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1. Variation in Akt protein kinases in human populations
by Peter Rotwein
American Journal of Physiology, ISSN 0363-6119, 12/2017, Volume 313, Issue 6, p. R687
The three Akt kinases are related proteins that are essential for normal growth and metabolic regulation and are implicated as key signaling mediators in many... 
Nucleotide sequence | Genomics | Genes | Diabetes mellitus | AKT2 protein | AKT protein | Kinases | Population genetics | 1-Phosphatidylinositol 3-kinase | Amino acid substitution | Proteins | Consortia | Human populations | Molecules | Signaling | Receptors | Period protein | Genetics | Physiology | Mutation | Deoxyribonucleic acid--DNA | Cancer
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2. Full Text Large-scale analysis of variation in the insulin-like growth factor family in humans reveals rare disease links and common polymorphisms
by Rotwein, Peter
The Journal of biological chemistry, ISSN 0021-9258, 06/2017, Volume 292, Issue 22, pp. 9252 - 9261
The insulin-like growth factors IGF1 and IGF2 are closely related proteins that are essential for normal growth and development in humans and other species and... 
Exome | Glycoproteins - genetics | Carrier Proteins - genetics | Insulin-Like Growth Factor II - genetics | Gene Frequency | Humans | Alleles | Receptors, Somatomedin - genetics | Insulin-Like Growth Factor I - genetics | Polymorphism, Genetic | Genomics and Proteomics | growth factor | population genetics | IGF receptor | insulin | insulin-like growth factor (IGF) | human evolution | genomics | functional genomics | IGF binding proteins | human variation
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3. Full Text Erratum: Large-scale analysis of variation in the insulin-like growth factor family in humans reveals rare disease links and common polymorphisms (Journal of Biological Chemistry (2017) 292 (9252–9261))
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 48, p. 19608
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4. Similarity and variation in the insulin-like growth factor 2 - H19 locus in primates
by Peter Rotwein
Physiological Genomics, ISSN 1094-8341, 06/2018, Volume 50, Issue 6, p. 425
Insulin-like growth factor 2 (IGF2), a small, secreted protein, is critical for fetal and prenatal growth in humans and other mammals. The IGF2 gene and its... 
Nucleotide sequence | Exons | Fetuses | Insulin-like growth factors | Mammals | Gene expression | Monkeys & apes | Insulin | Promoters | Conserved sequence | Imprinting | H19 gene | Insulin-like growth factor II | Speciation
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5. Full Text Diversification of the insulin-like growth factor 1 gene in mammals
by Rotwein, Peter
PLoS ONE, ISSN 1932-6203, 12/2017, Volume 12, Issue 12, p. e0189642
Insulin-like growth factor 1 (IGF1), a small, secreted peptide growth factor, is involved in a variety of physiological and patho-physiological processes,... 
MESSENGER-RNAS | IGF-I | FACTOR-I GENE | BINDING-PROTEIN-DELTA | HORMONE RECEPTOR | MULTIDISCIPLINARY SCIENCES | POSTNATAL-GROWTH | TRANSCRIPTION | FUNCTIONAL-ANALYSIS | EXPRESSION | SEXUAL-DIMORPHISM | Cellular signal transduction | Genetic aspects | Research | Mammals | Insulin-like growth factor 1 | Transcription factors | Physiological effects | Peptides | Insulin-like growth factor I | Exons | Genomics | Genes | Lipids | Genomes | Insulin-like growth factors | Kinases | Proteins | Conserved sequence | Rodents | Physiology | Lipid metabolism | Species | Speciation | Deoxyribonucleic acid--DNA | Carbohydrates | Wildlife conservation | Nucleotide sequence | Igf1 gene | Introns | Cascade control | Gene expression | Metabolism | Insulin | Loci | Signaling | Enhancers | Growth hormones | Growth hormone | Evolution & development | Deoxyribonucleic acid | DNA
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6. Full Text Insulinlike Growth Factor 1 Gene Variation in Vertebrates
by Rotwein, Peter
Endocrinology, ISSN 0013-7227, 06/2018, Volume 159, Issue 6, pp. 2288 - 2305
IGF1-a small, single-chain, secreted peptide in mammals-is essential for normal somatic growth and is involved in a variety of other physiological and... 
MESSENGER-RNAS | BODY-WEIGHT | IGF-I | FACTOR-I GENE | BINDING-PROTEIN-DELTA | PROMOTER ELEMENTS | POSTNATAL-GROWTH | ENDOCRINOLOGY & METABOLISM | FUNCTIONAL-ANALYSIS | CARCASS TRAITS | WHOLE-GENOME DUPLICATION | Genetic Variation | Promoter Regions, Genetic | Animals | Vertebrates - classification | Vertebrates - genetics | Exons | Introns | Humans | Insulin-Like Growth Factor I - genetics | Sequence Analysis, DNA | Evolution, Molecular | Reptiles | Insulin-like growth factor I | Igf1 gene | Genes | Gene regulation | Biological evolution | Birds | Homology | Regulatory sequences | Mammals | Kinases | Gene expression | Proteins | Vertebrates | Enhancers | Protein kinase | Janus kinase 2 | Growth hormone | Growth factors
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7. Full Text The insulin-like growth factor 2 gene and locus in nonmammalian vertebrates: Organizational simplicity with duplication but limited divergence in fish
by Rotwein, Peter
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 41, pp. 15912 - 15932
The small, secreted peptide, insulin-like growth factor 2 (IGF2), is essential for fetal and prenatal growth in humans and other mammals. Human IGF2 and mouse... 
