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1. Full Text Angina and Future Cardiovascular Events in Stable Patients With Coronary Artery Disease: Insights From the Reduction of Atherothrombosis for Continued Health (REACH) Registry
by Eisen, Alon and Bhatt, Deepak L and Steg, P. Gabriel and Eagle, Kim A and Goto, Shinya and Guo, Jianping and Smith, Sidney C and Ohman, E. Magnus and Scirica, Benjamin M and REACH Registry Investigators and the REACH Registry Investigators
Journal of the American Heart Association, ISSN 2047-9980, 10/2016, Volume 5, Issue 10, p. n/a
Background The extent to which angina is associated with future cardiovascular events in patients with coronary artery disease has long been debated. Methods... 
cardiovascular events | coronary artery disease | angina | Cardiovascular events | Coronary artery disease | Angina | CARDIAC & CARDIOVASCULAR SYSTEMS | OUTPATIENTS | MYOCARDIAL-ISCHEMIA | RISK | SYMPTOMS | RATES | HEART-DISEASE | SOUL | PECTORIS | CLARIFY REGISTRY | CLINICAL-OUTCOMES | United States - epidemiology | Myocardial Infarction - epidemiology | Prognosis | Humans | Middle Aged | Proportional Hazards Models | Hospitalization - statistics & numerical data | Male | Case-Control Studies | Myocardial Revascularization - utilization | Angina, Stable - epidemiology | Cardiovascular Diseases - mortality | Female | Registries | Stroke - epidemiology | Aged | Coronary Artery Disease - epidemiology | Odds Ratio | Heart Failure - epidemiology
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2. Full Text Appropriate Chemotherapy Dosing for Obese Adult Patients With Cancer: American Society of Clinical Oncology Clinical Practice Guideline
by Jennifer J. Griggs and Pamela B. Mangu and Holly Anderson and Edward P. Balaban and James J. Dignam and William M. Hryniuk and Vicki A. Morrison and T. May Pini and Carolyn D. Runowicz and Gary L. Rosner and Michelle Shayne and Alex Sparreboom and Lara E. Sucheston and Gary H. Lyman and American Society of Clinical Oncology
Journal of Clinical Oncology, ISSN 0732-183X, 05/2012, Volume 30, Issue 13, pp. 1553 - 1561
Purpose To provide recommendations for appropriate cytotoxic chemotherapy dosing for obese adult patients with cancer. Methods The American Society of Clinical... 
POSITIVE BREAST-CANCER | CELL LUNG-CANCER | ADJUVANT CHEMOTHERAPY | REFRACTORY PROSTATE-CANCER | MASS INDEX | ONCOLOGY | BODY-SURFACE AREA | TREATMENT-RELATED TOXICITY | NON-HODGKINS-LYMPHOMA | ANTICANCER DRUGS | RECEIVED DOSE INTENSITY | Pharmacogenetics | Body Weight | Obesity - complications | Humans | Treatment Outcome | Practice Patterns, Physicians | Antineoplastic Agents - administration & dosage | Evidence-Based Medicine | Neoplasms - drug therapy | Neoplasms - complications | Drug Dosage Calculations | Antineoplastic Agents - adverse effects | Adult | Antineoplastic Agents - pharmacokinetics | Body Surface Area | Index Medicus
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3. Full Text Neoadjuvant PD-1 Blockade in Resectable Lung Cancer
by Forde, Patrick M and Chaft, Jamie E and Smith, Kellie N and Anagnostou, Valsamo and Cottrell, Tricia R and Hellmann, Matthew D and Zahurak, Marianna and Yang, Stephen C and Jones, David R and Broderick, Stephen and Battafarano, Richard J and Velez, Moises J and Rekhtman, Natasha and Olah, Zachary and Naidoo, Jarushka and Marrone, Kristen A and Verde, Franco and Guo, Haidan and Zhang, Jiajia and Caushi, Justina X and Chan, Hok Yee and Sidhom, John-William and Scharpf, Robert B and White, James and Gabrielson, Edward and Wang, Hao and Rosner, Gary L and Rusch, Valerie and Wolchok, Jedd D and Merghoub, Taha and Taube, Janis M and Velculescu, Victor E and Topalian, Suzanne L and Brahmer, Julie R and Pardoll, Drew M
The New England Journal of Medicine, ISSN 0028-4793, 05/2018, Volume 378, Issue 21, pp. 1976 - 1986
In a pilot study, two doses of neoadjuvant nivolumab administered to patients with resectable lung cancer resulted in a major pathological response in 45% and... 
