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Current topics in medicinal chemistry, ISSN 1568-0266, 2013, Volume 13, Issue 15, pp. 1771 - 1786
Tacrine (1) was the first acetylcholinesterase inhibitor (AChEI) introduced in therapy for the treatment of Alzheimer's disease (AD), but similarly to the most... 
Multi-target-directed ligands (MTDLs) | Dual binding acetylcholinesterase inhibitors | Neurodegenerative diseases | Tacrine hybrids | Dedicated to Professor Carlo Melchiorre on the occasion of his 70th birthday | Tacrine homodimers | Tacrine | Tacrine heterodimers | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Calcium Channels - metabolism | Humans | Calcium Channel Blockers - therapeutic use | Receptors, N-Methyl-D-Aspartate - metabolism | Receptor, Muscarinic M1 - antagonists & inhibitors | Enzyme Inhibitors - chemical synthesis | Tacrine - therapeutic use | Amyloid beta-Peptides - metabolism | Drug Design | Tacrine - analogs & derivatives | Calcium Channel Blockers - chemical synthesis | Alzheimer Disease - physiopathology | Alzheimer Disease - drug therapy | Nootropic Agents - therapeutic use | Nootropic Agents - chemical synthesis | Enzyme Inhibitors - therapeutic use | Tacrine - chemical synthesis | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Peptides - antagonists & inhibitors | Alzheimer Disease - metabolism | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Amyloid beta-Peptides - chemistry | Cholinesterases - metabolism | Receptor, Muscarinic M1 - metabolism
Journal Article
Journal of medicinal chemistry, ISSN 1520-4804, 11/2013, Volume 57, Issue 7, pp. 2821 - 2831
Redox impairment is a prominent feature of Alzheimer's disease (AD). It has led to the "oxidative stress hypothesis", which proposes antioxidants as beneficial... 
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Alzheimer Disease - drug therapy | Antioxidants - therapeutic use | Oxidative Stress - drug effects | Humans | Index Medicus
Journal Article
Frontiers in aging neuroscience, ISSN 1663-4365, 2014, Volume 6, pp. 38 - 38
Objective: Given the limited effectiveness of pharmacological treatments, non-pharmacological interventions to treat Alzheimer's disease (AD) have gained... 
Training | Stimulation | Memory | Tdcs | Dementia | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Geriatrics & Gerontology | Science & Technology | Names | Electrical currents | Studies | Neurodegenerative diseases | Rehabilitation | Alzheimers disease | Patients | Alzheimer's disease | training | tDCS | stimulation
Journal Article