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PLoS ONE, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, p. e0160388
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening thrombotic microangiopathy linked to a deficiency in the metalloprotease ADAMTS13. In the... 
VONWILLEBRAND-FACTOR | MYOCARDIAL-INFARCTION | VWF | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MICE | VON-WILLEBRAND-FACTOR | ISCHEMIC-STROKE | FACTOR-CLEAVING PROTEASE | UPSHAW-SCHULMAN SYNDROME | DEFICIENCY | Recombinant Proteins - therapeutic use | Epitope Mapping | Humans | Protein Multimerization | Antibodies, Monoclonal - therapeutic use | Male | von Willebrand Factor - genetics | Recombinant Proteins - biosynthesis | Antigen-Antibody Reactions | ADAMTS13 Protein - blood | Recombinant Proteins - isolation & purification | ADAMTS13 Protein - immunology | Purpura, Thrombotic Thrombocytopenic - drug therapy | Female | Antibodies, Monoclonal - immunology | Disease Models, Animal | Purpura, Thrombotic Thrombocytopenic - metabolism | von Willebrand Factor - metabolism | Reproducibility of Results | Enzyme-Linked Immunosorbent Assay | ADAMTS13 Protein - metabolism | Mice, Knockout | Antibodies, Monoclonal - genetics | Purpura, Thrombotic Thrombocytopenic - pathology | Animals | Platelet Count | Recombinant Proteins - immunology | von Willebrand Factor - chemistry | ADAMTS13 Protein - genetics | Mice | Antibodies, Monoclonal - metabolism | Viral antibodies | Thrombocytopenic purpura | Care and treatment | Von Willebrand factor | Antibodies | Physiological aspects | Genetic aspects | Research | Diagnosis | Thrombotic microangiopathy | Antigens | Animal models | Drug delivery systems | Congenital diseases | Heart attacks | Laboratories | Injection | Thrombosis | Blood clots | Thrombotic thrombocytopenic purpura | Ischemia | Rodents | Medical prognosis | Preeclampsia | Monoclonal antibodies | Life sciences | Metalloproteinase | Mutation | Inhibition | Health risk assessment | Enzyme-linked immunosorbent assay
Journal Article
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 5922 - 5922
Background: Pre-existing neutralizing antibodies (NAbs) are a major hurdle in adeno-associated virus 8 (AAV8) gene therapy and result in patients being... 
Journal Article
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 3356 - 3356
Introduction. Adeno-associated virus (AAV)-based factor VIII (FVIII) gene therapy holds great promise to provide clinical benefit in patients with hemophilia... 
Journal Article
Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 4633 - 4633
Introduction: Adeno-associated virus (AAV)-based factor IX (FIX) gene therapy has the potential to provide clinical benefit in patients with hemophilia B.... 
Journal Article
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 12/2019, Volume 17, Issue 12, pp. 2099 - 2109
Background ADAMTS13, a plasma metalloprotease, cleaves von Willebrand factor (VWF) to regulate its function. Additionally, ADAMTS13 is thought to regulate... 
catalysis‐independent regulation | ADAMTS13 | free thiols | von Willebrand factor | homo‐oligomerization
Journal Article
Haematologica, ISSN 0390-6078, 08/2012, Volume 97, Issue 8, pp. 1181 - 1186
Journal Article
Analytical and Bioanalytical Chemistry, ISSN 1618-2642, 2/2014, Volume 406, Issue 5, pp. 1411 - 1421
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 2238 - 2238
Abstract Thrombotic thrombocytopenic purpura (TTP) is characterized by a functional deficiency in the plasma metalloprotease ADAMTS13, caused by mutations in... 
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 25, pp. 2739 - 2746
ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin motif repeats 13) has antithrombotic properties because it cleaves von Willebrand factor... 
Stroke - blood | Enzyme-Linked Immunosorbent Assay | Humans | Middle Aged | Risk Factors | Proportional Hazards Models | Female | Male | Aged | ADAMTS13 Protein | ADAM Proteins - blood | Cohort Studies
Journal Article