MISMATCH-REPAIR DEFICIENCY | TRIAL | MEDICINE, GENERAL & INTERNAL | MULTICENTER | PEMBROLIZUMAB | RESPONSE CRITERIA | SOLID TUMORS | IMMUNE CHECKPOINT BLOCKADE | IMMUNOTHERAPY | OPEN-LABEL | CHEMOTHERAPY | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - adverse effects | Aged, 80 and over | Female | Neoadjuvant Therapy | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - surgery | Carcinoma, Non-Small-Cell Lung - genetics | Pilot Projects | B7-H1 Antigen - antagonists & inhibitors | Biopsy | Nivolumab | Lung Neoplasms - surgery | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Drug therapy | Lung cancer | Peptides | PD-1 protein | Body weight | Lymphocytes T | Cancer therapies | Lymphocytes | Immunotherapy | Surgery | Peripheral blood | Drug dosages | Antigens | Lymphatic system | Cell survival | Cloning | Feasibility studies | Non-small cell lung carcinoma | T cell receptors | Gene expression | Patients | Side effects | Chemotherapy | PD-L1 protein | Tumors | Apoptosis
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4. Full Text Bayesian Methods in Regulatory Science
by Rosner, Gary L
Statistics in Biopharmaceutical Research, ISSN 1946-6315, 10/2019, pp. 1 - 7
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5. Bayesian approaches to evaluating doses of drugs
by Rosner, Gary L
Clinical Advances in Hematology and Oncology, ISSN 1543-0790, 04/2018, Volume 16, Issue 4, pp. 258 - 261
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6. Full Text A Bayesian nonparametric causal inference model for synthesizing randomized clinical trial and real‐world evidence
by Wang, Chenguang and Rosner, Gary L
Statistics in Medicine, ISSN 0277-6715, 06/2019, Volume 38, Issue 14, pp. 2573 - 2588
With the wide availability of various real‐world data (RWD), there is an increasing interest in synthesizing information from both randomized clinical trials... 
randomized clinical trial | real‐world evidence | causal inference | Bayesian nonparametric hierarchical model | propensity score | VENTRICULAR SYSTOLIC DYSFUNCTION | REGRESSION | MORTALITY | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | DESIGN | real-world evidence | METAANALYSIS | MEDICAL INFORMATICS | RATIONALE | STATISTICS & PROBABILITY | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | DECISION-MAKING | MATHEMATICAL & COMPUTATIONAL BIOLOGY | ENALAPRIL | Clinical trials | Models
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7. Full Text Phase II Placebo-Controlled Randomized Discontinuation Trial of Sorafenib in Patients With Metastatic Renal Cell Carcinoma
by Mark J. Ratain and Tim Eisen and Walter M. Stadler and Keith T. Flaherty and Stan B. Kaye and Gary L. Rosner and Martin Gore and Apurva A. Desai and Amita Patnaik and Henry Q. Xiong and Eric Rowinsky and James L. Abbruzzese and Chenghua Xia and Ronit Simantov and Brian Schwartz and Peter J. O'Dwyer
Journal of Clinical Oncology, ISSN 0732-183X, 06/2006, Volume 24, Issue 16, pp. 2505 - 2512
This phase II randomized discontinuation trial evaluated the effects of sorafenib (BAY 43-9006), an oral multikinase inhibitor targeting the tumor and... 