gene structure | gene phylogeny | ZEBRAFISH | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | MUSCLE | gene annotation | genetic database | H19 GENE | gene evolution | FACTOR-II GENE | ALLELIC EXPRESSION | GENOME | genetics | EVOLUTION | insulin-like growth factor (IGF) | FACTOR SYSTEM GENES | genomics | phylogenetics | vertebrate speciation | gene expression | IGF-II | Genomics and Proteomics
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8. Full Text The complex genetics of human insulin-like growth factor 2 are not reflected in public databases
by Rotwein, Peter
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 12, pp. 4324 - 4333
Recent advances in genetics present unique opportunities for enhancing knowledge about human physiology and disease susceptibility. Understanding this... 
SEQUENCE ELEMENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | TRANSCRIPTION | DEVELOPMENTAL REGULATION | INITIAL-CHARACTERIZATION | PROMOTER | EXPRESSION | FACTOR-II GENE | IMPRINTED GENES | IGF-II | Genomic Imprinting | Promoter Regions, Genetic | Animals | Insulin-Like Growth Factor II - genetics | Neoplasms - genetics | Humans | Gene Expression Regulation | Mice | RNA, Long Noncoding - genetics | Genome | Databases, Factual | Polymorphism, Genetic | Genomics and Proteomics | human genetics | gene variation | genetics | insulin-like growth factor (IGF) | gene regulation | gene mapping | genomics | gene annotation | genetic database | insulin-like growth factor 2 | gene expression
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9. Full Text Variation in the insulin-like growth factor 1 gene in primates
by Rotwein, Peter
Endocrinology, ISSN 0013-7227, 04/2017, Volume 158, Issue 4, pp. 804 - 814
Insulin-like growth factor 1 (IGF1) is a multifunctional peptide that is involved in a wide range of physiological and pathophysiological processes in many... 
MESSENGER-RNAS | IGF-I | HORMONE | FACTOR-I GENE | BINDING-PROTEIN-DELTA | POSTNATAL-GROWTH | TRANSCRIPTION | ENDOCRINOLOGY & METABOLISM | FUNCTIONAL-ANALYSIS | PROMOTER | EXPRESSION | Papio anubis - genetics | Promoter Regions, Genetic | Cheirogaleidae - genetics | Exons | Introns | Callithrix - genetics | Pan troglodytes - genetics | Databases, Genetic | Insulin-Like Growth Factor I - genetics | Macaca - genetics | Genetic Variation | Gorilla gorilla - genetics | Animals | Enhancer Elements, Genetic | Evolution, Molecular | Similarity | Insulin-like growth factor I | Biological evolution | Insulin-like growth factors | Regulatory sequences | Conserved sequence | Rodents | Primates | Children | Species | Speciation | Deoxyribonucleic acid--DNA | Binding | Level (quantity) | Nucleotide sequence | Tissue engineering | Igf1 gene | Metabolism | Gene expression | Insulin | Monkeys & apes | Loci | Regeneration | Enhancers | Growth hormones | Adults | Growth hormone
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10. Full Text Large-scale analysis of variation in the insulin-like growth factor family in humans reveals rare disease links and common polymorphisms
by Rotwein, Peter
Journal of Biological Chemistry, ISSN 0021-9258, 06/2017, Volume 292, Issue 22, pp. 9252 - 9261
The insulin-like growth factors IGF1 and IGF2 are closely related proteins that are essential for normal growth and development in humans and other species and... 
IGF-BINDING-PROTEINS | EVOLUTION | GENE | HOMOZYGOUS MUTATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | POSTNATAL-GROWTH | RECEPTOR | PATIENT | FACTOR-I | SHORT STATURE | INSIGHTS
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11. Full Text Mapping the growth hormone–Stat5b–IGF-I transcriptional circuit
by Rotwein, Peter
Trends in Endocrinology & Metabolism, ISSN 1043-2760, 2012, Volume 23, Issue 4, pp. 186 - 193
Growth hormone (GH) and insulin-like growth factor-I (IGF-I) exert powerful influences on somatic growth, metabolism, and tissue repair, and have been... 
