOR | B-RAF | CRAF | ONCOGENIC BRAF | Neoplasms - metabolism | ras Proteins - genetics | Phosphorylation | raf Kinases - antagonists & inhibitors | Humans | Protein Multimerization | Transcriptional Activation - drug effects | ras Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Neoplasms - genetics | Adenosine Triphosphate - metabolism | Indoles - pharmacology | raf Kinases - genetics | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Cell Line | raf Kinases - chemistry | Catalytic Domain | Neoplasms - enzymology | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Animals | MAP Kinase Signaling System - drug effects | Models, Biological | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Cell Line, Tumor | Protein Binding | Mice | Protein Kinase Inhibitors - pharmacology | Protein Kinase Inhibitors - metabolism | Care and treatment | Enzyme inhibitors | Gene mutations | Cellular signal transduction | Genetic aspects | Research | Health aspects | Cancer | Proteins | Competition | Drugs | Mutation | Kinases | Tumors | Index Medicus
Journal Article
Virtual Reality, ISSN 1359-4338, 01/2016, Volume 351, Issue 6273, pp. 1 - 9
Journal Article
Journal of the American Musicological Society, ISSN 0003-0139, 07/1998, Volume 51, Issue 2, pp. 373 - 384
Journal Article
Journal of the American Musicological Society, ISSN 0003-0139, 07/1998, Volume 51, Issue 2, pp. 373 - 384
Journal Article
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7547, pp. 368 - 372
Drug resistance invariably limits the clinical efficacy of targeted therapy with kinase inhibitors against cancer(1,2). Here we show that targeted therapy with... 
CNS CELL-TYPES | MELANOMA | METASTASIS | MICROENVIRONMENT | TRANSLATIONAL PROFILING APPROACH | MULTIDISCIPLINARY SCIENCES | RAF INHIBITOR RESISTANCE | ACQUIRED-RESISTANCE | KINASE INHIBITORS | DRUG-RESISTANCE | CANCER CHEMORESISTANCE | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Clone Cells - drug effects | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Proto-Oncogene Proteins c-fos - deficiency | Adenocarcinoma - metabolism | Neoplasm Metastasis - drug therapy | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Proto-Oncogene Proteins c-akt - metabolism | Melanoma - metabolism | Tumor Microenvironment - drug effects | Cell Survival - drug effects | Melanoma - pathology | Down-Regulation - drug effects | Enzyme Activation - drug effects | Adenocarcinoma - drug therapy | Disease Progression | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Cell Movement - drug effects | Lung Neoplasms - secretion | Melanoma - secretion | Animals | Clone Cells - pathology | Metabolome - drug effects | Signal Transduction - drug effects | Neoplasm Metastasis - pathology | Protein Kinase Inhibitors - therapeutic use | Melanoma - drug therapy | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Adenocarcinoma - secretion | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Antimitotic agents | Pharmaceutical research | Care and treatment | Oncology, Experimental | Dosage and administration | Research | Drug therapy | Drug resistance | Antineoplastic agents | Tumors | Cancer | Melanoma | Mutation | Metastasis | Kinases | Cancer therapies
Journal Article
Science, ISSN 0036-8075, 02/2016, Volume 351, Issue 6273, pp. 604 - 608
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 03/2009, Volume 106, Issue 11, pp. 4519 - 4524
Tumors with mutant BRAF and those with receptor tyrosine kinase (RTK) activation have similar levels of phosphorylated ERK, but only the former depend on ERK... 
Braf mutation | Mitogen-activated protein kinase | Extracellular signal-regulated kinase kinase inhibition | Dual specificity phosphatase | dual specificity phosphatase | mitogen-activated protein kinase, extracellular signal-regulated kinase kinase inhibition | Biological Sciences | BRAF mutation
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2016, Volume 534, Issue 7609, pp. 647 - 651
Therapeutic targeting of KRAS-mutant lung adenocarcinoma represents a major goal of clinical oncology. KRAS itself has proved difficult to inhibit, and the... 
COLON-CANCER | SELECTIVE INHIBITOR | POTENT | FEEDBACK ACTIVATION | MEK INHIBITION | MODELS | RAS | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | MEDIATED REACTIVATION | RECEPTOR TYROSINE KINASE | Lung Neoplasms - drug therapy | Colonic Neoplasms - genetics | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Drug Resistance, Neoplasm | Lung Neoplasms - pathology | Pyridazines - pharmacology | Female | Pyrimidinones - pharmacology | Adenocarcinoma - genetics | Cell Death - drug effects | Imidazoles - therapeutic use | Phosphorylation - drug effects | Pyridazines - therapeutic use | Disease Models, Animal | Lung Neoplasms - genetics | Pancreatic Neoplasms - pathology | Pyrimidinones - therapeutic use | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Mutant Proteins - genetics | Antineoplastic Combined Chemotherapy Protocols | Pancreatic Neoplasms - genetics | Imidazoles - pharmacology | Enzyme Activation - drug effects | Adenocarcinoma - drug therapy | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Xenograft Model Antitumor Assays | Feedback, Physiological | Animals | MAP Kinase Signaling System - drug effects | Colonic Neoplasms - pathology | Cell Proliferation - drug effects | Mice | Pyridones - therapeutic use | Mutation | Pyridones - pharmacology | Drug Screening Assays, Antitumor | Molecular targeted therapy | Care and treatment | Cell death | Lung cancer | Methods | Cancer cells | Phosphorylation | Chemotherapy | Inhibitor drugs | Drug resistance | Tumors
Journal Article
Nature, ISSN 0028-0836, 05/2016, Volume 534, Issue 7606, pp. 272 - 276
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 11 - 15
Journal Article