Niacinamide - analogs & derivatives | Pyridines - administration & dosage | Drug Administration Schedule | Administration, Oral | Carcinoma, Renal Cell - pathology | Humans | Middle Aged | Male | Treatment Outcome | Phenylurea Compounds | Antineoplastic Agents - administration & dosage | Benzenesulfonates - administration & dosage | Benzenesulfonates - adverse effects | Disease-Free Survival | Pyridines - adverse effects | Antineoplastic Agents - adverse effects | Survival Analysis | Adult | Female | Aged | Carcinoma, Renal Cell - drug therapy | Kidney Neoplasms - drug therapy | Kidney Neoplasms - secondary
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8. Full Text Bayesian Nonparametric Nonproportional Hazards Survival Modeling
by De Iorio, Maria and Johnson, Wesley O and Muller, Peter and Rosner, Gary L
Biometrics, ISSN 0006-341X, 09/2009, Volume 65, Issue 3, pp. 762 - 771
We develop a dependent Dirichlet process model for survival analysis data. A major feature of the proposed approach is that there is no necessity for resulting... 
Censoring | Markov chain Monte Carlo | Dependent Dirichlet process | Reliability functions | Censored data | Point masses | Biometric Methodology | Statistical distributions | Clinical trials | Inference | Censorship | Regression analysis | Modeling | Probabilities | REGRESSION | DISTRIBUTIONS | DIRICHLET PROCESS MIXTURE | BIOLOGY | MATHEMATICAL & COMPUTATIONAL BIOLOGY | STATISTICS & PROBABILITY | ACCELERATED FAILURE-TIME | Data Interpretation, Statistical | Risk Assessment | Computer Simulation | Risk Factors | Bayes Theorem | Endpoint Determination - methods | Proportional Hazards Models | Survival Analysis | Survival Rate | Clinical Trials as Topic | Models, Statistical | Biometry - methods | Monte Carlo method | Analysis | Oncology, Experimental | Markov processes | Models | Research | Public health | Cancer | Index Medicus
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9. Full Text An ANOVA Model for Dependent Random Measures
by De Iorio, Maria and Müller, Peter and Rosner, Gary L and MacEachern, Steven N
Journal of the American Statistical Association, ISSN 0162-1459, 03/2004, Volume 99, Issue 465, pp. 205 - 215
We consider dependent nonparametric models for related random probability distributions. For example, the random distributions might be indexed by a... 
Hierarchical models | Nonparametric Bayes | Dependent Dirichlet process | Simulations | Point masses | Theory and Methods | Statistical distributions | Inference | Nonparametric models | Dosage | Sampling distributions | Modeling | Parametric models | Probabilities | dependent Dirichlet process | NONPARAMETRIC PROBLEMS | PRIORS | MIXTURE | nonparametric Bayes | STATISTICS & PROBABILITY | INFERENCE | BAYESIAN-ANALYSIS | DISTRIBUTIONS | TRIAL | hierarchical models | DIRICHLET PROCESS PRIOR | FUNCTIONALS | SCHEMES | Research | Statistics | Methods | Analysis of variance | Probability | Mathematical models | Random variables | Variance analysis
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10. Full Text Comprehensive Pharmacogenetic Analysis of Irinotecan Neutropenia and Pharmacokinetics
by Federico Innocenti and Deanna L. Kroetz and Erin Schuetz and M. Eileen Dolan and Jacqueline Ramírez and Mary Relling and Peixian Chen and Soma Das and Gary L. Rosner and Mark J. Ratain
Journal of Clinical Oncology, ISSN 0732-183X, 06/2009, Volume 27, Issue 16, pp. 2604 - 2614
Purpose We aim to identify genetic variation, in addition to the UGT1A1*28 polymorphism, that can explain the variability in irinotecan (CPT-11)... 
