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Drug Metabolism Letters, ISSN 1872-3128, 11/2015, Volume 9, Issue 2, pp. 88 - 98
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 09/2017, Volume 45, Issue 9, pp. 1008 - 1018
Surrogate assays for drug metabolism and inhibition are traditionally performed in buffer systems at pH 7.4, despite evidence that hepatocyte intracellular pH... 
IN-VIVO EXTRAPOLATION | INTRACELLULAR TISSUE WATER | ORAL MIDAZOLAM | HUMAN CYTOCHROME P4502C9 | ENZYME-INHIBITION | SYSTEMIC ANTIMYCOTICS | PHARMACOLOGY & PHARMACY | METABOLIC-CLEARANCE | HUMAN LIVER-MICROSOMES | INTRINSIC CLEARANCE | VITRO DATA | Humans | Warfarin - metabolism | Cytochrome P-450 CYP3A Inhibitors - pharmacokinetics | Dextromethorphan - metabolism | Male | Hepatocytes - metabolism | Testosterone - pharmacokinetics | Warfarin - pharmacology | Testosterone - metabolism | Plasma - metabolism | Drug Interactions | Computer Simulation | Female | Dextromethorphan - pharmacokinetics | Cytochrome P-450 CYP2C9 - metabolism | Diclofenac - analogs & derivatives | Midazolam - pharmacokinetics | Diclofenac - pharmacokinetics | Warfarin - pharmacokinetics | Warfarin - analogs & derivatives | Cytochrome P-450 CYP3A Inhibitors - metabolism | Cytochrome P-450 CYP3A - metabolism | Plasma - enzymology | Midazolam - metabolism | Kinetics | Diclofenac - metabolism | Hepatocytes - enzymology | Hydrogen-Ion Concentration | Protein kinase A | Liver | Amiodarone | Dextromethorphan | Inactivation | pH effects | Diclofenac | Drug metabolism | Inhibition | Nonsteroidal anti-inflammatory drugs | Buffers | Itraconazole | Warfarin | Deactivation | Parameters | Fluconazole | Incubation | Substrate inhibition | Pharmacology | Clozapine | Metabolism | Substrates | Testosterone | Predictions | In vivo methods and tests | Midazolam | Intracellular | Enzyme kinetics | Fluvoxamine | Index Medicus
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 2014, Volume 42, Issue 11, pp. 1921 - 1925
The UDP-glucuronosyltransferase (UGT) enzymes are critical for regulating nutrients, hormones, and endobiotics, as well as for detoxifying xenobiotics. Human... 
Animals | Blastocyst - enzymology | Glucuronosyltransferase - metabolism | Fluorescent Antibody Technique | Glucuronidase - metabolism | Mice | Blotting, Western | Index Medicus | Short Communications
Journal Article
Placenta, ISSN 0143-4004, 2011, Volume 33, Issue 1, pp. 77 - 80
Journal Article
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