Endocrinology & Metabolism | INSULIN | LIFE-SPAN | STAT5B | FACTOR-I GENE | ENDOCRINOLOGY & METABOLISM | FUNCTIONAL-ANALYSIS | BINDING-SITES | IDENTIFICATION | EXPRESSION | HORMONE REGULATION | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Growth Hormone - genetics | Animals | Growth Hormone - metabolism | Models, Biological | Humans | Insulin-Like Growth Factor I - genetics | Transcription, Genetic - genetics | Insulin-Like Growth Factor I - metabolism | Physiological aspects | Genetic research | Somatotropin | Genetic aspects | Genetic transcription | Growth | Index Medicus
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12. Full Text Characterizing the complexity of Australian marsupial insulin-like growth factor 1 genes
by Rotwein, Peter
Molecular and Cellular Endocrinology, ISSN 0303-7207, 05/2019, Volume 488, pp. 52 - 69
Insulin-like growth factor 1 (IGF1) actions are essential for somatic growth and tissue repair. gene regulation is controlled by many inputs, with growth... 
Gene evolution | IGF1 | Gene expression | Genomics | Gene regulation | IGF-I | TRANSCRIPTION | MATURATION | FAMILY | CELL BIOLOGY | INSULIN | HORMONE | EVOLUTION | ENDOCRINOLOGY & METABOLISM | EXPRESSION | GROWTH-FACTOR-I | AXIS | Medical colleges | Somatotropin | Anopheles | Messenger RNA | Analysis | Genes | Genetic transcription
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13. Full Text The new genomics: What molecular databases can tell us about human population variation and endocrine disease
by Rotwein, Peter
Endocrinology, ISSN 0013-7227, 07/2017, Volume 158, Issue 7, pp. 2035 - 2042
Major recent advances in genetics and genomics present unique opportunities for enhancing our understanding of human physiology and disease predisposition.... 
ACTIVATION | JAK-STAT PATHWAY | KINASE | ENDOCRINOLOGY & METABOLISM | LARON SYNDROME | GENETIC CAUSES | GROWTH-HORMONE RECEPTOR | DOMAINS | CANCER | DEFICIENCY | INSIGHTS | Databases, Chemical | Human Growth Hormone - genetics | Humans | Signal Transduction - genetics | Endocrine System Diseases - genetics | Genomics - methods | Genomics - trends | Human Growth Hormone - physiology | Genetic Variation - physiology | Receptors, Somatotropin - genetics | Polymorphism, Genetic | Genomics | Kinases | Consortia | Proteins | Human populations | Endocrine systems | Signal transduction | Databases | Janus kinase 2 | Genetics | Physiology | Children | Chromosomes | Protein-tyrosine kinase | Deoxyribonucleic acid--DNA | Tyrosine | Nucleotide sequence | Amino acid sequence | Biological activity | Signaling | Period protein | Human growth hormone | Mutation | Growth hormone | Variation
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14. Full Text Large-scale analysis of variation in the insulin-like growth factor family in humans reveals rare disease links and common polymorphisms (vol 292, pg 9252, 2017)
by Rotwein, P
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 12/2017, Volume 292, Issue 48, pp. 19608 - 19608
BIOCHEMISTRY & MOLECULAR BIOLOGY | Additions and s
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15. Full Text Quantifying promoter‐specific Insulin‐like Growth Factor 1 gene expression by interrogating public databases
by Rotwein, Peter
Physiological Reports, 01/2019, Volume 7, Issue 1, pp. e13970 - n/a
The actions of insulin‐like growth factor 1 (IGF1), a small, secreted protein, are essential for normal somatic growth in children and are important for tissue... 
genomics | IGF1 | Gene expression | gene regulation | Transcription | Insulin-like growth factor I | Igf1 gene | Gene regulation | Liver | Mammals | Ribonucleic acid--RNA | Insulin | Skeletal muscle | Children | Growth factors | Species
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16. Full Text Similarity and variation in the insulin-like growth factor 2 - H19 locus in primates
by Rotwein, Peter
Physiological Genomics, ISSN 1094-8341, 06/2018, Volume 50, Issue 6, pp. 425 - 439
Insulin-like growth factor 2 (IGF2), a small, secreted protein, is critical for fetal and prenatal growth in humans and other mammals. The IGF2 gene and its... 
IGF2 | H19 | Primate evolution | Parental imprinting | Genomics | Gene transcription | gene transcription | PHYSIOLOGY | SEQUENCES | MOUSE | TRANSCRIPTION | DEVELOPMENTAL REGULATION | IDENTIFICATION | FACTOR-II GENE | CELL BIOLOGY | parental imprinting | EVOLUTION | primate evolution | GENETICS & HEREDITY | genomics | INITIAL-CHARACTERIZATION | EXPRESSION | IGF-II
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17. Full Text Variation in the repulsive guidance molecule family in human populations
by Rotwein, Peter
Physiological Reports, 02/2019, Volume 7, Issue 3, pp. e13959 - n/a
Repulsive guidance molecules, RGMA, RGMB, and RGMC, are related proteins discovered independently through different experimental paradigms. They are encoded by... 
population genetics | Genomics | hemochromatosis | hemojuvelin | human variation | repulsive guidance molecule | RGMB | RGMC | RGMA | Alternative splicing | Hemochromatosis | Gene frequency | Amino acid sequence | Physiology | Genomes | Mutation | Ribonucleic acid--RNA | Gene expression | Variation | Population genetics | Genotypes
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