CELL LUNG-CANCER | GENETIC POLYMORPHISMS | MESSENGER-RNA | ONCOLOGY | SLCO1B1 POLYMORPHISM | RESISTANCE | HUMAN LIVER | EXPRESSION | METASTATIC COLORECTAL-CANCER | FUNCTIONAL-SIGNIFICANCE | JAPANESE SUBJECTS | Multivariate Analysis | Glucuronides - pharmacokinetics | Hepatocyte Nuclear Factor 1-alpha - genetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Biotransformation - genetics | Male | Organic Anion Transporters - metabolism | Patient Selection | Glucuronosyltransferase - genetics | Antineoplastic Agents, Phytogenic - administration & dosage | Organic Anion Transporters - genetics | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Adult | Camptothecin - administration & dosage | Female | Multidrug Resistance-Associated Proteins - genetics | Neutropenia - chemically induced | Neutropenia - genetics | Antineoplastic Agents, Phytogenic - pharmacokinetics | Colorectal Neoplasms - metabolism | Antineoplastic Agents, Phytogenic - adverse effects | Camptothecin - analogs & derivatives | Camptothecin - pharmacokinetics | Camptothecin - adverse effects | Genetic Predisposition to Disease | Drug Administration Schedule | Risk Assessment | Risk Factors | Treatment Outcome | Polymorphism, Genetic | Bilirubin - blood | Phenotype | Glucuronosyltransferase - metabolism | Aged | Solute Carrier Organic Anion Transporter Family Member 1b1 | Multidrug Resistance-Associated Proteins - metabolism | Index Medicus | Original Reports | Gic7 | Faze
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11. Full Text Recruitment and retention of participants in a pragmatic randomized intervention trial at three community health clinics: Results and lessons learned
by Warner, Erica T and Glasgow, Russell E and Emmons, Karen M and Bennett, Gary G and Askew, Sandy and Rosner, Bernard and Colditz, Graham A
BMC Public Health, ISSN 1471-2458, 2013, Volume 13, Issue 1, pp. 192 - 192
Background: Obesity and hypertension and their associated health complications disproportionately affect communities of color and people of lower socioeconomic... 
Hypertension | Obesity | Pragmatic trial | Retention | Weight-loss | Health disparities | Recruitment | PREVENTION | ADULTS | FOLLOW-UP | PREVALENCE | WOMEN | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | COHORT | AFRICAN-AMERICANS | TERM WEIGHT-LOSS | PROGRAM | Community Health Centers - organization & administration | Follow-Up Studies | Humans | Middle Aged | Obesity - ethnology | Hispanic Americans - statistics & numerical data | Male | Patient Selection | African Americans - statistics & numerical data | Weight Reduction Programs - utilization | Time Factors | Hypertension - ethnology | Obesity - prevention & control | Hypertension - prevention & control | Community Health Centers - utilization | Female | Patient Participation - statistics & numerical data | Aged | Program Evaluation | Boston | Poverty - statistics & numerical data | Call centers | Clinics | Community hospitals | Health | Clinical trials | Social medicine | Research | Economic incentives | Health aspects | Studies | Weight control | Womens health | Public health | Intervention | Incentives | Complications | Adaptability | Income | Outsourcing
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12. Full Text A Bayesian design for phase I cancer therapeutic vaccine trials
by Wang, Chenguang and Rosner, Gary L and Roden, Richard B.S
Statistics in Medicine, ISSN 0277-6715, 03/2019, Volume 38, Issue 7, pp. 1170 - 1189
Phase I clinical trials are the first step in drug development to test a new drug or drug combination on humans. Typical designs of Phase I trials use toxicity... 
clinical trial | Phase I | cancer therapeutic vaccine | Bayesian | HPV | MEDICINE, RESEARCH & EXPERIMENTAL | VIRUS | EFFICACY | MEDICAL INFORMATICS | SAFETY | CLINICAL DEVELOPMENT | I/II | CONTINUAL REASSESSMENT METHOD | STATISTICS & PROBABILITY | TOXICITY | IMMUNOGENICITY | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | IMMUNOTHERAPY | MATHEMATICAL & COMPUTATIONAL BIOLOGY | ESCALATION | Clinical trials | Vaccines | Health aspects | Papillomavirus infections | Cancer
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13. Full Text A Bayesian design for phase I cancer therapeutic vaccine trials
: Bayesian Phase I Design for Cancer Therapeutic Vaccine
by Wang, Chenguang and Rosner, Gary L and Roden, Richard B.S
Statistics in Medicine, ISSN 0277-6715, 03/2019, Volume 38, Issue 7, pp. 1170 - 1189
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14. Full Text Individualized treatment effects with censored data via fully nonparametric Bayesian accelerated failure time models
by Henderson, Nicholas C and Louis, Thomas A and Rosner, Gary L and Varadhan, Ravi
Biostatistics (Oxford, England), ISSN 1465-4644, 07/2018
Individuals often respond differently to identical treatments, and characterizing such variability in treatment response is an important aim in the practice of... 
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15. Full Text DPpackage: Bayesian semi- and nonparametric modeling in R
by Jara, Alejandro and Hanson, Timothy E and Quintana, Fernando A and Müller, Peter and Rosner, Gary L
Journal of Statistical Software, ISSN 1548-7660, 2011, Volume 40, Issue 5, pp. 1 - 30
Data analysis sometimes requires the relaxation of parametric assumptions in order to gain modeling flexibility and robustness against mis-specification of the... 
Markov chain monte carlo | Random probability measures | Bayesian semiparametric analysis | Random functions | REGRESSION | DENSITY-ESTIMATION | SURVIVAL ANALYSIS | STATISTICS & PROBABILITY | FRAILTY | INFERENCE | MIXTURES | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | Markov chain Monte Carlo | DIRICHLET PROCESSES | PACKAGE | random functions | POLYA TREE DISTRIBUTIONS | random probability measures | BERNSTEIN POLYNOMIALS
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16. Full Text A Prospective Study of Hippocampal-Sparing Prophylactic Cranial Irradiation (PCI) in Limited Stage Small Cell Lung Cancer (SCLC)
by Redmond, Kristin J., M.D., M.P.H and Hales, Russell K., M.D and Anderson-Keightly, Heather, B.S and Zhou, Xian C., M.S and Kummerlowe, Megan, B.S and Sair, Haris, M.D and Duhon, Mario, B.S and Kleinberg, Lawrence, M.D and Rosner, Gary L., Sc.D and Vannorsdall, Tracy, Ph.D
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2017, Volume 98, Issue 3, pp. 603 - 611
Abstract Objectives Neurocognitive toxicity may be related to hippocampal dose. This prospective study evaluated cognitive function and intra-cranial failure... 
Radiology | Hematology, Oncology and Palliative Medicine | COGNITIVE DYSFUNCTION | ONCOLOGY | NEUROCOGNITIVE FUNCTION | METASTASES | SUBVENTRICULAR ZONE CELLS | MEMORY FUNCTION | NEUROGENESIS | WHOLE-BRAIN RADIOTHERAPY | ADULT MAMMALIAN FOREBRAIN | QUALITY-OF-LIFE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | IMPAIRMENT | Prospective Studies | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Cranial Irradiation - methods | Hippocampus - diagnostic imaging | Small Cell Lung Carcinoma - secondary | Organ Sparing Treatments - methods | Brain Neoplasms - secondary | Cognition - physiology | Adult | Female | Radiotherapy Planning, Computer-Assisted | Cognition - radiation effects | Chemoradiotherapy - methods | Lung Neoplasms - therapy | Brain Neoplasms - prevention & control | Neuropsychological Tests | Small Cell Lung Carcinoma - prevention & control | Disease-Free Survival | Sample Size | Small Cell Lung Carcinoma - pathology | Hippocampus - radiation effects | Aged | Small Cell Lung Carcinoma - therapy | Lung cancer, Small cell | Research | Oncology, Experimental | Radiation | Cancer | Metastasis | IRRADIATION | PATIENTS | NMR IMAGING | GY RANGE | NEOPLASMS | CLINICAL TRIALS | RADIATION HAZARDS | LUNGS | RADIOLOGY AND NUCLEAR MEDICINE | RADIATION DOSES | BRAIN | COMBINED THERAPY
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